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  • Isoelectric Point: Modified Amino Acids

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    Aciel Cruz
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    The document discusses modified amino acids and isoelectric points. It explains that hormones like epinephrine alter enzyme activity by phosphorylating serine and threonine amino acid residues. It also shows calculations for determining the isoelectric points of different amino acids based on their acid dissociation constants (pK values). The isoelectric point is the pH at which the amino acid has no net charge.

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    C2 Aa n P 4

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    The document discusses modified amino acids and isoelectric points. It explains that hormones like epinephrine alter enzyme activity by phosphorylating serine and threonine amino acid residues. It also shows calculations for determining the isoelectric points of different amino acids based on their acid dissociation constants (pK values). The isoelectric point is the pH at which the amino acid has no net charge.

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    © All Rights Reserved
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    11 views2 pages

    Isoelectric Point: Modified Amino Acids

    Uploaded by

    Aciel Cruz
    The document discusses modified amino acids and isoelectric points. It explains that hormones like epinephrine alter enzyme activity by phosphorylating serine and threonine amino acid residues. It also shows calculations for determining the isoelectric points of different amino acids based on their acid dissociation constants (pK values). The isoelectric point is the pH at which the amino acid has no net charge.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 2

    8/28/18

    Modified Amino Acids


    Phosphoryl Groups
    • hormones, such as epinephrine
    (adrenaline), alter activity of enzymes by
    phosporylating they hydroxyl groups in
    serine and threonine.

    Isoelectric Point
    25 26

    Isoelectric Point (pI) Isoelectric Point (pI)


    𝑝𝐾#- + 𝑝𝐾#/ 𝑝𝐾#- + 𝑝𝐾#/
    𝑝𝐼 = 𝑝𝐾# = 3.86 𝑝𝐼 =
    𝑝𝐾# = 9.60
    2 2
    𝑝𝐾# = 9.82
    2.34 + 9.60 2.09 + 3.86
    𝑝𝐼 = 𝑝𝐼 =
    2 2
    𝑝𝐾# = 2.34 𝑝𝐾# = 2.09
    𝒑𝑰 = 𝟓. 𝟗𝟕 𝒑𝑰 = 𝟐. 𝟗𝟖

    27 28

    7
    8/28/18

    Isoelectric Point (pI)


    𝑝𝐾# = 6.00
    𝑝𝐾#- + 𝑝𝐾#/
    𝑝𝐼 =
    2
    𝑝𝐾# = 9.17
    6.00 + 9.17
    𝑝𝐼 =
    2
    𝑝𝐾# = 1.82 𝒑𝑰 = 𝟕. 𝟓𝟗

    29

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