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Original Paper

Psychopathology Received: November 8, 2016


Accepted after revision: March 24, 2017
DOI: 10.1159/000472154
Published online: May 18, 2017

Validation of the Five-Factor Model of the Arabic


Version of the Positive and Negative Syndrome
Scale in Schizophrenia
Arij Yehya a Suhaila Ghuloum d Ziyad Mahfoud b Mark Opler e Anzalee Khan f, g
Samer Hammoudeh a Yahya Hani d Hassen Al-Amin c
Departments of a Research, b Health Policy and Research and c Psychiatry, Weill Cornell Medicine – Qatar, and
d
Department of Psychiatry, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar; e CSO-Prophase LLC,
New York, NY, f NeuroCog Trials, Durham, NC, and g Nathan S. Kline Institute for Psychiatric Research,
Orangeburg, NY, USA

Keywords these components. Conclusion: Our results support the


Schizophrenia · Arabic Positive and Negative Syndrome common 5-dimension PANSS model shown in other cultures
Scale · Cultural psychiatry · Principal components analysis with different languages. Nevertheless, there were minor
differences, which could reflect cultural or semantic differ-
ences. © 2017 S. Karger AG, Basel
Abstract
Background: The Positive and Negative Syndrome Scale
(PANSS) is a widely used assessment for patients with schizo-
phrenia across clinical and research settings. This scale al- Introduction
lows the classification of the psychotic symptoms to better
understand the psychopathology in patients with schizo- Schizophrenia is a chronic mental disorder that affects
phrenia. There are no available data on the different compo- multiple domains of human emotions, thinking and be-
nents of psychopathology in Arab patients with schizophre- havior. A systematic review has shown that the lifetime
nia. Objectives: This study examined the factor structure of prevalence of schizophrenia worldwide is 4 per 1,000 per-
the validated Arabic version of the PANSS in a sample of Arab sons [1]. Schizophrenia is known to affect the patients’
patients with schizophrenia. Methods: The Arabic version of daily functioning and social activities, which in turn re-
the PANSS was administered to 101 patients with schizo- sult in an increased burden on the patients’ family and
phrenia, and principal component analysis (PCA) was carried society [2]. Kay et al. [3] developed the Positive and Neg-
out after the cross-cultural adaptation and validation of this ative Syndrome Scale (PANSS) to capture the symptoms
version. Results: This sample had more males (66.3%) than observed in patients with schizophrenia. This scale has
females (33.7%) with a mean age of 35.03 years (SD = 9.99). been translated into Arabic and validated in the Arab
PCA showed that 28 items loaded on 5 components: cogni- population [4]. The PANSS is made up of 30 items that
tive, negative, excited, depressed and positive. These factors use a Likert-type scale ranging from 1 “absent” to 7 “ex-
explained 63.19% of variance. The 2 remaining items, gran- treme.” The authors of the scale originally grouped the
diosity and somatic concerns, did not load well on any of items into 3 subscales: positive symptoms, negative symp-
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Univ. of California San Diego

