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Current Psychiatry Reports (2018) 20: 79

https://doi.org/10.1007/s11920-018-0932-9

EATING DISORDERS (S WONDERLICH AND JM LAVENDER, SECTION EDITORS)

An Overview of Conceptualizations of Eating Disorder Recovery, Recent


Findings, and Future Directions
Anna M. Bardone-Cone 1 & Rowan A. Hunt 2 & Hunna J. Watson 3,4,5

Published online: 9 August 2018


# Springer Science+Business Media, LLC, part of Springer Nature 2018

Abstract
Purpose of Review This review delineates issues in the conceptualization and operationalization of eating disorder recovery,
highlights recent findings about recovery (since 2016), and proposes future directions.
Recent Findings A longstanding problem in the field is that there are almost as many different definitions of recovery in eating
disorders as there are studies on the topic. Yet, there has been a general shift to accepting that psychological/cognitive symptoms
are important to recovery in addition to physical and behavioral indices. Further, several operationalizations of recovery have
been proposed over the past two decades, and some efforts to validate operationalizations exist. However, this work has had
limited impact and uptake, such that the field is suffering from “broken record syndrome,” where calls are made for universal
definitions time and time again. It is critical that proposed operationalizations be compared empirically to help arrive at a
consensus definition and that institutional/organizational support help facilitate this. Themes in recent recovery research include
identifying predictors, examining biological/neuropsychological factors, and considering severe and enduring anorexia nervosa.
From qualitative research, those who have experienced eating disorders highlight recovery as a journey, as well as factors such as
hope, self-acceptance, and benefiting from support from others as integral to the process of recovery.
Summary The field urgently needs to implement a universal definition of recovery that is backed by evidence, that can parsi-
moniously be implemented in clinical practice, and that will lead to greater harmonization of scientific findings.

Keywords Eating disorders . Recovery . Course . Outcome . Remission . Transdiagnostic

Introduction is seen as the ideal end-goal, giving rise to a number of critical


questions including how recovery is defined and operational-
Every field of psychopathology cares about recovery. ized, what predicts recovery, and what interventions should
Regardless of the specific psychological disorder, recovery look like to best facilitate recovery. In this review, we provide
an overview of conceptualizations of recovery and then focus
This article is part of the Topical Collection on Eating Disorders on recent eating disorder recovery research (since 2016). We
will also occasionally refer to research on remission and
* Anna M. Bardone-Cone “good outcomes” when there is little work specifically on
bardonecone@unc.edu recovery. Of note, these various terms (recovery, remission,
good outcomes) represent overlapping but distinct constructs
1
Department of Psychology & Neuroscience, University of North which are sometimes used interchangeably; the need for a
Carolina at Chapel Hill, CB #3270 Davie Hall, Chapel consistent terminology for better communication is discussed
Hill, NC 27599, USA
as part of future directions.
2
Department of Psychology, Drexel University, Philadelphia, PA,
USA
3
Department of Psychiatry, University of North Carolina at Chapel
Hill, Chapel Hill, NC, USA Defining and Operationalizing Recovery
4
School of Psychology, Curtin University, Perth, Western Australia,
Australia Researchers have done an excellent job acquiring volumes of
5
School of Paediatrics and Child Health, The University of Western data on outcomes and course of illness, particularly for an-
Australia, Perth, Western Australia, Australia orexia nervosa (AN) and bulimia nervosa (BN), [1–3].
79 Page 2 of 18 Curr Psychiatry Rep (2018) 20: 79

However, they have failed miserably at defining outcome in a approach are that medical professionals and researchers but
consistent way, making it almost impossible to integrate this not patients define the meaning of recovery (although criteria
vast body of literature. Depending on the source, it is virtually may reflect important constructs reported by patients) and that
impossible to achieve recovery, or exceptionally likely. In her health is seen predominantly in terms of the reduction of
review, Berkman [1] found recovery rates of 8 to 88% for symptoms rather than building wellness. Criticisms of the
studies reporting four or more years of follow-up of AN, and qualitative approach are that findings can be difficult to
recovery rates of 56 to 99% for studies following BN for at operationalize, and criteria are too broad and non-specific
least 1 year. In a review of 119 studies, Steinhausen [3] found (e.g., “personal growth” [15••]), leading to too high a bar for
recovery rates for AN to be between 0 to 92% and in 79 recovery.
studies of BN, between 5 to 73% [4]. Couturier and Lock Which criteria/domains should be included in a recovery
[5] demonstrated that the large variation in recovery rate is definition, which measurements should be used, and what
due in part to the wide-ranging definitions of recovery. thresholds and duration of time should be considered? [15••]
Using the same sample of individuals, and applying different Answers to these questions should be informed by quantita-
commonly used definitions, they found that 57 to 94% of tive and qualitative data.
patients were “recovered.” Without a standard definition of
recovery and measurement strategy, the field cannot: mean- Criteria Contemporary clinical literature suggests that recov-
ingfully compare recovery rates across studies; make strong ery from eating disorders should be measured in terms of
claims about relative treatment effectiveness; identify reliable physical, behavioral, and psychological/cognitive criteria [5,
predictors of recovery; and report meaningful relapse rates, 6••, 13, 16]. This is not the status quo for assessing outcome in
given that relapse is predicated on recovery. many medical settings, where physical and behavioral criteria
How does the eating disorder field—pragmatically—go are central. This is also not yet widespread in the literature; for
about acquiring a standard definition of recovery? Efforts with example, from 2016 through March 2018, only a minority of
respect to psychiatric disorders have predominantly taken two the publications on recovery explicitly included these three
routes, differing in philosophy and methods. In the first, more dimensions in their definition of recovery (see Table 1). And
quantitative approach, criteria are proposed based on yet, there are strong arguments for the inclusion of a psycho-
established conventions, expert working groups, or critical logical dimension as part of a comprehensive definition of
reviews of the literature, i.e., [6••, 7, 8••, 9–12]. Next, these recovery. Residual eating disorder cognitions (e.g., body im-
criteria are subjected to empirical validation to test their ro- age disturbance) increase risk for relapse [72, 73]. Measuring
bustness [5, 6, 9, 13, 14]. One way to test for validity is to recovery using only physical and behavioral indices yields a
compare a group meeting the proposed recovery criteria to a group heterogeneous on eating disorder thinking and thus
group meeting criteria for an eating disorder as well as to a with systematically differential risk for relapse. Indeed, some
group of non-eating disorder controls on constructs that are have argued that this identifies a “pseudo-recovery” state
related to disordered eating attitudes and behaviors, but using where someone may seem recovered via visible indicators
measures not included in the operationalization of recovery. (weight, behaviors), but still engage in the same eating disor-
For example, groups could be compared on measures of eat- dered thinking [74]. Further, excluding psychological criteria
ing pathology, body image, thin-ideal internalization, and ob- from a definition of recovery does not fit patients’ subjective
sessive cognitions related to food, eating, and weight/shape. reports of recovery where changes in thinking are key [15••].
Evidence of validity of the operationalization of recovery
would emerge if the recovered group looked significantly bet- Measurement and Thresholds For the physical criterion of
ter than the group with eating disorders on the validation recovery, body mass index (BMI) is the most commonly used
criteria, but did not differ significantly from controls, suggest- indicator. However, minimum thresholds are variable. Since
ing a return to “normative” levels of these constructs (i.e., 2016, BMI thresholds for recovery have included 17.5 [24,
[6••]). Another way to test for validity is to use a longitudinal 47], 18 [49, 75], 18.5 [20, 59, 76•], and 19 [60, 77]. Of these
research design to compare recovery operationalizations on thresholds, a minimum BMI of 18.5 has been most often used
subsequent relapse rates (i.e., [9]). In this case, in recent years and has the backing of being the minimum
operationalizations with lower relapse rates over time would BMI for a normal/healthy weight range, per the World
be highlighted as particularly valid and meaningful Health Organization and the Centers for Disease Control and
operationalizations of recovery. Prevention. Weight and height measurements have been self-
The second approach to characterizing the concept of re- reported and measured, with objective measures preferred due
covery uses primarily qualitative methodology [15]. This ap- to the potential for bias or, for those who do not weigh them-
proach situates patients’ narratives of their experiences with selves, guessing. Historically, regular menses has also been
recovery as primary. Both approaches have value and can used as an indicator of recovery, for example, paired with ≥
bridge important gaps in the other. Criticisms of the first 85% ideal body weight for a “good” outcome using the
Table 1 Dimensions of eating disorder recovery included in operationalizations from 2016 through the current review in 2018

Reference Eating disorder Physical Behavioral Psychological/cognitivea Duration Other/notes

2016
Bang, Rø, and Endestad [17] AN BMI > 18.0 No bingeing, purging, or – 1 year
severely restricted food
intake
Bang, Rø, and Endestad [18] AN BMI > 18.0 No bingeing, purging, – 1 year
excessive or
Curr Psychiatry Rep (2018) 20: 79

compulsive exercise,
or severely restricted
food intake
Bardone-Cone, Butler, Balk, All EDs included BMI ≥ 18.5 No bingeing, purging, or EDE-Q subscale scores 3 months for behaviors;
and Koller [19] fasting within 1 SD of duration of other criteria not
age-matched specified
community norms
Bardone-Cone, Higgins, St. All EDs included BMI ≥ 18.5 No bingeing, purging, or EDE-Q subscale scores 3 months for behaviors;
George, Rosenzweig, fasting within 1 SD of duration of other criteria not
Schaefer, Fitzsimmons-Craft, age-matched specified
and … Preston [20] community norms
Bernardoni, King, Geisler, AN BMI > 18.5 for 18+ No bingeing, purging, or – 6 months for behaviors; unclear
Stein, Jaite, Nätsch, and … years; BMI > 10th restrictive eating if this applied to physical criteria
Ehrlich [21] percentile for patterns
< 18 years; regular
menses
Boehm, Geisler, Tam, King, AN BMI > 18.5 for 18+ No bingeing, purging, or – 6 months for BMI; duration
Ritschel, Seidel, and … years; BMI > 10th substantial restrictive of other criteria not specified
Ehrlich [22] percentile for eating patterns
< 18 years; regular
menses
Dapelo, Hart, Hale Morris, and AN BMI ≥ 18.5 See other EDE-Q scores < 3;unclear 1 year for absence of ED No ED symptoms
Tchanturia [23] if for global score or symptoms; duration of
subscale scores other criteria not specified
Egger, Wild, Zipfel, Junne, AN BMI > 17.5 See other See other Not specified Psychiatric Status Ratings
Konnopka, Schmidt, and … (PSR) ≤ 2—this indicates
König [24] few or no ED symptoms
Ely, Wierenga, and Kaye [25] AN Weight between 90 – – 1 year
and 120% ideal
body weight;
regular menses
Errichiello, Iodice, Bruzzese, AN BMI ≥ 18.5; regular No bingeing or purging – 1 year Referred to as “clinical
Gherghi, and Senatore [26] menses recovery”
Frank, Collier, Shott, and AN BMI between Healthy exercise regime – 1 year
O’Reilly [27] 18.5–24.9; regular and food intake
menses
Frank, Shott, Keffler, and AN Normal weight; Normal exercise patterns – 1 year
Cornier [28] regular menses
Page 3 of 18 79
Table 1 (continued)

