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Arterial Blood Gas Analysis
Arterial Blood Gas Analysis
An arterial blood gas is a laboratory test to monitor the patient’s acid-base balance. It is used
to determine the extent of the compensation by the buffer system and includes the
measurements of the acidity (pH), levels of oxygen, and carbon dioxide in arterial blood.
Unlike other blood samples obtained through a vein, a blood sample from an arterial blood
gas (ABG) is taken from an artery (commonly on radial or brachial artery).
pH
The pH is the concentration of hydrogen ions and determines the acidity or alkalinity of body
fluids. A pH of 7.35 indicates acidosis and a pH greater than 7.45 indicates alkalosis. The
normal ABG level for pH is 7.35 to 7.45.
HCO3 (Bicarbonate)
HCO3 or bicarbonate ion is an alkaline substance that comprises over half of the total buffer
base in the blood. A deficit of bicarbonate and other bases indicates metabolic acidosis.
Alternatively, when there is an increase in bicarbonates present, then metabolic alkalosis
results.
BE (Base Excess)
BE. Base excess or BE value is routinely checked with HCO 3 value. A base excess of less than –2
is acidosis and greater than +2 is alkalosis. Base excess, the normal range is –2 to +2 mmol/L
For the purpose of this guide, we have set three (3) goals that we need to accomplish when
interpreting arterial blood gases. The goals are as follows:
1. Based on the given ABG values, determine if values interpret ACIDOSIS or ALKALOSIS.
2. Second, we need to determine if values define METABOLIC or RESPIRATORY.
3. Lastly, we need to determine the compensation if it is: FULLY COMPENSATED,
PARTIALLY COMPENSATED, or UNCOMPENSATED.
We need to keep these goals in mind as they’ll come up later in the steps for the ABG
interpretation technique.
The recommended way of memorizing it is by drawing the diagram of normal values above.
Write it down together with the arrows indicating ACIDOSIS or ALKALOSIS. Note that PaCO 2 is
intentionally inverted for the purpose of the Tic-Tac-Toe method.
If the blood pH is between 7.35 to 7.39, the interpretation is NORMAL but SLIGHTLY
ACIDOSIS, place it under the NORMAL column.
If the blood pH is between 7.41 to 7.45, interpretation is NORMAL but SLIGHTLY
ALKALOSIS, place it under the NORMAL column.
Any blood pH below 7.35 (7.34, 7.33, 7.32, and so on…) is ACIDOSIS, place it under the
ACIDOSIS column.
Any blood pH above 7.45 (7.46, 7.47, 7.48, and so on…) is ALKALOSIS, place it under the
ALKALOSIS column.
Please use the diagram below to help you visualize whether the normal value is ACIDOSIS or
ALKALOSIS.
Once you’ve determined whether the pH is under the ACIDOSIS or ALKALOSIS, plot it on your
tic-tac-toe grid under the appropriate column.
For this step, we need to interpret if the value of PaCO 2 is within the NORMAL range, ACIDIC,
or BASIC and plot it on the grid under the appropriate column. Remember that the normal
range for PaCO2 is from 35 to 45:
Next, we need to interpret if the value of HCO 3 is within the NORMAL range, ACIDIC, or BASIC
and plot it under the appropriate column in the tic-tac-toe grid. Remember that the normal
range for HCO3 is from 22 to 26:
Now, we will start solving for our goals. Looking at the tic-tac-toe grid, determine whether in
what column the pH is placed and interpret the results:
Looking back again on the tic-tac-toe grid, determine if pH is under the same column as
PaCO2 or HCO3 so we can accomplish our goal #2 of determining if the ABG is RESPIRATORY
or METABOLIC. Interpret the results as follows:
Lastly, we need to determine the compensation to accomplish our goal #3. Interpret the
results as follows:
It is FULLY COMPENSATED if pH is normal.
It is PARTIALLY COMPENSATED if all three (3) values are abnormal.
It is UNCOMPENSATED if PaCO2 or HCO3 is normal and the other is abnormal.
Application and Examples
Let’s solve for the ABG interpretation with the examples below:
1. Inform that client about the procedure and that there is no food or fluid restriction
imposed.
2. Note if the client is taking anticoagulant therapy or aspirin as this may affect results.
3. Note if the client is receiving oxygen therapy (flow rate, type of administration device),
and the client’s current temperature.
4. Using a heparinized needle and syringe, collect 1 to 5 mL of arterial blood. Common
sites for drawing arterial blood are the radial and brachial artery.
5. Put the syringe with arterial blood in an ice-water bag to minimize the metabolic
activity of the sample.
6. Deliver the blood sample immediately to the laboratory.
7. Apply pressure to the puncture site for 5 minutes or longer.
When acid-base imbalances occur, the body activates its compensatory mechanisms (the
lungs and kidneys) to help normalize the blood pH. The kidneys compensate for respiratory
acid-base imbalances while the respiratory system compensates for metabolic acid-base
imbalances. This does not correct the root cause of the problem, if the underlying condition is
not corrected, these systems will fail.
Respiratory Acidosis
Respiratory acidosis occurs when breathing is inadequate (alveolar hypoventilation) and the
lungs are unable to excrete enough CO2 causing PaCO2 or respiratory acid builds up. The
extra CO2 combines with water to form carbonic acid, causing a state of acidosis — a
common occurrence in emphysema. The kidneys activate its compensatory process (albeit
slow, often 24 hours or more) by increasing the excretion of metabolic acids through
urination, which increases blood bicarbonate.
Risk Factors
Hyperventilation is a sign that respiratory alkalosis is most likely to occur. However, low
carbon dioxide levels in the blood also have a number of physical effects, including:
The treatment for respiratory alkalosis depends on the underlying cause. Treating the
condition is a matter of rising carbon dioxide levels in the blood. The following strategies and
tips are useful for respiratory alkalosis caused by over-breathing due to panic and anxiety.
Breathe into a paper bag. Breathing through a paper bag fills it with carbon dioxide
helping in inhaling exhaled air back into the lungs.
Treat underlying condition:
Medications. Administering an opioid pain reliever or anti-anxiety medication to
reduce hyperventilation.
Relaxation techniques. Breathing exercises that help relax and breathe from the
diaphragm and abdomen, rather than chest wall.
Safety. Stay with the patient.
Lavage. After massive aspirin ingestions, aggressive gut decontamination is
advisable, including gastric lavage.
Correction of hypokalemia and hypocalcemia.
Oxygenation as indicated. Providing oxygen to help keep a person from
hyperventilating.
Metabolic Acidosis
Metabolic acidosis is when there is a decrease in bicarbonates and a buildup of lactic acid
occurs. This happens in diarrhea, ketosis, and kidney disorders. It has three main root causes:
increased acid production, loss of bicarbonate, and a reduced ability of the kidneys to excrete
excess acids.
Risk Factors
Risk Factors
Metabolic alkalosis may not show any symptoms. People with this type of alkalosis more often
complain of the underlying conditions that are causing it. These can include:
Numbness
Vomiting
Diarrhea
Swelling in the lower legs (peripheral edema)
Fatigue
Tingling sensation
Agitation
Disorientation
Seizures
Coma
Management of Metabolic Alkalosis