Atherosclerosis Male

Old Age
Diet

Chronic HPN
LIKSHK
systemic
↓
Narrowing of pre
glomerular
arteries and arterioles

The term nephrosclerosis describes a microstructural

biopsy pattern of global glomerulosclerosis,
arteriosclerosis, and interstitial fibrosis with tubular
↓
atrophy.
reduction in glomerular
blood
flow
Glomerular and ↑ Glomerular Pressure
Tubular Ischemia
Hypertiltratim
↓ Podocyti injury
Nlesangial ECM

expansion
Hypoxia ↓
loss
Podocyt
Endothelial ↑ flomvmlar and
↑ RAH overacting
dysfunction ofsws Interstitial Pomeranians
↓

|
ECM deposition
↓
↓ NO
\
'

trioxide vasodilator)
__

↑ Renin
" "" "" ohhh"" " " ' """ ""
↑ ""
↓
_

↑PD6F-B
↑ Angiotensin I
↑T6Fp ↑ glomerular → Ptiltratim
permeability in proteins

T
/ Ana
resorption
↳
☐

Na retention
insertion
Edema
albumin
and
macromolecules

&

Increased
peripheral
✓ ↓
Nag give
Proteinuria

>
vasoconstriction Extrallllar diuretics ? * Insert lab Mutt

Isosorbide Volume
pinnate

( vasodilator ✓ expansion

" " "" " °'

meds
ottelmisartan
ieimiiaaan - is ↑ Bp Hardin
(ARB ) output ①
meant enlargement
③ Carbamazepine
" tampons .im
-

nagtoituteangpt?
④ Levothynxine -

hypothyroid angpt?
* Caco } see 1311-11-4,1-3

Tubular atrophy and interstitial fibrosis ⑥ Aspirin -

Reduce an

ÉPO production ④ NAHIO}

µÑ
A¥emia Give Eposinoltpoietin Alfa ) ⑧ Sorbitrate

tv GFR & ⑨ Neuron'm vitb complex

④

uaNµµH&V0 Progressive Nephron Loss

tgltuidexwetimd-61.ve sodium
Bicarb
for metabolic Acidosis

Abnormal Calcium phosphate Balance ← Give calcium carbonate

-

Ehnn