Y. Omura - Beneficial Effects & Side Effects of DHEA

ACUPUNCTURE & ELECTRO-THERAPEUTICS RES.. INT. J., Vol. 30. pp. 219-261.
2005
Copyright (c) 2005 Cognizant Communication Corp. Printed in the USA.
0360-1293/95 $20.00 + .00
Beneficial Effects & Side Effects of DHEA: True Anti-Aging & Age-
Promoting Effects, as well as Anti-Cancer & Cancer-Promoting
Effects of DHEA Evaluated From the Effects on the Normal
& Cancer Cell Telomeres & Other Parameters
Yoshiaki O m u r a , M D , ScD, FACA, FICAE, D A A P M , D A B F M , FA A I M , F R S M

Director of Medical Research. Heart Disease Research Foundation; Adjunct Prof. Dept.
of C o m m u n i t y & Preventive Medicine, N e w York Medical College; President. Int'l
College of Acupuncture & Electro-Therapeutics; Prof., Dept. of N o n - O r t h o d o x
Medicine, Ukrainian National Kiev Medical University
Correspondence: Yoshiaki Omura, M D , ScD, 800 Riverside Dr. (8-1) N e w York, NY

10032 (Tel: (212) 781-6262 Fax: (212) 9 2 3 - 2 2 7 9 )
(Received October 3 1 , 2005; Accepted with Revisions D e c e m b e r 24, 2005)
ABSTRACT:
T h e author evaluated the effects of D H E A (Dehydroepiandrosterone) on
the amount of telomeres of normal cells & cancer cells and found the
following: Contrary to the literature, which often r e c o m m e n d e d 25-50 m g
of D H E A daily for the average adult human being, the author found that,
depending on the individual, the m a x i m u m increase o f normal cell
telomere w a s obtained by a single optimal dose of 1.25-12.5 mg. This
w a s examined in 50 people, both males and females, between the ages of
20-80 years old. When one optimal dose was given to each individual, the
average telomere amount in normal tissues, measured in Bi-Digital O-
Ring Test units, often increased from anywhere between 25-300 ng to
between 500-530 ng. Cancer cell telomere reduced from higher than 1100
2 4
ng to less than 1 yg ( = 1 0 g) with equally significant normalization of
abnormal cancer parameters (such as Integrili α<βι. O n c o g e n C-fosAbj.
-
Acetylcholine, etc.). Circulator) improvement and an increase in grasping
force of up to 2 5 % were also detected, along with the changing of a few
white hairs to black hairs. The beneficial effects of one optimal dose of
D H E A generalij' lasted between 1 to 4 months, though in s o m e
individuals it lasted for a much shorter period o f time due to a number of
negative factors such as excessive stress/work, excessive exposure to low
temperatures and toxic substances, or use of c o m m o n pain medicines. On
the other hand, if a patient took an excessive dose o f D H E A , the amount
of normal cell telomere decreased, while there w a s an increase in cancer
219
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220 OMURA, Y.
cell telomere. It w a s found that those who took an overdose o f 25-50 m g

daily for m o r e than 3 months had a high incidence o f cancer of the
prostate gland, breast, colon, lung, and stomach. Also, w h e n the average
normal cell telomere levels were less than 110 ng, c o m p a r e d with a
normal value o f 120-130 ng, and when D H E A in different parts o f the
body w a s also extremely low (less than 1-2 ng), o n e could suspect the
possible presence of a malignant tumor s o m e w h e r e in the body. When
normal cell telomere was less than 110 ng, most individuals felt very
weary with marked tiredness in the eyes, and grasping force w a s often
reduced.
K E Y W O R D S : D H E A ; Anti-aging effect o f D H E A ; A g e - p r o m o t i n g
effect o f D H E A ; Anti-cancer effect of D H E A ; Cancer-promoting effect of
D H E A ; Bi-Digital O-Ring Test; Pain; Circulatory disturbance; White &
black hairs; Prostate cancer; Astrocytoma; Non-steroidal A n t i
inflammatory drugs (NSAIDs); Hand writings
INTRODUCTION:
W h e n the author looked into the early literature on Dchydroepiandrosterone ( D H E A ) , the

oldest related literature quoted w a s a German article from 1934 on steroid derivatives in
human urine, with special e m p h a s i s on Dehydro-androsterone and A n d r o s t c r o n c , by
Adolf Butenandt and H a n s D a n n e n b a u m (1). The 2 next oldest articles quoted in the
literature, published b e t w e e n 1943 and 1954, did not use the currently used chemical
name Dchydroepiandrosterone. Rather, they used the different word " D e h y d r o -
isoandrosterone" ( D H I A ) or its sulfate ester "Dehydroisoandrosterone Sulfate" (DH1A-S)
( 2 , 3 ) . This chemical w a s first detected from human urine in 1934 and then in 1943 ( I ,
2) and h u m a n peripheral plasma in 1954 ( 3 , 4 ) . In 1961, Roberls, K D et al. of Columbia
University further studied the mechanism of conversion of Dehydroisoandrosterone
sulfate to A n d r o s t e r o n e and Etiocholanolone Glucuronidates (5). In 1961, Roberts was
still using the term "Dehydroisoandrosterone." This same terminology w a s used by other
scientists in the 1960s. T h e study by Roberts, K D et al. demonstrated that by injecting a
normal subject with radioisotope tritium-labeled potassium Dehydroisoandrosterone
sulfate, labeled Androsterone and Etiocholanolone could be isolated from Glucuronidase-
hydrolyzed urine. T h i s isolation established an equilibrium between
Dehydroisoandrosterone sulfate and Dehydroisoandrosterone in the h u m a n body. Instead
of "Dehydroisoandrosterone," the chemical term " D c h y d r o e p i a n d r o s t e r o n e " appeared to
be first used by Etienne-Emile Baulieu, M D , of Laboratoire d ' E n d o c r i n o l o g i e - C h i m i e
Medicale, Faculty o f Medicine, University of Paris. This w a s in his 5-page article of
N o v e m b e r 2 7 , 1959, as part of the "Letters to the Editor" section of the Journal of
Clinical Endocrinological Metabolism (4). In this article, the author Baulieu reported
that after administration o f A C T H , plasma Dchydroepiandrosterone sulfate increased
relatively m o r e than 2 other steroids (Androsterone sulfate and Etiocholanolone sulfate).
D H E A is also k n o w n as Prasterone, Hydroxyandrostenone, or 3ß-Hydroxy-5-androstcn-
17-one. D H E A has a molecular formula of C19H28O2, with a molecular weight of 288.43.
Recent reports on the effects o f D H E A (dehydroepiandrosterone) h a v e described
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BENEFICIAL EFFECTS & SIDE EFFECTS OF DHEA 221
Fig. 0: Metabolic Pathways Among Cholesterol, DHEA,

Various Steroid Hormones & Sex Hormones
(by Omura, Y. 2005)
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222 OMURA, Y.
beneficial effects ( 6 - 1 0 , 1 2 - 1 5 , 1 7 - 3 5 , 3 7 - 4 4 ) ranging from those characterized by anti-

aging, anti-osteoporosis, anti-obesity (anti-fat), anti-viral, anti-bacterial, anti-stress, anti-
memory deficiency, anti-cardiovascular disease, anti-diabetic, anti-cancer, a n d i m m u n e -
enhancing properties, as well as the extremes of prostate and breast cancer-promoting
effects ( 1 1 , 1 6 , 3 6 , 4 5 - 5 2 ) . T h e molecular structure o f D H E A and metabolic pathways
a m o n g cholesterol, D H E A , various steroid hormones, and sex h o r m o n e s are illustrated in
Figure 0. T h e s e completely contradictory reports are very confusing a n d disturbing for
not only patients and medical professionals but also average individuals interested in
health. In order to find out the truth, the author began to study the effects of D H E A .
First, the author noticed that most of the amounts of D H E A r e c o m m e n d e d for the
average adult in popular books ranged anywhere from 25-50 m g daily to 50-100 m g
daily, although they suggested a lesser amount for w o m e n (6, 8). Using the Bi-Digital O-
Ring Test, the optimal dose for each patient or volunteer w a s examined and found in
most of the subjects t o b e anywhere between 1.25-12.5 m g for 50 males and females
ranging from 2 0 - 8 0 years old. This was contrary to the widely used 25-50 m g daily dose.
Initially, when the author started using the optimal dose 2-3 times daily, the total amount
w a s still close to or less than the recommended daily dose. W h e n the author examined
the effects o f D H E A o n normal cell telomere when one optimal dose a day w a s given, it
w a s found that in m o s t o f the individuals with reduced normal cell telomere, normal cell
telomere usually increased significantly. However, when the author g a v e o n the s a m e
n d
day a 2 dose o f t h e s a m e originally determined optimal dose, the normal cell telomere
significantly decreased; the telomere further decreased w h e n an optimal d o s e w a s given a
3 time on the s a m e day. Because of this, the author decided to study h o w long the
effects of o n e optimal dose of D H E A on the normal cell telomere would last. A s a
consequence, the author found that in the majority of average adults, o n e dose of the
optimal a m o u n t o f D H E A lasted anywhere between 1-4 months. N o t only that, but when
one optimal dose w a s given, cancer cell telomere and other abnormally increased cancer
parameters b e c a m e close to zero.
On the other hand, w h e n 2 5 m g o f D H E A was given, normal cell telomere never

increased but instead decreased in every subject, although transitionally most people felt
their general condition to be improved. When one optimal dose of D H E A w a s given to
an individual, average normal cell telomere increased to a m i n i m u m of 500 ng and a
m a x i m u m o f 5 3 0 n g in Bi-Digital O-Ring Test units, and the abnormally increased (of
24
more than 1100 ng) cancer cell telomere became practically zero (1 y g = 1 0 ' g, or less).
W h e n 25 m g , w h i c h is an overdose for almost every individual (except for excessively
overweight people), w a s given every day, not only did the amount o f normal cell
telomere not increase, but it actually went down below the original a m o u n t . Cancer cell
telomere and other abnormally increased cancer parameters also increased by giving an
overdose o f D H E A , such a s 2 5 or 50 m g . In this article, the author describes these
important relationships that can clarify previously published completely contradictory
claims of the beneficial and adverse effects of D H E A .
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MATERIALS AND M E T H O D S :
In order to measure telomere in Bi-Digital O-Ring Test units the author used known
amounts of synthesized pure telomere (TTAGGG) embedded between 2 thin sheets of
chemically-inactive transparent plastic sheets that were shaped like microscope slides. A
known amount of pure telomere sample was in the white, round-shaped filter papers that
had diameters of about 5 mm. This sample was sandwiched between two identically
thin, inactive, and transparent plastic sheets and sealed without using any chemical or
adhesive substance, and without applying any heat on the sample. Known amounts of
pure reference control substances including DHEA, Thromboxine B (TXB ), Cortisol, 2 2
Substance P, Bradykinine, Integrin α β., Oncogen C-fosAb , monoclonal bacteria and

5 2
viral slides were prepared in a similar manner. The slides with known amounts of
different reference control substances were obtained from ORT Life Science Research
Institute, Kurume City, Japan. Average normal cell telomere was measured non-
invasively by detecting strong electromagnetic resonance between the known amounts of
telomere used as a reference-controlled substance and the identical substance in the body
tissue. This was done using the Bi-Digital O-Ring Test Resonance Phenomena between
two identical molecules (45-63). This resonance became maximized when both identical
molecules were present in identical amounts. The author commonly used the right upper
arm, above the biceps muscle, to test the average amount of telomeres of normal cell in
Bi-Digital O-Ring Test units.
DHEA | j g g i | i g i g T - Surface capsule

(Dehydroepiandrosterone)
Zona glomerulosa
1
CH layer)
3 0
r
·•<
Zona fasciculate СЛ
nd
У ( 2 layer) о
>
e-
S
Molecular Formula: C H 0
19 2S 2
о
о
; CH 0 3 a
f χ
J
5
Ш»
Medulla of
Adrenal gland
Molecular Formula:
DHEA-S
C19H28O5S Щ
Ganglion
Multinucleated mass
(Dehydroepiandrosterone Sulfate) of Protoplasm
Figure 01 Figure 02
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224 OMURA. Y.
D H E A is produced naturally as a Pre-Hormone by the adrenal cortex and is the most

abundant steroid h o r m o n e . D H E A is also produced in the brain by neurons and
astrocytes (10). T h e adrenal cortex consists of 3 zones layered u n d e r a surface capsule.
s<
T h e l layer is the Z o n a glomerulosa, which produces mineral corticoids. T h e 2 and
м
thickest layer is the Z o n a fasciculata. It is about 3-4 times thicker than the I layer and
, d 1
about 2 times thicker than the 3 layer. T h e 3" layer is the Z o n a reticularis. Below these
3 layers of t h e adrenal cortex is the medulla of the adrenal cortex, which secretes
n d , d
Epinephrine and Norepinephrine. T h e 2 and 3 layers are the primary sources o f
Glucocorticoids such as Cortisol and a secondary source of androgens such as
testosterone, Dehydrotestosterone ( D H T ) , Androstenedione, and D H E A , as well as
female sex h o r m o n e s . T h e release o f D H E A is stimulated by Adrenocorticotrophic
hormone ( A C T H ) , which is produced by the anterior pituitary gland. A C T H stimulates
the conversion of Cholesterol to D H E A , which is released to the bloodstream mainly as
D H E A Sulfate ( D H E A - S ) . D H E A is also synthesized in the brain and skin. D H E A can
be converted to Androstenedione, which can be converted to both Testosterone and
Estrone, both which can be converted to Estradiol. Testosterone can also be converted to
Deyhydrotestosterone ( D H T ) . D H E A is also known as the " A n t i - A g i n g H o r m o n e " and
its effects resemble the h u m a n Growth Hormone (hGH).
Unlike very expensive h G H , most o f the commercially available D H E A c o m e s in small

bottles containing 10 or 25 m g of 60-100 tablets or capsules which are relatively
inexpensive (S6-S15) in U . S . drug stores in 2005. D H E A is sold as a nutritional
supplement without a prescription in the United States, but it is declared as an anabolic
steroid in Canada. It is illegal to use o r sell D H E A in Canada without a prescription (11).
In the U S A , D H E A is commercially available by Country Life in H a u p p a u g e , N e w York,

