waktu kadar obat ln kadar obat

1 125 4.8283137373 y = bx + a
2 110 4.7004803658 bx = slope
3 96 4.5643481915 a = intercept
4 85 4.4426512565
6 66 4.189654742
9 45 3.8066624898 Chart Title
12 31 3.4339872045 6
15 21.5 3.0680529351
5
Slope -0.125856885 f(x) = − 0.125856885313905 x + 4.9473386
4 R² = 0.999909947465869
intersept 4.9473386198
anti ln insept 140.7997432

Axis Title
3

no 1 di kertas algoritmik 2
no 2 Ct = 140,80.e^(-0,1259*t)
no 3 Vd = Div/Co Co = anti ln ins 1
Vd = Div/Co 355.11363636 ml
Div = 50000 mcg 0
0 2 4 6 8 10 12 14
Co = 140,80
cari klirens dll Axis Title
no 4 jam ke 10 ?
Ct = 140,80.e^(-0,1259*t)
39.978445394 40 mcg/ml 39.97845
NO 5 kadar 5 pada jam berapa?
Ct = 140,80.e^(-0,1259*t)
5 = 140,80.e^(-0,1259*t)
5/140,80 = e^(-0,1259*t)
0,03511 = e^(-0,1259*t)
Ln 0,035511 -3.3379127713
t t= -3.3379/-0.1259
27
 Chart Title

0.125856885313905 x + 4.94733861984893
999909947465869

Column C
Linear (Column C)

6 8 10 12 14 16
Axis Title

0.283938
39.97847
NO 2
Waktu kadar obat ln kadar obat
0.25 8.21 2.1053529235
0.5 7.87 2.0630580624
1 7.23 1.9782390362
3 5.15 1.6389967147 Chart Title
6 3.09 1.1281710909 2.5
12 1.11 0.1043600153
2 f(x) = − 0.170282105970003 x + 2.1486975
18 0.4 -0.916290732 R² = 0.999999444180398
1.5

Slope -0.170282106 1

Axis Title
Intersept 2.1486975613 0.5
anti ln intersept 8.573684424 0
0 2 4 6 8 10 12 14 16 1
-0.5
A Ct = 8.57*e^(-0.1703*t)
-1
B Div = 250000 mcg
-1.5
Co = 8.57
Vd = Div/Co Axis Title
250000/8.57
Vd 29171.528588098
Klirens AUC = Co/k
Co = 8.5737
k = 0.1703
AUC = 50.344685849
Cl = Div/AUC
Cl = 250000/8.5737 4965.7364187
t1/2 = 0.693/k
0.693/0.1703
4.06928948913682
C durasi berapa 1,5 mcg?
Ct = 8.57.e^(-0.1703*t)
1.5 = 8.57.e^(-0.1703*t)
1.5/8.57 = e^(-0.1703*t) 0.175029 -1.742802625
0.175029 = e^(-0.1703*t)
ln 0.17502 -1.74280262450152
t = -1.7428/-0.1703 10.233705226 10.233720637 jam
t = 10.2337 jam
D t mengeliminasi 99.2% ?
E dosis obat 2x lipat?
Co = 2*8.5737
Co 17.1474
t 99.2% 0.8/100*Co 0.30103
log cp 0.0685894753919552
parameter berubah = Ct
Ct = 17.14737*e^(-0.1703*12.61941
exp 0.116590728577493
1.99922436148785
 Chart Title

0.170282105970003 x + 2.14869756133962
99999444180398

Column D
Linear (Column D)

4 6 8 10 12 14 16 18 20

Axis Title

2.093419 28.30971

99.2/100*8.573684 -1.163743
8.505095
LOG 0.929679

1.99681

17.14
NO 1
waktu kadar obat ln kadar obat
2 10 2.302585092994
6 5 1.609437912434
2.5
SLOPE -0.17328679514
f(x) = − 0.173
INTERSEPT 2.649158683274 2 R² = 1
LN INTERCEPT 14.14213562373
1.5
A Ct = 14.14*e^(-0,1733*t)