Reference Eating disorder Physical Behavioral Psychological/cognitivea Duration Other/notes

Godier, de Wit, Pinto, AN BMI between 18.5 – Global EDE and EDE-Q 1 year for BMI; duration of No longer meeting criteria for an
79 Page 4 of 18

Steinglass, Greene, Scaife, and 25 scores within 1 SD of other criteria not specified ED diagnosis; not meeting criteria
and … Park [29] scores for young for any DSM-IV disorder
women
Hartmann, Zeeck, Herzog, AN BMI > 17.5 See other See other Not specified Psychiatric Status Ratings (PSR) ≤ 2—
Wild, de Zwaan, Herpertz, this indicates few or no ED
and … Löwe [30] symptoms
Las Hayas, Padilla, Barrio, All EDs included See other See other – 1 year No ED symptoms
Beato-Fernandez, Muñoz,
and Gámez-Guadix [31]
Levallius, Roberts, Clinton, and BN, EDNOS See other See other – 90 days No longer meeting criteria for
Norring [32] an ED diagnosis
McAdams, Jeon-Slaughter, AN BMI > 19.0 – – 2 years Explicitly referred to “weight
Evans, Lohrenz, Montague, recovery”
and Krawczyk [33]
Monteleone, Monteleone, AN BMI ≥ 18.5 – – Not specified Explicitly referred to “weight
Serino, Amodio, Monaco, recovery”
and Maj [34]
Mustelin, Latvala, Raevuori, All EDs included Restoration of weight; No bingeing or purging – 1 year for behaviors; unclear
Rose, Kaprio, and return of regular if this applied to physical
Keski-Rahkonen [35] menses (if criterion
applicable)
Mustelin, Lehtokari, and OSFED, UFED Not underweight No bingeing or – 1 year Since symptoms in OSFED and
Keski-Rahkonen [36] inappropriate UFED diagnoses are so varied,
compensatory interviewers used “clinical
behaviors judgment” as part of determining
recovery status
Mustelin, Silén, Raevuori, AN Restoration of weight; No bingeing or purging – 1 year for behaviors;unclear if this
Hoek, Kaprio, and return of regular applied to physical criteria
Keski-Rahkonen [37] menses (if
applicable)
O’Hara, Keyes, Renwick, Giel, AN > 85% of average No bingeing, purging (or EDE-Q scores not 1 year for behaviors; unclear if this
Campbell, and Schmidt [38] body weight other compensatory clinically significant applied to physical criterion;
behaviors), or (i.e., all < 2.80); unclear duration not specified for other
significant restrictive if for global score or criterion
eating patterns subscale scores
O’Hara, Keyes, Renwick, AN > 85% of average No bingeing, purging (or EDE-Q scores not 1 year for behaviors; duration not
Leyton, Campbell, and body weight other compensatory clinically significant specified for other criteria
Schmidt [39] behaviors), or (i.e., all < 2.80); unclear
significant restrictive if for global score or
eating patterns subscale scores
Pfuhl, King, Geisler, AN BMI > 18.5 for 18+ No bingeing, purging, or – 6 months for BMI criterion;
Roschinski, Ritschel, Seidel, years; BMI > 10th significant restrictive duration not specified for menses
and … Ehrlich [40] percentile for eating patterns or behavioral criteria
< 18 years; regular
menses
Curr Psychiatry Rep (2018) 20: 79
Table 1 (continued)

Reference Eating disorder Physical Behavioral Psychological/cognitivea Duration Other/notes

Phillips, Jimerson, Pillai, and AN Weight in a normal No bingeing or purging – 8 weeks Explicitly referred to “weight
Wolfe [41] range recovery” but also had behavior
requirements
Scaife, Godier, Reinecke, AN BMI between No significant eating Global EDE-Q score 1 year for behaviors; duration not
Harmer, and Park [42] 18.5–25.0 disorder pathology within 1 SD of scores specified for other criteria
for young women
Curr Psychiatry Rep (2018) 20: 79

Shih, Yang, Morisseau, AN BMI ≥ 18.0 – – Not specified; referred to


German, Scott-Van Zeeland, “maintaining” the required BMI
Armando, and … Kaye [43]
Shott, Pryor, Yang, and Frank AN Normal weight for Normal exercise behavior – 1 year
[44] height; regular and food intake
menses
Sultson, van Meer, Sanders, AN BMI > 18.5; regular – See other 1 year Not significantly different from study’s
van Elburg, Danner, Hoek, menses controls on global EDE-Q score
and … Smeets [45] (viewed as confirmation of recovery
rather than an a priori requirement)
Telléus, Fagerlund, Jepsen, AN BMI > 15th – – Not specified Explicitly referred to “weight
Bentz, Christiansen, Valentin, percentile, recovery”
and Thomsen [46] corresponding to a
BMI ≥ 18.5 for
ages 18+ years
Wild, Friederich, Zipfel, AN BMI > 17.5 See other See other Not specified Psychiatric Status Ratings (PSR)
Resmark, Giel, Teufel, and ≤ 2—this indicates
… Herzog [47] few or no symptoms
2017
Bailer, Price, Meltzer, Wagner, AN – – – Not specified No definition provided
Mathis, Gamst, and Kaye
[48]
Bang, Rø, and Endestad [49] AN BMI > 18.0 No bingeing, purging, or – 1 year
severe food restriction
Bang, Rø, and Endestad [50] AN BMI > 18.0 No bingeing, purging, – 1 year
excessive or
compulsive exercise,
or severely restricted
food intake
Baucom, Kirby, Fischer, AN BMI > 18.5 No bingeing, vomiting, or EDE subscale scores 28 days for psychological criteria; Physical AND (behavioral OR
Baucom, Hamer, and Bulik restrictive eating within 1 SD of duration of physical criterion not psychological criteria) *OR* BMI
[51] population norms specified between 17.5–18.5 AND both
behavioral AND psychological
criteria
Bentz, M., Guldberg, J., AN Normal body weight No eating disorder Global EDE score within 1 1 year for “normal” body No ongoing treatment for an ED;
Vangkilde, Pedersen, Plessen, pathology SD of published mean weight; duration of other criteria “generally favorable outcome”
and Jepsen [52] not specified (≥ 9 points on Morgan-Russell
outcome scores)
Bentz, Jepsen, Pedersen, Bulik, AN Normal body weight No eating disorder Global EDE score within 1 1 year for BMI; 3 months for “Generally favorable outcome”
Pedersen, Pagsberg, and pathology SD of non-AN norms eating disorder pathology (≥ 9 points on Morgan-Russell
Plessen [53] outcome scores)
Page 5 of 18 79
Table 1 (continued)

Reference Eating disorder Physical Behavioral Psychological/cognitivea Duration Other/notes

Bentz, Jepsen, Telléus, Moslet, AN BMI ≥ 18.5 for 16+ No eating disorder Global EDE score within 1 1 year for BMI; duration of “Generally favorable outcome”
79 Page 6 of 18

Pedersen, Bulik, and Plessen years; BMI > 25th pathology SD of non-AN mean other criteria not specified (≥ 9 points on Morgan-Russell
[54] percentile, outcome scores)
corrected for age
for 14–15 years
Calugi, Ghoch, and Grave [55] AN BMI ≥ 18.5 – Global EDE score < 1 SD Not specified Used term “full response” to
of community norms represent highest level of recovery
(i.e., < 1.74)
Eddy, Tabri, Thomas, Murray, AN, BN ≥ 95% expected body No binge or purge See other 1 year Psychiatric Status Ratings (PSR) ≤ 2
Keshaviah, Hastings, … weight (for AN, per behaviors (for BN)— for both AN and BN—this indicates
Franko [56] PSR) per PSR few or no symptoms
Erdur, Weber, AN BMI between Normal eating behavior – 5 years
Zimmermann-Viehoff, Rose, 18.5–25.0; regular
and Deter [57] menses
Forsberg, Darcy, Bryson, AN ≥ 95% of expected – Global EDE score within 1 Not specified This study focused on parent data, but
Arnow, Datta, Le Grange, body weight SD of community linked this to treatment outcome
and Lock [58] norms including recovery status of
daughter
Halvorsen, Reas, Nilsen, and AN BMI ≥ 18.5 No bingeing, purging, or EDE-Q global score ≤ 2.5 3 months for behaviors; These criteria were for “fully
Rø [59] other compensatory duration of other criteria recovered.” Also reported on
behaviors not specified “weight recovered” (BMI ≥ 18.5)
Harper, Brodrick, Van AN BMI > 19.0 – – 1 year Explicitly referred to “weight
Enkevort, and McAdams recovery”
[60]
Kuipers, den Hollander, van der AN, BN See other See other – Not specified No longer meeting criteria for
Ark, and Bekker [61] an ED diagnosis
Leppanen, Dapelo, Davies, AN BMI between See other – Not specified No eating disorder symptoms
Lang, Treasure, and 18.5–25.0
Tchanturia [62]
Martin Monzon, Henderson, AN ≥ 85% of expected – – Not specified Explicitly referred to “weight
Madden, Macefield, Touyz, body weight recovery”
Kohn, and … Hay [63]
Scaife, Godier, Filippini, AN BMI between No bingeing, purging, Global EDE-Q score 1 year for BMI; duration of other
Harmer, and Park [64] 18.5–25.0 restricting, or within 1 SD of mean criteria not specified
excessive exercise scores for young
women
Swenne, Parling, and Ros [65] OSFED –AN See other See other Global EDE-Q score < 2 Not specified Also looked at a recovered group
(i.e., the value at or defined by not meeting
below + 1 SD of diagnostic criteria for an ED
adolescent community
norms)
Xu, Harper, Van Enkevort, AN Sustained weight See other – Weight recovery and controlled Adequate control of eating
Latimer, Kelley, and recovery eating disorder symptoms disorder symptoms; explicitly
McAdams [66] enabled them to be without referred to “weight recovery”
treatment or only outpatient
treatment for 12 months
following initial study
Curr Psychiatry Rep (2018) 20: 79
Table 1 (continued)