in p h a r m a c e u t i c a l ^ pure form in capsules of 10 mg, although the capsule contains
cellulose, gelatin, silica, and magnesium sterate. Another c o m p a n y that carries a
pharmaceutically pure form o f D H E A is Swanson Health Products in Fargo, North
Dakota, U S A . Their 25 m g capsules also contain rice flour and gelatin. Another
commonly used D H E A is a white tablet made by Schiff which c o m e s in a 2 5 m g dose
but also contains 1 m g of trans-ferulic acid and 140 m g calcium carbonate. T h e reason 1
m g of trans-ferulic acid is included is because it is an important part o f g a m m a oryzanol.
G a m m a oryzanol is a naturally occurring mixture of plant chemicals called sterols and
fcrulic acid esters. T h e r e is a possibility that g a m m a oryzanol increases testosterone
levels, stimulates the release of endorphins, and promotes the growth o f lean muscle
tissue, but usually the c o m m o n l y used amount of trans-ferulic acid is 500 m g . However,
the daily requirement is not yet established.
O n e o f the a d v a n t a g e s o f using the Bi-Digital O-Ring Test is not only that o n e can
determine whether a certain substance is beneficial or harmful, but also that one can
determine the optimal dose (if beneficial) before giving the actual substance to the
patient. Therefore, the author called this method of testing specific drug effects without
having the patient actually take the drug "Virtual Drug T e s t i n g " (See e x a m p l e of Testing
in clinical case #2). T h e author tested all of these commercially available D H E A brands
in approximately the s a m e amounts. T h e results were more or less identical, in spite of
some of them having small amounts o f different impurity materials other than D H E A .
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The a u t h o r ' s previous 10 years of research on the right and left handwritings indicated
that invisible, hidden medical information such as normal tissue cell average telomere,
D H E A , Integrin α 5 β 1 , O n c o g e n C-fos A b j , and other molecules can be estimated
accurately using Bi-Digital O-Ring Test Resonance Phenomena between 2 identical
substances. T h e result w a s almost identical to the values measured directly from the
same p e r s o n ' s hand and arm. Some of these studies have been reported and
demonstrated during the Annual Scientific Meeting of the American College o f Forensic
Medicine & Forensic Examiners in 2004. Using this Bi-Digital O-Ring Test examination
of the amount o f telomere, D H E A , Integrin ctsßi, and Oncogen C-fosAb2 etc. found in
the right and left handwritings, it w a s often possible to detect malignancy with rather
high accuracy. T h e author w a s able to suspect various cancers such as breast, lung,
colon, ovary, and prostate gland cancer, usually by performing Bi-Digital O-Ring Test on
handwriting and signatures found in the patients' letters. Typically, the abnormality
showed up w h e n it w a s in the same side of the body as the dominant (usually right) side
of handwriting. Still, one cannot exclude the possibility of a malignant t u m o r in the
other side o f the body simply because the dominant-side handwriting is normal. For
brain tumors, including very malignant brain tumors such as Astrocytoma, or
Glioblastoma Multiforme, right mouth and left mouth writing can provide more reliable
diagnostic information. Therefore, the author often used at least right and left
handwriting for preliminary quick cancer screenings. However, ideally it w a s desirable
to have right m o u t h writing and left mouth writing, right handwriting and left
handwriting, and right foot writing and left foot writing. Right m o u t h writing is carried
out by holding a ball point pen, which is sterilized with alcohol, in the right side o f the
mouth, and then writing the letter " R " (even just one short deformed line), n o matter h o w
illegible. Left m o u t h writing is carried out by putting a ball point pen in the left side of
the mouth and then attempting to write anything, but usually the letter " L " . Usually, it is
better to hold the pen with the upper and lower teeth of the same side. Right foot writing
is usually done by holding a ballpoint pen between the right big toe and right second toe,
and then m a k i n g an effort to write the letter "R". The left side is d o n e in the same
manner, only with the left big toe and left second toe and attempting to write an " L " .
Any line d r a w n contains the hidden medical information, even w h e n it is illegible. T h e
author compared the original mouth, foot, and handwritings and the ones sent by fax.
T h e information w a s almost identical. Therefore, when the author received any
handwriting or a signature, he often examined it to see if the Bi-Digital O-Ring test was
abnormal or normal. If it is found to be very abnormal, the author measured the a m o u n t
of telomere and D H E A , and if these values were also very low, then there w a s a high
probability o f the presence o f a malignant tumor. T o exclude the possibility of a
malignant tumor, additional Integrin α β , and Oncogen C - F o s A b would be examined. If
} 2
any one o f them were over 2 0 0 ng, a malignant tumor would be immediately suspected.
Then, the next step w a s to find out which malignant tumor microscope slide would
produce very strong resonance and thus identify which organ had a potential malignancy.
Once this w a s found, it w a s suggested that the patient see a physician or oncologist to
exclude the possibility o f malignancy by standard laboratory test. With this method,
within the past 4 m o n t h s , the author found about 10 cases of potential malignancy. Three
were confirmed by standard laboratory tests, while others could not be confirmed, mostly
because they were at very early stages and not big enough to be detected by a standard
laboratory test.
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226 OMUflA. Y.
After initially giving o n e optimal dose of D H E A , in order to follow u p o n people w h o

lived far a w a y , the author had the people send at least right handwriting and left
handwriting o f their n a m e , age, date, time and telephone number via mail or fax. T h i s
w a s done every 3 to 7 days, and the handwriting w a s evaluated. T h e a u t h o r ' s previous
studies indicated that w h e n invisible hidden medical information in the original
handwriting and the photographed handwriting (taken through an optical or digital
camera or through fax) w a s compared, the results were almost identical.
RESULTS
Some of the typical e x a m p l e s of the effects of one optimal dose of D H E A o n average

telomere and D H E A of normal cells, measured in Bi-Digital O-Ring Test units, and on
the treatment o f pain, circulatory disturbances, prostate cancer, breast cancer, and
Astrocytoma o f the brain, as well as clinical cases of the result o f the daily intake of an
overdose o f D H E A p r o m o t i n g prostate cancer and lung cancer, will be described in the
following series o f clinical cases:
Clinical C a s e # l :
Beneficial Effects of O n e Optimal Dose of D H E A (6 mg) on Chronic Intractable Pain on
the Sole o f the Left Foot
A 58 year-old Caucasian female physician with a body weight o f 7 7 k g had intractable

pain in the upper third part o f the sole o f her left foot, (near the base o f the toes) and
complained of persistent pain when she walked. The pain started more than a year ago.
In the past, she explained that acupuncture only gave temporary relief that did not last for
more than a few days. Since she w a s complaining of pain, the author e x a m i n e d
Substance P, which w a s increased in the presence of pain, and T h r o m b o x a n e B2, which
w a s increased in the presence o f pain or circulatory disturbance. Although she claimed
to have a m a x i m u m pain o f +4 to +6 on 0-10 pain scale, when Substance Ρ w a s
measured, it w a s 2 4 0 ng w h i c h w a s too low to have +5 or + 6 grading o f pain; it usually
corresponded to about + 4 on a grading scale for pain. Her optimal dose o f D H E A w a s
E F F E C T S O F O P T I M A L D O S E O F D H E A (6 m g ) O N T H E T E L O M E R E ,
SUBSTANCE P, AND T X B F O R PAINFUL S O L E O F L E F T F O O T
2
A v e r a g e normal Substance Ρ (at Thromboxane Pain

cell Telomere painful area of B2 (at painful grading
levels in R-arm the sole of the area o f the sole in 0-10
in B D O R T units foot) of the foot) scale
Before taking 120 ng 2 4 0 ng 2 5 0 ng 4-6

optimal dose of
DHEA 6 mg
10 M i n . after taking 5 1 0 ng 10 ng < 1 ng 0
optimal dose of
DHEA 6 mg
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6 m g . More than 5 minutes after taking her optimal dose of D H E A o f 6 m g , substance Ρ

and Thromboxane B2 were measured in the painful area and telomere w a s measured in
the right upper arm.
Within 5 minutes after taking one optimal dose o f D H E A , the p a i n completely

disappeared, even after test walking for several minutes, and pain did not c o m e back.
The effect lasted at least one week. W h e n the beneficial effects o f o n e optimal dose of
D H E A does not last even one month, usually there is some contributing factor or factors
that will be discussed in the latter parts of this article.
Clinical Case # 2 :
Beneficial Effects of O n e Optimal Dose of D H E A (6.25 ms) o n Severe R - K n e e Joint
Pain After Sport T r a u m a
A 30-year-old, 59 kg Oriental male graduate student in one of the universities in N e w

York has actively participated in soccer for the past few years. In the s u m m e r of 2 0 0 5 ,
during a soccer match, h e twisted his knee and developed severe p a i n afterward.
Originally, the pain w a s only severe after sudden m o v e m e n t and walking; after about 4
months, the pain b e c a m e so severe that even without m o v e m e n t or mechanical load, he
would start to suffer pain that w a s rated as +5 on a 0-10 grading scale. T h e pain w a s
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228 OMURA, Y.
limited only to the medial side and back of the right knee joint. His knee w a s examined
by X-ray, and an impression of "unremarkable right k n e e " w a s reported approximately 2
months after the injury and the radiologist ordered an M R I o f the injured knee. The M R I
report stated "Impression: Non-acute mid substance tear of the anterior cruciate ligament,
horizontal tear in the posterior horn of the medial meniscus and grade I sprain in the
medial collateral ligament." The orthopedic surgeon at the university hospital informed
the patient that he should have surgery to improve the condition. However, at the
suggestion of the patient's relative w h o was familiar with the a u t h o r ' s work, the student
decided to temporarily postpone the surgery until he got the a u t h o r ' s evaluation.
As can be seen in Figure 2 A , there were two locations in the right knee and one m o r e
location behind the right knee that is not visible in this picture.
F I G U R E 2A
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D H E A in the normal part of his right hand and right leg w a s 130 ng, w h i c h w a s
completely normal, but in the painful area D H E A was 0.5 ng, T X B w a s 3 0 0 ng,
2
substance Ρ w a s 3 5 0 ng, Bradykinc was 136 ng, and there w a s a bacterial/viral infection.
A m o n g these the strongest infection w a s Chlamydia Trachomatis, w h i c h w a s measured
at about 800 ng. This finding clearly indicated that whatever p r o b l e m existed, the knee
had very poor circulation and there w a s very little chance of improvement. A s a result,
the author discussed a n u m b e r o f possible approaches. A m o n g these options w a s the
optimal dose o f D H E A , which the student decided to try and see the response. A l s o , the
author indicated that w h e n there w a s infection and any surgery w a s performed, the
infection could be further spread, possibly worse than before (unless t h e infection w a s
eliminated prior to the operation). Therefore, in order to find out the optimal dose o f
D H E A in the patient, the author performed a Virtual Drug Test by asking the patient to
hold different a m o u n t s of D H E A . Before the Virtual Drug Test w a s carried out, the
patient indicated that his entire left side of the body felt very heavy, and w h e n t h e author
examined both the right and left sides, the following distinctive differences w e r e found
before optimal dose o f D H E A (6.25 mg) was orally taken:
Right Arm Left A r m

Before After taking Before After taking
optimal dose optimal dose
of D H E A of DHEA
6.25mg 6.25mg
Telomere 275 n R 510ng 55 n g 520 ng
DHEA 130 n e 130 ng 1 ng 120 n g
TXB 2 1 ng 0.5 ng 175 n g 0.5 n g
A s can be seen from the above table, the measurement o f the telomere, D H E A and T X B 2
in the right and left sides were quite different, as opposed to the majority o f patients in
w h o m they are the same. T h e left side itself w a s very abnormal and the patient felt very
heavy. In order to evaluate the optimal dose of D H E A , the Virtual D r u g T e s t w a s
performed. T h e result is shown in the following table, which s h o w s the Virtual Drug
Test of D H E A o n the telomere:
VIRTUAL DRUG TEST T O ESTIMATE THE OPTIMAL DOSE O F DHEA

Right A r m Telomere Left A r m T e l o m e r e
Before After Before Holding After
Holding Holding DHEA Holding
DHEA DHEA DHEA
+ 25 m g D H E A 2 7 5 ng 15 ng 55 ng 100 n g
+ 12.5 m g D H E A 2 7 5 ng 260 ng 55 ng 505 n g
+6.25 m g D H E A 275 n R 510 пц 55 n g 520 ng
+ 3.12 m g D H E A 275 ng 430 ng 55 n g 450 ng
Based on these findings, the author concluded that the optimal dose o f D H E A w a s 6.25
mg. W h e n 6.25 m g of D H E A w a s administered orally with a half c u p o f water, the
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230 OMURA, Y.
patient noticed that within 5 minutes, he no longer felt any pain. Not only that, by
moving his right leg and changing the angle of the knee, no pain was felt. After oral
intake of one optimal dose of DHEA (6.25 mg), abnormal circulation with increased
TXB2 of 300 ng became significantly reduced to 0.01 ng. This was completely normal;
the normal range is less than 1 ng. Abnormally increased Substance P, which
approximately corresponded to his pain level of+5, became reduced to 0.1 ng, which
essentially indicated that there was no pain. When he changed the angle of the right leg,
no pain was induced. He stood to walk, but no pain was felt.
Painful areas of Before taking After taking

right-knee DHEA optimal dose of
DHEA 6.25mg
DHEA 0.5 ng 115 ng
TXB 2
300 ng 0.01 ng
Substance Ρ 315 ng 0.1 ng
Bradykine 136 ng 0.1 ng
Chlamydia 800 ng 100 ng
Tracomatis
Grading of Pain +5 0
(0-10 scale)
F I G U R E 2B
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T h e next day, h e informed the author that no pain returned. A t the t i m e , h e w a s leaving
N e w York o n vacation to T o k y o for a few weeks, and after that the author will be able to
follow u p with this patient.
T h e changes o f t h e abnormal parameters before and after the optimal d o s e o f D H E A

administration a r e s h o w n in the above table o f the right knee only.
About 1 w e e k after one optimal dose of D H E A (6.25 m g ) w a s taken orally, he informed

the author from T o k y o that e v e n after long distance traveling, no pain returned, and his
right and left hand writing sent by fax indicated that normal cell telomere o f a r m s w a s
500 ng. T w o w e e k s after the treatment, the beneficial effects still r e m a i n e d . T e l o m e r e
also remained around 5 0 0 ng. D H E A of his arms w a s 8 0 ng. A l t h o u g h it w a s reduced, it
w a s an acceptable l o w normal value.
Clinical Case # 3 :
Beneficial Effects o f O n e Optimal Dose of D H E A (6 m e t o n W h i p l a s h . Severe
Dizziness. Difficulty in Memorizing, and Foreetfulness After C a r Accident.
Patient is a 60 year-old, Oriental female artist with a body weight of 4 5 kg. She had a
normal cell telomere level of about 70 ng with possible A d e n o c a r c i n o m a o f the colon. In
the a u t h o r ' s previous study, w h e n the normal cell telomere m e a s u r e d in the upper a r m
reduced to less than 110 ng, cancer often existed somewhere in t h e body. W h e n the
author examined t h e subject, there w a s an increased level o f Integrin α β ι , which w a s
5
located in the descending colon area, which had an abnormally high value o f 3 5 0 ng. A
microscope slide o f the A d e n o c a r c i n o m a o f the colon produced strong r e s o n a n c e
indicating possible A d e n o c a r c i n o m a o f the colon. This patient agreed to take an optimal
dose o f D H E A after informed consent form w a s signed, since the a u t h o r ' s previous study
shows that o n e optimal d o s e of D H E A has significant anti-cancer effects. After б m g of
optimal d o s e o f D H E A w a s given, normal cell telomere levels w e n t u p from 7 0 ng to 5 1 0
n g and the cancer telomere o f the descending colon went d o w n from 1150 n g to less than
2 4
1 y g (yg= 1 0 ' g ) . D H E A at colon cancer positive area, as well a s n o r m a l parts o f the
body, w e n t u p from 2 n g to 120 ng. T h e following day similar beneficial results w e r e
maintained from the p r e v i o u s day. However, that evening she w a s in h e r friend's car and
someone hit t h e car from behind, giving her whiplash a n d c a u s i n g h e r to d e v e l o p severe
dizziness w i t h s o m e pain in the occipital area. W h e n her normal tissue t e l o m e r e w a s
measured from h e r right upper arm, it w a s reduced to 4 5 ng at t h e b a s e o f t h e skull at the
occipital area. T h e measured a m o u n t o f Thromboxane B2 w a s 5 2 5 n g , w h i c h indicated
extremely strong circulatory disturbance in the occipital area at t h e b a s e o f the skull.
Substance Ρ in t h e s a m e area w a s measured at 75 ng, which indicated t h e presence of
mild pain. T h e author also decided to give another optimal d o s e o f D H E A , which w a s 6
я
m g , since t h e effect o f the I optimal dose o f D H E A (6 m g ) disappeared completely and
й
became w o r s e than her I visit. Immediately after the car accident she w a s examined
and told there w a s n o serious problem and an emergency r o o m physician told h e r she did
not require an M R I . Twenty-four hours after the accident, the author e x a m i n e d the
subject and e x a m i n e d changes in Substance P, ТХВг, and normal cell telomere before
and after oral intake o f optimal dose of D H E A (6mg), as s h o w n in t h e following Table:
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232 OMURA, Y.
N o r m a l cell Substance Ρ Thromboxane B 2 Dizziness

