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May – June 2020

ISSN: 0193-4120 Page No. 25473– 25478

Traceability and Detection of Counterfeit Medicine


Supply Chain through Blockchain
Smita S.Bhosale#1, Supriya H.Lokhande*2, Varsha A.Abhang#3
#
Computer Engineering Department, #Computer Engineering Department, #Information Technology,
SPPU University
ssbhosale_sits@sinhgad.edu, shlokhande_sits@sinhgad.edu, abhangvarsha123@gmail.com

Article Info Abstract:


Volume 83
Page Number: 25473– 25478 The creation and conveyance of fake medicine is a squeezing and progressively
Publication Issue: basic generally issue, especially in creating nations. The market estimation of
May - June 2020 pharmaceutical fashioning has shown up at billions of dollars consistently. One
purpose behind medications misrepresenting is the flawed stock flexibly chain
framework in pharmaceutical industry. Meds change possession from makers to
distributer; distributer and thereafter tranquilize authority before it show up at the
customer. In current gracefully chain framework , information isn 't shared between
structures, producers wear ́t grasp what came upon their things , drugs authoritative
authority has zero capacity to see of the system, surveys are jumbled and
extravagant, and associations can't get up to speed patients. In this paper we
disclose how to use square chain innovation in pharmaceutical flexibly chain to
incorporate recognisability, detectable quality and security to the prescriptions
gracefully system. The proposed system will be used in pharmaceutical industry to
follow the prescriptions from its collecting until its transport to open minded. After
Article History the utilization of a medicine, its effect on patient will be recorded to a database for
Article Received: 11 May 2020 future estimations. An approval square chain will be used for taking care of trades
Revised: 19 May 2020 and just accepted get-togethers will be allowed to join the framework and push data
Accepted: 29 May 2020 to square chain.
Publication: 12 June 2020
Keywords: Blockchain, counterfeiting, supply chain management, pharmaceutical
industry, traceability, security.

advanced security threats. This situation of SCM


I. INTRODUCTION
prompts the creation, flow, and usage of phony
Pharmaceutical Research and Development is a
drugs. Counterfeit meds have made a particularly
mind-boggling process that takes a significant
hazardous general prosperity peril and logically
drawn-out period of time from sedate disclosure to
sharp in general issue especially in making
cure improvement and administrative endorsement.
countries.
Exactly when all the technique is done and a
These phony drugs straightforwardly and in a
standard thing is made, the accompanying test for
roundabout way antagonistically influence
creators is to pass on the thing to the proposed
wellbeing. These meds don't contain the estimation
customer in its novel structure and to ensure that the
or dynamic administrator required to slaughter the
customer get the genuine thing that is made by the
malady, that finally reason tranquilize safe strains,
true maker, not by falsifier. In any case, the current
and a short time later regardless, using the principal
Supply Chain Management (SCM) course of action
meds are trivial. Even more authentically, such
of pharmaceutical industry is out of date, and
fakes may contain dynamic fixings, anyway the
doesn't give detectable quality and control to
total is unnecessarily low or too much high, or
producers and regulatory authority over meds
conveyed in a polluted way that contains deadly
scattering and it can't withstand the 21st century
Published by: The Mattingley Publishing Co., Inc. 25473
March-April 2020
ISSN: 0193-4120 Page No. 2712 - 2725

