Journal Pre-proof

Factors affecting mental illness and social stress in hospital workers treating
COVID-19: paradoxical distress during pandemic era

Yukiko Matsumoto, Junya Fujino, Hiroki Shiwaku, Miho Miyajima, Satomi Doi,
Nobuhide Hirai, Daisuke Jitoku, Shunsuke Takagi, Takehiro Tamura, Takashi
Maruo, Yuki Shidei, Nanase Kobayashi, Masanori Ichihashi, Shiori Noguchi, Kanako
Oohashi, Takashi Takeuchi, Genichi Sugihara, Takayuki Okada, Takeo Fujiwara,
Hidehiko Takahashi

PII: S0022-3956(21)00151-5
DOI: https://doi.org/10.1016/j.jpsychires.2021.03.007
Reference: PIAT 4359

To appear in: Journal of Psychiatric Research

Received Date: 4 November 2020

Revised Date: 21 February 2021
Accepted Date: 2 March 2021

Please cite this article as: Matsumoto Y, Fujino J, Shiwaku H, Miyajima M, Doi S, Hirai N, Jitoku D,
Takagi S, Tamura T, Maruo T, Shidei Y, Kobayashi N, Ichihashi M, Noguchi S, Oohashi K, Takeuchi
T, Sugihara G, Okada T, Fujiwara T, Takahashi H, Factors affecting mental illness and social stress in
hospital workers treating COVID-19: paradoxical distress during pandemic era, Journal of Psychiatric
Research, https://doi.org/10.1016/j.jpsychires.2021.03.007.

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© 2021 Published by Elsevier Ltd.

Role of the funding sources

This work was supported by a grant-in-aid for Scientific Research on Innovative

Areas (16H06572) from the Ministry of Education, Culture, Sports, Science and

Technology of Japan (MEXT). The agency had no further role in the study design,

collection, analysis, and interpretation of data, writing of the report, or in the decision to

submit the paper for publication.

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Acknowledgements

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We would like to thank those who participated in the study. We would also like to
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thank the staff for collaborating for mental health care during the COVID-19 pandemic.
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Authors’ contributions
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YM, JF: Data curation, Formal analysis, Writing - original draft, Writing - review

& editing, HS, MM, SD: Data curation, Formal analysis, Writing - review & editing,
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NH, DJ, ST, TT, TM, YS, NK, MI, SN, KO, TT, GS, TO: Data curation, Writing -
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review & editing, TF: Conceptualization, Writing - review & editing, Project

administration. HT: Conceptualization, Writing - review & editing, Funding acquisition,

Project administration.
Title: Factors affecting mental illness and social stress in hospital workers treating

COVID-19: paradoxical distress during pandemic era

Authors and Affiliations

Yukiko Matsumoto1#, Junya Fujino1#, Hiroki Shiwaku1, Miho Miyajima1, Satomi Doi2,

Nobuhide Hirai3, Daisuke Jitoku1, Shunsuke Takagi1, Takehiro Tamura1, Takashi

Maruo1, Yuki Shidei1, Nanase Kobayashi1, Masanori Ichihashi1, Shiori Noguchi1,

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Kanako Oohashi1, Takashi Takeuchi1, Genichi Sugihara1, Takayuki Okada1, Takeo

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Fujiwara2, Hidehiko Takahashi1*

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1. Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental
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University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

2. Department of Global Health Promotion, Tokyo Medical and Dental University

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Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

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3. Health Administration Center, Tokyo Medical and Dental University. 1-5-45,

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Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

*Corresponding author: Hidehiko Takahashi M.D., Ph.D.

Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental

University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

TEL: +81-3-5803-5238, FAX: +81-3-5803-0135, E-mail: hidepsyc@tmd.ac.jp

# These authors contributed equally to this work.

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Abstract

Background: The coronavirus disease 2019 (COVID-19) has affected all countries in

the world. Hospital workers are at high risk of mental illness, such as anxiety and

depression. Furthermore, they also face many social stresses, such as deterioration of

human relations and income reduction. Apart from mental illness, these social stresses

can reduce motivation and lead to voluntary absenteeism, which contribute to a collapse

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of medical systems. Thus, for maintaining medical systems, it is crucial to clarify risk

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factors for both mental illness and increased social stress among hospital workers.