© 2017 S. Karger AG, Basel Hassen Al-Amin, MD


Weill Cornell Medicine – Qatar, Education City
PO Box 24144
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E-Mail karger@karger.com
Doha (Qatar)
www.karger.com/psp
E-Mail haa2019 @ qatar-med.cornell.edu
toms and general psychopathology [3]. The former 2 sub- published study that analyzed the factor model in the
scales are made up of 7 items each, while the third com- Arab population. The aim of this study is to explore the
prises 16 items that cover symptoms such as depression, factor structure of the Arabic version of the PANSS in
anxiety, guilt feelings, and impulse control. White et al. Arab patients with schizophrenia. This will help in under-
[5] derived a model by performing exploratory factor standing the specific domains of the symptomatology of
analysis (EFA) that resulted in 5 factors from a pentago- schizophrenia in this population.
nal model. These factors were labeled: positive, negative,
dysphoric mood, activation, and autistic preoccupation.
It is this 5-factor model that is presently proposed in the Methods
manual for the PANSS (Multi-Health Systems Inc.,
This cross-sectional study is part of a larger project done in
PANSS). The PANSS has good reliability and validity [3]
Qatar to validate several Arabic rating scales that are used in the
and is currently the most used tool in clinical and research assessment and treatment of patients with schizophrenia. It is
settings. Although schizophrenia has been viewed as hav- noteworthy that the EFA was done on the same sample in which
ing the same manifestations worldwide especially in se- the version was validated. The Institutional Review Boards at Ha-
vere cases [6], other studies have shown that developed mad Medical Corporation and Weill Cornell Medicine in Qatar
both approved this study. All participants signed a consent form
countries have dominantly delusions and thought disor-
after the procedures involved and their duration had been ex-
der while in many developing countries the predominant plained. The study was conducted between February 2013 and No-
symptoms are hallucinations [7, 8]. vember 2014.
Studies across cultures characterized the different di- There has been a debate about the sample size needed for a
mensionality of the PANSS using principal component proper recovery of population factors. Comrey and Lee [25] pro-
posed a sample less than 300 to be fair. However, in circumstances
analysis (PCA). Different models of factor structure were
when the most communalities are good (generally >0.60) and fac-
proposed and supported by diverse samples. For instance, tor structure is robust, a sample size of 100 is considered sufficient
Kay and Sevy [9] proposed a 4-factor model. Bell et al. for PCA [26, 27]. We opted to recruit 100 patients in this study to
[10] showed a 5-factor model of the PANSS that best fit ensure generalizability of the results to the Arab population in
the published data. Van den Oord et al. [11] supported a Qatar.
6-factor model while Emsley et al. [12] showed the stabil-
Subjects
ity of a 7-factor model. Levine and Rabinowitz [13] used Participants were recruited from the Psychiatry Department at
the parallel analysis and PCA and confirmed the 5 dimen- Rumailah Hospital in Doha, Qatar. This psychiatric facility is the
sions of the PANSS using a large sample from 2 clinical only available one in Doha, and it has 70 inpatient beds (95% oc-
trials. These new models changed the assessed outcomes cupancy) and 10 daily outpatient clinics that receive about 120
patients per day. Most of the inpatients are admitted with acute
of the treatments given in clinical settings [14] and helped psychosis, and about 25% of outpatients have schizophrenia. Pa-
to create specialized treatments based on the patients’ tients recruited had to be between 18 and 65 years of age and know
scores on different factors [15, 16]. The 5-factor model Arabic as their native language. Patients with a history of drug or
was found to be the most stable across the studies done alcohol abuse or who were at risk of harming themselves or others
on different cultures and in many countries [17]. These were excluded from this study. The diagnosis of schizophrenia
among these eligible patients was confirmed by the Arabic version
countries included France [18], Germany [19], Greece of the Mini International Neuropsychiatric Interview for Schizo-
[20], the USA [21], Brazil [21], and China [21, 22]. The phrenia and Other Psychotic Disorders (MINI-6) [28]. MINI-6
factors are commonly referred to as positive, negative, uses a semistructured interview and follows the DSM-IV-TR
cognitive (or disorganized), excited (or hostility) and de- (American Psychiatric Association, 2000) criteria to establish the
pressive/anxiety. The items loaded on each factor are very diagnosis.
similar to the ones reported by White et al. [5]; the posi- Procedure
tive and negative ones still carry the same labels but the Trained raters administered the Arabic version of the Struc-
dysphoric mood corresponds to the item now known as tured Clinical Interview for the PANSS to 101 patients (see Yehya
depressive/anxiety, the activation one refers to the excited et al. [4] for details). This interview was developed by Kay et al. [29]
factor and the autistic preoccupation fits the cognition (or to assist in PANSS rating and took 30–45 min to complete. Infor-
mation about the sociodemographics of the patients was collected
disorganized) factor. (such as gender, nationality, marital status, education). In addi-
Schizophrenia is prevalent in the Arab region as well tion, patients’ clinical features were recorded including duration
[23]. Ghuloum et al. [24] reported that the prevalence of of illness, duration of treatment, current treatment type and anti-
schizophrenia in patients visiting primary care settings in psychotic dosage.
Qatar was 3.6%. However, to our knowledge, there is no
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2 Psychopathology Yehya/Ghuloum/Mahfoud/Opler/Khan/
DOI: 10.1159/000472154 Hammoudeh/Hani/Al-Amin
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Statistical Analysis Table 1. Sociodemographics of the sample
The data collected were analyzed using the Statistical Package
for Social Sciences version 23 (SPSS v23.0, Chicago, IL, USA). For Frequency Percentage
summarizing the data (sociodemographic and clinical), mean and
standard deviation were calculated for the continuous measures Gender
while the discrete data were expressed as a percentage. The dose Males 67 66.3
equivalences were calculated based on chlorpromazine 100 mg as Females 34 33.7
reported in Andreasen et al. [30]. To determine the number of com- Nationality
ponents that lie behind the 30 items of the PANSS we followed the Egypt 5 5.0
approach by Levine and Rabinowitz [13]. We performed parallel Qatar 61 60.4
analysis using the SPSS syntax available online (https://people. Sudan 13 12.9
ok.ubc.ca/brioconn/nfactors/rawpar.sps) [31]. This program was Other 22 21.7
run on all data sets using the principal axis/common factor analysis Education
for 20 simulations of normally distributed random data generation No schooling 2 2
with the percentile of 90. EFA was also carried out using principal Elementary/intermediate 36 35.6
component extraction analysis (PCA) with varimax rotation. This Secondary/high school 39 38.6
analysis is robust to normality, multicollinearity and singularity, Vocational/diploma 2 2.0
and it has limited assumptions [32]. The factor structure of the College/postgraduate degree 22 21.8
PANSS was fitted, with eigenvalues higher than 1 being retained for Employment
factor extraction. Factor loadings of 0.5 or higher were considered Employed 31 30.7
in the interpretation of the factors. The scree plot was inspected to Unemployed 55 54.5
determine the number of factors with an eigenvalue greater than 1 Student 10 9.9
as cutoff [33]. Items that factored less than 0.30 were dropped from Retired 3 2.97
the EFA. Anti-imaging correlation tables were inspected as well as Not reported 2 1.98
the Kaiser-Mayer-Olkin and Bartlett tests. The internal consistency Marital status
of each factor was determined by Cronbach’s α. Married 27 26.7
Single 62 61.4
Other (divorced/widowed) 12 11.9

