QUESTIONS

1. H. pylori  has multiple virulence factors. Which factors are responsible

for interfering with gastric acid secretion? For adhering to the gastric
epithelium? For disrupting the gastric mucus? For interfering with
phagocytic killing?

2. How can ammonia be used to diagnose H. pylori infection?

3. Mutant strains of H.pylori that don´t have the ability to produce urease
don´t cause infection when ingested. Infection occurs, however, if a
tube is used to insert them directly into the mucous layer that lines the
stomach epithelium. What does this indicate about the role of urease in
the pathogenicity of bacteria?

4. Although a few years ago infections with Bordetella were considered

relatively uncommon and primarily restricted to pediatric patients, this
has changed dramatically in recent years. Why have infections with B.
pertussis increased in recent years?

5. What is the epidemiologic source of B. pertussis infections?

6. Why is pertussis in adults clinically different from disease in young

children?

7. Why is culture not a good diagnostic test for B. pertussis?