Axis Title
B t paru eliminasi ?
1

ln 2 0.693147180559945 dibukuuuu
0.5
0.17325
4
0
t1/2 = 0.693/k
1.5 2 2.5 3 3.5
0.693/0.1733
Ax
3.99884593190998 4 jam
C C pada t = 0 ?
Ct = 14.14*e^(-0,1733*t)
Ct = 14.14*e^(-0,1733*0)
Ct = 14.14*1
14.14
D VD VD = Div/Co 65*2 = 130 mg 130.000 mcg
Vd = 130000/14.14
Vd 9193.77652050919
Cl Cl = Div/AUC AUC = Co/k
14.14/0.1733 81.59261 mcg.jam/mL 81.59261
130000/81.59261 mcg dari satuan 14.14
1593.28154841474 jam dari waktunya di atas
harus gunakan ml
 Chart Title
2.5

f(x) = − 0.173286795139986 x + 2.64915868327402

2 R² = 1

1.5
Axis Title

Column D
Linear (Column D)
1

0.5

0
1.5 2 2.5 3 3.5 4 4.5 5 5.5 6 6.5
Axis Title
no 1
bb 65 kg waktu dosis ln dosis
dosis 2 mg/kg 2 10 2.30258509299405
2.5
6 5 1.6094379124341
f(x) = − 0.
2 R² = 1
SLOPE -0.17328679514
INTERSEPT 2.64915868327402 1.5

Axis Title
ANTI LN INTERSEPT 14.142135623731
1

0.5
A persamaan Ct = Co* e^(-k*t)
Ct = 14.14*e^(-0.1733*t)
0
1.5 2 2.5 3
B T 1/2 T1/2 = 0.693/K
0.693/0.1733
3.99884593190998 4 JAM

C kadar pada T = 0 Ct = 14.14*e^(-0.1733*t)

14.14*e^(-0.1733*0) 1 1
14.14*1 0.840885
14.14 mcg/ml

D parameter lain
VD = Div/Co Div = 2 mg/kg*65 kg
Div = 130 mg 130000 mcg
Co = 14.14 mcg/ml
VD = Div/Co
130000/14.14
9193.77652050919 ml
AUC = Co/k Co = 14.14 mcg/ml
k = 0.1733
AUC = Co/k
14.14/0.1733
81.5926139642239 mcg.jam/ml
CL = Div/AUC Div = 130000 mcg
AUC = 81.59261396 mcg.jam/ml
CL = Div/AUC
130000/81.59261396
1593.28147108672 ml/jam
 Chart Title
2.5

f(x) = − 0.173286795139986 x + 2.64915868327402

2 R² = 1

1.5
Axis Title

Column D
1 Linear (Column D)

0.5

0
1.5 2 2.5 3 3.5 4 4.5 5 5.5 6 6.5
Axis Title
NO 2
50 kg Waktu kadar obat ln kadar obat
5 mg/kg bb 0.25 8.21 2.10535292346434
0.5 7.87 2.06305806242931 2.5
1 7.23 1.97823903617067 2 f(x) = − 0.1
3 5.15 1.63899671467564 R² = 0.9999
1.5
6 3.09 1.12817109090965
1
12 1.11 0.104360015324243

Axis Title
18 0.4 -0.91629073187416 0.5
0
SLOPE -0.17028210597 0 2 4
-0.5
INTERCEPT 2.14869756134 -1
ANTI LN INTERCEPT 8.5736844239944
-1.5

A Persamaan Ct = Co*e^(-k*t)
Ct = 8.57*e(-0.1703*t)

B Semua parameter
VD VD = Div/Co
Div = 5 mg/kg*50 kg
Div = 250 mg 250000 mcg
Co = 8.57 mcg/ml
VD = Div/Co
250000/8.57
29171.528588098 ml
AUC AUC = Co/k
8.57/0.1703
50.3229594832648 mcg.jam/ml
CL CL = Div/AUC
250000/50.32295948
4967.9113188754 ml/jam
T1/2 T1/2 = 0.693/k
0.693/0.1703
4.06928948913682 jam

C durasi efek obat 1.5 mcg/ml 0.175029171529

Ct = Co*e^(-k.t) LN -1.742803
1.5 = 8.57*e^(-0.1703*t)
1.5/8.57 = e^(-0.1703*t) -1.742802624502
0.17502917 = e^(-0.1703*t)
t = -1.742802625/-0.1703
10.2337052260716 jam -10.23372063712

D mengeliminasi 99.2% obat

99.2% = 7*T1/2 t = 7*4.069289489
 28.485026423 jam

E (Di kertas)
 Chart Title
2.5
2 f(x) = − 0.170282105970003 x + 2.14869756133962
1.5 R² = 0.999999444180398

1
Axis Title

Column D
0.5 Linear (Column D)
0
0 2 4 6 8 10 12 14 16 18 20
-0.5
-1
-1.5
Axis Title

100.6459

14585.76