Telomere levels (at painful (at painful
in R-arm occiptal area) occipital area)
Before taking 45 ng 75 ng 525 ng severe
optimal dose of •Ι Ι Η 1 1 I-
DHEA 6 mg
After taking 510 ng 1.5 ng 0.1 ng 0
optimal dose of
DHEA 6 mg
Within a few minutes after oral intake of optimal dose of D H E A of 6 m g her severe
dizziness, mild pain, and forgetfulness completely disappeared. In order to m a k e sure
there would be n o possible damage to her brain, an M R I of the head and neck w a s
performed. It w a s normal and the patient's symptoms never c a m e back, even after a few
months passed. Telomere levels remained between 500-510 n g for more than 2 months
after 2" optimal dose of D H E A (6 mg) w a s taken.
In figure ЗА, the patient's m a i n abnormal sensation w a s localized at the occipital area at
the junction between the base of the skull and the cervical vertebrae, as s h o w n by
patient's index finger. All of the measurements were done in this area. In figure 3 B , the
patient also indicated that there was abnormal sensation at the throat behind the chin,
where similar abnormal measurements were detected.
F I G U R E ЗА F I G U R E 3B
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Clinical Case # 4 :
Beneficial Effects o f O n e Optimal Dose of D H E A on a Female Patient With Post-
Menopausa! Hot Flashes
This 58 year-old Oriental w o m a n with body weight of about 45 k g w a s a former high

school teacher and then went back to college. She had been suffering from post
menopausal hot flashes for about 15 years. For her hot flashes she had been given
premarin daily. Recently, she w a s told by her obstetrician that c o n t i n u o u s use of
premarin had a potential risk of causing breast cancer and therefore, she c a m e to see the
author for treatment. She described her hot flashes as mainly appearing in the occipital
area and space between both ears, as well as the neck. They c a m e an average o f 4-5
times daily. Each time lasted about 5-10 minutes. W h e n they h a p p e n e d , the occipital
area and back o f the neck felt very hot and were hot to the touch. A l s o , with the hot
flashes, she often noticed that sweat started coming out from her neck, face, and back.
T h e author thought hot flashes were usually due to circulatory disturbance related to
abnormal circulation and since the author's study indicated abnormal circulation often
improves significantly with one optimal dose of D H E A , the patient w a n t e d to try an
optimal d o s e o f D H E A which w a s about 6 m g for her. Before she took D H E A , her
normal cell telomere level w a s about 120 ng. As soon as she took o n e optimal dose of
D H E A , telomere level w e n t up to 500 ng and the next day she reported for the first time
that she had about 9 0 % disappearance of hot flashes. At the time this article w a s written
she w a s already more than 2 months after taking one dose o f D H E A and average normal
cell telomere in both hands w a s still 500 ng, D H E A w a s 80 ng, and 8 0 % of the hot
flashes had disappeared, though the remaining 2 0 % still remained. However, the number
of the hot flashes slightly diminished. T i m e duration of each hot flash often did not last
more than 1-2 minutes, and the intensity of the hot flashes w a s about 2 0 % o f the original
pre-treatment level. On one ocassion, the author tried to wait until her hot flashes
appeared. After about 4 hours she indicated that she w a s starting to have a hot flash on
both ears, but by the time the author tried to measure with non-contacting infrared skin
thermometer, within 1 minute the symptoms had already disappeared. T h e author w a s
never able to measure the increase in temperature in the short time w h e n she felt hot.
Clinical Case # 5 :
Effects o f O n e Optimal Dose of D H E A on Nosebleeding Induced By Electromagnetic
Field Hypersensitivity D u e to More Than 1 Minute's Use o f Cellular Phone
A 50-year-old female o f Chinese descent (with 2 daughters) had a chief complaint of

nosebleeding that often occurred after using a cellular phone for m o r e than 1 minute.
Otherwise, she w a s a normal housewife without any other s y m p t o m s . B e c a u s e of this,
the author speculated that the electromagnetic field must induce a significant circulatory
disturbance. According to the author's previous study, those w h o have an
electromagnetic Held hypersensitivity had a very significant reduction in Acetylcholine
and an increase in T X B . T h e telomere of normal cell tissue w a s also markedly reduced.
2
She stated that w h e n she holds a cellular phone and keeps it close to her left ear for
longer than 1 minute, about 1 hour later her nostril would start to bleed for a n y w h e r e
between 5-10 minutes before gradually disappearing. Therefore, the author wanted to
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234 OMURA, Y.
see whether administration of the optimal dose of D H E A would stop the appearance of
most nosebleeds. Before giving the optimal dose of D H E A , the basic related parameters
were examined. Pre-treatment measurements were as follows: average normal tissue
Telomere in the upper a r m w a s 50 ng; Acetylcholine at the nose w a s 5 0 μ g ; T X B 2 w a s
190 ng; D H E A w a s 1.0 n g at both sides of the nose. Her optimal d o s e o f D H E A w a s
about 12.5 m g . Before the author gave D H E A , he used the Bi-Digital O-Ring Test
Virtual D r u g Effect Testing method, and estimated what would be the final m a x i m u m
telomere amount. A n optimal dose of about 12.5 mg of D H E A held in the palm of the
right hand and covered by 5 fingers of right hand showed a m a x i m u m increase in
Telomere o f 510 ng. Therefore, before the author gave an estimated optimal dose of
D H E A 12.5mg, she used her cellular phone to talk to her friend for 1.5 minutes. T h e
author measured the change in parameters before and after the cellular phone use. T X B 2
increased from 190 n g to 5 5 0 ng; Acetylcholine went down from 50 to 2 5 μ g ; telomere
decreased from 5 0 μ g to 3 5 ng; D H E A went down to from 1.2 ng to 0.8 ng. Twenty
minutes after the cellular phone exposure, she took the optimal d o s e of D H E A (12.5 mg)
and waited for 3 hours; n o nosebleeding occurred. Meanwhile, the author examined the
changes in the parameters about 2 0 minutes after and found T X B w a s less than 1 ng and
2
D H E A was 110 ng; the telomere w a s 510 ng, and Acetylcholine w a s 4 0 0 p g . Three
hours later, n o nosebleeds had appeared. Twenty-four hours later, she did not have
s
nosebleeding. F o u r w e e k s later, she had the I ' nosebleed after using the p h o n e ;
however, the a m o u n t o f the nosebleed was about 3 0 - 4 0 % of the previous nosebleeds.
About 10 days after the nosebleed, the author w a s able to reach her for the first time and
at that time, the telomere went d o w n to from 510ng to 55 ng and D H E A went d o w n from
120 ng to 1.5 n g . T h i s l o w normal cell telomere value, after the effects o f optimal dose
Before 5 min. 20 min. 1-3 First 2 7 M o r e than 28

Exposure after 1.5 after hours days days after taking
to min. taking after after o n e optimal dose
Electro exposure optimal taking taking o f D H E A 12.5
magnetic to cellular dose of DHEA DHEA mg
field phone DHEA 12.5 12.5 m g
12.5 m g mg
Telomere R- 50ng 35ng 510ng 510ng 500- 55ng
Arm 510пц
D H E A at L- 1.2ng 0.8ng HOng 120ng 1 ΙΟ 1.5ng
Nose Ι 20ns
T X B 2 at L - I90ng 550ng <lng <lng <lng 155ng
Nose
Acetylcholine 50μ 8 25μ β
400pg 450pg 400- 60pg
at L-Nose 450pg
L-Nose 0 0 0 0 0 mild nose
bleeding bleeding after
u s e o f cellular
phone
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o f D H E A had disappeared, indicated that there was a possible malignancy. Since

Integrin α β , and O n c o g e n C-fosAb2 values were 280 ng at right handwriting while left
5
hand writing had 0.5 ng, cancer of the right side of the body w a s suspected. Right
handwriting also s h o w e d strong Bi-Digital O-Ring Test resonance with breast cancer.
She will be evaluated in a future meeting by non-invasive screening o f cancer.
Clinical Case # 6 :
Prostate Cancer Promoted by Excessive Daily Dose o f D H E A (25 ma) for 3 M o n t h s and
Safe and Effective Treatment Using Press Needle Stimulation o f T r u e St. 3 6 along with
E P A + D H A . Cilatnro Tablet. & Folic Acid
A 70-year-old dentist (white male) from South Carolina noticed a lack of energy and low
interest in sex, as well as extreme tiredness. He consulted his physician, and the
physician suggested that he take D H E A . Thus, he has been taking 25 m g o f D H E A
every day for the past 3 months. When the author examined his right and left
handwriting by Bi-Digital O-Ring Test 3 months after continuous daily intake of D H E A
(25 m g ) , it showed a telomere of both handwritings that indicated about 6 0 ng, which is
abnormally low, and D H E A w a s extremely low (1 ng) at both right and left handwriting,
both of which indicated the possibility of the presence o f cancer s o m e w h e r e in the body.
By actually measuring the amount of telomere, the author found a very l o w a m o u n t o f 6 0
n g o f average normal cell tissues at both upper arms, and D H E A o f both h a n d s w a s less
than 1 ng. Therefore, as a next step, Integrin α β , and O n c o g e n C-fosAb2, which
5
increase in the presence o f cancer, were examined from right and left handwritings.
Right handwriting s h o w e d that both values were 350 ng. Left handwriting s h o w e d
values of less than 5 ng. This indicated that there w a s a possibility o f cancer in the right
side of the body. In order to determine the type of cancer through handwriting, the
author used a cancer screening kit consisting of microscope slides o f different cancers o f
different internal organs. B y testing resonance between the right handwriting and the
microscope slides, the author found Adenocarcinoma o f the prostate gland w a s the only
one to s h o w strong resonance by Bi-Digital O-Ring test. D H E A w a s 1 ng, at both upper
arms and other normal parts o f the body. Therefore, the author non-invasively screened
for the possible presence o f cancer, using red spectral soft laser b e a m with 6 0 n g o f
Integrin α β , as a control reference substance. This indicated that he had strong positive
5
response at the right prostate gland. Upon questioning, the dentist (for the first time)
indicated that recent blood tests for PSA were found to be 12.4 ng/ml o f blood.
Apparently, the dentist wanted to see if the author could discover this without telling
him. At this point, he requested that the author treat his condition without standard
surgery, chemotherapy, o r radiotherapy. The author gave a choice o f a n u m b e r of
possible alternative m e t h o d s o f treatment. He decided to try the a u t h o r ' s well-tested (and
frequently successful) safe treatment using True ST. 36 stimulation by inserting a tiny
press needle into the center o f True ST. 36 acupuncture point, t h e shape o f which is
round and the diameter o f w h i c h is usually between 8-12 m m . At the point described as
the traditional acupuncture point ST. 36, using Bi-Digital O-Ring test resonance
phenomena between microscope slide of the fundus of the stomach, n o acupuncture point
could be found at the site described as ST. 36. Instead, at a slightly different location,
there is a true acupuncture point that produced strong resonance with microscope slide of
stomach tissue which the author described as True ST. 36. Stimulation o f T r u e ST. 3 6
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236 OMURA. Y.
produced all the benefits traditionally associated with ST. 3 6 . W h e n t h e press needle is
inserted into True S T . 36 and stimulated about 2 0 0 times by pressing and releasing,
abnormally increased cancer cell telomere of over 1100 ng b e c o m e s less than 1 y g (1
24
y g = 1 0 ' g) and all other c o m m o n cancer parameters b e c o m e close to 0. T h e exception is
Acetylcholine, which is reduced extremely low in cancer tissue (any a m o u n t between 1
l5 2 8
fg=l femtogram= 1 0 ' g and 1 z g = l zeptogram=10" ' ) and will increase very
significantly up to between 40-50 μg. The dentist has seen previously h o w effective
True ST. 36 press needle stimulation can be for cancer patients w h e n c o m b i n e d with a
mixture gelatin capsule o f E P A (180 m g ) and D H A (120 m g ) as a n anti-viral agent,
Cilantro tablet which r e m o v e s abnormally increased H g in the cancer cell nucleus, and
Folic acid (100 p g ) to prevent D N A mutation, when all are applied 4 t i m e s daily. H e
thus decided to try this method that w a s originally developed by the author about 10
years ago. W h e n the author tried this treatment, normal cell telomere w e n t u p from 6 0
ng to 555 ng, and D H E A o f the normal tissue went up from abnormally l o w 1 n g to 132
ng; cancer cell telomere o f the Adenocarcinoma of the right prostate gland w a s originally
24
around 1150 ng and it decreased to less than 1 yg ( = 1 0 ' g). T h i s i m p r o v e d condition
remained for at least two months until the author had a chance to speak with the dentist
after treatment. T w o m o n t h s after the treatment, the author wanted to find out what
happened after he started doing True ST. 36 stimulation treatment and found his normal
cell telomere w a s still 555 ng, and D H E A of normal tissue w a s 132 ng. T h e p a t i e n t ' s
general condition improved significantly. All the abnormal cancer parameters reduced to
practically 0.
Concerning the daily intake o f excessive dose o f D H E A (25 m g ) , retrospectively, in the

st
1 week after a daily intake o f 2 5 m g D H E A , he noticed that he felt less tired and that his
general condition improved, but 1 month after starting to take a daily dose o f D H E A of
25 m g , he thought general conditions became worse than before he started taking D H E A .
They progressively got w o r s e until True ST. 36 stimulation w a s initiated. T h e author has
requested that he repeat the standard blood PSA. About 1 m o n t h after initiation of
present treatment, the standard blood P S A w a s repeated by the s a m e clinical laboratory.
T h e result indicated that blood P S A reduced from 12.4 ng/ml of blood to 10.0 ng/ml
PSA. Since the author w a s expecting better results than this, in order t o find o u t what
w a s preventing reduction o f P S A , the author has decided to see the dentist during the
next N e w York conference.
Clinical Case # 7 :
L u n e Cancer Induced o r Promoted By Excessive Daily Intake o f Total o f 37.5 m g D H E A
for 3 M o n t h s
This 68-year-old white m a l e (also a dentist) with body weight of about 65 k g h a d right
and left handwriting w h i c h w a s examined as a part o f the demonstration o f h o w to
analyze handwriting for possible detection of cancer by measuring the n o r m a l cell
telomere, D H E A of normal tissue, and Integrin α β , (or O n c o g e n C-fosAfe). U p o n
5
examination, the author found his telomere level w a s extremely low for b o t h right and
left handwriting (about 55 n g ) . D H E A was found to be also very l o w (2 ng) at both
hands. Integrin oi5ßl in the left handwriting was over 300 ng, but it w a s only less than 5
n g in the right hand. Therefore, the author screened non-invasively for cancer and found
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an Adenocarcinoma o f the lung-positive area on the left upper chest. U p o n questioning,

the patient indicated that he w a s taking the optimal dose of D H E A (12.5 m g ) 3 times a
day (as determined several months ago as 12.5 mg). H e has b e e n taking o n e optimal
dose o f D H E A o f 12.5 m g 3 times daily for the past 3 months. A s a result, the total
amount that he w a s receiving daily was 37.5 m g , which is highly excessive and toxic.
U p o n examining his previous record, he indicated that at about the same location, the
author found the early stages of Adenocarcinoma o f the lung, but using T r u e ST. 36
stimulation and a combination of E P A and D H A , cilantro, and the Selective D r u g Uptake
Enhancement method, his Adenocarcinoma-positive area of the left u p p e r lung
completely disappeared for the previous 4 years. T h e excessive daily intake o f D H E A ,
however, seemed to re-induce the early stages of Adenocarcinoma in t h e s a m e location.
Clinical Case # 8:
Anti-Cancer Effects o f O n e Optimal Dose of D H E A (6 m e i o n Breast Cancer.
A 58 year-old Oriental female artist with body weight of about 4 5 k g c a m e to the a u t h o r ' s
seminar and workshop with Adenocarcinoma of the right breast b e t w e e n 1:00 and 2:00
position and with a diameter o f about 3 c m round shaped area. Integrin α β ι , which5
increases in the presence of malignancy, w a s 345 ng, which indicates a strong positive
for the presence of malignancy. Normal cell telomere examined in t h e right upper arm
w a s 85 ng. Cancer telomere of the right breast cancer positive area w a s 1230 ng.
1 5
Acetylcholine w a s 10 fg ( = 1 0 ' g) compared with normal tissue o f o v e r 5 0 0 μ g . She
also had A d e n o c a r c i n o m a o f the colon-positive area at the left lower a b d o m e n in the
descending colon area and where cancer cell telomere w a s 1550 ng, Integrin cisßi w a s
350 ng, and A c e t y l c h o l i n e w a s again 10 fg. Her normal cell telomere w a s 85 n g at both
upper arms. Virtual Drug Test indicated that the optimal dose o f D H E A w a s 6 m g . W h e n
6 m g o f D H E A w a s taken orally, telomere of the right upper a r m increased from 85ng to
510ng. Also, the right breast cancer telomere of 1230ng reduced to less than l y g (= 10'
2 4
g ) , colon cancer telomere reduced from 1550ng to less than l y g , and Integrin ctjßi at
both cancer positive areas reduced to less than l y g . Abnormally reduced Acetylcholine
of 10 fg increased to 4 0 μ g . This one optimal dose of D H E A induced c h a n g e s that m a d e
it impossible for cancer cells to divide as cancer telomere w a s almost 0.
Clinical Case # 9 :
Anti-Cancer Effects o f O n e Optimal Dose of D H E A (7 m g ) o n A d e n o c a r c i n o m a o f
Prostate Gland
A 6 0 year-old Caucasian male financial adviser from North Carolina w h o w a s suffering