Reference Eating disorder Physical Behavioral Psychological/cognitivea Duration Other/notes

2018
Boehm, Flohr, Steding, AN BMI > 18.5 for 18+ No bingeing, purging, or – 6 months for BMI; duration of
Holzapfel, Seitz, Roessner, years; BMI > 10th significant restrictive other criteria not specified
and Ehrlich [67] percentile for eating patterns
< 18 years; regular
menses
Curr Psychiatry Rep (2018) 20: 79

Castellini, Lelli, Cassioli, AN, BN BMI > 18.5 No objective bingeing, Global EDE-Q score < 1 28 days for behaviors; duration of
Ciampi, Zamponi, Campone, vomiting, or laxative SD above community other criteria not specified
and … Ricca [68] use mean
Franko, Tabri, Keshaviah, AN, BN ≥ 95% expected body No binge or See other 1 year Psychiatric Status Ratings
Murray, Herzog, Thomas, weight (for AN, per purge behaviors (PSR) ≤ 2 for both AN and
and … Eddy [69] PSR) (for BN)—per PSR BN—this indicates few or no
symptoms
Lavagnino, Mwangi, Cao, AN BMI > 18.5; regular Normal exercise behavior – 1 year
Shott, Soares, and Frank [70] menses and food intake
McAdams, Harper, and Van AN BMI > 19.0 – – 2 years Explicitly referred to “weight
Enkevort [71] recovery”

These data come from a PsycINFO search of peer-reviewed, quantitative articles published in 2016–2018 (to date–through March 2018) that explicitly refer to recovery, and not only remission; search terms
were as follows: “anorexia or bulimia or binge eating disorder or eating disorder” and “recovery or recovered.” Terms used in the table represent terms used in the articles (e.g., “normal,” “significant”).
Studies varied in how they did their assessments and how consistent they were in specifying this (e.g., self-report vs. measured weight vs. not indicated; behaviors assessed via structured interview or other
means, specified or not). When recovery criteria were listed as absence of eating disorder symptoms/pathology or no longer meeting criteria for an ED diagnosis, we included that information as “other.”
Some studies reported exclusion criteria for recovery (e.g., no axis I pathology in the past year), but that information is not reported here. Duration reported is in relation to assessment, so 1 year means 1 year
(= 12 months = 52 weeks) prior to assessment; also, durations all refer to a minimum (e.g., “at least” 1 year)
AN anorexia nervosa, BN bulimia nervosa, OSFED other specified feeding or eating disorder, UFED unspecified feeding or eating disorder, ED eating disorder
a
Although duration of psychological/cognitive criteria was generally not specified, when the EDE-Q was used, this can be assumed to refer to the past 28 days
Page 7 of 18 79
79 Page 8 of 18 Curr Psychiatry Rep (2018) 20: 79

Morgan-Russell criteria [78]. This will likely be less used absence of an eating disorder diagnosis is necessary but not
given the removal of amenorrhea as a criterion of AN in the sufficient. A methodological question is whether this criterion
Diagnostic and Statistical Manual (DSM-5) [79]. is best established via clinical interview vs. self-report survey.
For the behavioral criterion of recovery, most research re- Unfortunately, in some of the recovery research, it is un-
quires abstinence of eating disorder behaviors, but which be- clear how recovery was operationalized [48, 50, 70, 97–99].
haviors and how they are assessed varies. For example, since The absence of detailed information about measurements,
2016, most research has deemed abstinence from binge eating thresholds, and durations stymies replication efforts and the
and purging as necessary [17, 18, 20–23, 26•, 38, 49, 52, 59, progression of knowledge.
67, 75, 80], while others include a concession for limited
residual episodes [81, 82]. Some have required abstinence Duration In addition to the aforementioned issues in
from restrictive eating patterns [20, 44], and others have not operationalizing recovery, a further significant complexity in-
[59]. Yet others have used additional criteria such as “healthy” cludes the duration for which the criteria need to be met. In
exercise regimens but without operationalization [27, 44]. some cases, different durations are required for different
Ways of assessing eating disorder behaviors have included criteria (e.g., certain number of months for absence of behav-
the frequencies of objective binge eating, vomiting, and laxa- iors, but no time frame for cognitions—although those using
tive use in the Eating Disorder Examination-Questionnaire the EDE-Q generally involve the past 4 weeks); in some cases,
(EDE-Q) [83], the binge eating module of the Eating a duration is required for all criteria; and in some cases, no
Disorder Examination (EDE) [84], unstructured interviews, duration is specified. Most typically, duration is noted for
and semi-structured interviews, such as the Eating Disorders eating disorder behaviors. Since 2016, examples of durations
Longitudinal Interval Follow-up Evaluation Interview [85], for a behavioral criterion of recovery have included: 1 month
which involves annotating calendar months with events sa- [51], 8 weeks [100], 3 months [20, 59, 76•], 6 months [21, 22,
lient to the individual and asking, week by week, about the 101], and 12 months [18, 26, 38, 49, 56•, 69, 80, 95].
presence of any target eating disorder behaviors. Franko et al. [69] noted that having to recall symptoms
There has been less discussion around constructs that over a long period of time can create the potential for
should be captured as part of psychological recovery, but since recall bias and yield data constrained by the ability to
2016, most researchers who examined this component have remember symptoms of interest in the time frame. The
focused on eating disorder cognitions. For example, eating need to balance a sufficiently long duration without symp-
concern, weight concern, shape concern, and a dietary re- toms with confidence that participants can provide reli-
straint mentality are captured in the EDE-Q and the EDE. able and accurate memories over that time period is im-
Scores similar to community norms (within one standard de- perative. However, no work has empirically evaluated an
viation) have been required for all the EDE-Q subscales [20, optimal duration of absence of eating disorder behaviors
51], EDE-Q global score [42, 52, 64, 81, 86–90], and EDE and cognitions to constitute recovery. Of note, given that
global score [55, 91–93]. Others have used cut-offs on the psychological recovery appears to emerge after behavioral
EDE-Q as an index of psychological recovery, including recovery [76•], it can be argued that if psychological re-
“non-clinically significant” global scores on the EDE-Q de- covery is assessed, then a shorter duration may be re-
fined as < 2.5 [59], < 2.8 [38], < 2.83 [77], ≤ 3 [23], and < 4 quired for behavioral recovery (with, relatedly, less con-
[94]. Some studies on recovery have allowed for the presence cerns about bias or forgetting).
of cognitive symptoms [69•], particularly those that use the
Psychiatric Status Rating Scale (PSR) scores of 2 or less to Operational Definitions Despite the clinical and academic im-
define recovery [82, 85] since scores of 2 for AN allow for the portance of operationalizing recovery in a consistent manner,
presence of overvaluation of weight/shape, fat phobia, and/or the volume of research on the topic is disappointingly meager,
body image disturbance, and scores of 2 for BN allow for and the existing work—which is rich and foundational—is not
presence of fighting urges to binge or purge as well as cogni- well-built upon.
tive symptoms. Other studies have used broader indices of Publications addressing recovery almost inevitably stress
psychological functioning, such as normative scores on all the need for uniformity in defining recovery [8].
subscales of the Eating Disorder Inventory-2 [95]. Importantly, operational definitions have been proposed, i.e.,
Some research specifies the absence of diagnostic criteria [6••, 8••, 10, 14, 102] and at least one working group effort
for any eating disorder, either as the sole criterion for recovery exists [9]. However, the impact has been limited, as can be
[96] or in conjunction with other recovery dimensions [6••]. seen in the diversity of definitions displayed in Table 1.
Although studies defining recovery as no longer meeting Notwithstanding, the field has operational definitions ripe
DSM criteria address overvaluation of weight/shape [32], this for empirical validation and for comparing against each other
arguably does not capture the pervasiveness of eating disorder to determine which are suitable and best supported by the data
cognitions that may increase risk for relapse [11]. Thus, and by clinical reality.
Curr Psychiatry Rep (2018) 20: 79 Page 9 of 18 79

Table 2 includes proposed operationalizations that have Predictors of Recovery


some validation support and are specific enough to permit
replication. Although most include criteria related to physical, Depending on the definition of recovery or “good outcome,”
behavioral, and psychological/cognitive dimensions, there are many factors have been implicated as being related to better
some important differences. For instance, Khalsa et al.’s [8••] outcome. Such factors include, but are not limited to, mother-
definition of recovery was specific to AN, Kordy et al. [9] pre- hood [76], selflessness [95], extraversion and assertiveness
sented different definitions by diagnosis (AN-restricting, AN- [32], and less impulsivity [88]. Franko et al. [69] found dif-
binge/purge, BN), and Bardone-Cone et al. [6••] proposed a ferent predictors of outcome at a 22-year follow-up, depend-
transdiagnostic definition to be applied regardless of eating dis- ing on diagnosis. A comorbid major depressive disorder at
order diagnosis. The proposals differ by minimum BMI required intake predicted having AN-restricting subtype at follow-up,
for recovery, but most require the absence of eating disorder an older age at intake and greater severity of AN or BN symp-
behaviors, with some variability in terms of which behaviors toms at intake assessment predicted having AN-binge/purge
are included. Regarding the psychological component, Khalsa subtype, and greater severity of BN symptoms at intake pre-
et al. and Bardone-Cone et al. use an established measure (EDE dicted having BN, suggesting the need to address these fea-
and EDE-Q, respectively), while Kordy et al. focus on one con- tures to promote recovery. The depression finding is in line
struct (e.g., fear of weight gain for AN, preoccupation with with work by Keski-Rahkonen and colleagues [105] who
figure for BN). Durations also vary, with absence of eating dis- found that the strongest predictor of failure to recover was
order behaviors ranging from 8 weeks to 12 months. Most premorbid depression.
groups also provide definitions/operationalizations for a “step With some exceptions—possibly premorbid depression
down” from recovery, called “partial recovery” by Khalsa et [69, 105]—the literature is lacking in replication of significant
al. and Bardone-Cone et al. and “full remission” by Kordy et predictors. Lack of replication is likely due to the lack of
al., which also vary in their specific criteria. consensus in defining and operationalizing recovery and dif-
Some initial work has begun the necessary comparison ferences in samples. Replication studies using the same con-
research. Ackard, Richter, Egan, and Cronemeyer [104] tested ceptualization of recovery are needed to provide more con-
a variety of definitions of remission in a female sample with a vincing support for useful predictors that would inform inter-
history of AN, BN, or EDNOS who had participated in an vention efforts and psychoeducation.
eating disorder treatment outcome study. Included in the com- With the caveat of variable recovery definitions, Vall and
parisons were: absence of a DSM eating disorder; Morgan- Wade [106] performed a meta-analysis to evaluate predictors
Russell criteria [78]; and criteria set forth by Pike [10], Kordy of treatment outcome. They found support for the following in
et al. [9], and Bardone-Cone et al. [6••]. Although the authors predicting better outcomes (but not necessarily recovery):
refer to remission, it appears that recovery was compared, greater motivation to recover, fewer comorbidities, lower de-
albeit not always with the durations specified (e.g., for pression, less severe eating pathology (fewer binge/purge be-
Kordy et al., duration of recovery applied was 3 months rather haviors, lower weight/shape concern), higher BMI, better in-
than the 12 months recommended). Ackard et al. [96] argue terpersonal functioning, and fewer family problems.
that a robust definition of remission would “prove applicable
for each ED diagnosis, demonstrate moderate to high agree
agreement with other remission definitions and particularly Recovery and Biological
across each ED diagnosis, including a measure of psycholog- and Neuropsychological Markers
ical wellbeing, and distinguish between remitted and not re-
mitted patients on quality of life”—with these guidelines in Recent recovery research tries to elucidate whether there are
mind and based on their empirical findings, they recommend biological differences between recovered individuals and
adopting the Bardone-Cone et al. [6••] criteria for assessing those with a current eating disorder, as a way to tease apart
recovery. More work comparing operationalizations is need- whether biological/neuropsychological markers are state-
ed, including longitudinal work to test the predictive validity related (and resolve with eating disorder recovery) or possible
of definitions (i.e., a valid definition should be associated with precursors (e.g., premorbid features that may serve as poten-
low relapse rates). tial risk factors for eating disorders) or scars of the eating
Of note, to date, operationalizations of recovery have not disorder (e.g., a consequence of the eating disorder that re-
included broad well-being as a criterion. We argue that exam- mains even after an eating disorder has been resolved). Of
ining well-being is important in understanding recovery and note, if individuals recovered from an eating disorder look
as a target of intervention and monitoring, but should not be similar to those with an eating disorder on a biological feature
part of the definition, given that non-eating disorder-related or neuropsychological marker, although that provides evi-
factors could be responsible for well-being, including psychi- dence against a state-related effect, it cannot distinguish be-
atric comorbidity. tween a premorbid biological difference and a scar effect,
79 Page 10 of 18 Curr Psychiatry Rep (2018) 20: 79