Results

Sociodemographic Measures Table 2. Clinical features of the sample


Patients in this study were 18–62 years old, with a
mean age of 35.03 years (SD = 9.99). Table 1 shows the Range Mean SD
sociodemographic information of the sample. The latter
Duration of illness, years 0 – 40 11.69 8.98
had more males than females. Many of the participants Duration of treatment,
were Qatari but not all Arab countries were equally rep- years 0 – 39 11.02 8.74
resented in this sample; however, the sample included Ar- AP dose equivalence, mg 43.84 – 4,848.81 1,067.11 1,424.61
abs from various countries (i.e. Egypt, Sudan, Algeria, PANSS total score 30 – 128 73.22 23.18
Bahrain, Jordan, Lebanon, Libya, Saudi Arabia, Syria, and PANSS positive 7 – 37 19.88 7.07
PANSS negative 7 – 39 18.76 8.71
Yemen). In general, patients were educated with at least
PANSS general
an elementary degree, and 21.8% had a college degree. psychopathology 16 – 65 34.57 11.53
More than half of the patients were unemployed and sin-
gle. AP (antipsychotics) dose equivalence was based on chlorprom-
azine 100 mg [29].
Clinical Features
The clinical and treatment profile of the patients in this
study is presented in Table 2. The duration of illness of
these schizophrenia patients ranged from less than 1 to 40 were on a combination of first- and second-generation
years. Similarly, the duration of treatment showed high antipsychotics, while only 9 (8.9%) were on first-genera-
variability with a mean of 11.02 years and a standard de- tion antipsychotics only. The rest were not currently on
viation of 8.74. As for the treatment profiles, the number any antipsychotics (30 patients, 29.7%). Those who were
of hospitalizations for patients ranged between 1 and 18 under antipsychotic treatment had a mean equivalent
with a median of 3. When recruited, 44 patients (43.6%) dose of 1,067.1 mg (SD = 1,424.61). Patients scored a
were on second-generation antipsychotics, 18 (17.8%) mean of 73.22 (SD = 23.18; range 30–128) on the PANSS
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Factor Structure of Arabic PANSS Psychopathology 3


