Test Patient value Normal values Units

Hb 8,5 ↓ 11 - 16 g/dl

Ht 25.7% 36-46 %

Red Blood Cells 2.14∙10⁶ 4∙10⁶ - 5.5∙10⁶/mmc

Reticulocytes 0.5% 0.5 – 1.5%(!)

MCV VEM 120 ↑ 80 - 100 µmc(fl)

MCHC CHEM 33 N 32 - 36 g/dl E

White Blood Cells 3.200 4.000 – 10.000/mmc

Platelets 110.000 150.000-400.000/mmc

LDH  220 100 - 180 U/L

Total Bilirubin  1.7 0.3 – 1 mg/dl

Direct Bilirubin  0.4 0 – 0.2 mg/dl

Indirect Bilirubin  1.3 0 – 0.8 mg/dl

Serum Iron 148 50 – 150 µg/dl

TIBC  380 300 – 400 µg/dl

Serum Cobalamin 120↓ 220 – 850 pg/dl

Serum Folate 5.7 >5.5 ng/dl

ANEMIE MEGALOBLASTICA prin DEFICIT DE B12

Test Schilling: 1a etapa excretie de 0,98% (N>7%); a 2a etapa excretie de 19%  deficit de
absorbtie dependent de FI: gastrectomie, anemia Bierner,
 ANEMIE FERIPRIVA- hipocroma microcitara
Test Patient value Normal values Units

Hb 8↓ 11 - 16 g/dl

Ht 28.5% 36-46 %

Red Blood Cells 3.9∙10⁶ 4∙10⁶ - 5.5∙10⁶/mmc

Reticulocytes 1% 0.5 – 1.5%

MCV = VEM 73 ↓ 80 – 100 µmc(fl)

MCHC = CHEM 28 ↓ 32 – 36 g/dl E

White Blood Cells 5.500 4.000 – 10.000/mmc

Platelets 300.000 150.000-400.000/mmc

SIDEREMIE 30 ↓ 45 – 150 µg/dl

CTLF 420 ↑ 300 – 410 µg/dl

ANEMIE din BOLILE CRONICE: deficit relative de Fe

Analiza Valoare determinate Valori normale Unitate de masura
Hb 8,9 ↓ 11-16 g/dl
Ht 28% 36-46%
Nr eritrocite 3,4 x 10 la puterea 6 4 x 10.. 5,5 x 10…
Reticulocyte 7la mie 5-15 la mie
VEM 76 ↓ 80-100
CHEM 28 ↓ 32-36
Nr leucocite 4 600 4 000 – 10 000
Nr trombocite 240 000 150 000 – 400 000
Sideremie 40 ↓ 45 – 150

CTLF 250 ↓ 300 – 410

Haptoglobina -
Vt B12 300 220 – 850
Ac folic 5,7 >5,5
Test Patient value Normal values Units

Hb 7 11 - 16 g/dl

Ht 26% 36-46 %

Red Blood Cells 3.7∙10⁶ 4∙10⁶ - 5.5∙10⁶/mmc

Reticulocytes 7% 0.5 – 1.5%

MCV 70,2 80 – 100 µmc(fl)

MCHC 26,9 32 – 36 g/dl E

White Blood Cells 4.500 4.000 – 10.000/mmc

Platelets 320.000 150.000-400.000/mmc

LDH  300 100 – 180 U/L

Total Bilirubin  2 0,3 – 1 mg/dl

Direct Bilirubin  0.4 0 – 0,2 mg/dl

Indirect Bilirubin  1,6 0 – 0,8 mg/dl

Sideremie 220 50 – 150 µg/dl

TIBC  323 300 – 400 µg/dl

Serum Cobalamin 232 220 – 850 pg/dl

Serum Folate 5.6 >5.5 ng/dl

electrophoresis: Hb A = 86%; HbA2 = 5%; HbF = 9%

 TALASEMIE beta majora-intermediara ; singura

anemie hemolitica hipocroma microcitara
 Scade Hb A1, si compenseaza celelalte 2 crescand

AHAI cu Ac la rece: anemie usoara, normocroma normocitara, cu semne de hemoliza

(Bilirubina indirecta, LDH mai mare)  anemie hemolitica
 -ptc testele Coombs sunt negative pt Ac, dar positive pt Complement  cu Ac la rece

; daca erau toate positive  cu Ac la cald

Test Patient value Normal values Units

Hb 10 11 - 16 g/dl

Ht 30% 36-46 %

Red Blood Cells 3.56∙10⁶ 4∙10⁶ - 5.5∙10⁶/mmc

Reticulocytes 4% 0.5 – 1.5%

MCV 84.2 80 - 100 µmc(fl)

MCHC 33,3 32 - 36 g/dl E

White Blood Cells 9.000 4.000 – 10.000/mmc

Platelets 384.000 150.000-400.000/mmc

LDH  395 100 - 180 U/L

Total Bilirubin  3 0.3 – 1 mg/dl

Direct Bilirubin  0.3 0 – 0.2 mg/dl

Indirect Bilirubin  2,7 0 – 0.8 mg/dl

Serum Iron 131 50 - 150 µg/dl

TIBC  353 300 - 400 µg/dl

 Test Coombs direct POZITIV pt complement

 Test Coombs direct NEGATIV pt anticorpi

 Test Coombs indirect NEGATIV pt anticorpi

SICLEMIE, probabil forma homozigota ptc e >80%

 -daca in loc de electroforeza era test al fragilitatii osmotice; hemoliza incepe la 8g/dl si e totala la 4,5 
SFEROCITOZA EREDITARA

Analiza Valoare determinate Valori normale Unitate masura

Hb 8,5 11-16 g/dl
Ht 25% 36-46%
Nr eritrocite 2,78 x 10 la a 6a 4 x 10… - 5,5 x 10….
Reticulocyte 25 la mie 5-15 la mie
VEM 90 80-95
CHEM 34 32-36
Bilirubina totala 2,4 0,3-1
Directa 0,6 0 – 0,2
Indirecta 1,8 0 – 0,8
Haptoglobina Usor scazuta
Vit B12 300 220 – 850
Ac folic 6 >5,5
Electroforeza hemoglobinei = Hb S > 80%

Toate anemiile hemolitice:

 Normocrome normocitare, cu exceptia talasemiilor

 Prezinta semne de hemoliza: Bilirubina totala ↑ pe seama celei indirecte
 3 corpusculare: testele pt ele:

Sferocitoza ereditara  testul fragilitatii osmotice

Siclemie  electroforeza hemoglobinei si prezenta Hb S

Talasemiile  electroforeza hemoglobinelor

-daca e talasemia alfa  Hb noi, anormale  Hb Bart (nou-nascut) / Hb H

-daca e talasemia beta  modificarea procentelor normale ale Hb normale  Hb A1 ↓,

cu ↑ compensatory a Hb A2 si Hb F