from frequent urination, which had recently become worse with an average o f 5 to 7
times a night and every 60-90 minutes in the daytime for the past year, w a s brought by
his dentist, Dr. A n d r e w Pallow o f California, to one of the a u t h o r ' s 3 d a y weekend
seminars and w o r k s h o p s in N e w York City. Recently, he went to a urologist, and P S A
w a s found to be 9.5 ng/ml o f blood and a biopsy indicated A d e n o c a r c i n o m a of left
prostate gland in N o v e m b e r 2 0 0 5 . H e did not wish to have surgery or radioactive needle
implantation and w a n t e d to explore any alternative treatment and see the result; based on
that, he wanted to determine his future treatment. T h e previous study indicated that
without giving actual medication the author can evaluate potential drug effects very
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238 OMURA. Y.
accurately by using Bi-Digital O-Ring Test Virtual Drug Test. B y doing this, the author
does not need to expose the patient to potential danger by giving a n o v e r d o s e o f
potentially beneficial medication. T h e patient's average normal cell t e l o m e r e in Bi-
Digital O-Ring Test units indicated a very low value o f 60 ng. A g a i n , the previous study
indicated w h e n t h e average normal cell telomere in Bi-Digital O - R i n g T e s t measurement
at the upper a r m w a s less than 110 ng, frequently there is a cancer s o m e w h e r e in the
body. Therefore, t h e author non-invasively screened for cancer b y projecting a red
spectrum soft laser placed next to 60 ng of Integrin α β , in the hand o f the intermediary
5
person using indirect Bi-Digital O-Ring Test. T h e laser b e a m w a s projected in the right
hand, left hand, supra-sternal notch, between the nipples, navel, right and left inguinal
, h
area, and o n the back of the body, including the back of the right and left h a n d s , 7
cervical vertebrae, in the center of the spine at the back o f the chest, the lumbar area,
anus, and the right and left gluteal groove. If there w a s identical Integrin α , β , existing in
the area o f the b o d y w h e r e the laser beam w a s projected or in its vicinity, it would
produce resonance between the information carried from the laser b e a m o n Integrin α β , 5
and its amount. W h e n these have identical amounts, the electromagnetic resonance
would b e c o m e a m a x i m u m . Empirically, when 1 or 2 O-Rings open (-1 or -2), it is
considered to be within normal limits. If 3 O-Rings open (O-Ring test -3), it is
considered to b e borderline. If 4 O-Rings (-4) or more O-Rings open, it is considered to
be cancer positive. If 6 O-Rings open (-6), it is considered to be strongly cancer-positive.
In this patient, the right arm w a s -4, the supra-sternal notch w a s -6, between the nipples
w a s - 5 , navel w a s - 5 , both right and left inguinal areas were - 6 . Therefore, to localize
cancer-positive areas, X-axis and Y-axis laser beam scanning with 6 0 n g o f Integrin α$βι
found that there w a s a strong cancer-positive area in the upper part o f the chest which
w a s found to h a v e strong resonance with a microscope slide of A d e n o c a r c i n o m a o f the
prostate gland. This indicated possible metastasis of prostate cancer to upper chest. At
the left lower a b d o m e n , there w a s a strong cancer positive area that produced strong
resonance with A d e n o c a r c i n o m a of the colon. Then, the entire left prostate gland area
w a s -6 and part o f the right prostate gland was also -6. These prostate gland areas
produced strong resonance with a microscope slide of A d e n o c a r c i n o m a o f the prostate
gland. For this patient, after an informed consent form w a s signed, optimal dosage of
D H E A w a s found to be 7 m g when the Virtual Drug Test w a s performed and w h e n the
effect o f D H E A (10 m g ) w a s examined, telomere further decreased from an already
abnormally l o w level of 5 0 ng. W h e n the patient w a s tested with 2 0 m g o f D H E A ,
telomere levels b e c a m e less than 25 ng. However, w h e n the effect o f o n e optimal dose
o f D H E A (7 m g ) on normal cell telomere w a s examined, normal cell telomere went up to
520 ng, which is the ideal response, since all of the author's previous study indicated
when the optimal d o s e of D H E A is given (usually 1.25 mg-12.5 m g depending upon the
individual), normal cell telomere always increases to anywhere b e t w e e n a m i n i m u m of
500 ng a n d a m a x i m u m o f 530 ng. In the cancer-positive area, the local a m o u n t o f
D H E A w a s a l w a y s less than 1 or 2 ng and T X B 2 w a s an abnormally h i g h 3 0 0 ng, which
indicated the presence o f moderate circulatory disturbance in the cancer tissue.
Acetylcholine w a s 5 n g , which is markedly diminished compared with normal tissue of at
least a few h u n d r e d μ g , and average cancer tissue telomere w a s 1300 n g in both prostate
cancer positive area and Adenocarcinoma of colon positive area. Integrin ctjßi w a s 350
ng, which w a s very high and a characteristic c o m m o n finding in the cancer tissue.
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Before the author g a v e a n optimal dose of D H E A , the author also noticed that by visual
inspection, the hair o n t h e patient's head corresponding t o the o r g a n representation area
o f d i e prostate gland w a s m u c h thinner than the rest o f t h e head. Therefore, t h e author
marked an organ representation area of the prostate gland o n t h e right a n d left sides o f
the top o f t h e head. O n the right side of the top o f the head, located slightly posterior
from the center o f t h e h e a d corresponding to the left prostate gland representation area as
s h o w n in round-shaped area, there w a s a strong positive Bi-Digital O - R i n g T e s t
resonance with microscope slide o f Adenocarcinoma of prostate gland. O n the other
hand, o n the left side o f t h e t o p o f the head corresponding to the right prostate gland in a
rectangular s h a p e , a small part o f the area had a A d e n o c a r c i n o m a of prostate-positive
response, w h i c h indicated either it coexisted at the same t i m e a s left prostate cancer o r
that t h e left prostate c a n c e r m i g h t h a v e spread to part o f the right prostate gland. ( S e e
figures 4 A - 4 C ) .
Similarly, t h e author examined the prostate gland representation a r e a o n t h e sole of the

f o o t In the left foot, t h e entire prostate gland representation area in t h e lateral side o f t h e
left heel h a d a strong positive resonance with A d e n o c a r c i n o m a o f the prostate gland.
W h e n the right foot prostate gland representation area w a s m a p p e d , a small part also
produced a strong resonance with prostate cancer, which also indicated that there m a y be
s o m e metastasis to t h e right prostate gland or coexisted simultaneously as left prostate
cancer.
In the p a l m o f the p a t i e n t ' s left hand, a triangular shape corresponding to t h e prostate

gland h a d a strong A d e n o c a r c i n o m a o f the prostate gland response. O n t h e right h a n d
p a l m , part o f the triangular-shaped prostate gland representation area also s h o w e d
A d e n o c a r c i n o m a o f t h e prostate gland response.
W h e n one optimal d o s e o f p u r e D H E A (7 m g ) for this patient w a s given orally, a s t h e

Virtual D r u g Test predicted, average normal cell telomere increased from 4 5 n g to 520
ng. Within 10 minutes after oral intake of one optimal dose o f D H E A (7 m g ) w i t h water,
2 4
Integrin a j ß ι and cancer cell telomere reduced from 1300 n g to less t h a n 1 y g ( И О ' g),
and Т Х В г b e c a m e reduced from 3 0 0 ng to much less than 1 n g . Acetylcholine went up
u
from 5 a g ( = 1 0 ' g) t o 4 0 p g as can be seen in the figures 4 a to 4 c . W h e n very high
cancer cell telomere o f 1200 n g is reduced to 1 y g or less, the cancer cell c a n n o longer
divide.
T h e next m o r n i n g , w h e n t h e patient c a m e back, he w a s very happy t o report that his

frequent urination m a r k e d l y reduced; in fact for the first t i m e in m o n t h s h e only needed
to go to the b a t h r o o m o n c e during the night. A l s o , similarly, d a y t i m e urination
frequency reduced m a r k e d l y . Forty-eight hours later, for the first t i m e , h e d i d not w a k e
u p e v e n once during the night to use the bathroom. D a y t i m e urination frequency reduced
t o normal levels, h e felt m u c h m o r e vigorous, and it w a s easier to think a n d concentrate,
st
because for t h e 1 time h e w a s able to sleep without interruptions.
During the 3-day w e e k e n d seminar and workshop in N e w York, after initial treatment
with o n e optimal dose o f D H E A o f 7 m g , without giving a n y additional medication, the
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240 OMURA, Y.
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measurement w a s repeated daily. T h e effect remained the s a m e o n S u n d a y a n e m o o n ,

two days after treatment. In order to prevent possible decrease in n o r m a l cell telomere,
the patient w a s supposed t o fax the author right and left handwriting s a m p l e s a s well a s
right and left foot writing samples, from which it w a s possible to estimate the a m o u n t of
normal cell telomere and D H E A , as well as any abnormal increase in Integrin α β , or 5
Oncogen C-fos A b . Six d a y s after the first treatment, h e h a s b e e n sending handwriting

2
samples e v e r y 3 d a y s w h i c h indicate both normal cell telomere a n d D H E A remained the

same after the first treatment; meanwhile, the author requested that h e carry o u t a
repeated P S A blood test periodically by the same clinical laboratory. T e n d a y s after
initial treatment with o n e optimal dose of D H E A (7 m g ) , the standard b l o o d P S A w a s
examined a n d t h e value o f this laboratory test w a s reported t o b e 4 . 7 n g / m l , w h i c h w a s
still slightiy higher than the normal range of 0-4 ng/ml. C o m p a r e d with his initial P S A
testing before the author gave one optimal dose o f D H E A (7 m g ) treatment, there w a s a
significant reduction from 9.S ng/ml to 4.7 ng/ml 10 days after intake o f o n e optimal
dose o f D H E A . T w e n t y days after the first optimal dose o f D H E A , t h e p a t i e n t ' s P S A
w a s repeated a n d it w a s further reduced to 3.4 ng/ml. All o f these i m p r o v e m e n t s w e r e
obtained by only giving o n e optimal dose o f D H E A .
Clinical Case # 1 0 :
Safe Anti-Cancer Effects o f O n e Optimal Dose o f D H E A (1.5 m e i o n A s t r o c y t o m a o f
Brain and Severe Shoulder Pain
A 71 year old dentist c a m e to the seminar and explained h o w successfully h e lost 35

p o u n d s in 1 m o n t h . H e went from 2 3 0 pounds to 195 lbs b y eating a special chocolate
flavored nutritional supplement called "Chocolate Natural M e a l R e p l a c e m e n t B a r s . "
Since it gave the author the impression that losing 35 p o u n d s i n o n e m o n t h is a n
unusually rapid loss, the author wanted to find out what the effect o f this rapid body
weight loss w a s on values of the normal cell telomere (and D H E A ) . W h e n the average
value o f right upper arm telomere w a s measured, it w a s extremely l o w at 4 5 n g and
normal cell D H E A w a s also very low at I ng at the right upper a r m . Therefore, the
author immediately suspected the possible presence o f malignancy at s o m e part o f t h e
body, because average normal cell telomere o f less than 110 n g and average normal
tissue D H E A o f very low value (less than 2 ng) often indicated t h e possible presence o f a
malignant rumor s o m e w h e r e in the body. Therefore, the author non-invasively screened
the dentist for possible cancer using 6 0 n g o f Integrin α β , as a reference control
5
substance and red spectrum soft laser beam. T h e result o f the resonance b e t w e e n 6 0 n g
o f control Integrin α β ι a n d the s a m e substance in a different part o f t h e b o d y indicated
5
that the right a r m a n d left arm were - 5 , the supra-sternal notch w a s - 6 , b e t w e e n the
nipples w a s - 2 , and the rest o f the body w a s either -1 o r - 2 . A s m a l i g n a n t t u m o r o f the
neck o r head w a s suspected, both ear lobules were e x a m i n e d and it w a s found that only
t h e right e a r lobule w a s - 6 , which indicated possible malignancy i n t h e right side o f t h e
brain. B y scanning the brain at the area corresponding to the right h i p p o c a m p u s , there
w a s -6 resonance with 6 0 ng of Integrin a ß „ and a n u m b e r of possible m i c r o s c o p e slides
s
o f the malignant t u m o r were examined for resonance. This examination indicated that
the round area slightly larger than a quarter (U.S. 2 5 cent c o i n ) a t right h i p p o c a m p u s area
had strong resonance with Astrocytoma o f the brain. T h e dentist indicated that recently
h e noticed he w a s forgetting things easily; therefore, the author e x a m i n e d both
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242 OMURA, Y.
parameters c o m m o n to all the malignant tumors as well as β-Amyloid (1-42) w h i c h

always increases in A l z h e i m e r ' s patients' hippocampus. According to the a u t h o r ' s non
invasive measurement technique, β-Amyloid (1-42) is less than 3 n g in a normal
individual. However, in the early stages of A l z h e i m e r ' s it increases t o 7 n g or higher. In
the right side, corresponding to the Astrocytoma positive area, w h i c h also occupies the
right hippocampus area, β-Amyloid (1-42) was 10 n g (which is equivalent to an
Alzheimer's finding), and in the left hippocampus area, ß-Amyloid (1-42) w a s 2 ng and
normal. Although, accidentally, the author detected the very early stages of
Astrocytoma, which m a y or m a y not be detected b y M R I , the patient has no significant
symptoms.
The patient's chief complaint w a s persistent severe pain (of grade + 8 o n a 0-10 pain
scale) in his right shoulder spastic muscle, which w a s originally developed while he w a s
traveling in Hungary and exposed to cold weather with strong w i n d blowing o n his neck.
FIGURE 5
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For his painful spastic shoulder muscle, he received a local intramuscular injection by a
paramedical for recurrent shoulder muscle spasticity. T h e location w h e r e the injection
w a s made became more painful and more spastic. T h e Virtual D r u g Test predicted that
his optimal dose o f D H E A would be 1.5 m g and m a x i m u m normal cell telomere o f right
upper arm would be 500 ng. Because of severe shoulder pain, he decided to try o n e
optimal dose o f D H E A for possible improvement of the severe shoulder pain a n d
possible brain tumor, Astrocytoma. Since the amount of his optimal d o s e o f D H E A w a s
extremely low (1.5 m g ) , the author suspected that he w a s most likely taking D H E A .
Upon questioning, he indicated that he took about 6 m g of D H E A 2 d a y s earlier.
In the following tables, changes in various parameters after taking one d o s e o f the
optimal dose of D H E A (1.5 mg) are summarized. Within 5 minutes after taking o n e
optimal dose o f D H E A , the patient's severe shoulder pain reduced to 0 in about 8 0 % o f
the painful area, with the exception of a small painful area where the injection w a s
originally m a d e ; this area w a s reduced to a +4 pain grading from the original + 8 pain
grading. His average normal upper arm tissue telomere increased from 4 5 n g to 5 0 0 ng
with an increase o f D H E A from 1 m g to 110 m g .
In addition to this Astrocytoma o f the brain, recently the author already e x a m i n e d the
effects of one optimal dose of D H E A with patients with m u c h larger A s t r o c y t o m a tumor.
They were evaluated before and after one optimal dose of D H E A . O n e female patient,
about 50 years old, w h o already had surgical removal of the tumor, received radiotherapy
and chemotherapy after surgery. Supposedly, the t u m o r ' s activity w a s arrested. Upon
examination, the author found malignant cell telomere w a s extremely high (over 1500
ng), which can only be found in the active form of Astrocytoma o r Glioblastoma
Multiforme. Integrin α β , and Oncogen c - f o s A b amounts w e r e extremely high (over
5
500 ng). Again, this can only be seen in the active forms o f these t u m o r s . D H E A o f
tumor w a s less than 0.1 ng. D H E A in normal parts of the body w a s less than 1 ng. T h e
patient w a s taking about 20 different nutritional supplements at the time. W h e n the
author examined her, most of them were toxic. W h e n the author gave the optimal dose
o f D H E A , all of the patient's cancer parameters became practically 0. Acetylcholine w a s
markedly reduced, increased from about 1 zg to 40 p g . Similarly, the author found in
another dentist with an extensive area of the brain with an Astrocytoma strong-positive
response, with all the measurable abnormalities with the Bi-Digital O-Ring Test.
However, because of very early stage detection of malignancy, he did not have any
symptoms. Still, his normal cell telomere and normal cell D H E A w e r e extremely low,
PAINFUL RIGHT Before optimal dose of 10 min. after one optimal

SHOULDER DHEA doseofDHEA(1.5mg)
Substance Ρ 220 ng 1 ng
TXB 2
650 ng 0.5 n g
Bradykinine 155 ng 0.2 n ß
Folic Acid <iyg 40 ng
DHEA 1 ng llOnii
Pain (0-10 pain grading) +8 0-+3
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244 OMURA, Y.
ASTROCYTOMA OF Before D H E A After taking optimal dose o f

RIGHT HIPPOCAMPUS D H E A (12. 5 m g )
Telomere HOOng <i yg
DHEA 1 ng HOng
TXB 2 2 5 0 ng 0.3 n g
Integrin α , β , 4 5 0 ng <iyg
Folic Acid 1 yg 40 ng
Acetylcholine ι fg 35 μg
ß-Amyloid (1-42) 10 ng 1 ng
which initiated screening o f the cancer. T h e hand writing and m o u t h writing, before
administration of one optimal dose of D H E A , showed an extremely high abnormal value
of Integrin α β , and O n c o g e n C-fosAbz on the same side of the tumor.
5
Case #11 (Non-Clinical)