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However, little attention has been paid to factors affecting social stress, and thus, we
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aimed to address this gap.
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Methods: In this cross-sectional survey of 588 hospital workers, the levels of anxiety,
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depression, and social stress were assessed using the 7-item Generalized Anxiety
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Disorder scale (GAD-7), 9-item Patient Health Questionnaire (PHQ-9), and Tokyo
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Metropolitan Distress Scale for Pandemic (TMDP). Multiple regression analyses were

conducted to identify the demographic variables affecting these problems.

Results: Older age and female sex were common risk factors for anxiety, depression,

and social stress. Moreover, occupational exposure to COVID-19 and hospital staff

other than doctors/fewer non-work days were risk factors for increased anxiety and

depression, respectively. Furthermore, living with families/others was a risk factor for

increased social stress during this pandemic.

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Conclusion: Our findings could be useful for developing policies and practices to

minimize the risk of mental illness and increased social stress among hospital workers,

highlighting that attention should be paid to social factors, such as an individual’s

household situation.

Keywords: COVID-19; risk factor; mental illness; voluntary absenteeism; social stress

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 1 Title: Factors affecting mental illness and social stress in hospital workers treating

2 COVID-19: paradoxical distress during pandemic era

4 Abstract

5 Background: The coronavirus disease 2019 (COVID-19) has affected all countries in

6 the world. Hospital workers are at high risk of mental illness, such as anxiety and

7 depression. Furthermore, they also face many social stresses, such as deterioration of

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8 human relations and income reduction. Apart from mental illness, these social stresses

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9 can reduce motivation and lead to voluntary absenteeism, which contribute to a collapse

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of medical systems. Thus, for maintaining medical systems, it is crucial to clarify risk
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11 factors for both mental illness and increased social stress among hospital workers.
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12 However, little attention has been paid to factors affecting social stress, and thus, we

13 aimed to address this gap.

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14 Methods: In this cross-sectional survey of 588 hospital workers, the levels of anxiety,
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15 depression, and social stress were assessed using the 7-item Generalized Anxiety
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16 Disorder scale (GAD-7), 9-item Patient Health Questionnaire (PHQ-9), and Tokyo

17 Metropolitan Distress Scale for Pandemic (TMDP). Multiple regression analyses were

18 conducted to identify the demographic variables affecting these problems.

19 Results: Older age and female sex were common risk factors for anxiety, depression,

20 and social stress. Moreover, occupational exposure to COVID-19 and hospital staff

21 other than doctors/fewer non-work days were risk factors for increased anxiety and

22 depression, respectively. Furthermore, living with families/others was a risk factor for

23 increased social stress during this pandemic.

24 Conclusion: Our findings could be useful for developing policies and practices to

1
1 minimize the risk of mental illness and increased social stress among hospital workers,

2 highlighting that attention should be paid to social factors, such as an individual’s

3 household situation.

5 Keywords: COVID-19; risk factor; mental illness; voluntary absenteeism; social stress

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 1 Introduction

3 The coronavirus disease 2019 (COVID-19) has affected all countries around the

4 world, after the epidemic was confirmed in China in December 2019 (An et al., 2020;

5 Rajkumar, 2020; Xiang et al., 2020). Since April 2020, Japan has also been severely

6 affected by COVID-19 (Shigemura et al., 2020; Shiwaku et al., 2020; Ueda et al., 2020).

7 Many general hospitals treated COVID-19 patients while limiting other medical

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8 services (Lai et al., 2020; Pappa et al., 2020; Shiwaku et al., 2020). The impact of the

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9 COVID-19 pandemic can be expected to last for a long time, thus ensuring the smooth

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functioning of medical systems is of the utmost importance (Chen et al., 2020; Lai et al.,
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11 2020; Liu et al., 2020; Pappa et al., 2020; Shanafelt et al., 2020; Shiwaku et al., 2020).
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12 Hospital workers are at high risk of mental illness, such as increased anxiety and

13 depressive symptoms (Chen et al., 2020; Lai et al., 2020; Liu et al., 2020; Pappa et al.,
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14 2020; Shanafelt et al., 2020; Shiwaku et al., 2020). In addition, hospital workers may
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15 also face many social stresses during the COVID-19 pandemic (An et al., 2020;
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16 Rajkumar et al., 2020; Shigemura et al., 2020; Shiwaku et al., 2020; Ueda et al., 2020;

