INICET NOV 2020

PHARMACOLOGY
A patient was prescribed a high dose of penicillin along with gentamicin.
Which of the following statement is true regarding this
a. TDM must be done for penicillin
b. TDM must be done for gentamicin
c. TDM done for both penicillin and gentamicin
d. TDM need not be done.
A patient is not responding to treatment. Physician suspects sub optimal
drug dose. Which technique used for drug monitoring
a. Flow Cytometry
b. HPLC
c. Spectrophotometry
d. Nuclear magnetic resonance
Analytical methods for monitoring of therapeutic drugs

Although immunoassays are most commonly used for therapeutic drug

monitoring they suffer from many limitations, including interference from
endogenous (high bilirubi n, triglyceride, heterophilic antibody) and exogenous
compounds (drug metabolite).
However, analytical methods such as chromatography and chromatography
combined with tandem mass spectrometry (LC-MS) are advantageous for drug
monitoring because such techniques are less often affected by issues of
interference.
A 15 year old female, complaints of cough and sore
throat. She was prescribed an antibiotic,
following which she came back with the symptoms
as shown in figure. Which drug would have caused
it?
a. Fexofenadine
b. Salbutamol
c. Amoxicillin
d. Corticosteroids
Match the dilution of adrenaline and its route of administration
A. 1: 1000 1. Intra-cardiac

B. 1 : 10,000 2. Intra-muscular
C. 1 : 1,00,000 3. Local Anaesthesia

A. A1,B2,C3
B. A2,B1,C3
C. A2,B3,C1
D. A1,B2,C3
Which of the following drugs worsens myasthenia gravis?
a. Meropenem
b. Alpha blockers
c. Lignocaine
d. Penicillin
Which of the following drugs will not produce fixed dilated pupils?
a. Cocaine
b. Pilocarpine
c. Phenylephrine
d. Amphetamine
Mechanism of anti-migraine drug causing angina like symptoms is:
a. Releases NO
b. Inactivates calcium channel
c. 5-HT agonist
d. 5-HT antagonist
Which of the following drugs is/are used for absence seizures?
1. Carbamazepine
2. Valproate
3. Ethosuximide
4. Gabapentin

a. 1,2 and 3
b. 2,3 only
c. 2 only
d. 4 only
Drugs causing least sexual side effects:
a. Fluoxetine
b. Venlafaxine
c. Mirtazapine
d. Imipramine
Codeine with dextromethorphan combination as anti-tussive
a. Should not be used as it is irrational
b. Can be used to treat cough effectively
c. Can be used as it has different MOA
d. Should not be used due to addiction
True about Disulfiram
a. Action persists for days after being stopped
b. Anti-craving drug
c. Respiratory depression and reduced consciousness if given with alcohol
d. Used in unmotivated patients
e. Inhibit ALDH reversibly
Drug that promotes bone formation among the following
a. Bisphosphonates
b. Raloxifene
c. Calcitonin
d. Teriparatide
Drug that reduces mortality in COVID patients:
a. Steroids
b. Remdesivir
c. Favipiravir
d. LMWH
Most common drawback of Salbutamol inhaler?
a. Portability
b. Does not provide instant relief
c. Drug deposited in oropharynx
d. Must be administered in hospital settings
Match the drug and antidote combination

Drug Antidote
1. Heparin A. Levocarnitine
2. Ethylene glycol B. Protamine
3. Hydroflouric acid C. Fomepizole
4. Valproate D. Calcium gluconate

A. 1A,2B,3C,4D
B. 1B,2C,3D,4A
C. 1D,2B,3C,4A
D. 1A,2B,3C,4D
Match the drug and antidote combination
Drug Antidote
1. Zinc Chloride A. Abortifacient
2. Chloral Hydrate B. Irritant
3. Quinine C. Corrosive
Potassium
4. D. Stupor
Carbonate
A. 1A,2B,3C,4D
B. 1B,2D,3A,4C
C. 1D,2B,3C,4A
D. 1A,2B,3C,4D
Match the organism with its DOC

Drug organism
1. Metronidazole A. MRSA
2. Vancomycin B. Haemophilus
3. Ceftriaxone C. Klebsiella
4. Meropenem D. Bacteroides

A. 1A,2B,3C,4D
B. 1D,2A,3B,4C
C. 1D,2B,3C,4A
D. 1A,2B,3C,4D
Sub-epidermal tense Blister with Neutrophils.
Treatment of choice?
a. Rituximab
b. Dapsone
c. Cyclosporine
d. Azathioprine