Brophomauuhcs PhamocokintHos BP604T

Maximum nd Minimum Cmunbrghion duing

MulpDoAing Dr. Parjanya Shukla

Dr.M.P. 8tngh Clase

n i s tKa number o doxa adminiotersd

K max Cmin obBainud on mulHpb doaing

offer n dosA i iven as

C mox Co1-e-hKet
1-e-Ket

Cn, min Co - e DkEt - ket

I- e KET

OY Cn, min Cn, max e-Ke T

X maxinum and minimum Conuntrahons o drug in
las ma a staady /ake au ound by-
Co
Cs, max e-ket
1-e-KeT

CoCo e-ket
Css, min 1-e-KeET

OY Css, mir Css, ma eket

whu Co Cmuntrakion tKat wauld bi aBainud rom

rom
i'nstantanoJus absorphion and disibuHon

obtainod by extapolaion of eliminaion nva to Hmu 0)

Juchwahonis dafined as t Maio a Cmax/ Cmin.

9TAaer tR xaho qsaktr tka qlucduahon.
Li
X Lik accumulahon
Dr. Parjanga Shukla
&
ildsbends upon dosing raquuny, kalf t ar. M. P.Singh Clases
drug and aho dbexds on ahs of obsorphon.
quatestuckuahon obsArvsd in i.v. bolus

x fluctuahion is Amall whun drug i glvah exravasularby

duu to Conhnuos absorbhon.

Hvraq Conuntraion and body Cmtant on Mulh

M
Doaing
V6 Atiody Atake.
Th OVArag drug Conunkakon al staady s/ake Css,o
I's o unchcn
Maintenonu doss Xo
trachon cdoas absor.bud F
Doaing intrva T and
Chorohu dT (OY Vo and Ke or t/a) d dru

Css, av = FXo
7T
doss)
44 F Xo - AUc (Singlu
Vd T T

whu cosiu'sn 1.44 s uuprocas o0-693

* Sinu X = Va C
Tk body Comtent af steady state is -

XSs, av 99 F Xo t