absent longitudinal data collected prior to the development of were significant differences that emerged, often in study de-
the eating disorder. signs comparing individuals recovered from AN and controls.
Fuglset, Landro, Reas, and Ro [107] reviewed neuroimag- For example, in Fuglset et al.’s review [107], they reported
ing studies (n = 14) of individuals recovered from AN. research that recovered individuals demonstrated: increased
Neuroimaging techniques (e.g., fMRI) investigated neural ac- activation in visual processing regions in response to viewing
tivation in response to visual processing of one’s own and faces, elevated activation in the ventral anterior insula (impli-
other’s bodies/appearance, food stimuli, gustatory processing, cated in processes related to focal attention) in anticipation of
and emotional stimuli. Additionally, these authors reviewed seeing images of food, and reduced activity in the medial
neuroimaging studies involving the neurobiological reward prefrontal cortex (which mediates decision-making) in the
system and executive functioning (i.e., set-shifting, working context of an inhibition task. Thus, this literature has identified
memory, inhibitory control). However, how recovery was de- biological/neuropsychological mechanisms that may underlie
fined was not made explicit, and Fuglset et al. also noted the or maintain some of the symptoms of AN.
difficulty in synthesizing findings due to the inconsistent par- Some recent findings suggest that biological or neurologi-
adigms used to assess neurobiological processes, making the cal deficits may be a premorbid feature or a scar of eating
findings difficult to interpret. With these caveats in mind, there disorders (i.e., serum zinc, brain connectivity in specific

Table 2 Operationalizations proposed with some validation support that are specific enough to permit replication

Pike [10] Kordy et al. [9] Couturier and Lock [5]

ED diagnoses addressed AN AN-restricting, AN-binge/purge, BN AN (in adolescents)


Criteria for full recovery
Physical BMI ≥ 20 or ≥ 90% of recommended weight; > 191,2 ; unspecified3 ≥ 90% of ideal body
normal menstrual functioning; weight
absence of acute medical problems
related to AN (excludes long-term
problems such as osteoporosis)
Behavioral Absence of compensatory behaviors Absence of binging2,3; absence of
vomiting or laxative abuse1,2,3
Psychological A RCI ≥ 1.96 and a score more likely to be No extreme fear of weight gain1,2; Restraint subscale
drawn from the functional than no extreme preoccupation of within 1 SD of
dysfunctional population on measures of shape and weight3 community norms
(a) weight and shape concerns
(i.e., EDE Weight Concern and Shape
Concern subscales, Body Shape
Questionnaire, Mizes Anorectic
Cognitions Scale) and dietary restriction
(i.e., EDE Restraint, EDI Drive for Thinness
subscale; Eating Inventory Restraint subscale)
Duration Minimum of 8 weeks 12 months1,2,3 Unspecified
Other illness statuses Initial treatment response, relapse, remission Full remission, partial remission,
defined relapse, and recurrence

Bardone-Cone et al. [6••] Khalsa et al. [8••]


ED diagnoses addressed Transdiagnostic AN
Criteria for full recovery
Physical BMI ≥ 18.5 BMI ≥ 20 or ≥ 85% of ideal body weight
Behavioral Absence of bingeing, purging, or fasting; not No restricting, bingeing, or purging
meeting criteria for current eating disorder
Psychological EDE-Q subscales within 1 SD of age-matched EDE within 1 SD of normal
norm
Duration 3 months for behavioral criteria; 1 month for 12 months
psychological
Other illness Partially recovered, active eating disorder Partial recovery, full remission, partial
statuses defined remission, partial relapse, and full
relapse

For Kordy et al. [9], 1 indicates criteria for AN-restricting, 2 indicates criteria for AN-binge/purge, and 3 indicates criteria for BN
RCI reliable change index as described by Jacobson and Truax [103]
Curr Psychiatry Rep (2018) 20: 79 Page 11 of 18 79

regions, gray matter)—that is, that these biological/ enduring showed comparable recovery rates at 12-month fol-
neurological features remain in recovery [64, 80]. However, low-up, challenging the idea that SE-AN is intractable to good
there is also evidence that recovery is associated with normal- therapeutic outcomes. Likewise, Eddy and colleagues [56]
ization of a wide host of neurobiological markers (i.e., cortical found that of those with AN who were not recovered at a 9-
thickness, white matter microstructure, olfactory sensitivity) year follow-up, half attained recovery at a 22-year follow-up.
[21, 49, 52, 70]. Some studies show mixed evidence, with These findings align with earlier work suggesting that those
restoration in some indices (i.e., gray matter, brain connectiv- with SE-AN were able to attain full recovery across physical,
ity) but not in others that are related or are in related regions behavioral, and psychological dimensions [109], providing
[22, 63]. optimism even among longstanding cases of AN and raising
Recent work has examined an array of neuropsychological questions about best ways to intervene. At what point, if any,
features, often in conjunction with other constructs, with in- might a shift occur away from staying the course with more
teresting implications. For example, anxiety appears to influ- active treatment and the goal of recovery toward a primary
ence cognitive inhibition in those remitted from AN [25]; focus on quality of life? [110].
since elevated cognitive inhibition contributes to the cognitive
rigidity, proposed as an endophenotype of AN [108], knowing
that anxiety exacerbates cognitive inhibition bolsters the need Qualitative Perspectives on Recovery
to treat anxiety as part of treating AN. In another finding,
higher activation in frontal regions during a visual stimulus Qualitative research on patients’ perspectives on eating disor-
processing task was associated with poor set-shifting in fe- der recovery is important in developing meaningful
males recovered from AN [45]. This finding highlights the operationalizations of recovery. Findings from qualitative
different but related mechanisms that may serve to maintain studies are constrained, however, by small sample sizes and
symptoms of AN, since both the enhanced cognitive control participants self-identifying as recovered or in recovery (most
linked to the brain activation and the cognitive rigidity inher- often from AN) rather than as a result of an assessment.
ent in poor set-shifting may contribute to rigid control over One main finding identified from these studies was that the
food intake, including in the context of visual cues of food. clinical reliance on biometrics (i.e., weight) and food intake,
Interestingly, recent research found no differences between was insufficient, and does not address the psychological part
individuals with first-episode AN, recovered from AN, or of recovery [111, 112]. In their qualitative meta-analysis, de
controls on set-shifting, working memory, sustained attention, Vos and colleagues [15••] reviewed 18 studies that included
and processing [54]. Importantly, this was in a sample of ad- 286 recovered individuals to find that psychological well-
olescents and young adults. The authors suggest that some being was the most endorsed criterion (making up 52% of
neuropsychological differences may be related to longer pe- recovery criteria endorsed), followed by reduction in eating
riods of starvation and appear later in adulthood as a scar, disorder pathology, including behaviors, cognitions, and
providing a window of opportunity for neuropsychological physical components (21% of criteria). Additionally, in a
intervention (e.g., cognitive remediation) earlier in the disor- unique qualitative study of women who identified as recov-
der, or that abnormalities may not be detectable until the at- ered and met physical, behavioral, and psychological criteria
tainment of fuller maturation. for recovery, participants reported a “reprogramming” via al-
In summary, it appears that some biological and neuropsy- tered thinking as a key indicator of recovery [109].
chological differences suggest possible trait vulnerabilities for A second key finding from these studies is that recovery is a
eating disorders, and some abnormalities observed in patients process and not just an outcome. Hence, examining pathways
with eating disorders normalize following a period of recov- to recovery (i.e., cultivating hope, developing self-compassion,
ery. Limitations of this body of work include the focus on AN benefiting from the support of others, and more specific pro-
and the tendency to not explicitly describe recovery cesses such as metamorphosing pride in AN to pride in self) is
operationalization. With consensus recovery criteria applied, important in addition to understanding what recovery “looks”
the neurobiological underpinnings of recovery seem ripe for like (outcome) [113–115]. Combining the importance of hope
further investigation. and support of others, preliminary work has shown that having
a recovered mentor available to instill hope that recovery is
possible was important to promoting recovery [99].
Severe and Enduring Anorexia Nervosa