17 Xiang et al., 2020). For example, hospital workers might experience a downturn in

18 human relations and a decline in income as a result of stigma and fear of contagion

19 (Shiwaku et al., 2020; Xiang et al., 2020). Some hospital workers were encouraged by

20 their families to quit their jobs, some of them were avoided by others owing to the

21 nature of their work, and some of them were eventually prevented from working in

22 multiple facilities, leading to financial issues (Shiwaku et al., 2020; Xiang et al., 2020).

23 These social stresses reduce motivation, which can result in voluntary absenteeism

24 (Chen et al., 2020; Chong et al., 2004; Imai et al., 2010; Shiwaku et al., 2020; Tei et al.,

3
 1 2015, 2014; Valdez and Nichols, 2013; Xiang et al., 2020). Apart from mental illness,

2 voluntary absenteeism can also contribute to a collapse of medical systems (Chen et al.,

3 2020; Chong et al., 2004; Imai et al., 2010; Shiwaku et al., 2020; Tei et al., 2015, 2014;

4 Valdez and Nichols, 2013; Xiang et al., 2020). To ensure the smooth functioning of

5 medical systems, both mental illness and social stress among hospital workers need to

6 be understood, and individuals who may be more vulnerable to these problems during

7 the COVID-19 pandemic should be identified.

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8 To date, a number of studies (Lai et al., 2020; Liu et al., 2020; Pappa et al., 2020)

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9 have examined mental illness among hospital workers during the COVID-19 pandemic

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using the scales of general anxiety and depression, such as the 7-item Generalized
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11 Anxiety Disorder scale (GAD-7; Spitzer et al., 2006) and the 9-item Patient Health
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12 Questionnaire (PHQ-9; Kroenke et al., 2001). The studies revealed several risk factors,

13 such as female sex and occupational exposure to COVID-19, for increased anxiety and
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14 depressive symptoms (Lai et al., 2020; Liu et al., 2020; Pappa et al., 2020). Yet, little
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15 attention has been paid to factors affecting social stresses, partially because the general
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16 anxiety and depression scales (e.g., GAD-7 and PHQ-9) do not include

17 pandemic-specific elements (Kroenke et al., 2001; Spitzer et al., 2006).

18 To estimate social stress among hospital workers during the COVID-19 pandemic,

19 we developed a novel scale, the Tokyo Metropolitan Distress Scale for Pandemic

20 (TMDP; Shiwaku et al., 2020). The TMDP consists of nine items specifically for a

21 pandemic, such as the risk of infection, anxiety concerning transmitting the virus to

22 others, whether the work environment can control the infection, a deterioration of

23 human relationships related to engaging in medical practice for the infection, and

24 financial issues (Shiwaku et al., 2020). Our previous study confirmed that TMDP

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1 consists of two factors, concerns for infection and social stress during the COVID-19

2 pandemic, and that these factors can be easily and reliably assessed (Shiwaku et al.,

3 2020).

4 In the present study, we investigated mental illness and social stress during the

5 COVID-19 pandemic in hospital workers in Japan using GAD-7 (Spitzer et al., 2006),

6 PHQ-9 (Kroenke et al., 2001), and TMDP (Shiwaku et al., 2020). Significant factors

7 affecting these problems were examined using multiple regression analyses.

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 1 Methods

3 Ethics statement

4 The Institutional Ethics Committee of Tokyo Medical and Dental University

5 approved this study, which was conducted in accordance with the Code of Ethics of the

6 World Medical Association. Because this study was an observational retrospective study

7 using anonymized data from the below-mentioned medical records, an opt-out

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8 procedure was used. The university’s website provided information about the research

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9 in order to give participants the option to refuse participation in this study.

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11 Study cohort
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12 All samples were selected from staff members who work in the Tokyo Medical and

13 Dental University Hospital and who received mental health assessments between April
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14 20, 2020 and June 12, 2020 at the Department of Psychiatry in the same hospital. The
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15 assessments were conducted for the purpose of maintaining the mental health and
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16 wellbeing of staff members now and following the COVID-19 pandemic. Participants

17 with incomplete responses to the variables necessary for the analysis were excluded.