DOI: 10.1159/000472154
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Table 3. PCA of the Arabic version of the PANSS

h2 Cognitive Negative Excited Depressed Positive Sixth Seventh


factor factor factor factor factor factor factor

P2 conceptual disorganization 0.74 0.729


N5 difficulty in abstract thinking 0.66 0.771
N7 stereotyped thinking 0.69 0.715
G10 disorientation 0.70 0.725
G11 poor attention 0.62 0.687
G13 disturbance of volition 0.69 0.628
G15 preoccupation 0.71 0.531
N1 blunted affect 0.78 0.707
N2 emotional withdrawal 0.79 0.771
N3 poor rapport 0.77 0.695
N4 passive apathetic social withdrawal 0.75 0.815
N6 lack of spontaneity and flow of conversation 0.82 0.647
G12 lack of judgment and insight 0.66 0.486
G16 active social avoidance 0.75 0.747
P4 excitement 0.70 0.689
P7 hostility 0.70 0.710
G4 tension 0.64 0.453
G5 mannerisms and posturing 0.68 0.495
G7 motor retardation 0.69 –0.496
G8 uncooperativeness 0.47 0.602
G14 poor impulse control 0.74 0.548
G2 anxiety 0.65 0.743
G3 guilt feelings 0.64 0.770
G6 depression 0.72 0.786
P1 delusions 0.71 0.510
P3 hallucinatory behavior 0.84 0.872
P6 suspiciousness persecution 0.67 0.481
G9 unusual thought content 0.77 0.570
P5 grandiosity 0.77 0.838
G1 somatic concerns psychopathology 0.69 0.691
Percentage variance explained 32.77% 12.92% 8.09% 4.98% 4.42%