Potential Factors Reducing the Effects of the Optimal Dose o f D H E A and the Effect of
O n e Optimal D o s e o f D H E A (5 mg) On the Normal Cell T e l o m e r e . N o r m a l Cell D H E A .
and Grasping Force
O n September 2 4 , 2 0 0 5 the author examined the effects o f optimal d o s e o f D H E A on the

normal cell telomere a n d D H E A levels for about 2 0 dentists and medical doctors.
Regardless o f the original a m o u n t o f the normal tissue telomere and D H E A , in every
person w h o w a s given an optimal dose of D H E A , estimated b y Virtual D r u g Testing,
their a m o u n t o f normal cell telomere went up anywhere between 500-530 n g . Because o f
this, the author himself decided to try one optimal dose o f D H E A o n himself. At that
particular week, for s o m e reason, most of the volunteers (of m o r e than 2 0 M.D.s and
D.D.S.s) had relatively l o w telomere compared to any previous meetings. This could be
due to extraterrestrial electromagnetic field or other unknown force. B e c a u s e o f this,
everyone wanted to take the optimal dose of D H E A . T h e result w a s that regardless o f
original values o f normal cell telomere and D H E A at upper arm, everyone w h o
participated had their n o r m a l cell telomere increase to between 500-530 n g . T h e author
labeled each o f t h e m w h o had their telomere increase to 500 n g or m o r e as m e m b e r s o f
the " 5 0 0 n g C l u b . " T h e y had their telomere and D H E A examined every day during the
meeting. Between subsequent meetings, their average normal cell telomere and D H E A
were estimated by examining right and left hand writing. A s they provided almost the
same value as direct m e a s u r e m e n t from actual individuals, the telomere a n d D H E A of
many m e m b e r s o f the " 5 0 0 ng C l u b " were examined once every 3 to 7 days by faxing
right and left hand writings. However, about 22 days later, only the a u t h o r ' s telomere
w a s reduced to 105 ng at 9 P M on October 16. T h e reason behind this s u d d e n decrease in
telomere w a s that the author w a s working day and night with very little sleep to finish a
s t
4-day scientific p r o g r a m of the 2 1 Annual International S y m p o s i u m o n Acupuncture,
Electrotherapeutics, & the Bi-Digital O-Ring Test held at the School o f International
Affairs at C o l u m b i a University. In the previous 3 days, the author only h a d an average
of 3 hours sleep, sitting in front o f the computer, with an air conditioner immediately
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behind him. Although the air conditioner was off, the space between the air conditioner
and w i n d o w allowed a cold breeze to blow through the room. Cold air w a s b l o w i n g and
the r o o m w a s extremely chilly, although he did not measure the actual temperature.
W h e n the author measured the telomere at 9:00 pm o n October 16, it w a s reduced to 105
ng, while at n o o n time o n the same day it was 500 ng. Therefore, without taking an
additional optimal dose of D H E A , the author decided to m a k e the r o o m w a r m e r by
preventing the cold air from c o m i n g into the room and to get e n o u g h sleep. O n e day
later, the author e x a m i n e d the normal tissue telomere of the upper a r m a n d it had g o n e up
to 115 ng. T w o days later, it had gone up to 180 ng. A t that point, the author h a d 2
nights o f good rest and had prevented exposure to cold temperature. During this period,
the author examined D H E A and T X B at the right hand, eyes, heart, h i p p o c a m p u s , motor
2
cortex, pons, and Medulla Oblongata. A s can be seen, w h e n normal tissue telomere at
right hand w a s 105 ng, D H E A w a s extremely low at 1.5 ng in the right h a n d . T h i s
usually indicated a high probability of the presence of a malignant t u m o r s o m e w h e r e in
the body. T h e rest o f the organs listed had less than 1 ng of D H E A . After 2 days of
good rest and a w a r m e r environment, normal cell telomere went up to 180 ng, but D H E A
Oct. 1 6 , 2 0 0 5 Oct. 1 7 , 2 0 0 5 Oct. 18, 2 0 0 5 After

9:00 p.m. 11:00 a.m. 3:00 a.m. optimal
dose of
DHEA
(5 m g )
3:20 a.m.
Normal Tissue T e l o m e r e at R- 105 ng 115ng 180ng 500 n g
hand
DHEA R-hand 1.5 ng 5 ng 11.5ng 125 n g
(TXB )2
(275 ng) (220 ng) (65 ng) (0.5 ng)
Eyes 0.16 ng 0.22 ng 1 ng 30 ng
(150 ng) (125 ng) (50 ng) (0.5 ng)
Heart 0.1 ng 0.21 ng 1 ng 4 0 ng
(100 ng) (75 ng) (40 ng) (0.5 ng)
Hippocampus 0.1 ng 0.14 n g 1 ng 40 ng
(125 ng) (105 ng) (25 ng) (0.5 ng)
M o t o r Cortex 0.1 ng 0.14 ng 1 ng 4 0 ng
(175 ng) (105 ng) (25 ng) (0.5 ng)
Pons 0.15 ng 0.65 ng 1 ng 4 0 ng
(175 ng) (105 ng) (25 ng) (0.5 ng)
Medulla Oblongata 0.15 ng 0.65 ng 1 ng 4 0 ng
(175 ng) (105 ng) (25 ng) (0.5 ng)
Grasping R-hand 22 kg 25 kg 3 0 kg 37 k g
Force L-hand 17 kg 19 kg 2 4 kg 2 9 kg
Table 1. Effects o f Oral Intake o f O n e Optimal Dose o f D H E A on 71 year-old M a l e on his

Normal Cell T e l o m e r e and T X B a t Different Parts of the Body (R-hand, E y e s , Heart,
2
Hippocampus, M o t o r Cortex, Pons, Medulla Oblongata) and Grasping F o r c e .
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246 OMURA. Y.
went up to only 11.5 ng. Meanwhile, very low D H E A and very high T X B 2 indicated the
presence of circulatory disturbances. When the amount of telomere and D H E A of the normal
tissue w a s very low, and T X B 2 w a s relatively high, grasping force o f both right and left hands
was also reduced. W h e n the telomere went up to 180 ng, the grasping force increased. On
October 18, at 3 A . M . and w h e n the telomere was 180 ng, t h e author repeated the other
parameters and the grasping force of right and t e n hand and decided to find out what changes
parameters might take place if an optimal dose of D H E A w a s taken. A s can be seen from the
following table, the optimal dose of D H E A (5 mg) w a s estimated for the author by Virtual
Drug Testing, which indicated a potential maximum value of telomere to be 5 0 0 ng. Therefore
the author took o n e optimal dose o f D H E A orally.
About 2 0 minutes after oral intake of one optimal dose of D H E A (5 m g ) , all o f the
measurements w e r e repeated. D H E A in the hand increased from 11.5 ng to 125 ng in the
hand, and T X B 2 reduced from 6 5 ng to 0.5 ng. D H E A in eye, heart, h i p p o c a m p u s , motor
cortex, p o n s , and Medulla Oblongata all increased from 1 n g to 4 0 ng (the eye to 3 0 ng).
T X B 2 in all areas reduced to less than 1 ng, which represented completely normal
circulation. Grasping force measured by hand dynamonometcr in the right hand went up
from 30 kg to 3 7 kg, which w a s approximately a 2 5 % increase. T h e left hand grasping
force increased from 24 to 29 kg, which was approximately a 2 0 % increase. This
grasping force m e a s u r e m e n t w a s an average of 3 repeated trials with each hand.
Therefore, at least, o n e can state that an oral intake of one optimal d o s e o f D H E A (5 mg)
increased the grasping force between 2 0 - 2 5 % in this particular study. See the following
table for all o f the results.
Case #12 (Non-Clinical)

Effects of Optimal Dose o f D H E A (5 mg) Intake On Black and White Hairs of the Head
Since the author took o n e optimal dose o f D H E A on September 2 4 , 2 0 0 5 , after normal

cell telomere rapidly reduced from 500 ng to 105 ng on October 1 6 , 2 0 0 5 (after 2 2 days
n d
of effective period) until the 2 optimal dose o f D H E A w a s c o n s u m e d , there w a s a 3-day
n d
period o f relatively low body D H E A . After 2 optimal dose of D H E A w a s taken on
October 18, the a u t h o r ' s telomere remained between 500-530 ng depending on what the
author ate or drank. For example, when the author swallowed cactus honey p o w d e r (1 g)
or when he drank p l u m wine or red port wine (15-25 cc), the telomere increased an
additional 15-50 ng temporarily. T h e average D H E A level at a normal part o f the body
w a s anywhere between 115-130 ng. On December 2 0 , 2 0 0 5 , while the author was
washing his face and c o m b i n g his hair, he noticed that s o m e o f the hair c a m e out in the
c o m b . T h e author had a very interesting finding; namely, s o m e of the hair that c a m e out
w a s white for the s a m e length at the upper part of one long hair and then c h a n g e d to
black all the way to the root. A m o n g about 35 hairs collected by repeated combing, there
were 2 such hairs, and the rest of the hair was either completely black or completely
white.
T h e author placed s o m e of these detached hairs on a white sheet of the surface of typing
paper and fixed them with Bi-Digital O-Ring Test positive Scotch tape. T h e author
numbered them from 1-4. N u m b e r 1 was completely white, from tip to root, with about
12
8.3 cm from the root containing detectable D H E A with 0.5 pg (1 picogram= 10" grams)
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D H E A sample. N u m b e r 2 w a s white at the upper part, with a small portion of the lower
part black (this hair, however, lost the root). N u m b e r 3 had a 3 c m white upper part of
hair and the remaining 9 cm o f hair was black, including the root. T h e bottom 8.3 c m
contains detectable D H E A (with 0.5 pg D H E A sample). N u m b e r 4 w a s entirely black.
8.3 cm from the root contained a detectable amount o f D H E A (with 0.5 pg D H E A
sample). N u m b e r 5 and N u m b e r 6 were pulled out together. N u m b e r 5 w a s entirely
white, with the first 8.2 cm containing detectable D H E A (with 0.5 pg D H E A sample).
The entire length of hair N u m b e r 6 had a black color but 8.3 c m o f the lower part from
the root had detectable D H E A (with 0.5 pg sample). This lower 8.3 c m o f hair from the
root containing a m i n i m u m o f 0.5 p g of D H E A was grown between September 24 and
December 20, during a period o f about 3 months. This indicated that the hair o f the
author's head g r o w s at a rate o f about 2.6 cm/month (1 inch= 2.54 c m ) . In all o f these
hairs, within every 8.3 c m of black part of hair from the root of the hair, there w a s about
15
2 m m with very l o w D H E A of 0.1 fg ( 1 femtogram= 10" grams), which corresponded to
n d
the time the a u t h o r ' s telomere w a s very low before he took the 2 optimal dose of
D H E A (5 m g ) . Beyond 8.3 c m of black part of hair from the hair root, D H E A can be
detected only with very low D H E A of 0.1 fg. The big difference between white hair and
black hair is that all the black hair at the first 2-3 m m from the root contains about 5-20
pg of D H E A , which is the highest in any part of the hair. T h e white hairs, beginning at
the root, in the first few m m , contain a maximum o f 5-10 pg o f D H E A . F r o m this, it is
possible to conclude that after oral intake of one optimal dose o f D H E A , the detectable
amount of D H E A in the hair also increased in the part o f the hair g r o w n after D H E A w a s
given. T h e root o f the white hair often had half of the amount of D H E A o f the root of
the black hair. A l s o , from hair N u m b e r 2 and N u m b e r 3, one can state that after optimal
dose of D H E A w a s taken, s o m e of the white hair changed to black hair. T h e ratio of
such a change o f the hair w a s found only in 2 hairs out of 35 hairs. T h e remaining 33
hairs were either full white or black, with about half being each. T h i s finding indicated
that by taking one optimal dose of D H E A and keeping normal cell telomere o f upper arm
over 500 ng and D H E A to be 120-130 ng, s o m e of the white hair had the possibility to
change to black hair.
At the time the final manuscript of this article was prepared, the sheet with 6 hairs
described in this article disappeared and therefore the author repeated similar
measurements with newly collected 3 hairs obtained by combing hair (A: one 14.4 cm
hair consisting of the upper part (4.7 c m ) was white hair and the r e m a i n i n g 9.7 cm
between the root and the end o f the white part was black hair, B : one w a s completely
black hair with 13.5 c m length between the root of the hair and the tip o f the hair, and C:
one hair w a s entirely white with length of 13.8 cm between the root o f the hair and the
tip). However, this time the author measured the amount of Melatonin and D H E A at
different parts o f the hair. In the particular hair A with white upper part and black lower
part at a distance o f 10.2 c m from the root, Melatonin suddenly increased from 1 p g to 3
pg and D H E A slightly increased from 0.3 pg to 0.35 pg. T h e color o f the hair at this
point w a s still white. A t 9.7 c m from the root of the hair, Melatonin increased to 4 pg
and D H E A increased to 0.55 pg. Below that point, the hair b e c a m e visibly black until
the root o f the hair. T h i s increase of Melatonin from 1 pg to 3 pg m a y correspond to
September 2 4 , 2 0 0 5 , w h e n the author took one optimal dose o f D H E A , 5 m g , which
increased the a u t h o r ' s normal cell Telomere from the low value o f 120 n g to o v e r 500 ng.
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248 OMURA, Y.
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F i g u r e 6: A m o u n t of Melatonin & D H E A measured in 3 different hairs of the s a m e head
of a 72-year old m a l e o f Japanese origin and his corresponding average normal cell
sl
telomere. A ) T h e 1 hair consists of a white upper part o f the hair followed by a black
part o f the hair, w h i c h e n d s at the root of the hair. This indicated that the white hair
changed to black hair shortly after 1" optimal dose of D H E A (5 m g ) w a s taken on
л
September 24. B) T h e 2 hair is entirely black. C) The З' is entirely white. T h e I
n d я
date the T e l o m e r e w a s increased from about 120 ng to 500 ng after taking o n e optimal
dose of D H E A (5 m g ) w a s September 24. That should correspond to around the time the
amount o f D H E A and Melatonin in the above 3 hairs significantly began to increase. In
the part of the hair a b o v e the wide arrow w a s the time when the normal cell T e l o m e r e
went d o w n to 105 ng on October 16, and then by October 18, it w e n t u p to 180 ng and
n d
the 2 optimal dose o f D H E A (5 m g ) was taken and normal cell telomere w e n t u p to 500
ng. Until these hairs were collected on January 15 the average normal cell T e l o m e r e of
over 500 ng w a s maintained for about 3 months after o n e optimal d o s e of D H E A (5 m g )
w a s taken on October 18. In the reproduced copy, the white hair b e c o m e s invisible, but
j u s t a b o v e the upward arrow the white hair is indicated. All the black hair h a s relatively
high Melatonin o f over 3 0 pg within 4 m m from the root of the hair, but white hair h a s
Melatonin o f less than 3 p g in the same area near the root of the hair. Melatonin in the
rest of the black hair is usually 10 pg or higher, while in the white hair it is less than 2 pg.
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A significant increase in D H E A appeared 9.7 cm from the root of the hair. T h e wide
arrow may correspond to October 1 6 , 2 0 0 5 , when the a u t h o r ' s T e l o m e r e went d o w n to
105 ng. Until October 18 at 3:20 A M after a second dose o f one optimal dose o f D H E A
(6.25 m g ) w a s taken, Telomere again increased to over 500 ng. Just before the second
dose of the optimal d o s e of D H E A , 5 m g , w a s taken normal cell telomere w a s 180 ng.
Both black hair and white hair also had similar very low Melatonin and D H E A levels.
There was a period s h o w n by a wide arrow where Melatonin and D H E A were very low.
Compared with the previous study, Melatonin measurement provided n e w information
that indicated that under normal conditions, in order to have a black hair, Melatonin
usually should be 4 pg or higher but the change of the hair color required m o r e than 3
days, as can be seen as exception where area corresponding to w i d e a r r o w had very low
Melatonin of 0.1 pg but hair did not change to white. A s can be seen from Figure 6
showing measurements of the Melatonin and the D H E A o f 3 hairs, w h e n the normal cell
Telomere w a s relatively low the corresponding part of the hair w o u l d s h o w significantly
reduced amount o f Melatonin and D H E A . Hair root o f the black hair had relatively high
Melatonin level of m o r e than 3 0 pg, while white hair root had very l o w Melatonin level
of 2 pg, which w a s l / l 5 o f the black hair root. In these newly collected 3 hair examples,
the amount of D H E A did not show significant correlation, contrary to previous hair
analysis. Judging from this simple analysis of the amounts of Melatonin and D H E A in
hairs of the same p e r s o n ' s head it is most likely possible to measure m a n y other
biologically important substances from even one hair. This finding indicates that one
optimal dose o f D H E A seems to gradually increase the amount o f Melatonin in both
white and black hair. Therefore, it may be possible to accelerate this tendency by
simultaneously, with one optimal dose of D H E A , giving an optimal dose o f Melatonin.
This may further accelerate an increase in the amount of Melatonin in the hair and
increase the possibility of changing white hair to black hair or darker hair. However,
most o f the commercially available Melatonin tablets are 3 m g o r higher, which is
already an overdose for most individuals. An optimal dose of Melatonin is usually 1.5
m g or less and therefore, one should be careful not to take an excessive d o s e of
Melatonin.
DISCUSSION & SUMMARY
Initially, the author tried to find out why D H E A is beneficial for s o m e and harmful for
others and suspected that an overdose may cause harmful effects and an optimal dose
may produce m a n y beneficial effects. To evaluate this concept, the optimal dose of
D H E A w a s measured using Virtual Drug Test based on Bi-Digital O-Ring Test for
different individuals with different ages and sex and found that the optimal dose ranges
anywhere between 1.25-12.5 m g for the age group between 20-80 years old, for both
male and female, contrary to commonly recommended daily intake o f 25-50 m g or even
higher dose of 50-100 m g . U p to now, 50 subjects (25 w e r e M . D . s and D.D.S.s w h o
volunteered and 25 were patients with a variety o f medical problems) h a v e been given
the optimal dose, regardless of the amount of pre-treatment telomere and D H E A . After
taking an optimal dose o f 1.25-12.5 m g of D H E A , the amount o f telomere o f normal
tissue measured at the right upper or lower arm always became b e t w e e n 500-530 ng,
regardless of age, sex, and original amount of average telomere, and they all became
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250 OMURA, Y.
m e m b e r s o f the " 5 0 0 ng C l u b . " However, when 25 m g of D H E A w a s tested with Virtual