18 The samples partially overlapped with those included in our previous study (Shiwaku et

19 al., 2020).

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21 Data collection

22 The following variables were investigated as background characteristics: age, sex,

23 job title [doctors, other medical staff (nurses, rehabilitation staff, technologists, and

24 paramedics), or clerks/other staff], living conditions (living alone or with others), and

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 1 non-work days (< 2 days/week or ≥ 2 days/week). Additionally, we investigated the

2 experience of occupational exposure to COVID-19 and being quarantined.

3 To assess the symptoms of anxiety and depression, GAD-7 (Spitzer et al., 2006)

4 and PHQ-9 (Kroenke et al., 2001), which are well-validated tools, were used,

5 respectively. High scores indicate high levels of depression and anxiety, respectively, in

6 the two scales.

7 Furthermore, we also collected the data using the TMDP (Shiwaku et al., 2020).

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8 The TMDP is comprised of nine items specifically for a pandemic, such as the risk of

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9 infection, anxiety about transmitting virus to other individuals, whether the working

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environment can control infection, deterioration of human relationships related to
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11 engaging in medical practice for infection, and financial issues. Response options for all
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12 items were: “Never,” “Rarely,” “Occasionally,” “Often,” and “Most of the time,” scored

13 as 0, 1, 2, 3, and 4, respectively. High scores indicate high levels of stressful conditions.

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14 Our previous study confirmed that the TMDP is composed of two factors: concerns for
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15 infection and social stress during the COVID-19 pandemic (Shiwaku et al., 2020).
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17 Statistical analysis

18 Statistical analyses were performed using SPSS 24 (IBM Corp., Armonk, NY).

19 Results were considered statistically significant at p < 0.05 (two-tailed). Correlation

20 analysis was performed to verify the relationships between the levels of TMDP and

21 those of GAD-7 and PHQ-9.

22 To explore potential risk factors for symptoms of anxiety and depression (i.e.,

23 GAD-7 and PHQ-9, respectively), we performed separate multiple logistic regression

24 analyses based on previous studies (Lai et al., 2020; Pappa et al., 2020; Shiwaku et al.,

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 1 2020). Factors including age, sex, job title (reference: doctors), living condition,

2 non-work days, occupational exposure to COVID-19, and experience of being

3 quarantined were included as independent variables in the backward elimination model.

4 Probabilities of 0.05 and 0.10 were used as entry and removal criteria, respectively

5 (SPSS’s default values). Based on previous studies (Kroenke et al., 2001; Shiwaku et al.,

6 2020; Spitzer et al., 2006), we adopted the cutoff for GAD-7 and PHQ-9 as 10 for both

7 scales. A GAD-7 cutoff of 10 is regarded as moderate anxiety, and the sensitivity and

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8 specificity for anxiety disorder, as defined by the Diagnostic and Statistical Manual of

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9 Mental Disorders-IV-TR (DSM-IV-TR), are 89% and 82%, respectively (Spitzer et al.,

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2006). A PHQ-9 cutoff of 10 is also regarded as moderate depression, and the sensitivity
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11 and specificity for major depressive disorder, as defined by DSM-IV-TR, are 88% and
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12 88%, respectively (Kroenke et al., 2001).

13 Multiple linear regression analysis (stepwise model) was used to examine

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14 significant factors associated with each of the TMDP total scores and the scores of two
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15 subscales (concerns for infection and social stress), because of the continuous nature of
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16 this scale (Shiwaku et al., 2020). As in the above-mentioned analyses, age, sex, job title,

17 living condition, non-work days, occupational exposure to COVID-19, and experience

18 of being quarantined were included as independent variables. The probabilities of 0.05

19 and 0.10 were used as entry and removal criteria, respectively (SPSS’s default values).