fixings, at the present time can cause extraordinary  Pharmaceutical companies face many
clinical issues. Counterfeit prescriptions creators to challenges regarding counterfeit medicines.
a great extent use the brand logo of true producers  Detecting fake medicines in order to save
and make fake things used in regular daily existence, public life.
that is less frightful however a significant part of
the time they impact the drugs for the treatment of 1.2Problem Statement
threatening development, painkillers, To design system for traceability and detection
cardiovascular disarranges, hostile to microbial, of fake medicine supply chain using blockchain
contraceptives and other specialist endorsed meds which provides traceability of drugs from
that can incite extraordinary outcomes. manufacturer to end consumer and detection of
manufacturing process of medicines to overcome
According to the International Anti-Counterfeiting drug safety issue.
Coalition (IACC), copying has gotten one of
world's greatest and rapidly creating criminal
II. RELATED WORK
associations, with a normal estimation of more than
Writing overview is the most critical
US$ 600 billion yearly. For the neutralization of
development in any sort of research. Before begin
phony drugs, pharmaceutical industry needs a
creating we have to consider the past papers of our
capable store flexibly chain the board system, and
space which we are working and premise on study
the best available response for develop a perfect
we can foresee or produce the downside and begin
SCM structure is the Block-chain advancement.
working with the reference of past papers. In this
Square chain is a pass on record system (directly off
area, we quickly survey the related work on
the bat introduced by a pseudonym Nakamoto in
Traceability of the Counterfeit meds and their
2008 ) that has demonstrated expansive adaptability
various procedures.
starting late and a combination of market territories
searched for strategies for solidifying its abilities
In this paper, we suggest G coin blockchain as the
into their assignments. But, so far by far most of the
base of the data stream of meds to make direct
accentuation budgetary organizations industry,
prescription trade data. Besides, the rule model of
however at this point reaches out in other assistance
the medicine creation gracefully chain could be
related zones, for instance, human administrations,
transformed from the appraisal and evaluation
essentialness and genuine firms in like manner
simply model to the surveillance net model, and
started using this miracle. Store arrange security is
every unit that is locked in with the drug stock
one point that has starting late won thought. Any
flexibly chain would have the choice to take an
thing subject to an unstable creation process and
intrigue at the same time to hinder counterfeit meds
sweeping reputational issues are connected with the
and to make sure about general prosperity,
last thing, the upsides of Block-chain are clear.
including patients. With Gcoin blockchain, the
Square chain is the best fit in those circumstances
organization model of the medicine creation
where assurance protection and data security is the
gracefully chain could move from overseeing (just
most raised need. Along these lines pharmaceutical
by government surveys) to observation net (by
stock gracefully chain presents a further use
every part who incorporates the store flexibly
example of Block-chain development.
chain). [1]

In this paper, the author utilizes the web which is


1.1 Motivation
encouraging the exchange by furnishing forgers

Published by: The Mattingley Publishing Co., Inc. 25474


March-April 2020
ISSN: 0193-4120 Page No. 2712 - 2725

with an enormous purchaser base and constrained added substance fabricating, item possession the
dangers. The dim net inside it takes into executives, basic pool asset the board, buying and
consideration unknown exchanges between maker, supply the executives, inventory network quality
distributer and customer. While some online drug administration, production network execution
stores are genuine, there are a developing number estimations. By and by, numerous individuals of the
of those that are unconfirmed which sell hazardous proposed systems based arrangements need genuine
fake items. Both the bundling and medicine are execution assessment on the modern setting. [4]
getting progressively refined, making it hard for
customers and law implementation to recognize In this paper, the author propose an imaginative
them without substance investigation. Fake bunches blockchain-based IOT engineering to help
have additionally been identified in set up lawful manufacture a progressively secure and dependable
exchange courses whereby they can, if undetected, IOT framework. By investigating the inadequacies
end up in high road drug stores and medical clinics. of the current IOT engineering and the advantages
Numerous associations have set up overall activities of the Blockchain innovation. We break down and
to disassemble the exchange anyway this is a redesign the first IOT engineering to frame another,
complex and developing issue that without huge multi-focus, halfway decentralized design. In this
changes to enactment may never be completely. [2] manner, the proposed design speaks to a critical
improvement of the first engineering, which gives
In the paper, the author propose a clinical another course to the IOT advancement. [5]
information sharing and assurance conspire
dependent on the Hospital's private blockchain to In this paper, the author propose a blockchain
improve the electronic wellbeing arrangement of empowered effective information assortment and
the emergency clinic. Directly off the bat, the plan secure sharing plan consolidating Ethereum
can fulfill different security properties, for example, blockchain and profound support learning (DRL) to
decentralization, receptiveness, and alter opposition. make a dependable and safe condition. Right now,
A solid system is made for the specialists to store is utilized to achieve the most outrageous measure
clinical information or access the chronicled of gathered information, and the blockchain
information of patients while meeting security innovation is utilized to guarantee security and
conservation. Moreover, a manifestations unwavering quality of information sharing. Broad
coordinating instrument is given between patients. re-enactment results show that the proposed plan
It permits patients who get similar manifestations to can give higher security level and more grounded
direct common confirmation and make a meeting protection from assault than a customary database
key for their future correspondence about the based information sharing plan for various
ailment. The proposed plot is actualized by utilizing levels/sorts of assaults. [6]
PBC and Open SSL libraries. At last, the security
and execution appraisal of the proposed contrive is Information sharing and joint effort by means of
given. [3] cloud specialist organizations is a fortress with the
expanding headway of current advancements
In this paper, the author presents an efficient driving the present society. Right now structure an
mapping concentrate so as to delineate all information sharing model between cloud specialist
significant research on SCM dependent on BCT. organizations utilizing the blockchain. By
The paper took an overview on other blockchain actualizing the proposed model, cloud specialist
applications in SCM that need extra examination, organizations will have the alternative to safely
for example, horticultural store network, security of accomplish information provenance and inspecting
Published by: The Mattingley Publishing Co., Inc. 25475
March-April 2020
ISSN: 0193-4120 Page No. 2712 - 2725

