SOME DRUG SUBSTRATES, INDUCERS AND INHIBITORS OF THE MAJOR CYTOCHROME P450 ISOZYMES

Substrate Inducer Inhibitor Substrate Inducer Inhibitor

CYP1A2 CYP2E1
Amitriptyline Cigarette smoke Erythromycin Enflurane Alcohol Cimetidine
Imipramine Barbiturates Ciprofloxacin Halothane (chronic) Disulfiram
Clomipramine Phenytoin Fluvoxamine Chlorzoxazone Isoniazid (1)
Theophylline Cimetidine Paracetamol
Clozapine Rofecoxib
Olanzapine
R-Warfarin
Tizanidine
Frovatriptan
Zolmitriptan
CYP2C9 CYP3A4
Diazepam Barbiturates Amiodarone Amiodarone Alfentanil Carbamazepine Clarithromycin
Diclofenac Carbamazepine Fluconazole Astemizole Buprenorphine Phenytoin Erythromycin
Celecoxib Dexamethasone Miconazole Terfenadine Fentanyl Barbiturates Itraconazole
Etoricoxib Primidone Voriconazole Busulfan Methadone Dexamethasone Ketoconazole
Valdecoxib Rifampin Fluvastatin Cyclophosphamide Propafenone Rifampicin Voriconazole
Fluvastatin St j w Fluoxetine Ifosfamide Amprenavir Rifabutin Fluconazole
Rosuvastatin Fluvoxamine Irinotecan Atazanavir St John's wort Cimetidine
Losartan Sulfinpyrazone Taxanes Darunavir Verapamil
Irbesartan Ticlopidine Teniposide Fosamprenavir Mibefradil
Phenytoin Zafirlukast Vinblastine Indinavir Diltiazem
Glibenclamide Vincristine Nelfinavir Grapefruit juice
Gliclazide Aprepitant Ritonavir Imatinib
Glimepiride Itraconazole Saquinavir Nefazodone
Glipizide Voriconazole Tipranavir Nicardipine
Tolbutamid Alprazolam Quetiapine Fluoxetine
Nateglinide Triazolam Quinidine Ritonavir
S-Warfarin (imp) Midazolam Reboxetine Indinavir
CYP2C19 Bromocriptine Rifabutin
Buspirone R-warfarin
Citalopram Rifampin Omeprazole
Diltiazem Sibutramine
Omeprazol Tranylcypromine
Felodipine Sildenafil
Diazepam Fluvoxamine
Carbamazepine Atorvastatin
Moclobemide Isoniazid (1)
Ciclosporin Lovastatin
Phenytoin Esomeprazole
Cilostazol Simvastatin
Proguanil Omeprazole
Cisapride Tacrolimus
Ticlopidine
Budesonide Tamoxifen
Valdecoxib
Dexamethasone Toremifene
CYP2D6 Fluticasone Tolterodine
Amitriptyline Rifampicin Amiodarone Hydrocortisone Amitriptyline
Desipramine Bupropion Methylprednisolone Imipramine
Imipramine Cimetidine Delavirdine Vardenafil
Nortriptyline Dextropropoxyphene Disopyramide Zolpidem
Trimipramine Diphenhydramine Ergot derivatives Zopiclone
Venlafaxine Duloxetine Imatinib
Fluoxetine Propafenone Lidocaine, oral
Codeine Quinidine Oral contraceptives
Haolperidol Ritonavir
Olanzapine Fluoxetine
Clozapine Paroxetine
Risperidone Sertraline
Propranolol Terbinafine
Carvedilol Valdecoxib
Metoprolol
Dextromethorphan
Tamoxifen
Tramadol
NOTE: (1) Isoniazid is inhibitor of CYP2C19 {clinically more important} and inducer of CYP2E1.
 Some Enzyme Inhibitors Frequently Implicated in Interactions
Antibacterials Antifungals GI Drugs
 Cipro  Keto  Cimetidine
 Clarithro  Itra  Omeprazole
 Erythro  Fluco
 INH  Mico Anti-rheumatic drugs
 Metronidazole  Allopurinol
CV Drugs  Phenylbutazone
Antidepressants  Amiodarone
 Fluoxetine  Diltiazem Other
 Fluvoxamine  Quinidine  Disulfiram
 Nefazodone  Verapamil  Propoxyphene
 Sod valproate
 Grapefruit juice

Some Enzyme Inducers Frequently Implicated in Interactions

Barbiturates Rifabutin St John's wort

Carbamazepine Rifampicin Cigarette smoke
Phenytoin