HEMATOLGY ASCP

Question Answer

what cell shape is most commonly associated with idiopathic

iron overload in tissue
hemochromatosis

a patient with polycythemia vera who is treated by phlebotomy is most

iron
likely to develop a deficiency of

The direct antiglobulin test is often positive in acquired hemolytic anemia

the hypoproliferative red cell population in the bone marrow of uremic decreased levels of circulating
patients is caused by erythropoietin

which of the following characteristics are common in H.spherocytosis, H.

red cell membrane defects
Elliptocytosis,H.stomatocytosis and paroxysmal nocturnal hemoglobinuria

The most likely cause of the macrocytosis that often accompanies anemia of
folic acid deficiency
myleofibrosis is

what is associated with megaloblastic anemia neutropenia and thrombocytopenia

relative polycythemia associated with

what type of polycythemia is severely burned patient most likely to have
dehydration

which of the following is seen in lead poisoning basophilic stippling

Giant vacuolated, multi erythroid precursors are present in which erythroleukemia

what is a significant feature of erythroleukemia/ acute erythroid

megaloblastoid erythropoiesis
leukemia(DiGuglielmo Syndrome)

M:E ratio in erythroleulemia is usually low

what is increased in erythrocytosis secondary to a congenital heart defect erythropoietin

what is a characteristic of polycythemia vera decreased or absent bone marrow stores

which of the RBC indices is a measure of the amount of hemoglobin in

MCH
individual red blood cells

The RDW-CV and RDW-SD performed by automated cells counters are an index of the distribution of RBC
calculations that provide volumes

the laboratory tests performed on a patient indicate macrocytosis, anemia vitamin B12 deficiency/ megaloblastic
leukopenia and thrombocytopenia. what would the patient most likely have anemia

Wright -staine anema smear would most likely show normocytic, hypochromic,erythrocytes

Evidence of active red cell regeneration may be indicated on a blood smear basophilic stippling, NRBC,
by polychromasia/accelerated heme
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synthesis

characteristics PB morphploogic feature in multiple myeloma is rouleaux formation

in polycythemia vera, the hemoglobin, HCT, RBC count and red cell mass are elevated

M;E ration in polycythemia vera sis usually normal to slightly elevated

ringed sideroblasts, nuclear dudding and

what is most closely associated with erythroleukemia
howell- jolly bodies

an increased amount of cytoplasmic basophilia in a blood cell indices

decreased cytoplasmic maturation
indicates

the term shift to the left refers to immature cell forms in PB

A term that means varying degrees of leukocytosis with a shift to the left
leukoerythroblastosis
and occasional NRBC in the PB

Cells that produce antibodies and lymphokines lymphocytes

The PB monocyte is an intermediate stage in the formation of the fibroblast

specific (secondary )granules of the neutrophilic granulocyte appear first at the myelocyte stage

Elevation of the total granulocyte count above 7.7x 10^3.ul(7.7x19^9/L) is

absolute neutrophilic leukocytosis
termed

Elevation of the granulocyte percentage above 75% relative neutrophilic leukocytosis

Elevation of the total white cell count above 12x10^3 is termed leukocytosis

elevation of lymphocyte percentage above 47% relative lymphocytosis

Terminal deoxynucleotidyl transferase (TdT) is a marker found on lymphoblasts

Multipotent stem cells are capable of producing lymphoid and myeloid stem cells

long are chromosome 22 and long arm

the phili chromsome is found by translocation between
chromosome 9

a shift in granulocytes from the

mechanism of cortisol- induced neutrophilia include
marginating pool to the circulating pool

which cells are involved in immediate hypersensitivity reactions basophils

feature of pernicious anemia hypersegmentation

which of the following conditions is not associated with high incidence of

megaloblastic anemia
leukemia

M;E ration in chronic myeloctyic leukemia is usually high

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in FAB classification, myelomonocytic leukemia would be M4

abnormalities found in erythroleukemia include megaloblastoid development

neutropenia is not associated with hodgkin disease

Auer rods are most likely present in acute myelocytic leukemia

Dwarf or micro megakaryoctes may be found in the PB of patients with myelofibrosis with myeloid metaplasia

which is associated with pseudo-pelger-huet anomaly myelogenous leukemia

predominately found in acute

Auer bodies are
myelogenous leukemia

the absence of the PH' chromosome in granulocytic leukemia suggest rapid progression of the disease

