DRUG NAME MECHANISM INDICATIO CONTRAINDICATI ADVERSE NURSING ONSIDERATION

OF ACTION N ON EFFECTS & RESPONSIBILITIES

Ceftriaxone Interferes with Indicated in Hypersensitive to CNS: headache, BASELINE ASSESSMENT
bacterial cell- patients with cephalosporins, confusion,  Asses CBC and kidney
Patient’s dose: wall-synthesis neurologic penicillin and related hemiparesis, and liver function test
2g and division by complications antibiotics. lethargy, results.
binding to cell , carditis and paresthesia,
wall, causing cell arthritis. It is syncope, seizures INTERVENTION/
Route: to die. Active also effective EVALUATION
against gram- in Gram CV: hypotension,  Monitor for extreme
I.V. / I.M.
negative and negative palpations, chest confusion, tonic-clonic
gram-positive infections; pain, vasodilation seizures, and mild
Classification: bacteria, with Meningitis, hemiparesis when giving
Third-generation expanded activity Gonorrhea. It EENT: hearing loss high doses.
cephalosporin. against gram- is also for  Monitor coagulation
negative bacteria. Bone and GI: nausea, studies
Therapeutic class: Exhibits minimal joint vomiting, diarrhea,
Anti-infective immunosuppressa infections, abdominal cramps,  Monitor for signs and
nt activity. Lower oral candidiasis, symptoms of
Dosage: respiratory pseudomembranous superinfection and other
 Infections of tract colitis, pancreatitis, serious adverse reactions.
respiratory infections, Clostridium
system, middle ear difficile-associated  Be aware that cross
bones, infection, diarrhea sensitivity to penicillin
joints, and PID, and cephalosporins may
skin: Septicemia GU: vaginal occur.
septicemia and Urinary candidiasis
Adults: 1 to 2 g/day Tract  Instruct patient to report
I.M. or I.V. or in infections Hematologic: persistent diarrhea,
equally divided lymphocytosis, bruising, or bleeding.
doses q 12 hours. eosinophilia,
Maximum daily bleeding tendency,
dosage is 4g. hemolytic anemia,
hypoprothrombinem
 Uncomplicat ia, neutropenia,
ed gonorrhea thrombocytopenia,
Adults: 250mg I.M. agranulocytosis,
as a single dose bone marrow
depression
 Surgical
prophylaxis Hepatic: jaundice,
Adults: 1g I.V. as a hepatomegaly
single dose
Musculoskeletal:
 Meningitis arthralgia
Adults: 1g to 2g I.V.
q 12 hours for 10 to Respiratory:
14 days. dyspnea

Children: Initially, Skin: urticaria,

100 mg/kg/day I.M. maculopapular or
or I.V. (not to erythematous rash
exceed 4g). Then
100 mg/kg/day I.M. Other: chills, fever,
or I.V. once daily or superinfection, pain
in equally divided at I.M. injection site,
doses q 12 hours anaphylaxis, serum
(not to exceed 4g) sickness
for 7 to 14 days.

 Otitis Media
Children: 50mg/kg
I.M. as a single dose:
maximum of 1g/dose

 Skin and
skin-
structure
infections
Children: 50 to 75
mg/kg/day I.V. or
I.M. once or twice
daily. Maximum
dosage is 2g daily.

 Other
serious
infections
Children: 50 to 75
mg/g/day I.V. or
I.M. once or twice
daily