How do individuals with severe and enduring AN (SE-AN) fit Future Directions
into thinking about recovery? Calugi and colleagues [55]
found that individuals with SE-AN (duration of illness > Consensus Definition Unquestionably, the most important fu-
7 years) and those with AN not characterized as severe and ture direction revolves around establishing a uniform,
79 Page 12 of 18 Curr Psychiatry Rep (2018) 20: 79

universal definition of recovery for the advancement of sci- assessments they are familiar with or due to recovery ques-
ence and clinical practice. Note that, given the absences of tions emerging post hoc without being able to planfully
such a consensus, all the findings reviewed above come with include relevant measures. Additionally, differing research
the caveat that results might be different, depending on the goals may prove a challenge to the universal adoption of a
definition and operationalization of recovery. It is troubling recovery definition. For example, a research team interested
when virtually every publication reporting on recovery fore- in the impact of physiological changes among those with
grounds the varying definitions of recovery as problematic, AN may have a rationale for focusing on “weight-recov-
and yet, as a field, this is a “broken record” that we keep ered” individuals, researchers engaged in a treatment out-
playing. This is a problem. However, there is a solution. come study may want to include in a recovery definition
Given the presence of specific operationalizations of recov- aspects that they hypothesize their treatment condition
ery with validation [6, 8, 9], these should continue to be exam- would alter, and research involving community samples
ined and compared. Decision-making related to what emerges may be motivated to examine the day to day lived experi-
as a consensus definition should rely on data demonstrating ences of recovery which they may feel requires a quality of
both concurrent validity cross-sectionally and predictive valid- life dimension as part of the recovery definition. Thus, it is
ity longitudinally (e.g., examining the stability of recovery). possible that, given the reality of different motivations
Researchers should also consider which definitions/ across studies, some would feel constrained by a universal-
operationalizations are most associated with common themes ly adopted definition. This is important to acknowledge, but
from patients’ reports, including self-acceptance and quality of should be weighed against what could be gained by having
life. Lastly, for criteria where normative levels are desired for a consensus definition to meaningfully compare study find-
recovery (e.g., eating disorder cognitions), population norms ings (and what is lost by not having an even playing field
that are age-matched and gender-matched are ideal [65]. for comparison). Perhaps researchers could be encouraged
In arriving at a consensus definition, it is worth considering to report findings both from a consensus definition and, if
dissemination of research findings into practice and other re- they so wish, from a variant that is of particular interest to
search studies. The public health impact of a treatment approach them—or to include these other constructs as validation
can be expressed as the product of the effectiveness of the inter- criteria for a consensus definition of recovery.
vention and its reach [116]. Similarly, it can be argued that the Researchers have stressed the need for leadership from
public health impact of recovery definitions/operationalizations clinical and research organizations (e.g., Academy for
results from the product of the validity of such definitions/ Eating Disorders, National Eating Disorders Association,
operationalizations and their reach. Thus, if a validated defini- Eating Disorders Research Society) to support a standard-
tion of recovery is not widely disseminated and applied consis- ized consensus definition for it to be successfully widely
tently in treatment outcome research, then the impact of this adopted and have an impact [8••, 14]. Specialty profes-
knowledge will be limited and, more specifically, the field will sional journals (e.g., International Journal of Eating
continue to be hamstrung by inconsistency. A contributor to Disorders) could also give much needed leadership in this
successful dissemination is “real world usability” [117], which area by encouraging research on operationalization/
includes consideration of cost and training needed. Being able to validation (i.e., special issue) and ensuring that “recov-
assess recovery criteria in a logistically streamlined way (such as ered” samples are operationalized sufficiently for replica-
assessing cognitions with the EDE-Q) should improve the reach tion and in line with the current conceptualization (i.e.,
of a consensus definition of recovery. combination of physical, behavioral, psychological/
In addition to the need for a consensus definition of recovery, cognitive).
there is also the need for consensus terminology of terms such
as recovery, partial recovery, remission, and relapse. For exam- Transdiagnostic or Tailored to Specific Eating Disorders?
ple, using the same dataset and the same criteria for outcome, Should we be looking for one definition/operationalization
different authors have referred to the same group as “recovered” of recovery to apply to all eating disorder diagnoses? In their
and “remitted” [56, 69]. While in some work, the idea of “par- qualitative meta-analysis, de Vos et al. [15••] intentionally
tial recovery” refers to some but not all aspects of recovery included studies regardless of eating disorder diagnoses
attained (physical and behavioral but not cognitive recovery since their interest was in overall criteria for eating disorder
[6••]), and in other work, partial and full recovery require iden- recovery. Bardone-Cone et al. [6••] have also argued for the
tical criteria except that the duration of the criteria is longer for benefit of one set of criteria so as to capture all eating dis-
recovery [8••]. Consistent terminology would aid in communi- orders, given the relatively common experience of diagnos-
cation among clinicians, patients, families, and researchers. tic migration and symptom fluctuation [118]. There is also
Why have existing operationalizations with evidence of value in parsimony. Rather than modifying definitions to fit
validity not had greater impact on recovery research? This AN, BN, binge eating disorder (BED), and other eating
could be due to researchers tending to stick with disorders, having one conceptualization makes it easier to
Curr Psychiatry Rep (2018) 20: 79 Page 13 of 18 79

communicate what recovery means and make comparisons. Also, it is striking how many recent studies on recovery
Importantly, even if one were to use a transdiagnostic def- focus solely on AN (80%); thus, recovery is much less
inition of recovery applicable across eating disorders, that examined for BN, BED, other specified feeding or eating
does not imply that predictors of such recovery would be disorder (OSFED), and unspecified feeding or eating dis-
the same across diagnoses. Indeed, Lock et al. [14] found order (UFED).
different predictors of full recovery (physical, behavioral, Recovery research has also predominantly focused on ad-
psychological): end of treatment weight gain best predicted olescents and young adults, females, and Caucasian popula-
recovery for those with AN and decreased rates of purging tions; this mirrors eating disorder research on topics other than
to less than 2×/month at end of treatment best predicted recovery. It has been well-established that eating disorders
recovery among those with BN. Nonetheless, future re- occur across the age span, affect males, and are experienced
search should examine whether tailored definitions of re- by individuals of diverse racial and ethnic backgrounds. What
covery are more valid than a transdiagnostic approach. is not known is whether current conceptualizations and
operationalizations of recovery are valid across these diverse
Process of Recovery Recovery is both a process and a state/ groups. Relatedly, we do not know if predictors of recovery
outcome, with the process dimension especially empha- differ across groups. Cultural factors may facilitate recovery
sized in qualitative research with individuals who self- or present additional barriers. For example, if eating disorders
identify as recovered (e.g., recovery as a “journey”). are less recognized in racial/ethnic minority groups (e.g., few-
Examining the impact of process variables empirically is er referrals), then they will likely begin treatment at a later age,
warranted (e.g., fostering the evolution of source of pride with implications for poorer outcomes [76•].
and self-concept across treatment; realistically promoting How the sample of controls is selected also warrants men-
hope; boosting self-acceptance). This could inform specific tion. If a research question requires comparing a recovered
aspects of intervention to focus on or develop in relation to group to controls, efforts should be made to match controls
the outcome of recovery. on key demographic variables of the recovered sample (e.g.,
age, gender). Although many researchers select controls with
Full Recovery for All? Should this concept of full recovery be no current or history of eating disorders or any psychological
something to aim for with all of our patients? The argument disorder, we believe this is ill-advised. Individuals with no
for an affirmative response is that we do not want to have history of any psychopathology are not very representative
patients settle for something less which might increase risk of the population. Further, comparing to individuals so free
for relapse. Further, evidence indicates that even particularly of psychopathology arguably makes it easier to find differ-
severe cases can attain this high level of recovery [109], and ences; more rigorous would be for comparison samples to
much of the qualitative work since 2016 has highlighted the have no history of eating pathology but be otherwise repre-
value of hope and being able to envision recovery as possible sentative of the diversity of psychopathology. A related impli-
[102, 113, 114, 119]. The argument against aiming for full cation of using “super-healthy” controls is that recovered in-
recovery for all is that, realistically, some individuals may dividuals are not being compared to normative expectations
experience residual eating disorder cognitions throughout but rather to a higher, and less epidemiologically likely, stan-
their lives and that, for these individuals, providing tools to dard given the known prevalence of psychological disorders
prevent their thoughts from transforming into actions (behav- [123]. Also, if recovery findings differ across studies that use
ioral symptoms) may be the most feasible and helpful ap- the same consensus definition but different ways of defining
proach. The challenge would be in how to determine that an controls (i.e., no eating disorder pathology vs. no psychopa-
intervention aimed at attaining cognitive recovery should end thology of any kind), discrepant findings could be due to the
or transition to a different approach. control group differences. For example, studies using certain
types of methods (e.g., neuroimaging) may recruit super-
Diversity of Samples Most recovery research recruits indi- healthy control participants to maximize the likelihood of de-
viduals who presented for treatment at an eating disorder tecting group differences [124].
clinic. However, only about 50% of cases of AN are de-
tected in the healthcare/medical system [120] and only a Mediators and Moderators Examining mediators and moder-
minority of these are seen for treatment in a specialty clinic ators of recovery has not been extensively examined. Once a
[121]; thus, our understanding of recovery has generally consensus definition of recovery has been adopted, this will be
been limited to those seeking treatment through eating dis- an important future avenue, especially in intervention work.
order clinics/centers. Given the existence of “spontaneous” For example, if we knew for whom certain interventions more
recovery unrelated to treatment [122], we might wonder if likely lead to recovery (moderator model), we could provide
a definition of recovery that is valid in treatment-seeking better referrals to match patients to treatment. And if we could
samples is valid in those who recover without treatment. determine which factors are changed by an intervention to
79 Page 14 of 18 Curr Psychiatry Rep (2018) 20: 79

form a pathway to recovery (mediator model), we could mod- Acknowledgements NIH Grant R01 MH095860 to Anna M. Bardone-
Cone (PI).
ify treatments to target those factors. A review paper [125]
sought to identify mediators and moderators of cognitive be-
havioral therapy for eating disorders. Regarding mediators,
Compliance with Ethical Standards
they found that early changes in behavioral and cognitive
Conflict of Interest The authors declare that they have no conflict of
symptoms led to better outcomes in these dimensions across interest.
eating disorder diagnoses. However, they were unable to iden-
tify consistent moderators of outcome and noted that a possi- Human and Animal Rights and Informed Consent This article does not
ble reason was due to the widely varying definitions of out- contain any studies with human or animal subjects performed by any of
the authors.
come. Researchers examining moderator and mediator
models are urged to select moderators and mediators on the
basis of theory rather than convenience.
References