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 1 Results

3 Demographic characteristics

4 In this study, 588 staff members [mean age: 35.4 ± 10.1 (S.D.) years, 291 (49.5%)

5 females] of the Tokyo Medical and Dental University Hospital were analyzed. The

6 characteristics of the participants are shown in Table 1. Among the participants, 296

7 (50.3%) of them were doctors, 185 (31.5%) of them were other medical staff, and 107

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8 (18.2%) of them were clerks or other staff members. Over 50% of the participants [343

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9 (58.3%)] lived with families or others, and 21.6% (127) of the participants had

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experienced occupational exposure to COVID-19.
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12 Relationships between scores of TMDP and GAD-7 / PHQ-9

13 The TMDP total scores and GAD-7 scores were significantly correlated (r =
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14 0.57, p < 0.001). The TMDP total scores and PHQ-9 scores were also significantly
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15 correlated (r = 0.50, p < 0.001).

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17 Risk factors detected by GAD-7 and PHQ-9

18 Among the 588 participants, 47 (8.0%) individuals reported GAD-7 scores of 10 or

19 higher. Multiple logistic regression analysis (backward elimination model) showed that

20 age, female sex, and experience of occupational exposure to COVID-19 were

21 significant risk factors for anxiety (Table 2). Regarding depression, 40 (6.8%)

22 individuals reported PHQ-9 scores of 10 or higher. Multiple logistic regression analysis

23 (backward elimination model) showed that age, female sex, job title (other medical staff

24 and clerk/others), and non-work days (< 2) were significant risk factors for depression

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 1 (Table 3). We confirmed that multiple logistic regression analyses (forced entry model)

2 did not greatly change the results (Tables S1 and S2).

4 Risk factors detected by TMDP

5 The mean TMDP score was 11.5 ± 5.3. Almost all [579 (98.5%)] the participants

6 provided ratings higher than a score of 0. Figure 1 shows the distribution of the scores.

7 Multiple linear regression analysis (stepwise model) showed that age, female sex, and

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8 living with families or others were significant factors associated with TMDP scores

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9 (Table 4). Multiple linear regression analysis (forced entry model) did not greatly

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change the results (Table S3). In the multiple regression analysis conducted for the two
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11 subscales of TMDP (concerns regarding infection and social stress), significant factors
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12 associated with concerns for infection were female sex, job title (other medical staff),

13 and living with families or others (Table S4); the significant factors associated with
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14 social stress were age, female sex, non-work days (< 2), and living with families or
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15 others (Table S5).

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 1 Discussion

3 In this study, we investigated significant factors affecting mental illness and social

4 stress during the COVID-19 pandemic in a relatively large number of hospital workers

5 in Japan. Our findings could help develop policies and practices for maintaining mental

6 health and preventing voluntary absenteeism of hospital workers during the COVID-19

7 pandemic.

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8 Among 588 participants, 47 (8.0%) and 40 (6.8%) individuals showed moderate to

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9 severe anxiety and depressive symptoms, respectively. These prevalence rates, although

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they are lower than the prevalence rates of previous studies performed in China (Lai et
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11 al., 2020; Zhang et al., 2020), are comparable to the prevalence rates reported in
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12 Singapore (Tan et al., 2020). When considered in combination with the TMDP results of

13 almost all [579 (98.5%)] the participants providing ratings with a score higher than 0,
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14 our findings emphasize the urgent need for psychological monitoring and support for
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15 hospital workers.
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16 The levels of TMDP scores were significantly correlated with the levels of GAD-7

17 and PHQ-9 scores. The results indicate that TMDP can reliably assess depression and

18 anxiety using pandemic-specific items, which is consistent with our previous study

19 (Shiwaku et al., 2020).

20 Multiple regression analyses revealed that older age and female sex were common

21 risk factors for all three scales (i.e., GAD-7, PHQ-9, and TMDP) during the COVID-19

22 pandemic. That is, older or female hospital workers are more vulnerable to both mental

23 illness and social stress during the COVID-pandemic. Compared to younger adults,

24 older adults are usually prone to experiencing physical discomforts and chronic physical

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 1 diseases that could contribute to mental illness (Dai et al., 2013; Jeong et al., 2014; Lin

2 et al., 2016; Zhou et al., 2020). With respect to female sex, several previous studies have

3 also shown that female sex is a significant risk factor for mental illness in hospital

4 workers during a pandemic, and the authors proposed that female sex as a risk factor

5 may partially reflect the already established sex gap for anxiety and depressive

6 symptoms (Albert, 2015; Lai et al., 2020; Pappa et al., 2020). It is noteworthy that older

7 age and female sex are also risk factors for increased social stress during a pandemic.