while sharing clinical information among other the way that this paper gives the specialized ground
cloud specialist organizations just as substances, for
to a total usage, a lot of exhaustive medical clinic
example, research and clinical foundations with no business procedures and strategies that bolsters the
hazard on information security. [7] administration of Unique Patient Identifier must go
with this arrangement so as to accomplish the
In this paper, the author exhibits a methodology general business objective. This incorporates
for taking care of clinical records, giving legitimate systems for the clinical group and
auditability, interoperability and availability by regulatory staff to inquiry and recognize the
means of a thorough log. Intended for record patient's character, just as the parting and
adaptability and granularity, MedRec empowers converging of Unique Patient Identifier by the
quiet information sharing and impetuses for clinical enlistment office. [10]
scientists to support the framework. We anticipate
III. PROPOSED METHOD
formalizing an on boarding method for clinical
research "excavators", and investigating mining The blockchain is valuable in monitoring the whole
information financial aspects. Sooner rather than assembling chain of the medication. Each new
later, we plan to do client studies to survey the exchanges added to a square is perpetual and time
attainability of the framework and to measure ventured which implies that the information can't be
patient and supplier intrigue. [8] altered. Organizations can either have an open or a
private blockchain. On these blockchain, the
In this paper, the author portrays about the organizations can have a conveyed record shared
Blockchain that offers various open doors for among the gatherings drew in with the assembling
utilization in the human services segment, for and circulation of the medication. In addition, get to
example in general wellbeing the board, client is just constrained relying upon data sharing
situated clinical research dependent on close to agreement between the two gatherings. Through
home patient information just as medication blockchain, we can get the all-out way of the
falsifying. The tremendous capability of this prescription. Each time the drug moves from a
innovation shows up any place, up to this point, a substance to another, the information is taken care
believed outsider was fundamental for the of on the blockchain which makes it easy to follow
settlement of market administrations. With the prescription and wipe off fakes from the racks.
Blockchain, direct exchanges out of nowhere Therefore the blockchain innovation will help with
become conceivable, whereby a focal on-screen two fundamental issues: first, it will permit
character, who controlled the information, earned organizations to follow their items down the
commission or even interceded in an editing design, flexibly chain, making an impenetrable circuit,
can be disposed of. [9] impermeable to fake items. Second, it will likewise
permit stake accomplices, and especially labs, to
This paper, we present an extensible One of a make a move a posteriori if there ought to be an
kind Patient Identifier System that can guarantee a event of an issue by perceiving the particular region
one of a kind ID for a patient to go across of their meds.
emergency clinics anyplace. It is a distributive
framework and has the favourable position in
adaptability, execution, and effortlessness. This
empowers us to manage the undertaking in stages,
and procuring the arrival on-speculation
consistently in the whole procedure. In disdain of
Published by: The Mattingley Publishing Co., Inc. 25476
March-April 2020
ISSN: 0193-4120 Page No. 2712 - 2725

Manufacture
Medicines/Drugs 8) Each round comprises: sub byte, move byte,
blend sections, include round key.
9) Output:
Information add to the
blockchain for verification 10) Cipher content (128 bit)

4.2 Mathematical Model


Sell to the Pharmacy
Initialization:
password, key, time, salt : string
Scan the QR code time <- get_time
input <- (password)
key <- salt + time
Detect the Counterfeit Drugs
Encryption:
TABLE I Ciphertext <- AES Encrypt(password, key)
Output (ciphertext)
Decryption:
Fig.1 Flow diagram Architecture key <- salt - time
for as much tolerance given time
if key = get_time
key <- salt + time
plaintext <- AES Decrypt(ciphertext, key)
end if
end for
output (plaintext)

