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Calcium Channel Blockers
Calcium Channel Blockers
INTRODUCTION-
PHARMACOLOGICAL ACTIONS..
11. PHARMACOKINECTICS.. § well absorbed through Git. § first pass metabolism. § highly bound to
plasma proteins. § metabolised in liver. § excreted through urine.
USES OF CCBs.. 1. angina pectoris – Due to decrease in myocardial oxygen consumption, and dilatation
of coronary arteries. 2. supraventicular arrhythmias – because of its depressant action on S-A and A-V
nodes. 3. hypertension – they control blood pressure by their vasodilatory effect. 4. Migraine 5.
raynaud’s phenomenon – due to their vasodilatory property.