Papers of particular interest, published recently, have been


Conclusions highlighted as:
• Of importance
Based on this review of recent research, we conclude that a •• Of major importance
suitable conceptualization of recovery will include assessment
of physical, behavioral, and (eating disorder-specific) 1. Berkman ND, Lohr KN, Bulik CM. Outcomes of eating disorders:
psychological/cognitive domains, as well as absence of any a systematic review of the literature. Int J Eat Disord. 2007;40(4):
293–309.
eating disorder (not only the presenting eating disorder).
2. Steinhausen H-C, Weber S. The outcome of bulimia nervosa:
Further, we recommend a conceptualization that can be ap- findings from one-quarter century of research. Am J Psychiatr.
plied transdiagnostically for parsimony and given the reality 2009;166(12):1331–41.
of diagnostic migration. Useful adjuncts that are relevant to 3. Steinhausen H-C. The outcome of anorexia nervosa in the 20th
understanding recovery but are not incorporated within the century. Am J Psychiatr. 2002;159(8):1284–93.
definition of recovery include quality of life and broader psy- 4. Steinhausen H-C. Outcome of eating disorders. Child Adolesc
Psychiatr Clin N Am. 2009;18(1):225–42.
chological well-being (i.e., comorbid psychopathology, self- 5. Couturier J, Lock J. What is recovery in adolescent anorexia
a c c e p t a n c e ) . Wi t h o u t a s t a n d a r d d e f i n i t i o n a n d nervosa? Int J Eat Disord. 2006;39(7):550–5.
operationalization of recovery, research progress is hampered, 6.•• Bardone-Cone AM, Harney MB, Maldonado CR, Lawson MA,
but confusion about what recovery means may also translate Robinson DP, Smith R, et al. Defining recovery from an eating
disorder: conceptualization, validation, and examination of psy-
to potential harms for patients by spilling over into clinical
chosocial functioning and psychiatric comorbidity. Behav Res
practice, for instance, by unintentionally squelching hope. Ther. 2010;48(3):194–202. This study provides a comprehen-
For example, Rance, Moller, and Clarke [112] reported that sive, transdiganostic definition of recovery including physical,
one patient noted: “I very much got the message from the behavioral, and psychological criteria and further elucidates
eating disorder service that an eating disorder was something the importance of psychological criteria of recovery.
7. Jarman M, Walsh S. Evaluating recovery from anorexia nervosa
I managed for the rest of my life…and I didn’t even know like and bulimia nervosa: integrating lessons learned from research
you could ever get fully better” (p. 589). and clinical practice. Clin Psychol Rev. 1999;19(7):773–88.
Several operationalizations of recovery that are specific 8.•• Khalsa SS, Portnoff LC, McCurdy-McKinnon D, Feusner JD.
enough to permit testing and replication have been proposed What happens after treatment? A systematic review of relapse,
remission, and recovery in anorexia nervosa. Int J Eat Disord.
[5, 6, 8–10, 102]. Building on previous validation testing [6••,
2017;5(1):20. This study reviews defintions of recovery and
9, 14] will clarify the direction of most value for the eating relapse in recent literature and proposes standardized criteria
disorder field. Once this has been achieved, more progress for recovery, remission, and relapse in AN.
will be able to be made on an array of critical topics: identi- 9. Kordy H, Krämer B, Palmer RL, Papezova H, Pellet J, Richard M,
fying predictors of recovery, biological and neurological et al. Remission, recovery, relapse, and recurrence in eating disor-
ders: conceptualization and illustration of a validation strategy. J
markers, treatments most strongly associated with recovery, Clin Psychol. 2002;58(7):833–46.
and similarities/differences across diverse samples. Clinically, 10. Pike KM. Long-term course of anorexia nervosa: response, re-
adopting a standardized definition does not negate the impor- lapse, remission, and recovery. Clin Psychol Rev. 1998;18(4):
tance of attending to the personal meaning of recovery for 447–75.
patients. While developing a standardized definition would 11. Williams SE, Watts TK, Wade TD. A review of the definitions of
outcome used in the treatment of bulimia nervosa. Clin Psychol
overcome a major barrier in the eating disorders field and have Rev. 2012;32(4):292–300.
far-reaching clinical implications, recovery remains a highly 12. Yu J, Agras WS, Bryson S. Defining recovery in adult bulimia
personal experience. nervosa. Eat Disord. 2013;21(5):379–94.
Curr Psychiatry Rep (2018) 20: 79 Page 15 of 18 79

13. Bachner-Melman R, Zohar AH, Ebstein RP. An examination of 31. Las Hayas C, Padilla P, Barrio AG, Beato-Fernandez L, Muñoz P,
cognitive versus behavioral components of recovery from anorex- Gámez-Guadix M. Individualised versus standardised assessment
ia nervosa. J Nerv Ment Dis. 2006;194(9):697–703. of quality of life in eating disorders. Eur Eat Disord Rev.
14. Lock J, Agras WS, Grange D, Couturier J, Safer D, Bryson SW. 2016;24(2):147–56.
Do end of treatment assessments predict outcome at follow-up in 32. Levallius J, Roberts BW, Clinton D, Norring C. Take charge:
eating disorders? Int J Eat Disord. 2013;46(8):771–8. personality as predictor of recovery from eating disorder.
15.•• de Vos JA, LaMarre A, Radstaak M, Bijkerk CA, Bohlmeijer ET, Psychiatry Res. 2016;246:447–52.
Westerhof GJ. Identifying fundamental criteria for eating disorder 33. McAdams CJ, Jeon-Slaughter H, Evans S, Lohrenz T, Montague
recovery: a systematic review and qualitative meta-analysis. J Eat PR, Krawczyk DC. Neural differences in self-perception during
Disord. 2017;5(1):34. This paper provides a systematic review illness and after weight-recovery in anorexia nervosa. Soc Cogn
of criteria for recovery described as integral by recovered Affect Neurosci. 2016;11(11):1823–31.
individuals 34. Monteleone AM, Monteleone P, Serino I, Amodio R, Monaco F,
16. Dawson L, Rhodes P, Touyz S. Defining recovery from anorexia Maj M. Underweight subjects with anorexia nervosa have an en-
nervosa: a Delphi study to determine expert practitioners’ views. hanced salivary cortisol response not seen in weight restored sub-
Adv Eat Disord Theory Res Pract. 2015;3(2):165–76. jects with anorexia nervosa. Psychoneuroendocrinology. 2016;70:
17. Bang L, Rø Ø, Endestad T. Normal gray matter volumes in wom- 118–21.
en recovered from anorexia nervosa: a voxel-based morphometry 35. Mustelin L, Latvala A, Raevuori A, Rose RJ, Kaprio J, Keski-
study. BMC Psychiatry. 2016;16(1):144. Rahkonen A. Risky drinking behaviors among women with eating
18. Bang L, Rø Ø, Endestad T. Amygdala alterations during an emo- disorders—a longitudinal community-based study. Int J Eat
tional conflict task in women recovered from anorexia nervosa. Disord. 2016;49(6):563–71.
Psychiatry Res Neuroimaging. 2016;248:126–33. 36. Mustelin L, Lehtokari VL, Keski-Rahkonen A. Other specified
19. Bardone-Cone AM, Butler RM, Balk MR, Koller KA. and unspecified feeding or eating disorders among women in the
Dimensions of impulsivity in relation to eating disorder recovery. community. Int J Eat Disord. 2016;49(11):1010–7.
Int J Eat Disord. 2016;49(11):1027–31. 37. Mustelin L, Silén Y, Raevuori A, Hoek HW, Kaprio J, Keski-
20. Bardone-Cone AM, Higgins M, St. George SM, Rosenzweig I, Rahkonen A. The DSM-5 diagnostic criteria for anorexia nervosa
Schaefer LM, Fitzsimmons-Craft EE, et al. Behavioral and psy- may change its population prevalence and prognostic value. J
chological aspects of exercise across stages of eating disorder Psychiatr Res. 2016;77:85–91.
recovery. Eat Disord. 2016;24(5):424–39. 38. O’Hara CB, Keyes A, Renwick B, Giel KE, Campbell IC,
Schmidt U. Evidence that illness-compatible cues are rewarding
21. Bernardoni F, King JA, Geisler D, Stein E, Jaite C, Nätsch D, et al.
in women recovered from anorexia nervosa: a study of the effects
Weight restoration therapy rapidly reverses cortical thinning in
of dopamine depletion on eye-blink startle responses. PLoS One.
anorexia nervosa: a longitudinal study. NeuroImage. 2016;130:
2016;11(10):e0165104.
214–22.
39. O’Hara CB, Keyes A, Renwick B, Leyton M, Campbell IC,
22. Boehm I, Geisler D, Tam F, King JA, Ritschel F, Seidel M, et al.
Schmidt U. The effects of acute dopamine precursor depletion
Partially restored resting-state functional connectivity in women
on the reinforcing value of exercise in anorexia nervosa. PLoS
recovered from anorexia nervosa. J Psychiatry Neurosci.
One. 2016;11(1):e0145894.
2016;41(6):377.
40. Pfuhl G, King JA, Geisler D, Roschinski B, Ritschel F, Seidel M,
23. Dapelo MM, Hart S, Hale C, Morris R, Tchanturia K. Expression et al. Preserved white matter microstructure in young patients with
of positive emotions differs in illness and recovery in anorexia anorexia nervosa? Hum Brain Mapp. 2016;37(11):4069–83.
nervosa. Psychiatry Res. 2016;246:48–51. 41. Phillips KE, Jimerson DC, Pillai A, Wolfe BE. Plasma BDNF
24. Egger N, Wild B, Zipfel S, Junne F, Konnopka A, Schmidt U, et levels following weight recovery in anorexia nervosa. Physiol
al. Cost-effectiveness of focal psychodynamic therapy and en- Behav. 2016;165:300–3.
hanced cognitive–behavioural therapy in out-patients with anorex- 42. Scaife JC, Godier LR, Reinecke A, Harmer CJ, Park RJ.
ia nervosa. Psychosom Med. 2016;46(16):3291–301. Differential activation of the frontal pole to high vs low calorie
25. Ely AV, Wierenga CE, Kaye WH. Anxiety impacts cognitive in- foods: the neural basis of food preference in anorexia nervosa?
hibition in remitted anorexia nervosa. Eur Eat Disord Rev. Psychiatry Res Neuroimaging. 2016;258:44–53.
2016;24(4):347–51. 43. Shih P-aB, Yang J, Morisseau C, German JB, Scott-Van Zeeland
26.• Errichiello L, Iodice D, Bruzzese D, Gherghi M, Senatore I. A, Armando AM, et al. Dysregulation of soluble epoxide hydro-
Prognostic factors and outcome in anorexia nervosa: a follow-up lase and lipidomic profiles in anorexia nervosa. Mol Psychiatry.
study. Eat Weight Disord. 2016;21(1):73–82. Through cluster 2016;21(4):537.
analysis, this study identifies prognostic factors associated 44. Shott ME, Pryor TL, Yang TT, Frank GK. Greater insula white
with good outcome (physical and behavioral indices of recov- matter fiber connectivity in women recovered from anorexia
ery) in patients with AN. nervosa. Neuropsychopharmacology. 2016;41(2):498.
27. Frank GK, Collier S, Shott ME, O’Reilly RC. Prediction error and 45. Sultson H, van Meer F, Sanders N, van Elburg AA, Danner UN,
somatosensory insula activation in women recovered from an- Hoek HW, et al. Associations between neural correlates of visual
orexia nervosa. J Psychiatry Neurosci. 2016;41(5):304. stimulus processing and set-shifting in ill and recovered women
28. Frank GK, Shott ME, Keffler C, Cornier MA. Extremes of eating with anorexia nervosa. Psychiatry Res Neuroimaging. 2016;255:
are associated with reduced neural taste discrimination. Int J Eat 35–42.
Disord. 2016;49(6):603–12. 46. Kjærsdam Telléus G, Fagerlund B, Jepsen JR, Bentz M,
29. Godier LR, de Wit S, Pinto A, Steinglass JE, Greene AL, Scaife J, Christiansen E, Valentin JB, et al. Are weight status and cognition
et al. An investigation of habit learning in anorexia nervosa. associated? An examination of cognitive development in children
Psychiatry Res. 2016;244:214–22. and adolescents with anorexia nervosa 1 year after first
30. Hartmann A, Zeeck A, Herzog W, Wild B, Zwaan M, Herpertz S, hospitalisation. Eur Eat Disord Rev. 2016;24(5):366–76.
et al. The intersession process in psychotherapy for anorexia 47. Wild B, Friederich H-C, Zipfel S, Resmark G, Giel K, Teufel M, et
nervosa: characteristics and relation to outcome. J Clin Psychol. al. Predictors of outcomes in outpatients with anorexia nervosa:
2016;72(9):861–79. results from the ANTOP study. Psychiatry Res. 2016;244:45–50.
79 Page 16 of 18 Curr Psychiatry Rep (2018) 20: 79