Table 1: Comparison between algorithms


Algorithm Result
Existing System 78
Fig.2 System Architecture Proposed System 89

IV. EXPECTED RESULT


In this project we are trying to detect the fake
medicine for the safety purpose and for saving the
patient’s life. So we are expected that we can
successfully detect the fake medicines.
4.1 Algorithm:
Advanced Encryption Standard:
1) Input:
2)128 bit /192 bit /256 bit input (0, 1)
3) Secret key (128 bit) +plain text (128 bit).
4) Process:
5)10/12/14-adjusts for-128 bit /192 bit /256 bit
input Chart: Comparison between algorithms
6) X or State Square (I /p)
7) Final cycle: 10, 12, 14
Published by: The Mattingley Publishing Co., Inc. 25477
March-April 2020
ISSN: 0193-4120 Page No. 2712 - 2725

V. CONCLUSION Reinforcement Learning", IEEE Transaction on


Industrial Volume: 15, Issue: 6 , June 2019.
The future of fake medicine and the states of [7] X. Qi, B. S. Emmanuel, O. Kwame, G. Jianbin, D.
general wellbeing relies upon the heading taken by Xiaojiang And G. Mohsen, "MeDShare: Trust-Less
sedate production and Government of India Medical Data Sharing Among Cloud Service
mutually. Bombing which a huge number of Indian Providers through Blockchain," IEEE Access, 2017.
[8] Asaph, E. Ariel, V. Thiago and L. Andrew,
are going to bite the dust. The phony medication "MedRec: Using Blockchain for Medical Data
danger can never be combatted with particular Access and Permission Management," in second
medicine associations guaranteeing their own International Conference on Open and Big Data,
picture and Government endeavouring to underplay Cambridge, MA, 02139, USA, 2016.
[9] M. Mettler, "Blockchain Technology in Healthcare:
the danger. As needs be it is principal to bring drug The Rovolution Starts Here," in IEEE eighteenth
makers to clasp hands along with the Government International 12 Conference on e-Health
for motivation to benefit Indians (the obligation of Networking, Applications and Services, Healthcom,
Government) and the purchasers of remedies (the 2016.
C. Edward, L. Ying, Z. Jia and L. Yang, "Human
duty of medicine manufactures).There is no other services benefits across China – on executing an
alternative. Further, grow all the more new ways to extensible generally exceptional patient identifier
deal with make it simpler for patients to distinguish framework," International Journal of Healthcare
authentic and safe providers of medications. Build Management , pp. 1-7, 2017.
up a powerful track and follow system to help the
wholesalers the retail drug specialist and the patient.
This instrument ought to be anything but difficult to
execute by all makers.

VI. REFERENCES
[1] Jen-Hung Tseng, Yen-Chih Liao, Bin Chong and
Shih-wei Liao, "Administration on the Drug Supply
Chain through Gcoin Blockchain", International
Journal of Environment Research and Public Health,
MDPI, 2018.
[2] Andrew O'Hagan, April Garlington, "Fake
medications and the online pharmaceutical
exchange, a danger to open security", Forensic
Research and Criminology International Journal,
Volume 6 Issue 3 – 2018.
[3] Xiaoguang Liu, Ziqing Wang, ChunhuaJin, Fagen
Li, And Gaoping Li, "A Blockchain-based Medical
Data Sharing and Protection Scheme", IEEE Access
(Volume: 7), 2019.
[4] YounessTribis, Abdelali El Bouchti, Houssine
Bouayad, "Inventory network Management
dependent on Blockchain: A Systematic Mapping
Study", MATEC Web of Conferences (2018).
[5] Jiafu Wan, Jiapeng Li, Muhammad Imran, Di Li,
Fazal-e-Amin, "A Blockchain-Based Solution for
Enhancing Security and Privacy in Smart
Factory",IEEE Transactions on Industrial
Informatics Volume: 15 , June 2019.
[6] Chi Harold Liu, Senior Member, IEEE, Qiuxia Lin,
Shilin Wen. "Blockchain-empowered Data
Collection and Sharing for Industrial IoT with Deep

Published by: The Mattingley Publishing Co., Inc. 25478

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