Drug Testing, telomere went down much lower than pre-treatment value (Age-promoting
effect) and often w e n t d o w n below 80 ng and cancer parameters w e r e increased. W h e n
50 m g w a s tested with Virtual Drug Testing, telomere, regardless o f h o w m u c h w a s pre
treatment value, w e n t d o w n below 4 0 ng with further increase in cancer parameters.
Therefore, it w a s potentially harmful to take a toxic overdose o f 2 5 m g or 5 0 m g of
D H E A . Furthermore, if it w a s taken every day, not only would normal cell telomere
amount b e c o m e extremely low, but it would also promote cancer. O n the other hand,
when one optimal dose o f D H E A w a s given, it had safe, excellent anti-cancer effects. It
reduced abnormally increased cancer cell telomere of over 1100 n g to less than 1 yg,
while increasing normal cell telomere to anywhere between 5 0 0 ng and 5 3 0 ng. This w a s
a true anti-aging effect.
In this study, there w e r e 2 groups of subjects between 20 and 8 0 years old, both m a l e and
female. D u e to the participants being located in different cities all over the United States,
as well as in Japan and G e r m a n y , it w a s not always easy to follow-up; follow-up w a s
accomplished by receiving right hand writing and left hand writing every 3-7 days by
fax. All o f these clinical cases and all other additional tests resulted in the following
conclusions:
1) A m o u n t of telomere estimated with Virtual Drug Testing w a s almost a l w a y s identical

to real drug test results measured within 10-60 minutes after the individual took the
same actual medication;
2) Regardless o f the amount o f telomere measured before, within 10 minutes after oral
intake optimal d o s e o f D H E A with water, telomere levels of the normal tissue
measured at the right upper (or lower) arm always went up a m i n i m u m o f 500 and a
m a x i m u m of 5 3 0 ng, depending on the individual, and the effects lasted for at least 3
months in most o f the volunteers after taking one optimal dose;
3) D H E A at different parts of the body increased to a m a x i m u m of 120-130 ng within 10

minutes after oral intake of optimal dose of D H E A ;
4) W h e n average normal cell telomere of arm w a s persistently less than 110 ng, often a
malignant tumor existed somewhere in the body (if normal cell telomere w a s less than
50 ng and persisted, then the possibility of A I D S also existed);
5) W h e n very l o w D H E A (measured at upper (or lower) right arm) persisted, particularly

w h e n it w a s less than 2 ng, cancer almost always existed s o m e w h e r e in the body;
6) Circulatory disturbance with abnormally increased T X B 2 and pain with increased

Substance Ρ and Bradykinine were both markedly improved by taking one optimal
dose of D H E A estimated by Virtual Drug Test;
7) Grasping force increased anywhere up to 2 5 % in right and left h a n d within 10 minutes

o f oral intake o f one optimal dose of D H E A estimated by Virtual D r u g Test;
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BENEFICIAL EFFECTS & SIDE EFFECTS OF DHEA
8) After taking one optimal dose of D H E A some of the white hair of the head due to
aging changed to black hair.
9) After taking an optimal dose of D H E A , estimated by the Virtual D r u g Test, the

amount of average normal cell telomere measured by Bi-Digital O-Ring units, reached
anywhere between 500-530 ng and D H E A of normal parts of the body reached
between 120-130 n g , but the following factors reduced the beneficial effects of one
optimal dose o f D H E A on telomere. T h e factors are (although they are dose
dependent):
a) Smoking
b) Additional D H E A (initial optimal dose or higher dose than optimal dose)
c) Excessive dose o f steroid hormones taken orally or used as a skin cream
or ointment containing a large amount of steroid h o r m o n e s (to reduce
inflammation o f skin)
d) Non-steroidal anti-inflammatory drugs ( N S A I D s ) , including Aspirin (even
with baby Aspirin), Tylenol (Acetaminophen), and Advil (Ibuprofen)
e) Neurontin (Anticonvulsant with potential side effects) used for pain
f) T o p a m a x (Anticonvulsant with potential side effects) used for pain
g) V i t a m i n C
h) Synthroid ( 112 μ g or higher)
i) Caffeine
j ) Vitamin E (over 200 IU)
k) Saiko-Keishi-Tou (Tsumura 10)
1) Cilantro (negative effect is less than baby Aspirin)
m ) Excessive doses of Folic Acid (more than 200-400 μ g , depending o n the
individual)
n) Excessive doses o f Vitamin В ц (more than 350-750 μg)
o) Prolonged exposure to low temperatures
p) Extreme physical exhaustion, including extreme tiredness of the e y e
q) Physical trauma
r) Exposure to strong electromagnetic field from various electrical devices,
including cellular phone, particularly while holding the phone and talking
s) Wearing Bi-Digital O-Ring Test strong negative materials, including
s o m e o f the following: underwear, necklace, watch with positive polarity
o f battery indirectly contacting body surface, hair d y e , eyeglass, cosmetic
materials, jewelry, socks
t) Stress
u) Watching a scary movie
A m o n g the above listed items, some of the substances are widely used every day, but
there is no evidence that they shorten life span significantly. Therefore, s o m e of these
effects may not last for a long period of time and also the side effects of all o f these dose-
dependent substances may be minimal or non-existent and a small a m o u n t is still
desirable for s o m e people.
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252 OMURA. Y.
10) When an optimal dose w a s used, the following well-known beneficial factors had a
significant telomere-increasing effect (38-41,64-92). However, w i t h the exception
of D H E A , the effects usually did not last more than a m a x i m u m o f a few d a y s , and a
minimum o f a few hours.
a) O n e optimal dose o f D H E A
b) Press needle stimulation o f acupuncture point True S T . 3 6 3-4 t i m e s a day.
Each stimulation consisted of 200 press and release sequences.
c) Application o f (+) Qi-gong energy stored paper
d) Application o f (+) special solar energy stored paper
e) Optimal dose o f Noni j u i c e or dried Noni
0 Optimal dose o f Shilajit
g) Optimal dose o f combination of E P A with D H E A , folic acid, and special
Cilantro tablet
h) Optimal d o s e o f Cactus honey or Cactus honey p o w d e r (about 2-5 g)
i) Optimal dose o f Grape seed extract (about 100-150 m g )
j ) Optimal d o s e o f combination of α-Lipoic Acid and Acetyl-L-Carnitine
k) Optimal d o s e o f C o Qio
I) Optimal d o s e o f Calcium Pyruvate
m ) Drinking small amounts (15-30 cc) of Bi-Digital O-Ring Test positive
alcohol, such as Plum wine, Red Port wine, Baileys Original Irish Cream,
Courvoisier C o g n a c , and Cointreau
n) W a t c h i n g cheerful movies
o) Laughing
T h e author also evaluated not only the above substances' normal cell telomere increasing
effects and cancer cell telomere reducing effects, but also studied h o w long these effects
would last. D u e to space limitation, this information could not be included in this article.
Within the past several years, the author has examined many drugs or nutritional
supplements which were supposed to prolong life span. W h e n the d r u g s w e r e evaluated,
many of them with r e c o m m e n d e d doses produced significant reduction in the normal cell
telomere and increased cancer cell telomere. In addition, even a m o n g the substances that
were tested to be Bi-Digital O-Ring Test positive, some o f them reduced the telomere.
Therefore, from this study one can conclude that any substance that increases normal cell
telomere significantly can be considered as a true Anti-aging substance and safe A n t i
cancer substance. A n y substance that reduces normal cell telomere significantly can be
called a true Age-promoting agent and they also promote cancer and cancer parameters
(Cancer-promoting agent). T h e author found that any substance that increases normal
cell telomere significantly, while decreasing cancer parameters and reducing cancer cell
telomere to less than 1 yg, is a true Anti-aging and Anti-cancer substance. Therefore,
true Anti-aging substances have safe true Anti-cancer effects.
Until the author performed this study, it was always uncertain why s o m e report D H E A as
a miracle drug, as the d r u g can produce so many beneficial effects, a n d others claim
D H E A to be a potential danger of promoting cancer of the breast and prostate gland.
However, the a u t h o r ' s study clearly indicated many desirable beneficial effects,
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including significant increase in normal cell telomere (=true Anti-aging effects), and a
marked decrease in cancer cell telomere (=safe and true Anti-cancer effects), improving
circulation, reducing pain, and increasing muscle strength and the significant Anti-cancer
effects for prostate cancer and Astrocytoma of the brain, as well as A d e n o c a r c i n o m a o f
the colon, Adenocarcinoma o f the lung, Adenocarcinoma of the breast, and small cell
carcinoma of the lung, although s o m e of these were not included in this study. These
many desirable effects can be obtained by a single optimal dose o f D H E A , which varies
depending on the individual. This ranges between 1.25 m g and 12.5 m g . T h e effects of
this single optimal d o s e often lasted 1-4 months as long as D H E A canceling negative
factors is not introduced. O n the other hand, daily intake o f an overdosed a m o u n t of
D H E A decreased normal cell telomere (=Agc-promoting effects), with an increase in
cancer cell telomere (=Cancer-promoting effects). Unfortunately, m a n y popular books
recommend daily intake of undesirable overdose of 25-50 m g , and s o m e even
recommend 50-100 m g daily. While no other drug tested has such long-lasting effects as
one optimal dose o f D H E A , with most other drugs, one optimal dose lasts between
several hours to a m a x i m u m of a few days. In most people the effects o f one optimal
dose o f D H E A can last at least 3-4 months, but because of additional intake o r exposure
to the inhibiting factors o f D H E A , the effect does not last in s o m e individuals. A l s o , the
effect of D H E A often appears within 10 minutes after oral intake o f o n e optimal dose,
unlike many other medications. Although further research is necessary, the author hopes
that the result of the present study can contribute to prevent the problem being created by
taking daily excessive overdose of D H E A .
ACKNOWLEDGEMENTS
The author w i s h e s to acknowledge the help received for valuable p u r e reference

control substances and s o m e of the references required for this study: Dr. Yasuhiro
Shimotsuura, M.D., F.I.C.A.E., Vice President of Japan Bi-Digital O-Ring Test Medical
Society and his associate, Mr. M o t o m u Ohki, M . S c , F.I.C.A.E., both of t h e m o f O R T
Life Science Research Institute, K u r u m e City, Fukuoka-Ken, Japan. T h e author is also
grateful to the following physicians and dentists who are active m e m b e r s of the
International College of Acupuncture & Electro-Therapeutics and w h o have helped in
clinical cases: Dr. E d w a r d Spiegel, D.D.S., F.I.C.A.E., Former Director o f C M E Program
of American A c a d e m y of Head, Neck, and Facial Pain, and C E O o f Health Technology
Inc., Phoenix, Arizona, Dr. Marilyn K. Jones, D.D.S., F.I.C.A.E., Director of Holistic
Dental Clinic, Houston, Dr. Harsha Duvvi, M.D., М.Р.И., F . I . C A . E . , Assistant
Professor, D e p ' t o f C o m m u n i t y and Preventive Medicine, and o f D e p ' t of Neurology,
N e w York Medical College, Dr. Abraham Henoch, M.D., F.I.C.A.E., Attending
physician at family practice dept., Columbia University Medical Center; Dr. A n d r e w
Pallos, D.D.S., Director o f Holistic Dental Clinic of Laguna Niguel, California, Dr.
Ignatius J. Kazella, D . D . S . of N e w Jersey. Mr. Victor W o n g , B.Sc. & Miss Junko
Furuya & Miss Diana Gerometta, M . S . for their volunteering work in these studies. T h e
author also wishes to acknowledge the help in preparation o f this manuscript from part-
time research assistants of the Heart Disease Research Foundation: Mr. Filip Jagodzinski,
M.S., PhD candidate in artificial intelligence at University of Massachusetts at Amherst;
Mr. Lawrence Kurtzman, Post-Baccalaureate Premcdical Sciences at C o l u m b i a
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254 OMURA. Y.
University; Miss Alison Hutchins, Graduate o f North Carolina State University with a
B.S. in Microbiology and a B.A. in Chemistry.
REFERENCES
1. Butenandt A , D a n n e n b a u m H . "Uber Androsteron HI. Isolierung eines neuen,

physiologisch unwirksamen Sterinderivates aus Mannerharn, seine Verknüpfung
mit Dehydro-androsteron und Androsteron: ein Beitrag zur Konstitution des
A n d r o s t e r o n s . " Hoppe-Sevlers Zeitschrift Fur Physiologische C h e m i e . Vol. 229,
p a g e s 192-208, 1934.
2. M u n s o n PI, Gallagher T F , Koch F C . "Isolation of dehydroisoandrosterone sulfate
from normal male urine." Journal of Biological Chemistry. Vol. 152, p a g e s 6 7 -
77,1944.
3. M i g e o n CJ, Plager J E . "Identification and isolation o f dehydro-isoandrosterone
from peripheral h u m a n plasma." Journal o f Biological Chemistry. Vol. 2 0 9 , pages
767-772,1954.
4 . Baulieu E E . " T h r e e sulfate esters of 17-ketosteroids in the plasma of normal
subjects and after administration of A C T H . " Journal of Clinical Endocrinological
Metabolism. Vol. 2 0 , pages 9 0 0 - 9 0 4 , 1 9 6 0 .
5. Roberts K D , VandeWiele R L , Lieberman S. "The conversion o f
Dehydroisoandrosterone sulfate to Androsterone and Etiocholanolone
Glucuronidates." Journal o f Biological Chemistry. Vol. 2 3 6 , N o . 8, pages 2 2 1 3 -
2215,1961.
6. Plager J E . " T h e binding of Androsterone sulfate, Etiocholanolone sulfate, and
Dehydroisoandrosterone sulfate by human plasma protein." Journal o f Clinical
Investigation. Vol. 4 4 , N o . 7, page 1 2 3 4 , 1 9 6 5 .
7. P o o r t m a n J, Preñen J A , Schwarz F, Thijssen J H . "Interaction o f delta-5-
androstene-3beta, 17bcta-diol with estradiol and dihydrotestosterone receptors in
h u m a n myometrial and m a m m a r y cancer tissue." Journal o f Clinical
Endocrinology & Metabolism. Vol. 40, pages 373-379, 1975.
8. L o b o R A , G o e b e l s m a n n U. "Dehydroepiandrosterone sulfate as an indicator of
adrenal androgen function. Obstetrics & Gynecology. Vol. 5 7 , pages 6 9 - 7 3 , 1 9 8 1 .
9. Z w a i n IH. "Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons o f
cerebral cortex o f rat brain." Endocrinology. Vol. 140(8), pages 3 8 4 3 - 3 8 5 2 ,
1990.
10. C o m s t o c k G W , G o r d o n G B , Hsing A W . " T h e relationship of serum
dehydroepiandrosterone and its sulfate to subsequent cancer o f the prostate."
C a n c e r Epidemiology. Biomarkers. & Prevention. Vol. 2 , 2 1 9 - 2 2 1 , M a y / J u n e
1993.
11. Schwartz A G , Pashko L L . "Cancer chemoprevention with the adrenocortical
steroid dehydroepiandrosterone and structural analogs." Journal of Cellular
Biochemistry (Supplement). Vol. 17G, pages 73-79, 1993.
12. Baulieu E-Ε. "Dehydroepiandrosterone (DHEA): a fountain o f y o u t h ? " Journal
o f Clinical Endocrinology and Metabolism. V o l . 8 1 , N o . 9, page 3 1 4 7 , 1 9 9 6 .
13. W a t s o n R R , Huls A, ct. al. "Dehydroepiandrosterone and diseases o f a g i n g . "
Drugs and A g i n g . Vol. 9(4), pages 2 7 4 - 2 9 1 , 1 9 9 6 .
IP: 193.93.194.253 On: Mon, 22 Oct 2018 15:43:38