48. Bailer UF, Price JC, Meltzer CC, Wagner A, Mathis CA, Gamst A, 65. Swenne I, Parling T, Ros HS. Family-based intervention in ado-
et al. Dopaminergic activity and altered reward modulation in lescent restrictive eating disorders: early treatment response and
anorexia nervosa—insight from multimodal imaging. Int J Eat low weight suppression is associated with favourable one-year
Disord. 2017;50(5):593–6. outcome. BMC Psychiatry. 2017;17(1):333.
49. Bang L, Rø Ø, Endestad T. Normal white matter microstructure in 66. Xu J, Harper JA, Van Enkevort EA, Latimer K, Kelley U,
women long-term recovered from anorexia nervosa: a diffusion McAdams CJ. Neural activations are related to body-shape, anx-
tensor imaging study. Int J Eat Disord. 2018;51(1):46–52. iety, and outcomes in adolescent anorexia nervosa. J Psychiatr
50. Bang L, Rø Ø, Endestad T. Threat-detection and attentional bias to Res. 2017;87:1–7.
threat in women recovered from anorexia nervosa: neural alter- 67. Boehm I, Flohr L, Steding J, Holzapfel L, Seitz J, Roessner V, et
ations in extrastriate and medial prefrontal cortices. Eur Eat Disord al. The trajectory of anhedonic and depressive symptoms in an-
Rev. 2017;25(2):80–8. orexia nervosa: a longitudinal and cross-sectional approach. Eur
51. Baucom DH, Kirby JS, Fischer MS, Baucom BR, Hamer R, Bulik Eat Disord Rev. 2018;26(1):69–74.
CM. Findings from a couple-based open trial for adult anorexia 68. Castellini G, Lelli L, Cassioli E, Ciampi E, Zamponi F, Campone
nervosa. J Fam Psychol. 2017;31(5):584. B, et al. Different outcomes, psychopathological features, and co-
52. Bentz M, Guldberg J, Vangkilde S, Pedersen T, Plessen KJ, Jepsen morbidities in patients with eating disorders reporting childhood
JRM. Heightened olfactory sensitivity in young females with abuse: a 3-year follow-up study. Eur Eat Disord Rev. 2018;26(3):
recent-onset anorexia nervosa and recovered individuals. PLoS 217–29.
One. 2017;12(1):e0169183. 69.• Franko DL, Tabri N, Keshaviah A, Murray HB, Herzog DB,
53. Bentz M, Jepsen JRM, Pedersen T, Bulik CM, Pedersen L, Thomas JJ, et al. Predictors of long-term recovery in anorexia
Pagsberg AK, et al. Impairment of social function in young fe- nervosa and bulimia nervosa: data from a 22-year longitudinal
males with recent-onset anorexia nervosa and recovered individ- study. J Psychiatr Res. 2018;96:183–8. This longitudinal study
uals. J Adolesc Health. 2017;60(1):23–32. (22-year follow-up) examines predictors of long-term recovery
54. Bentz M, Jepsen JRM, Telléus GK, Moslet U, Pedersen T, Bulik using the Psychiatric Rating Scale in individuals with AN and
CM, et al. Neurocognitive functions and social functioning in BN.
young females with recent-onset anorexia nervosa and recovered 70. Lavagnino L, Mwangi B, Cao B, Shott ME, Soares JC, Frank GK.
individuals. J Eat Disord. 2017;5(1):5. Cortical thickness patterns as state biomarker of anorexia nervosa.
Int J Eat Disord. 2018;51(3):241–9.
55. Calugi S, El Ghoch M, Dalle GR. Intensive enhanced cognitive
71. McAdams CJ, Harper JA, Van Enkevort E. Mentalization and the
behavioural therapy for severe and enduring anorexia nervosa: a
left inferior frontal gyrus and insula. Eur Eat Disord Rev.
longitudinal outcome study. Behav Res Ther. 2017;89:41–8.
2018;26(3):265–71
56.• Eddy KT, Tabri N, Thomas JJ, Murray HB, Keshaviah A,
72. Fairburn CG, Peveler RC, Jones R, Hope R, Doll HA. Predictors
Hastings E, et al. Recovery from anorexia nervosa and bulimia
of 12-month outcome in bulimia nervosa and the influence of
nervosa at 22-year follow-up. J Clin Psychiatry. 2017;78(2):184–
attitudes to shape and weight. J Consult Clin Psychol.
9. This longitudinal study used the Psychiatric Rating Scale to
1993;61(4):696.
examine both shorter-term (9 year) and longer-term (20–
73. Keel PK, Dorer DJ, Franko DL, Jackson SC, Herzog DB.
25 years) recovery in individuals with AN and BN and pro-
Postremission predictors of relapse in women with eating disor-
vides evidence that recovery from severe and enduring AN is
ders. Am J Psychiatr. 2005;162(12):2263–8.
possible.
74. Keski-Rahkonen A, Tozzi F. The process of recovery in eating
57. Erdur L, Weber C, Zimmermann-Viehoff F, Rose M, Deter HC.
disorder sufferers’ own words: an Internet-based study. Int J Eat
Affective responses in different stages of anorexia nervosa: results
Disord. 2005;37(S1):S80–6.
from a startle-reflex paradigm. Eur Eat Disord Rev. 2017;25(2):
75. Nakai Y, Nin K, Noma S, Hamagaki S, Takagi R, Teramukai S, et
114–22.
al. Clinical presentation and outcome of avoidant/restrictive food
58. Forsberg S, Darcy A, Bryson SW, Arnow KD, Datta N, Le Grange intake disorder in a Japanese sample. Eat Behav. 2017;24:49–53.
D, et al. Psychological symptoms among parents of adolescents 76.• Fichter MM, Quadflieg N, Crosby RD, Koch S. Long-term out-
with anorexia nervosa: a descriptive examination of their presence come of anorexia nervosa: Results from a large clinical longitudi-
and role in treatment outcome. J Fam Ther. 2017;39(4):514–36. nal study. Int J Eat Disord. 2017;50(9):1018–30. This study is a
59. Halvorsen I, Reas DL, Nilsen JV, Rø Ø. Naturalistic outcome of 20-year follow-up of individuals with anorexia nervosa and
family-based inpatient treatment for adolescents with anorexia reports on physical, behavioral, and (eating disorder-
nervosa. Eur Eat Disord Rev. 2017;26(2):141–5. specific) psychological/cognitive outcomes, psychiatric comor-
60. Harper JA, Brodrick B, Van Enkevort E, McAdams CJ. bidity, and diagnostic crossover.
Neuropsychological and cognitive correlates of recovery in an- 77. Parling T, Cernvall M, Ramklint M, Holmgren S, Ghaderi A. A
orexia nervosa. Eur Eat Disord Rev. 2017;25(6):491–500. randomised trial of acceptance and commitment therapy for an-
61. Kuipers GS, den Hollander S, van der Ark LA, Bekker MH. orexia nervosa after daycare treatment, including five-year follow-
Recovery from eating disorder 1 year after start of treatment is up. BMC Psychiatry. 2016;16(1):272.
related to better mentalization and strong reduction of sensitivity 78. Morgan H, Russell G. Value of family background and clinical
to others. Eat Weight Disord. 2017;22(3):535–47. features as predictors of long-term outcome in anorexia nervosa:
62. Leppanen J, Dapelo MM, Davies H, Lang K, Treasure J, four-year follow-up study of 41 patients. Psychol Med. 1975;5(4):
Tchanturia K. Computerised analysis of facial emotion expression 355–71.
in eating disorders. PLoS One. 2017;12(6):e0178972. 79. American Psychiatric Association. Diagnostic and statistical man-
63. Martin Monzon B, Henderson LA, Madden S, Macefield VG, ual of mental disorders. 5th ed. Arlington, VA: American
Touyz S, Kohn MR, et al. Grey matter volume in adolescents with Psychiatric Publishing; 2013.
anorexia nervosa and associated eating disorder symptoms. Eur J 80. Zepf FD, Rao P, Runions K, Stewart RM, Moore JK, Wong JW, et
Neurosci. 2017;46(7):2297–307. al. Differences in serum zinc levels in acutely ill and remitted
64. Scaife JC, Godier LR, Filippini N, Harmer CJ, Park RJ. Reduced adolescents and young adults with bulimia nervosa in comparison
resting-state Functional connectivity in current and recovered re- with healthy controls—a cross-sectional pilot study.
strictive anorexia nervosa. Front Psychiatry. 2017;8:30. Neuropsychiatr Dis Treat. 2017;13:2621.
Curr Psychiatry Rep (2018) 20: 79 Page 17 of 18 79