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8 Numerous older adults have many household responsibilities and economic burdens

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9 (Dai et al., 2013; Jeong et al., 2014; Lin et al., 2016; Zhou et al., 2020), and human

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relations, communication, and cooperation tend to be more important to women than to
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11 men (Christov-Moore et al., 2014; Fujino et al., 2020; Wilson and Liu, 2003). Therefore,
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12 older people and women may be more vulnerable to social stress during the COVID-19

13 pandemic. Our results indicate that older and female hospital workers should be closely
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14 monitored as individuals at high risk for both mental illness and social stress, and early
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15 intervention should be provided for these problems.

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16 Consistent with previous studies, we also found that occupational exposure to

17 COVID-19 was a risk factor for increased anxiety (Liu et al., 2020; Xiao et al., 2020).

18 Participating in treatments or procedures for infected patients was challenging for

19 hospital workers because they were at high potential risk of infection (Liu et al., 2020;

20 Xiao et al., 2020). High rates of mortality from COVID-19 pneumonia can intensify the

21 perception of personal danger (Liu et al., 2020; Xiang et al., 2020; Xiao et al., 2020).

22 Moreover, the time between infection and the onset of COVID-19 pneumonia could be

23 relatively long; as a consequence, sustained and cumulative stress over time can turn

24 into anxiety (Liu et al., 2020; Xiang et al., 2020; Xiao et al., 2020).

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 1 Additionally, having fewer non-work days was a significant risk factor for

2 depression; this finding emphasizes that sufficient rest and non-work activity are

3 important for maintaining mental health (Chen et al., 2020; Hallgren et al., 2017; Xiang

4 et al., 2020). Further, we found that other medical staff and clerks or others reported a

5 higher prevalence of depression than doctors. Previous studies have shown that nurses

6 and medical technicians exhibited higher rates of depression than doctors; this finding

7 could be attributed to the fact that nurses experience more and closer contact with

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8 COVID-19 patients than doctors (Lai et al., 2020; Pappa et al., 2020; Zhu et al., 2020).

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9 Clerks and other non-medical staff are reported to experience reduced access to medical

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information and formal psychological support than doctors (Matsuishi et al., 2012; Tan
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11 et al., 2020). Thus, limited knowledge regarding the COVID-19 virus, medical supplies,
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12 and self-care may cause their vulnerability to depression. It is important to spread

13 sufficient information about infection, proper training for self-protection, and effective
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14 psychological intervention to all hospital workers.

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15 Notably, analysis with TMDP identified that living conditions were a significant
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16 factor for social stress, which was not detected in the analyses with the other two scales

17 (i.e., GAD-7 and PHQ-9). Living conditions were a significant risk factor not only for

18 the TMDP total score, but also for the scores of its two subscales: concerns for infection

19 and social stress. That is, hospital workers living with families or other individuals felt

20 extremely high social stress during the COVID-19 pandemic. The COVID-19 virus

21 demonstrates a high transmission rate, and, thus, hospital workers worry about bringing

22 the virus home and passing it on to loved ones and family members, especially elderly

23 parents, newborns and immunocompromised relatives (Chen et al., 2020; Tsamakis et

24 al., 2020). Furthermore, hospital workers often feel fearful and guilty because of social

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 1 stigma imposed on their families (Chen et al., 2020; Tsamakis et al., 2020). In addition,

2 during the COVID-19 pandemic, the Japanese government is requesting that people

3 refrain from going outside unless they urgently need to do so. People spend additional

4 time with family members at home, which could lead to increased family conflicts

5 during this hardship (Shiwaku et al., 2020; Guo et al., 2020). It should be noted that

6 living with family, which in general is a normally protective factor for well-being (Miki

7 et al., 2021), could be a risk factor for increased social stress during a pandemic.

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8 In a similar manner, hospital workers experience many social stressors related to

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9 COVID-19. Apart from anxiety and depression, the social stresses can lead to reduced

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motivation and voluntary absenteeism, which can contribute to a collapse of medical
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11 systems (Chen et al., 2020; Chong et al., 2004; Imai et al., 2010; Shiwaku et al., 2020;
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12 Tei et al., 2015, 2014; Valdez and Nichols, 2013; Xiang et al., 2020). For this reason,

13 early detection of these problems during a pandemic is vital. Our findings highlight the
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14 fact that attention should be paid to social factors, such as an individual’s household
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15 composition and family relationships. Considering these issues, organizations should

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16 provide reasonable work arrangements and sufficient logical support for hospital

17 workers.

