1111 twt effective lg la:

O taM

lgE

lgD

lgA

tgG
• The lg that la produced early in the primary
to infection is:

lgE

lgA
 lgM only

all five classes of antibodies activate

complements

lgA only

5. Which of the following antibodies is expressed

as the component of BCR on immature B Cells?

lgD

lgA

0 '9M
 1mmunogen has both the 1mmunog nl tty
and the 1mmunoreactlvlty

immunogen has the 1mmunoreact1vity

tmmunogen is a hapten

0 immunogen is a complete antigen

7. TCR can bind to

B cell epitope

0 both T cell epitope and B ce II epitope

conformational epltope

n ar epttope
 uppresslon

cal property

• n. MAC does not include:

0
 CCJn

ca

CSb

10. The C3 convertase in the classical pathway of

the complement system is:

C4b2a

0 C3bBb

C3b8b3b

C3b
 r-.maomls

NK cells

All nucleated cells

0 Professional APCs

12. The cytokine that serves as the most potent

activator of macrophages is ( )

Q IFN-y

L-6

10
 Mature erythrocytes

B cells

14. B cells are distinguished from T cells by the

p,11ence of ( )

Class I MHC antigen

O SUrfacelg
 rheumatoid arthritis

myasthenla gravls

systemic lupus erythematosus (SLE)

16. 8-1 cells are: ( )

B cells which respond to mostly to T-

dependent antigens.

CDS+ 8-cells.

0 CDS- B-cells.

Ek:ells which predominate In later life

 autocrlne

antagonistic

endocrine

18. The cytokine which is most involved in the

class switch to lgE production is ( )

IL-3

0 IL..4

IL-1

IL 2
 Class I MHC and antigen-peptide

PRR

0 Class II MHC and antigen-peptide

20. The signal transduction molecules associated

with BCR are ( )

O lga and lgJ3

CD40 and CD40L

C021 Ind CD81

 T-cell receptors have C region

Antigen binding site of TCR Is heterodlmer

0 T-cell receptors interact with MHC-peptide

complex presented by other cells

22. Cytotoxic T cells generally recognize antigen

In association with ...

all the above

class Ill MHC

0 class I MHC

clu1HMHC

,,, .
 do not produce TNF

can be classified Into Th 1 and Th2

subgroups

can bind free virus

24. Pattern recognition receptors (PRR) include

T cell receptor

Fe receptor

B eel I receptor

complement receptor

0 Ike receptor
 Surface lg

CD28

28. Which of the following represents the earliest

atage In T-cell development?

DP (Double Positive)

Mature T cell
 Th2

Th1

Memory T cell

30. Which of the following is not the features of

innate immunity?

recognize damaged self

recognize common structures to many

pathogens

0 Recognize the microbial antigens

specifically

- ~ft to I particular p1thogen

 mast cells

macrophages

32. Who found that inoculating with cowpox

could protect against smallpox?

Elie llya Metchnikoff

von Behring and Kitasato

Loulce Pasteur

MacFarlane Burnet

o-
 surface lg

34. Which one of the following is a primary

lyt1aphokl organ:

Peyer's patch

Lymph nodes
 tlon of antigen to cytotoxic T eel

presentation of antigen to Th1 cells

presentation of antigen to B cells

mostly peptides derived from extracellular

pathogens

31. The predominant antigen presenting cell In

CIOlltact poison ivy is the:

Langerhans cells

1. . . .
.
.
.'- - •' -
-----

-
 The antibody can be made by both T and B
cells

0 They are stronger and faster

They do not require T-cell help

Complement-fixing antibodies are made

40. Which cell type produces antibodies?

T- lymphocytes

Macrophages

0 Pluma cetl1
 Allergic rhinitis

Food allergies

42. Cytokines always act:

At long range.

Synerglstlcally with other cytoklnes.

0 By binding to specific receptors

 serum sickness

0 Graves' disease

Rheumatoid arthritis

systemic lupus erythematosus

44. Anaphylaxis can be triggered by cross-linking

of lgE receptors on:

8-cells.

Neutrophils.

Monocytes
 I• i. J

O cSa
C3

C5b

C3b

46. Molecules directly involved In NK cell

mediated killing include:

nitric oxide

0 granzyme A and B

superoxide
 •. I,

found prlmarlly In lymph nodes

~~se histamine

have receptors for lgM

Serum sickness occurs only:

when anti-basement-membrane antibodies

are present

In the absence of neutrophlls

aolllble Immune complex are .......--

 in the absence of neutrop h i Is

when anti-basement-membrane anti,bodies

arie present

when lgE antibody is produced

1
l1n case of extreme excess of antibody

when soluble Immune complex are f0 rmed 1

* 49 Hemolytic disease of the newbom due to RhD

1

•
1

incompatibility depends upon the,:

pir,oductlon of cytotoxi c antlbodl es by the

baby
1

transpla ncental passa 1

g1e of lgM anit-RhD
antibodi es

mother possess ing RhD 1 antigens not

present on the baby's red blood cellls
1

0 inaibi Itty of 1he baby to react against the

mother's r1 ed bloi0d ce~ Is

transp~ancental passage of lgG, ,anit-RhD

antibodies
 t,JII u u U\,; ll v 1 1 u 1
1 1 I\, J' 1. v Lu n, w 11..1, 111 u!IJ - - , ,.,.. .... - 1 •• -

baby

transplanoenta I passage of lgM an lt-RhD 1

1ant Ilb ad i1es

mother possessing RhD antigens not

present on the baby's red blood ceUs

inabil lty of the baby to react agal nst the

mother·s red blo,od eel Is

nc enta~ passage of lgG anlt-RhD

transpla1 1 1 1

antibodies

* 50. Which 1is NOT related with type I

1

lhypersensHivity?

0 red b1ood cells

mast cens

lgE

basophU

FcERI

* Student No.