1. The document lists 25 references related to the use of timolol for treating chronic wounds and ulcers.
2. Many of the references are studies that have evaluated the efficacy of topical timolol in promoting the healing of chronic wounds, leg ulcers, and pressure ulcers.
3. The references also examine the role of beta-adrenergic signaling in wound healing and the potential benefits of using beta-blockers like timolol to modulate this pathway.
1. The document lists 25 references related to the use of timolol for treating chronic wounds and ulcers.
2. Many of the references are studies that have evaluated the efficacy of topical timolol in promoting the healing of chronic wounds, leg ulcers, and pressure ulcers.
3. The references also examine the role of beta-adrenergic signaling in wound healing and the potential benefits of using beta-blockers like timolol to modulate this pathway.
1. The document lists 25 references related to the use of timolol for treating chronic wounds and ulcers.
2. Many of the references are studies that have evaluated the efficacy of topical timolol in promoting the healing of chronic wounds, leg ulcers, and pressure ulcers.
3. The references also examine the role of beta-adrenergic signaling in wound healing and the potential benefits of using beta-blockers like timolol to modulate this pathway.
1. The document lists 25 references related to the use of timolol for treating chronic wounds and ulcers.
2. Many of the references are studies that have evaluated the efficacy of topical timolol in promoting the healing of chronic wounds, leg ulcers, and pressure ulcers.
3. The references also examine the role of beta-adrenergic signaling in wound healing and the potential benefits of using beta-blockers like timolol to modulate this pathway.
1. Iqbal A, Jan A, Wajid MA, Tariq S, Jan K. Management of chronic non-healing
wound by Hirudotherapy. World J Pharm Sci. 2017; 5(2): 113-20 2. Mace LG, Oldenburg R, Chretien F, Demangel C. Pathogenesis of skin ulcers: Lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens. Cell Mol Life Sci.2014;71(13): 2443–50. 3. Batra RK, Aseeja V. VAC Therapy in Large Infected Sacral Pressure Ulcer Grade IV Can Be an Alternative to Flap Reconstruction?. Indian J Surg. 2014;76(2):162–4. 4. Qaseem A, Humphrey LL, Forciea MA, Starkey M, Denberg TD. Treatment of pressure ulcers: A clinical practice guideline from the American College of Physicians. Ann Intern Med. 2015;162(5):370–9. 5. Rai A, Janani K, Rai R. Efficacy of topical timolol versus saline in chronic venous ulcers: A randomized controlled trial. J Cutan Aesthet Surg. 2020;13(1):18–23. 6. Sivamani RK, Shi B, Griffiths E, Vu SM, Lev-Tov HA, Dahle S, et al. Acute wounding alters the beta2-adrenergic signaling and catecholamine synthetic pathways in keratinocytes. J Invest Dermatol. 2014;134(8):2258–66. 7. Braun LR, Lamel SA, Richmond NA, Kirsner RS. Topical Timolol for Recalcitrant Wounds. JAMA Dermatol. 2013;149(12):1400. 8. Chakkittakandiyil A, Phillips R, Frieden IJ, Siegfried E, Lara-Corrales I, Lam J, et al. Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: A retrospective multicenter cohort study. Pediatr Dermatol. 2012;29(1):28–31. 9. Jaul E, Barron J, Rosenzweig, J. P. & Menczel, J. An overview of co-morbidities and the development of pressure ulcers among older adults. BMC Geriatr. 2018;18(1):1– 11. 10. Cakmak SK, Gul U, Ozer S, Yiǧit Z, Gönü M. Risk factors for pressure ulcers. J Wound Care. 2009;22(9):412–5 11. Leblebici B, Turhan N, Adam M, Akman MN. Clinical and Epidemiologic Evaluation of Pressure Ulcers in Patients at a University Hospital in Turkey. J Wound Ostomy Cont Nurs. 2007;34(4):407–11. 12. Thomas B, Kurien JS, Jose T, Ulahannan SE, Varghese SA. Topical timolol promotes healing of chronic leg ulcer. J Vasc Surg Venous Lymphat Disord. 2017;5(6):844–50. 13. Manahan MN, Peters P, Scuderi S, Surjana D, Beardmore GL. Topical timolol for a chronic ulcer:a case with its own control. Med J Aust. 2014;200(1):49–50.. 14. Tang JC, Dosal J, Kirsner RS. Topical timolol for a refractory wound. Dermatologic Surg. 2012;38(1):135–8. 15. Grando SA, Pittelkow MR, Schallreuter KU. Adrenergic and Cholinergic Control in the Biology of Epidermis: Physiological and Clinical Significance. J Invest Dermatol. 2006;126(9):1948–65. 16. Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol. 2007;127(5):998–1008. 17. Pullar CE, Le Provost GS, O’Leary AP, Evans SE, Baier BS, Rivkah Isseroff R. β2AR Antagonists and β2AR Gene Deletion Both Promote Skin Wound Repair Processes. J Invest Dermatol. 2012;132(8):2076–84. 18. Donaldson DJ, Mahan JT. Influence of catecholamines on epidermal cell migration during wound closure in adult newts. Comp Biochem Physiol Part C Comp Pharmacol. 1984;78(2):267–70. 19. Nayak V, Chogtu B, Parimi A, Mahapatra AK, Vaishnav RL. Comparison of Different Adrenergic Blockers on Cutaneous Wound Healing in Wistar rats. Br Biomed Bull. 2014;(2):371–5. 20. Mohammadi AA, Bakhshaeekia A, Alibeigi P, Hasheminasab MJ, Tolideei HR, Tavakkolian AR, et al. Efficacy of Propranolol in Wound Healing for Hospitalized Burn Patients. J Burn Care Res. 2009;30(6):1013-17. 21. Liu DY, Fischer R, Fraga G, Aires DJ. Collagenase ointment and topical timolol gel for treating idiopathic pyoderma gangrenosum. J Am Acad Dermatol. 2014;71(5):225– 6. 22. Oberbeck R, Van Griensven M, Nickel E, Tschernig T, Wittwer T, Pape HC. Influence of β-adrenoceptor antagonists on hemorrhage-induced cellular immune suppression. Shock. 2002;18(4):331–5. 23. Moreira C, Lopes S, Cruz MJ, Azevedo F. Topical timolol for the treatment of pyoderma gangrenosum. BMJ Case Rep. 2017;2017:2016–17. 24. Vestita M, Filoni A, Bonamonte D, Annoscia P, Giudice G. Topical 0.5% Timolol for Chronic Refractory Wounds: an Observational Prospective Study. Plast Reconstr Surg Glob Open. 2017;5(9):21. 25. Kaur R, Fossuo TC, West K, Hadian Y, Gallegos A, Yoon D, et al. Beta-adrenergic antagonist for the healing of chronic diabetic foot ulcers: study protocol for a prospective, randomized, double blinded, controlled and parallel-group study. J BMC. 2020;21(1):1–14.