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    Sahil Arora
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    The literature shows there is often inappropriate use of blood products, including cryo - precipitate plasma, because of in - adequate education of physicians. Guidelines for cryoprecipitate transfusion have been developed by the Transfusion Medicine Advisory Group of British Columbia to educate clinicians and address transfusion practices in the province.

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    croprecipitate guidelines

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    The literature shows there is often inappropriate use of blood products, including cryo - precipitate plasma, because of in - adequate education of physicians. Guidelines for cryoprecipitate transfusion have been developed by the Transfusion Medicine Advisory Group of British Columbia to educate clinicians and address transfusion practices in the province.

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    © All Rights Reserved
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    6 views1 page

    Croprecipitate Guidelines

    Uploaded by

    Sahil Arora
    The literature shows there is often inappropriate use of blood products, including cryo - precipitate plasma, because of in - adequate education of physicians. Guidelines for cryoprecipitate transfusion have been developed by the Transfusion Medicine Advisory Group of British Columbia to educate clinicians and address transfusion practices in the province.

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    Guidelines for cryoprecipitate transfusion

    Table. Characteristics of four frozen plasma products.

    Frozen plasma Fresh-frozen plasma Cryoprecipitate plasma Cryosupernatant plasma


    (from whole blood collection) (from apheresis collection) (cryo) (cryo-poor plasma)

    Whole blood is centrifuged at Whole blood is processed Plasma is frozen for 24 hours, Plasma is frozen for 24 hours,
    high speed, allowing separa- through a cell separator to and then thawed at 1°– 6°C and then thawed at 1°– 6°C
    tion of plasma, red blood cells obtain plasma. Plasma is until insoluble proteins precip- until insoluble proteins precip-
    (RBCs), and the buffy coat frozen within 8 hours of col- itate. The pack is centrifuged itate. The pack is centrifuged
    layer (platelets, white blood lection and is designated as to obtain the cryoprecipitate. to obtain the supernatant.
    cells, some RBCs and plasma). fresh-frozen plasma (FFP). In The cryoprecipitate is then The supernatant, or cryo-poor
    Plasma is frozen within 24 general, 1 unit of FFP from refrozen for storage. plasma, is then refrozen for
    hours of collection and is des- apheresis collection is equiva- storage.
    ignated as frozen plasma (FP). lent to approximately 2 units Once thawed, the product
    It is prepared for use by thaw- of FP from whole blood collec- should be transfused immedi- Once thawed, the product
    Preparation
    ing at 37°C, a process that can tion. The two products can be ately, with completion of should be transfused immedi-
    take up to 30 minutes. used interchangeably. transfusion within 4 hours of ately, with completion of
    issuing product. transfusion within 4 hours of
    Once thawed, the product Once thawed, the product issuing product.
    should be transfused immedi- should be transfused immedi-
    ately, with completion of ately, with completion of
    transfusion within 4 hours of transfusion within 4 hours of
    issuing product. issuing product.

    Contains all of the coagulation Contains all of the coagulation Contains FVIII:C, von Is deficient in high molecular
    factors, including the labile factors, including the labile Willebrand factor (vWF), fib- weight vWF multimers and
    factors (FV and FVIII:C). For factors (FV and FVIII:C). rinogen, FXIII, and fibronectin. FVIII:C.
    product prepared within 24 Cryoprecipitate has the fol-
    hours of collection, FVIII:C lev- lowing factor activities:
    els are less than those found 91 IU of FVIII: C per bag,
    in fresh-frozen plasma pre- 113 IU of vWF per bag, and
    Factors pared within 8 hours of collec- 150 mg of fibrinogen per bag.
    tion, but levels are still at or
    above 0.50 IU/mL. FP can be
    used for coagulation factor
    replacement except for isolat-
    ed or severe FVIII deficiency.

    Each bag = 1 unit Each bag = 1 unit Each bag = 1 unit (5–15 mL) Each bag = 1 unit (>100 mL)
    Volume
    (200 – 250 mL) (100 – 600 mL)

    Typical adult dose of plasma is Typical adult dose of plasma is Typical adult dose of cryo is Typically 1.0–1.5 times plasma
    10–15 mL/kg body weight. 10–15 mL/kg body weight. 1 unit/5 kg body weight, up to volume exchange is
    a total dose of 10 units (bags). performed per plasma
    The pediatric dose of plasma The pediatric dose of plasma exchange (PLEX) run.
    is 10–15 mL/kg body weight. is 10–15 mL/kg body weight. The pediatric dose is
    1 unit/5–10 kg body weight or Indicated as replacement fluid
    Infusion rate is over 2–3 Infusion rate is over 2–3 5–10 mL/kg. in PLEX for thrombotic throm-
    Dose hours, or as required. hours, or as required. bocytopenic purpura.
    Will raise fibrinogen by
    Will raise factor levels by Will raise factor levels by 0.5 g/L, assuming there is no
    25%, assuming there is no 25%, assuming there is no ongoing consumption/loss of
    ongoing consumption/loss of ongoing consumption/loss of fibrinogen.
    factors. factors.

    VOL. 49 NO. 8, OCTOBER 2007 BC MEDICAL JOURNAL 443

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