Increased numbers of basophils are often seen in chronic myelocytic leukemia

a hypercellular marrow with M;E ratio of 6;1 is most commonly due to granulocytic hyperplasia

which is the most predominant form of secondary hematologic malignancy

acute myelomonocytic leukemia
seen in patients with multiple myeloma

in chronic myelocytic leukemia, blood histamine concentrations tend to

number of basophils present
reflect the

biochemical abnormalities characteristics of polycythemia vera include increased serum B12 binding capacity

are lysosome and acid phosphatase

Auer rods
positive

50%-90% myeloblasts in a PB is typical in acute myelocytic leukemia

The M: E ratio in acute myelocytic leukemia/AML is high

most closely associated with chronic myelomonocytic leukemia lysozymuria

the absence of intermediate maturing cells between the blast and mature
neutrophil commony seen in acute myelocytic leukemia and myelodysplastic leukemic hiatus
syndromes is called

most closely associated with chronic myelogenous leukemia/CML philadelphia chromosome

The bone marrow in the terminal stage of erythroleukemia is often

acute myelocytic anemia
indistinguishable from that seen in

A block in the difference of maturation of, and an accretion of immature

acute myelogenous leukemia
hematopoietic progenitors is a hallmark of
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all stages of neutrophils are most likely to be seen in the peripheral blood of
chronic myelocytic leukemia
a patient with

myelocytic leukemia, polycythemia

conditions of myeloproliferative disorders
leukemia, idiopathic thrombocythemia

A patient has a tumor that concentrates erythropoietin. He is most likely to

poltcythemia associated with renal disese
have which of the following types of polycythemia

what type of polycythemia is most often associated with emphesema polycythemia,secondary to hypoxia

hemorrhage in polycythemia vere is result of abnormal platelet function

a patient diagnosed with polycythemia 5 years ago NOW has a normal HCT,,
phlebotomy
decreased HBG and microcytic, hypochromic red cells. what is this cause

are morphologically more variable

in comparison to malignant lymphoma cells, reactive lymphocytes
throughout smear

T-cell acute lymphocytic leukemia (ALL) is closely related to lymphoblastic lymphoma

ine the FAB classification, acute lymphocytic leukemia is divided into groups
morphology
according to

increased levels of TdT activity are indicative of acute lymphocytic leukemia

massive accumulation of primitive lymphoid- appearing cells in bone

acute lymphoblastic leukemia (ALL)
marrow is true for what

the most common form of child hood leukemia acute lymphocytic leukemia(ALL)

accumulation of monoclonal B cells with a

chronic lymphocytic leukemia is
block in cell maturation

Hairy cells leukemia(leukemic reticuloendotheliosis) is a chronic leukemia of lymphocytic origin

pancytopenia,monoclear cells with ruffled

characteristics of hairy cell leukemia
edges,splenomgaly

increased resistance to infection is not a charateristic of what hairy cell leukemia

morphologic variants of plasma cells include flame cells, morula cells, grape cells

gaucher cells are not morphology of what cell plasma cell variants

what favors the diagnosis of multiple myeloma sheaths of immature plasma cells

what has a B cell origin waldenstrom macroglobulinemia

most likely identified in lesions of mycosis fungoides T lymphocytes

chronic lymphocytic leukemia cells are most likely to express which of the CD19,CD20,CD21,CD5
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following cell surface markers

which of the following markers typically detected in normal myeloid cells,

CD11c
are expressed on the surface of hairy cell leukemia lymphicyetes

surface marker that is expressed in neoplastic plasma cells and is helpful in

CD138
the diagnosis of myeloma is