BENEFICIAL EFFECTS 4 SIDE EFFECTS OF DHEA 255
14. Ravaglia G. " T h e relationship of dehydrocpiandrosterone ( D H E A S ) to endocrine-

metabolic parameters and functional status in the oldest-old. Results from an
Italian study on healthy free-living over-ninety-year-olds." Journal o f Clinical
Endocrinology and Metabolism, Vol. 81(3), pages 1173-1178, 1996.
15. Khorram O, Vu L, Yen SS. "Activation of immune function by D e h y d r o -
epiandrosterone ( D H E A ) in age-advanced men." Journals o f Gerontology Series
A: Biological Sciences and Medical Sciences. Vol. 52, Issue 1, M I - M 7 , 1997.
16. O ' B r i e n J. W h y e v e r y o n e ' s talking about D H E A : It slows aging, fights cancer &
heart disease, melts fat, boosts immunity and more! (63 page pocket book) Globe
C o m m u n i c a t i o n s Corp., Boca Raton, FL. 1997.
17. Morales AJ, Haubrich R H , Hwang JY, Asakura H, Yen S S . " T h e effect o f six
months treatment with a 100 m g daily dose of dchydroepiandrosterone ( D H E A )
on circulating sex steroids, body composition and muscle strength in a g e -
advanced men and w o m e n . " Clinical Endocrinology. Vol. 49(4), pages 4 2 1 - 4 3 2 ,
1998.
18. Rao K V N , J o h n s o n W D , Bosland M C , et. al. " C h e m o p r e v e n t i o n of rate prostate
carcinogenesis by early and delayed administration of dehydroepiandrosterone."
Cancer Research. Vol. 50, pages 3084-3089, July 1, 1999.
19. Barnhart K T , Freeman E, Grisso JA, Rader DJ, et. al. " T h e effect o f
dehydroepiandrosterone supplementation to symptomatic perimenopausal w o m e n
o n serum endocrine profiles, lipid parameters, and health-related quality of life."
Journal o f Clinical Endocrinological Metabolism. Vol. 84(11), pages 3896-3902,
1999.
20. Arlt W, H a a s J, Callies F, Reincke M, et. al. "Biotransformation o f oral
dehydrocpiandrosterone in elderly men: significant increase in circulating
estrogens." Journal of Clinical Endocrinological Metabolism. Vol. 84(6), pages
2 1 7 0 - 2 1 7 6 , 1999.
2 1 . Flynn M A , Wcaver-Ostcrholtz D , Sharpe-Timms KL, et. al.
"Dehydroepiandrosterone replacement in aging h u m a n s . " Journal o f Clinical
Endocrinological Metabolism. Vol. 84(5), pages 1527-1533, 1999.
2 2 . Reiter W J , et. al. " D H E A in the treatment of erectile dysfunction: a prospective,
double-blind, randomized, placebo-controlled study." Urology. Vol. 5 3 , pages
590-594, 1999.
2 3 . Arlt W, Callies F, et. al. "Dchydroepiandrosterone replacement in w o m e n with
adrenal insufficiency." N e w England Journal of Medicine. Vol. 341(14), pages
1013-1020, September 3 0 , 1 9 9 9 .
24. Callies F. "Influence of oral dehydrocpiandrosterone ( D H E A ) on urinary steroid
metabolites in males and females." Steroids. Vol. 65(2), pages 9 8 - 1 0 2 , 2 0 0 0 .
2 5 . Baulieu EE, T h o m a s G, Legrain S, et. al. "Dehydroepiandrosterone ( D H E A ) ,
D H E A sulfate, and aging: Contribution of the D H E A g e study to a
sociobiomedical issue." Proceedings of the National A c a d e m y o f Sciences. Vol.
97(8), pages 4 2 7 9 - 4 2 8 4 , April 11, 2000.
2 6 . Lee K S , et. al. "Effects o f D H E A on collagen and collegenase gene expression by
skin fibroblasts in culture." Journal of Dermatological Science. Vol. 2 3 , pages
103-110, 2000.
IP: 193.93.194.253 On: Mon, 22 Oct 2018 15:43:38

256 OMURA, Y.
2 7 . de Pergola G. " T h e adipose tissue metabolism: role of testosterone and D H E A . "

International Journal o f Obesity-Related Metabolic Disorders. Vol. 2 4 Suppl. 2,
pages S 5 9 - S 6 3 , 2 0 0 0 .
28. Stornati M , et. al. "Six month oral D H E A supplementation in early and late
p o s t m e n o p a u s e . " Gynecological Endocrinology. Vol. 14, p a g e s 3 4 2 - 3 6 3 , 2 0 0 0 .
2 9 . Khalil A, Fortin J P , Lehoux JG, et. al. "Age-related decrease o f
dehydroepiandrosterone concentrations in low density lipoproteins and its role in
the susceptibility o f l o w density lipoproteins to lipid peroxidation." Journal of
Lipid Research. Vol. 41(10), pages 1552-1561, October 2 0 0 0 .
30. Yen S S C . "Dehydroepiandrosterone sulfate and longevity: N e w clues for an old
friend." Proceedings o f the National Academy o f Sciences. V o l . 98(15"). pages
8167-8169, July 1 7 , 2 0 0 1 .
3 1 . Mazat L, et. al. "Prospective measurements of dehydroepiandrosterone sulfate in
a cohort o f elderly subjects: relationship to gender, subjective health, smoking
habits, and 10 year mortality." Proceedings of the National A c a d e m y of Sciences.
Vol. 98(14), pages 8145-8150, July 3 , 2 0 0 1 .
32. Null G. Gary N u l l ' s Power Aging. N e w American Library, 2 0 0 3 .
3 3 . Percheron G. "Effect of 1 year oral administration of dehydroepiandrosterone to
60-80 year-old individuals on muscle function and cross-sectional area: a double-
blind placebo-controlled trial." Archives of Internal M e d i c i n e . Vol. 163, pages
720-727,2003.
34. Suzuki M , Wright L S , M a r w a h P, et. al. "Mitotic and N e u r o g e n i c Effects o f
Dehydroepiandrosterone ( D H E A ) on human neural stem cell cultures derived
from the fetal c o r t e x . " Proceedings of the National A c a d e m y of Sciences U S A .
Vol. 101(9), p a g e s 3202-3207, March 2 , 2 0 0 4 .
3 5 . Algarte-Genin M , Cussenot O, Costa P. "Prevention of prostate cancer by
androgens: experimental paradox or clinical reality." European Urology. Vol.
46(3), pages 2 8 5 - 2 9 5 , Septemeber 2004.
36. S o m b o o n p o r n W, D a v i s SR. "Testosterone effects on the breast: Implications for
Testosterone T h e r a p y for W o m e n . " Endocrine Reviews. V o l . 25(3), pages 374-
388,2004.
37. T c h e r n o f A , et. al. "Dehydroepiandrosterone, obesity and cardiovascular disease
risk: a r e v i e w o f h u m a n studies." European Journal o f Endocrinology. Vol. 151,
p a g e s 1-14,2004
3 8 . Miller P L . T h e Life Extension Revolution: T h e N e w Science o f G r o w i n g Older
Without A g i n g . Bantam Press, 2 0 0 5 .
39. O m u r a Y. "Excessive use of steroid hormone & beneficial effects o f T r u e ST.
3 6 acupuncture o n malignant brain tumors—Part I; H o w to estimate non
i n v a s i v e ^ presence o f excess dose of steroid hormone in patients, baseball
players, & other professional athletes from its toxic effects on heart & pancreas,
as well as persistent or recurrent infection—Part II." Acupuncture & Electro-
Therapeutics: T h e International Journal. Vol. 30, pages 5 7 - 1 0 2 , 2 0 0 5 .
4 0 . O m u r a Y. " 6 m e t h o d s o f anti-aging approaches that increase normal cell
telomere, while functioning as an anti-cancer treatment by reducing cancer cell
telomeres to practically zero by which cancer cells can n o longer divide if
extremely low cancer cell telomere is maintained for prolonged periods of time."
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й1
Abstracts o f the 1 5 Annual Scientific Meeting of Japan Bi-Digital O-Ring Test
Medical Society, pages 97-98, July 16-17 2005.
41. Metzner N . "Complementarmedizinische diagnose und therapie v o n krebs nach
Prof. O m u r a . " Co" M e d . Vol. .pages 92-96, August 2 0 0 5 .
42. Jones JA, N g u y e n A , Straub M, et. al. "Use of D H E A in a patient with
Advanced prostate cancer: a case report and review." Urology. Vol. 50(5), pages
784-788,1997.
43. Goldberg M . "Dehydroepiandrosterone, Insulin-Like G r o w t h Factor-I, and
prostate cancer." Annals o f Internal Medicine. Vol. 129(7), pages 587-588,
October 1 , 1 9 9 8 .
44. Maggiolini M , D o n z c О, Jeannin E, ct. al. "Adrenal a n d r o g e n s stimulate the
Proliferation o f breast cancer cells as direct activators o f estrogen receptor a . "
Cancer Research. Vol. 5 9 , 4 8 6 4 - 4 8 6 9 , October 1, 1999.
4 5 . Wellman M , S h a n e - M c W ö r t e r L, Orlando PL, Jennings J P . " T h e role of
dehydroepiandrosterone in Diabetes Millitus." Pharmacotherapy. V o l . 19(5),
pages 5 8 2 - 5 9 1 , 1 9 9 9 .
4 6 . Morris K T , Toth-Fejel S, Schmidt J, et. al. "High dehydroepiandrostero- sulfate
predicts breast cancer progression during new aromatose inhibitor therapy and
stimulates breast cancer cell growth in tissue culture: a renewed role for
adrenalectomy." Surgery. Vol. 130(6), pages 9 4 7 - 9 5 3 , D e c e m b e r 2 0 0 1 .
4 7 . Powers M E . " T h e safety and efficacy of anabolic steroid precursors: W h a t is the
scientific e v i d e n c e ? " Journal of Athletic Training. Vol. 37(3), p a g e s 3 0 0 - 3 0 5 ,
2002.
48. Acacio B D , Stanczyk FZ, Mullin Ρ, et. al. "Pharmacokinetics of
Dehydroepiandrosterone and its metabolites after long-term daily oral
administration to healthy young men." Fertility and Sterility. V o l . 81(3), pages
595-604, M a r c h 2 0 0 4 .
49. Epel E S , Blackburn E H , et. al. "Accelerated telomere shortening in response to
life stress." Proceedings of the National Academy o f Sciences U S A . Vol.
101(49), p a g e s 1 7 3 1 2 - 5 , 2 0 0 4 .
50. O m u r a Y. " A new, simple, non-invasive imaging technique o f internal organs and
various cancer tissues using extended principles of the "Bi-Digital O-Ring Test"
without using expensive imaging instruments or exposing the patient to any
undesirable radiation ~ Part 1." Acupuncture & Electro-Therapeutics Research.
T h e International Journal. Vol. 10, pages 255-277, 1985.
5 1 . O m u r a Y. "Bi-Digital O-Ring Test Molecular Identification and Localization
Method" and its application in imaging of internal organs and malignant tumors as
well as identification and localization of neurotransmitters and micro-organisms --
Part 1." Acupuncture & Electro-Therapeutics Research. T h e International Journal.
Vol. 11(2), pages 65-100, 1986.
52. O m u r a Y . "Re-evaluation of the classical acupuncture concept of meridians in
oriental m e d i c i n e by the new method of detecting meridian-like n e t w o r k s
connected to internal organs using "Bi-Digital O-Ring T e s t " . " Acupuncture &
Electro-Therapeutics Research. T h e International Journal. Vol. 1 1 , p a g e s 2 1 9 - 2 3 1 ,
1986.
53. O m u r a Y. "Electro-magnetic resonance p h e n o m e n o n as a possible mechanism
related to the "Bi-Digital O-Ring Test Molecular Identification a n d Localization
Method." Acupuncture & Electro-Therapeutics Research. T h e International Journal.
Vol. 11(2), pages 127-145, 1986.
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25В OMURA, Y.
54. O m u r a Y. "Meridian-like networks of internal organs, corresponding t o traditional