81. Trottier K, Monson CM, Wonderlich SA, Olmsted MP. Initial individuals with and recovered from anorexia nervosa. J Clin
findings from project recover: overcoming co-occurring eating Nurs. 2017;27(5–6):e845–e57.
disorders and posttraumatic stress disorder through integrated 100. Mekori E, Halevy L, Ziv SI, Moreno A, Enoch-Levy A, Weizman
treatment. J Trauma Stress. 2017;30(2):173–7. A, et al. Predictors of short-term outcome variables in hospitalised
82. Murray HB, Tabri N, Thomas JJ, Herzog DB, Franko DL, Eddy female adolescents with eating disorders. Int J Psychiatry Clin
KT. Will I get fat? 22-year weight trajectories of individuals with Pract. 2017;21(1):41–9.
eating disorders. Int J Eat Disord. 2017;50(7):739–47. 101. Winkler LA-D, Frølich JS, Gudex C, Hørder K, Bilenberg N,
83. Fairburn CG, Beglin SJ. Assessment of eating disorders: interview Støving RK. Patient-and clinician-reported outcome in eating dis-
or self-report questionnaire? Int J Eat Disord. 1994;16(4):363–70. orders. Psychiatry Res. 2017;247:230–5.
84. Cooper Z, Fairburn C. The eating disorder examination: a semi- 102. Olmsted MP, Kaplan AS, Rockert W. Defining remission and
structured interview for the assessment of the specific psychopa- relapse in bulimia nervosa. Int J Eat Disord. 2005;38(1):1–6.
thology of eating disorders. Int J Eat Disord. 1987;6(1):1–8. 103. Jacobson NS, Truax P. Clinical significance: a statistical approach
85. Herzog DB, Sacks NR, Keller MB, Lavori PW, Von Ranson KB, to defining meaningful change in psychotherapy research. J
Gray HM. Patterns and predictors of recovery in anorexia nervosa Consult Clin Psychol. 1991;59(1):12.
and bulimia nervosa. J Am Acad Child Adolesc Psychiatry. 104. Ackard DM, Richter SA, Egan AM, Cronemeyer CL. What does
1993;32(4):835–42. remission tell us about women with eating disorders? Investigating
86. Accurso EC, Wonderlich SA, Crosby RD, Smith TL, Klein MH, applications of various remission definitions and their associations
Mitchell JE, et al. Predictors and moderators of treatment outcome with quality of life. J Psychosom Res. 2014;76(1):12–8.
in a randomized clinical trial for adults with symptoms of bulimia 105. Keski-Rahkonen A, Raevuori A, Bulik CM, Hoek HW, Rissanen
nervosa. J Consult Clin Psychol. 2016;84(2):178. A, Kaprio J. Factors associated with recovery from anorexia
87. Hughes EK, Le Grange D, Court A, Sawyer SM. A case series of nervosa: a population-based study. Int J Eat Disord. 2014;47(2):
family-based treatment for adolescents with atypical anorexia 117–23.
nervosa. Int J Eat Disord. 2017;50(4):424–32. 106. Vall E, Wade TD. Predictors of treatment outcome in individuals
88. Manasse SM, Espel HM, Schumacher LM, Kerrigan SG, Zhang F, with eating disorders: a systematic review and meta-analysis. Int J
Forman EM, et al. Does impulsivity predict outcome in treatment Eat Disord. 2015;48(7):946–71.
for binge eating disorder? A multimodal investigation. Appetite. 107. Fuglset TS, Landrø NI, Reas DL, Rø Ø. Functional brain alter-
2016;105:172–9. ations in anorexia nervosa: a scoping review. J Eat Disord.
89. Le Grange D, Hughes EK, Yeo M, Crosby RD, Sawyer SM. 2016;4(1):32.
Randomized clinical trial of parent-focused treatment and 108. Holliday J, Tchanturia K, Landau S, Collier D, Treasure J. Is
family-based treatment for adolescent anorexia nervosa. J Am impaired set-shifting an endophenotype of anorexia nervosa?
Acad Child Adolesc Psychiatry. 2016;55(8):683–92. Am J Psychiatr. 2005;162(12):2269–75.
90. Wade S, Byrne S, Allen K. Enhanced cognitive behavioral therapy 109. Dawson L, Rhodes P, Touyz S. “Doing the impossible” the pro-
for eating disorders adapted for a group setting. Int J Eat Disord. cess of recovery from chronic anorexia nervosa. Qual Health Res.
2017;50(8):863–72. 2014;24(4):494–505.
91. Allan E, Le Grange D, Sawyer SM, McLean LA, Hughes EK. 110. Wonderlich S, Mitchell JE, Crosby RD, Myers TC, Kadlec K,
Parental expressed emotion during two forms of family-based LaHaise K, et al. Minimizing and treating chronicity in the eating
treatment for adolescent anorexia nervosa. Eur Eat Disord Rev. disorders: a clinical overview. Int J Eat Disord. 2012;45(4):467–75.
2018;26(1):46–52. 111. LaMarre A, Rice C. Normal eating is counter-cultural: embodied
92. Rienecke RD, Lebow J, Lock J, Le Grange D. Family profiles of experiences of eating disorder recovery. J Community Appl Soc
expressed emotion in adolescent patients with anorexia nervosa and Psychol. 2016;26(2):136–49.
their parents. J Clin Child Adolesc Psychol. 2017;46(3):428–36. 112. Rance N, Clarke V, Moller N. The anorexia nervosa experience:
93. Wallis A, Miskovic-Wheatley J, Madden S, Rhodes P, Crosby RD, shame, solitude and salvation. Couns Psychother Res. 2017;17(2):
Cao L, et al. How does family functioning effect the outcome of 127–36.
family based treatment for adolescents with severe anorexia 113. Hannon J, Eunson L, Munro C. The patient experience of illness,
nervosa? J Eat Disord. 2017;5(1):55. treatment, and change, during intensive community treatment for
94. Lang K, Roberts M, Harrison A, Lopez C, Goddard E, Khondoker severe anorexia nervosa. Eat Disord. 2017;25(4):279–96.
M, et al. Central coherence in eating disorders: a synthesis of 114. Las Hayas C, Padierna JA, Muñoz P, Aguirre M, Gómez del
studies using the Rey Osterrieth Complex Figure Test. PLoS Barrio A, Beato-Fernández L, et al. Resilience in eating disorders:
One. 2016;11(11):e0165467. a qualitative study. Women Health. 2016;56(5):576–94.
95. Pinus U, Canetti L, Bonne O, Bachar E. Selflessness as a predictor 115. Faija CL, Tierney S, Gooding PA, Peters S, Fox JR. The role of
of remission from an eating disorder: 1–4 year outcomes from an pride in women with anorexia nervosa: a grounded theory study.
adolescent day-care unit. Eat Weight Disord. 2017;11:1–10. Psychol Psychother Theory Res Pract. 2017;90(4):567–85.
96. Amianto F, Spalatro A, Ottone L, Daga GA, Fassino S. 116. Glasgow RE, Lichtenstein E, Marcus AC. Why don’t we see more
Naturalistic follow-up of subjects affected with anorexia nervosa translation of health promotion research to practice? Rethinking
8 years after multimodal treatment: personality and psychopathol- the efficacy-to-effectiveness transition. Am J Public Health.
ogy changes and predictors of outcome. Eur Psychiatry. 2017;45: 2003;93(8):1261–7.
198–206. 117. Moessner M, Bauer S. Maximizing the public health impact of
97. Cornelissen KK, Cornelissen PL, Hancock PJ, Tovée MJ. Fixation eating disorder services: a simulation study. Int J Eat Disord.
patterns, not clinical diagnosis, predict body size over-estimation 2017;50(12):1378–84.
in eating disordered women and healthy controls. Int J Eat Disord. 118. Castellini G, Sauro CL, Mannucci E, Ravaldi C, Rotella CM,
2016;49(5):507–18. Faravelli C, et al. Diagnostic crossover and outcome predictors
98. Seitz J, Herpertz-Dahlmann B, Konrad K. Brain morphological in eating disorders according to DSM-IV and DSM-V proposed
changes in adolescent and adult patients with anorexia nervosa. J criteria: a 6-year follow-up study. Psychosom Med. 2011;73(3):
Neural Transm. 2016;123(8):949–59. 270–9.
99. Ramjan LM, Fogarty S, Nicholls D, Hay P. Instilling hope for a 119. Lord VM, Reiboldt W, Gonitzke D, Parker E, Peterson C.
brighter future: a mixed-method mentoring support program for Experiences of recovery in binge-eating disorder: a qualitative
79 Page 18 of 18 Curr Psychiatry Rep (2018) 20: 79

approach using online message boards. Eat Weight Disord. lifetime prevalence rates are doubled by prospective versus retro-
2018;23(1):95–105. spective ascertainment. Psychol Med. 2010;40(6):899–909.
120. Keski-Rahkonen A, Hoek HW, Susser ES, Linna MS, Sihvola E, 124. Horga G, Kaur T, Peterson BS. Annual research review: current
Raevuori A, et al. Epidemiology and course of anorexia nervosa in limitations and future directions in MRI studies of child-and adult-
the community. Am J Psychiatr. 2007;164(8):1259–65. onset developmental psychopathologies. J Child Psychol
121. Bulik CM, Sullivan PF, Tozzi F, Furberg H, Lichtenstein P, Psychiatry. 2014;55(6):659–80.
Pedersen NL. Prevalence, heritability, and prospective risk factors 125. Linardon J, Piedad Garcia X, Brennan L. Predictors, moderators,
for anorexia nervosa. Arch Gen Psychiatry. 2006;63(3):305–12. and mediators of treatment outcome following manualised
122. Ben-Tovim DI, Walker K, Gilchrist P, Freeman R, Kalucy R, cognitive-behavioural therapy for eating disorders: a systematic
Esterman A. Outcome in patients with eating disorders: a 5-year review. Eur Eat Disord Rev. 2017;25(1):3–12.
study. Lancet. 2001;357(9264):1254–7.
123. Moffitt TE, Caspi A, Taylor A, Kokaua J, Milne BJ, Polanczyk G,
et al. How common are common mental disorders? Evidence that

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