18 This study has several limitations. First, this study was performed in only one

19 hospital, which may limit the generalizability of the findings. Second, more than half of

20 the participants were doctors, which may bias the findings. Third, this study used a

21 cross-sectional study design, and thus causality between variables could not be

22 established. Longitudinal follow-up studies could help reveal causality in the future.

23 In summary, our findings emphasize the urgent need for psychological monitoring

24 and support for hospital workers during the COVID-19 pandemic, and it could be useful

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1 for developing policies and practices to minimize their risk of mental illness and

2 increased social stress. In conclusion, comprehensive assessments of both mental and

3 social factors are crucial for maintaining mental health and preventing voluntary

4 absenteeism of hospital workers during a pandemic.

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 1 References

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20 Christov-Moore, L., Simpson, E.A., Coudé, G., Grigaityte, K., Iacoboni, M., Ferrari,

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1 Figure 1. Distribution of the Tokyo Metropolitan Distress Scale for Pandemic

2 (TMDP) scores.

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Table 1. Demographic characteristics of the study cohort

Total (n = 588)

Age, years: mean ± S.D. 35.4 ± 10.1

Sex: n (%)

Male 297 (50.5)

Female 291 (49.5)

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Job title: n (%)

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Doctor 296 (50.3)

Other medical staff 185 (31.5)

Clerk/Others
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Living condition: n (%)
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Living alone 245 (41.7)

With family/others 343 (58.3)

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Non-work days: n (%)

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≥ 2 days/week 397 (67.5)

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< 2 days/week 191 (32.5)

Occupational exposure: n (%)

No/Not sure 461 (78.4)

Yes 127 (21.6)

Quarantined: n (%)

No/No information 555 (94.4)

Yes 33 (5.6)
Table 2. Results of logistic regression analysis of the 7-item Generalized Anxiety

Disorder scale scores

B (SE) Wald p Exp(B) 95%CI

Age 0.06 (0.01) 17.81 <0.01 1.06 1.03–1.09

Sex (female) 1.59 (0.39) 16.26 <0.01 4.91 2.27–10.65

Occupational exposure (yes) 0.97 (0.36) 7.30 <0.01 2.63 1.30–5.30

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Table 3. Results of logistic regression analysis of the 9-item Patient Health

Questionnaire scores

B (SE) Wald p Exp(B) 95%CI

Non-work days (< 2) 1.27 (0.44) 8.53 <0.01 3.58 1.52–8.42

Sex (female) 1.18 (0.43) 7.43 <0.01 3.25 1.39–7.59

Job title (clerk/others) 1.46 (0.59) 6.19 0.01 4.29 1.36–13.51

Age 0.04 (0.02) 6.05 0.01 1.04 1.01–1.08

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Job title (other medical staff) 1.28 (0.52) 6.02 0.01 3.61 1.29–10.06

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Occupational exposure (yes) 0.74 (0.41) 3.25 0.07 2.09 0.94–4.64

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Table 4. Results of linear regression analysis of the total scores of the Tokyo

Metropolitan Distress Scale for Pandemic

Unstandardized Standardized

Coefficient Coefficient

B (SE) β t p 95%CI

Sex (female) 2.05 (0.42) 0.19 4.88 <0.01 1.23–2.88

Living condition (with family/others) 1.66 (0.47) 0.16 3.51 <0.01 0.73–2.59

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Age 0.06 (0.02) 0.11 2.55 0.01 0.01–0.10

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 Figure 1

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Highlights

Social stress of hospital workers in a pandemic can lead to healthcare collapse.

Tokyo Metropolitan Distress Scale for Pandemic (TMDP) assesses social stress.

Living with someone is a risk factor for social stress during COVID-19 pandemic.

Workers’ social situation is a crucial factor for maintaining the healthcare system.

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Declaration of Competing Interest

The authors have no conflicts of interest to declare.

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