Chinese 12 m a i n meridians and their acupuncture points a s detectedЪу the "Bi-
Digital O-Ring Test Imaging Method:" Search for the corresponding internal organ
of western medicine for each meridian - Part 1." Acupuncture & Electro-
Therapeutics Research. T h e International Journal. Vol. 12. p a g e s 5 3 - 7 0 . 1 9 8 7 .
55. O m u r a Y. "Interrelationship between the heart and central nervous system:
localization o f neuro-transmitters and imaging of their associated nuclei, including
the raphe nuclei & the locus coeruleus, a s well as the imaging o f the heart and its
representation areas in slices of the h u m a n central nervous system using the "Bi-
Digital O-Ring Test" imaging method." Acupuncture & Electro-Therapeutics
Research. T h e International Journal. Vol. 12, pages 1 3 9 - 1 7 0 , 1 9 8 7 .
56. O m u r a Y, T a k e s h i g e C, Shimotsuura Y, Suzuki M . "Imaging o f the stomach and
localization o f the stomach meridian & its acupuncture points in a h u m a n cadaver
by the use o f the indirect "Bi-Digital O-Ring Test Imaging T e c h n i q u e " . "
Acupuncture & Electro-Therapeutics Research. T h e International Journal. Vol. 13,
pages 153-164, 1988.
57. O m u r a Y . "Connections found between each meridian (heart, stomach, triple
burner, etc.) & organ representation area o f corresponding internal organs in each
side of the cerebral cortex; release o f c o m m o n neurotransmitters a n d h o r m o n e s
unique t o each meridian and corresponding acupuncture point & internal organ after
acupuncture, electrical stimulation, mechanical stimulation (including Shiatsu), soft
laser stimulation o r Qi G o n g . " Acupuncture & Electro-Therapeutics Research. T h e
International Journal. Vol. 14, pages 155-186,1989.
58. O m u r a Y . "Transmission of molecular information through electro-magnetic waves
with different frequencies and its application t o non-invasive diagnosis o f patients
as well a s detection from patient's x-ray film of visible a n d not visible medical
information: Part 1." Acupuncture & Electro-Therapeutics Research. T h e
International Journal. Vol. 19(П. pages 39-63. 1994.
59. O m u r a Y, Shimotsuura Y, Oolu M , Noguchi T. "Estimation of the A m o u n t of
T e l o m e r e Molecules in Different H u m a n A g e Groups a n d t h e T e l o m e r e Increasing
Effect of Acupuncture and Shiatsu on ST.36, Using Synthesized Basic Units of the
H u m a n T e l o m e r e Molecules as Reference Control Substances for t h e Bi-Digital O-
Ring Test R e s o n a n c e Phenomenon, Presented as a guest speaker at 8th Annual
Congress of Japan Bi-Digital O-Ring Test Medical Society at S h o w a University,
T o k y o . " A c u p u n c t u r e & Electro-Therapeutics Research. T h e International Journal.
Vol. 2 3 Í 3 & 4 ) , pages 1 8 5 - 2 0 6 , 1 9 9 8 .
60. O m u r a Y. "Transmission of Molecular Information on Molecular Structures and
A m o u n t s o f the Molecules Through the Recorded Traces of Photons, Sound Waves,
and Electric Currents C o m i n g Through Biological Tissue and Their Clinical
Applications F o r N e w Non-invasive Diagnosis and Treatment o f Intractable
Medical Problems, presented at the 4th Biennial International S y m p o s i u m on the
Bi-Digital O-Ring Test, July 2 1 - 2 3 , 2 0 0 1 , at Waseda University, T o k y o . "
Acupuncture & Electro-Therapeutics Research. T h e International Journal. Vol.
26(1-2), pages 7 7 - 7 9 , 2 0 0 1 .
6 1 . D u w i H , O m u r a Y . "Evaluation o f the Bi-Digital O-Ring Test for t h e Detection of
Precancer from Rat Colon Photographs, presented at the 16th A n n u a l Symposium
on Acupuncture and Electro Therapeutics, October 1 9 - 2 2 , 2 0 0 0 , at t h e School of
International Affairs at Columbia University." abstract published in Acupuncture &
Electro-Therapeutics Research. T h e International Journal. Vol. 25(3-4), pages 2 4 9 -
250,2000.
62. O m u r a Y, T o b e Y . "Marked Beneficial Effects Obtained After A c u p u n c t u r e at True
St. 3 6 C o m p a r e d With Very Litde Effects Obtained F r o m A c u p u n c t u r e O n
Traditional St. 3 6 - L o c a l i z a t i o n o f True St. 36 & Traditional St. 3 6 and their
Acupuncture Effects Clarified Using the Bi-Digital O-Ring Test." (in Japanese) Ido
N o N i p p o n ( T h e Japanese Journal of Acupuncture & M a n u a l Therapies), Serial N o .
6 9 2 , p a c e s 129-150, Oct. 2 0 0 1 .
6 3 . O m u r a Y . "2 Minute Screening of Cancer and Localization o f the C a n c e r Using X-,
Y-Axis Laser line Scanning of the Whole Body and Effective T r e a t m e n t o f Cancer
using Selective Drug Uptake Enhancement Method Including Semi-Permanent
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Acupuncture o n True St. 36, Which Markedly Reduces Cancer Cell Telomere and
Enhances N o r m a l Cell Telomere.", pgs. 122-127, Abstract o f 5th Biennial
International S y m p o s i u m on Bi-Digital O-Ring Test, organized and published by
Japan Bi-Digital O-Ring Test Medical Society, held at Ibuka International
Auditorium, W a s e d a University, Tokyo, Japan, during July 1 9 - 2 1 , 2 0 0 2 .
64. Jackson J, Gajewski E, Schraufstatter I, Hyslop P, Fuciarelli A , Cochrane,
Dizdaroglu M . " D a m a g e to the bases in D N A induced by stimulated h u m a n
neutrophils." Journal of Clinical Investigation. Vol. 84(5), pages 1 6 4 4 - 1 6 4 9 , 1 9 8 9 .
65. Lu J, Shi L, W u Z , Liao Y, Zhou C, Li Y, Bin X, Z e n g В, C h e n J. "Study of 8-OH-
dG and its correlation with several cancer related gene in lung cancer tissues." Wei
Sheng Yan Jiu (Chinese journal). Vol. 32(4), pages 304-307, 2 0 0 3 .
66. Tsurudome Y, Hirano T, Hirata K, Higurc A, Nagata N , Takahashi K, Itoh H, Kasai
H. "Age-Associated Increase of 8-Hydroxydeoxyguanosine in H u m a n Colorectal
Tissue D N A . " T h e Journals of Gerontology Series A: Biological Sciences and
Medical Sciences. Vol. 56, pages B 4 8 3 - B 4 8 5 , 2 0 0 1 .
67. Kasai H. "Analysis o f 8-hydroxydcoxyguanosine as a marker for oxidative stress,
animal and h u m a n studies." Cancer Detection & Prevention. Vol. 24(Supplement
1), pages 101-103, Oct. 28-31 2000, Geneva, Switzerland.
68. Walters J. " M e t h a m p h e t a m i n e . " O N D C P : Drug Policy Information Clearinghouse
Fact Sheet. N o v . 2 0 0 3 .
69. Galanter M , Kleber D H , eds. American Psychiatric Press Textbook of Substance
n d
Abuse Treatment. 2 ed. American Psychiatric Press, 1999.
70. Guze B H , F e m g H K , Szuba M P , Richeimer SH. T h e Psychiatric Drug Handbook,
pages 1 8 4 - 2 6 0 , 1 9 9 5 .
7 1 . Dollcry C, cd. "Therapeutic Drugs." Churchill Livingstone Inc. N e w York: 1991.
72. Astrup A, T o u b r o S. "Thermogenic, metabolic, and cardiovascular responses to
ephedrine and caffeine in m a n . " International Journal of Obesity and Related
Metabolic Disorders. Vol. 17(Suppl), pages S 4 1 - S 4 3 , 1993.
73. Roxanas M G , Spalding J. "Ephedrine abuse psychosis." Medical Journal of
Australia. V o l . 2(19), pages 639-640, 1977.
74. Velasco M , Luchsinger A. "Dopamine: Pharmacologic and Therapeutic A s p e c t s . "
American Journal of Therapeutics. Vol. 5(1), pages 3 7 - 4 3 , 1998.
7 5 . Threlkeld D S , ed. "Respiratory Drugs, Bronchodilators, S y m p a t h o m i m e t i c s . " Facts
and Comparisons Drug Information, page 177-a, 1994.
76. Rang H P , Dale M M , Ritter J M , Moore PK. Pharmacology (5 ed), Edinburgh:
Churchill Livingstone, 2 0 0 3 .
77. Cass Terry. "Clinical Guidelines for Use in Antiagine Medicine." Integrative
Medical Therapeutics for Anti aging Conference (held September 1 1 - 1 3 , 2 0 0 4 at
Miami B e a c h Convention Center), pages 443-472, 2004.
78. O m u r a Y, Losco M , O m u r a AK, Takcshige С. Hisaniitsu Τ, Nakajima H, Soejima
К, Y a m a m o t o S, Ishikawa H, Kagoshima T, Watari N , Shimotsuura Y, Matsubara
T. "Bi-Directional Transmission of Molecular Information by Photon or Electron
B e a m s Passing in the Close Vicinity of Specific Molecules, and its Clinical and
Basic Research Applications: 1) Diagnosis of H u m a n s or Animal Patients Without
Any Direct Contact; 2) Light Microscope and Electron Microscope Localization of
Neuro-transmitters, Heavy Metals, Oncogen C-fos ( A B 2 ) , etc. o f Intracellular Fine
Structures o f N o r m a l and Abnormal Single Cells Using Light or Electro-
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260 OMURA, Y.
Microscopic Indirect Bi-Digital O-Ring Test." Acupuncture and Electro-

Therapeutics Research. T h e International Journal. V o l . 17, pages 2 9 - 4 6 , 1 9 9 2 .
79. Hagen T M , Ingersoll RT, Lykkesfeldt J, et al. "(R)-alpha-lipoic acid-supplemented
old rats have improved mitochondrial function, decreased oxidative d a m a g e , and
increased metabolic rate." F A S E B Journal. Vol. 13, pages 4 1 1 - 4 1 8 , 1999.
80. Natrej C V , Gandhi V M , Melon KKG. "Lipoic acid and diabetes: effect of
dihydrolipoic acid administration in diabetic rats and rabbits." Journal of
Biosciences. Vol. 6, pages 3 7 - 4 6 , 1 9 8 4 .
8 1 . Nickander K K , M c P h e e BR, L o w PA, Tritschler H. "Alpha-lipoic acid: antioxidant
potency against lipid peroxidation of neural tissues in vitro and implications for
diabetic neuropathy." Free Radical Biology & Medicine. Vol. 2 1 , pages 631-639,
1996.
82. Packer L, Tritschler HJ, Wessel К. "Neuroprotection by the metabolic antioxidant
alpha-lipoic acid." Free Radical Biology & Medicine. Vol. 2 2 , pages 3 5 9 - 3 7 8 ,
1997.
83. Packer L, Witt E H , Tritschler HJ. "Alpha-lipoic as a biological antioxidant." Free
Radical Biology & Medicine. Vol. 19, pages 227-250, 1995.
84. Reed LJ. " T h e chemistry and function o f lipoic acids." Advances in Enzvmology.
V o l . 18, pages 3 1 9 - 3 4 7 , 1 9 5 7 .
8 5 . W a g h S S , Natraj C V , Menon K K G . " M o d e of action of lipoic acid in diabetes."
Journal of Biosciences. Vol. 1 1 , pages 5 9 - 7 4 , 1 9 8 7 .
86. C h u a n g W W , Lin W W , L a m b DJ, Lipshultz LI. "Effect of acetylcarnitine on sperm
motility." Journal o f Urology. Vol. 163(4 Suppl), Abstract 1 3 2 4 , 2 0 0 0 .
87. Lolic M M , Fiskum G, Rosenthal RE. "Neuroprotective effects o f acetyl-L-carnitine
after stroke in rats." Annals of Emergency Medicine. Vol. 2 9 , p a g e s 758-765, 1997.
88. Onofrj M , Fulgente Τ, Melchiadona D, et al. "L-acetylcarnitine as a n e w
therapeutic approach for peripheral neuropathies with pain." International Journal
o f Clinical Pharmacology Research (Geneva). Vol. 15, pages 9-15, 1995.
89. Pettegrew J W , Klunke W E , Panchalingam K. "Clinical and biochemical effects of
acetyl-L-carnitine in A l z h e i m e r ' s disease." Neurobiology of Aging. Vol. 16, pages
1-4,1995.
90. Salvioli G, Neri M. "L-acctylcarnitine treatment of mental decline in the elderly."
Drugs U n d e r Experimental and Clinical Research. Vol. 20, pages 1 6 9 - 1 7 6 , 1 9 9 4 .
9 1 . Biewcnga G P , Haenen G R , Bast A. "The pharmacology o f the antioxidant lipoic
acid." General Pharmacology. Vol. 29(3), pages 3 1 5 - 3 3 1 , 1997.
92. Packer L, K r a e m e r K, Rimbach G. "Molecular aspects o f lipoic acid in the
prevention of diabetes complications." Nutrition. Vol. 17(10), pages 8 8 8 - 8 9 5 , 2 0 0 1 .
L a s t M i n u t e D e v e l o p m e n t s for Clinical C a s e # 2 as a S u p p l e m e n t to P a g e 1 3 :
About 2 0 days after the initial treatment, the author received a fax from the graduate
student, w h o is visiting in T o k y o . W h e n the author examined the left handwriting, it
showed strong abnormality (-6) of Bi-Digital O-Ring Test, while the right handwriting
had a mild abnormality of (-2). W h e n the telomere was examined, both right and left
handwriting showed an extremely low value of only about 20 ng, with a brief note stating
that s o m e o f his s y m p t o m s c a m e back. When the author examined the telomere through
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BENEFICIAL EFFECTS & SIDE EFFECTS OF DHEA
a telephone, both sides o f the hand were also 2 0 ng. T h e only way 500 ng of telomere a
few days ago is going to reduce to 2 0 ng is that he must have taken s o m e d r u g that
strongly inhibited D H E A . Upon questioning, he indicated that about 3 days ago he
caught a cold a n d developed a fever of 38°C and therefore he took cold medicine that
contained Ibuprofen (450 m g with 5 other chemical components). H e took this twice in
one day and the next day h e noticed that his previous discomfort gradually c a m e back in
a mild degree. H e has very fragile skin, particularly on the face, and he put o n his face
some cream that contained a large concentration of s o m e steroid h o r m o n e , which is
supposed to reduce inflammation of the skin. Then he noticed that after applying the
cream on his face, the pain further gradually came back again and the left side of the
body became very weak and the pain in his right knee c a m e back to about pain grading
of +4 o n a 0-10 grading system. W h e n he left N e w York, about 20 days earlier, the
author gave h i m s o m e D H E A to keep and using that, the author evaluated through
telephone the optimal dose of D H E A using Virtual Drug Testing. T h e optimal dose
came out to be about the same amount as before (6.25 m g ) with estimated telomere o f
505 ng. After he took this optimal dose, within 10 minutes his normal cell telomere in
the arms went u p to 505 ng, as predicted from Virtual Drug Test based o n Bi-Digital O-
s l st
Ring Test, and pain reduced from + 4 to + 2 . The l time the author gave the 1 one
optimal dose o f D H E A , the pain disappeared completely within 10 minutes, but this time
it took longer. A b o u t half an hour after taking optimal dose of D H E A , all of his pain and
weakness in the left half of the body disappeared. At this point, the patient sent his
handwriting and both handwritings, before and after taking one optimal dose of D H E A ,
are shown below. O n e hour after treatment, the handwriting s h o w n below also indicated
that the Bi-Digital O-Ring Test becomes a strong positive of (+3) in both right and left
handwritings. T e l o m e r e o f both right and left handwritings w a s 505 ng. At this point,
the author decided to evaluate the same cold medicine he took, and when he held one
recommended dose his average normal cell telomere went d o w n to 2 0 ng. However, as
soon as the drug w a s removed from his closed palm, average normal cell telomere in the
hand went up to 505 ng again. Then the author requested that he hold the face cream he
put on his face. Instead of putting it on his face, he kept it in his closed p a l m of his left
hand. Again, telomere went d o w n to 20 ng. W h e n he removed the c r e a m from his hand,
his telomere went back up to 505 ng. This indicated that both his cold medicine and face
cream containing steroid h o r m o n e were responsible for his drastic reduction o f average
normal cell telomere from 505 ng to 20 ng. A s a result, the author requested that the
patient not take these drugs any longer without first having the author evaluate any
medication.
nd
Before 2 optimal dose of DHEA (6.25 mg) was given,
with pain in the right knee & weakness of the left extremeties
30 minutes after one optimal dose of DHEA (6.25 mg-) was given,
with no symptoms
L-hahrJ
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ACUPUNCTURE & ELECTRO-THERAPEUTICS RES.. INT. J., Vol. 30. pp. 219-261.

Yoshiaki O m u r a , M D , ScD, FACA, FICAE, D A A P M , D A B F M , FA A I M , F R S M

Correspondence: Yoshiaki Omura, M D , ScD, 800 Riverside Dr. (8-1) N e w York, NY

(Received October 3 1 , 2005; Accepted with Revisions D e c e m b e r 24, 2005)

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cell telomere. It w a s found that those who took an overdose o f 25-50 m g

W h e n the author looked into the early literature on Dchydroepiandrosterone ( D H E A ) , the

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Fig. 0: Metabolic Pathways Among Cholesterol, DHEA,

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beneficial effects ( 6 - 1 0 , 1 2 - 1 5 , 1 7 - 3 5 , 3 7 - 4 4 ) ranging from those characterized by anti-

On the other hand, w h e n 2 5 m g o f D H E A was given, normal cell telomere never

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Substance P, Bradykinine, Integrin α β., Oncogen C-fosAb , monoclonal bacteria and

DHEA | j g g i | i g i g T - Surface capsule

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D H E A is produced naturally as a Pre-Hormone by the adrenal cortex and is the most

Unlike very expensive h G H , most o f the commercially available D H E A c o m e s in small

In the U S A , D H E A is commercially available by Country Life in H a u p p a u g e , N e w York,

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After initially giving o n e optimal dose of D H E A , in order to follow u p o n people w h o

Some of the typical e x a m p l e s of the effects of one optimal dose of D H E A o n average

A 58 year-old Caucasian female physician with a body weight o f 7 7 k g had intractable

A v e r a g e normal Substance Ρ (at Thromboxane Pain

Before taking 120 ng 2 4 0 ng 2 5 0 ng 4-6

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6 m g . More than 5 minutes after taking her optimal dose of D H E A o f 6 m g , substance Ρ

Within 5 minutes after taking one optimal dose o f D H E A , the p a i n completely

A 30-year-old, 59 kg Oriental male graduate student in one of the universities in N e w

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Right Arm Left A r m

VIRTUAL DRUG TEST T O ESTIMATE THE OPTIMAL DOSE O F DHEA

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Painful areas of Before taking After taking

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T h e changes o f t h e abnormal parameters before and after the optimal d o s e o f D H E A

About 1 w e e k after one optimal dose of D H E A (6.25 m g ) w a s taken orally, he informed

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N o r m a l cell Substance Ρ Thromboxane B 2 Dizziness

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This 58 year-old Oriental w o m a n with body weight of about 45 k g w a s a former high

A 50-year-old female o f Chinese descent (with 2 daughters) had a chief complaint of

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Before 5 min. 20 min. 1-3 First 2 7 M o r e than 28

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o f D H E A had disappeared, indicated that there was a possible malignancy. Since

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Concerning the daily intake o f excessive dose o f D H E A (25 m g ) , retrospectively, in the

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an Adenocarcinoma o f the lung-positive area on the left upper chest. U p o n questioning,

A 6 0 year-old Caucasian male financial adviser from North Carolina w h o w a s suffering

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Similarly, t h e author examined the prostate gland representation a r e a o n t h e sole of the

In the p a l m o f the p a t i e n t ' s left hand, a triangular shape corresponding to t h e prostate

W h e n one optimal d o s e o f p u r e D H E A (7 m g ) for this patient w a s given orally, a s t h e

T h e next m o r n i n g , w h e n t h e patient c a m e back, he w a s very happy t o report that his

Y. Omura - Beneficial Effects & Side Effects of DHEA

Y. Omura - Beneficial Effects & Side Effects of DHEA

Y. Omura - Beneficial Effects & Side Effects of DHEA