total composite score, suggesting that this group is “mod- of the factors (Table 3). Items on grandiosity (P5) and so-
erately ill” [34]. The score ranges on PANSS positive and matic concerns psychopathology (G1) factored alone and
negative subscales were almost equal (Table 2). hence were excluded from further analysis since they only
explained a small percentage of the variance (less than
Exploratory Factor Analysis 4%). Thus, the total variance explained by the 5 compo-
Using PCA, the items loaded on 7 factors. Bartlett’s nents (28 items) was 63.19%. The 5-dimension model was
test of sphericity indicates that the correlation matrix is also confirmed by the results of the parallel analysis (with
significantly different from an identity matrix, with 20 simulations) where only the eigenvalues of the first 5
χ2(435) = 1,871.57, p < 0.001. The sample adequacy for components from the raw data were greater than the
the EFA was verified using the approach of Field [35] means and the simulated eigenvalues of the 90th percen-
where the Kaiser-Mayer-Olkin test result (0.763 in this tile of randomly generated data [31].
sample) should be >0.60. The results showed that the Table  3 presents the factor loadings of the different
original 30 items of the PANSS were empirically summa- items. Table  4 provides the eigenvalues, percentage of
rized by 7 components that accounted for 70.59% of vari- variances and mean with standard deviation of each fac-
ance. Communality values tended to be high with a cutoff tor. The factor that explained the highest percentage of
of 0.45, and hence all were included in the interpretation variance was the cognitive factor, 32.77%. This factor had
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4 Psychopathology Yehya/Ghuloum/Mahfoud/Opler/Khan/
DOI: 10.1159/000472154 Hammoudeh/Hani/Al-Amin
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7 items: conceptual disorganization, difficulty in abstract Table 4. Scores on the different factors of the Arabic PANSS
thinking, disorientation, poor attention, disturbance of
Factors Items, n Mean (SD) Eigen- Total Cumulative
volition and preoccupation. The negative factor explained value variance, % variance, %
less variance, and it included the rest of the negative items
(blunt affect, emotional withdrawal, poor rapport, social Cognitive 7 17.76 (7.88) 9.832 32.77 32.77
withdrawal, lack of spontaneity), in addition to lack of Negative 7 17.98 (8.21) 3.875 12.92 45.69
judgment and insight and active social avoidance. The Excitement 7 11.19 (4.61) 2.427 8.09 53.78
Depression 3 7.21 (3.26) 1.495 4.98 58.76
excited factor explained 8.09% of variance and factored 7 Positive 4 15.28 (5.43) 1.327 4.42 63.19
items: poor impulse control, excitement, tension, hostil-
ity, mannerisms and posturing, uncooperativeness, and
motor retardation. The latter item negatively factored
with this excited component. Only 3 items factored on the
depression factor (anxiety, guilt feelings, depression), and found that the negative factor had this highest percentage
they explained 4.98% of the variance. The last was the in Greece. In our study, however, the negative factor had
positive factor, and it explained the least of the variance the second highest percentage of variance explained, and
(4.42%). Items that loaded on this factor were delusions, the excited factor explained more than the depressed
hallucinatory behavior, suspiciousness, persecution and one. This was also found when factoring the scores on the
unusual thought content. PANSS from patients in France [18]. The clinical factors
The cognitive and negative factors had the highest in each sample like the duration of illness and treatment
number of items with the highest PANSS mean scores. could play a major role in the differences between the
The positive factor had also a high mean when consider- variances of each factor; for example, the majority of our
ing that it had only 4 items (Table 4). Finally, the item patients have been taking relatively high doses of medi-
loadings of the 5 factors from our study and another 6 cations for several years (Table 2), which might had con-
different studies in other countries are summarized in Ta- tributed to the lower scores on the positive factor. How-
ble 5. The similarities and differences in these different ever, other studies suggested that variations in the psy-
cultures will be discussed below. chotic symptoms could reflect unique cultural aspects
[37]. In this regard, studies from the developing coun-
tries reported a higher frequency of hallucinations while
Discussion those from western developed ones showed more de-
pressive symptoms, delusions and thought insertion/
The aim of this project was to study the factor structure broadcasting [7, 8].
of the Arabic version of the PANSS in patients with Our loadings were compared to other cultures as pre-
schizophrenia. Our results showed that there are 5 fac- sented in Table 5. In this sample of Arab patients, some
tors: cognition, negative, excited, depressed, and positive. items loaded on the cognitive factor similarly to other
A review of the component analyses done on the PANSS studies [9, 18, 20]. In addition, items on volition and pre-
on other diverse samples showed that the 5-dimension occupation loaded on this factor too. Similar results were
model was the most common [17]. Our factor structure found in the Chinese population [22]. However, in other
provides a good model as it accounts for 63.19% of the studies, volition usually loaded on the negative factor [9,
total variance, which is very similar to that reported in 20]. Preoccupation loaded on depression/anxiety in Kay
several other studies as shown in Table 5. This is the first and Sevy’s [9] components analysis. For the negative fac-
study to administer the validated Arabic version of the tor, the items that loaded on it were similar to those in
PANSS in the Arab region and to validate the component other studies as shown in Table 5, except for the item on
loading in Arab patients with schizophrenia. lack of judgment and insight. This item was similarly fac-
The factor that explained the most variance in our tored with the negative items in China [22] but loaded on
study was cognition (32.77%). The factor that had the the positive factor in other studies [9, 18]. It is generally
highest percentage of variance explained differs from possible that items from the cognitive factor (also known
study to study. For instance, in the Chinese population as disorganized/concrete in other studies) might overlap
[36] the positive factor had the highest percentage of with the negative factor as many negative features might
variance explained. This positive factor explained the reflect cognitive deficits that are attributed to neurodevel-
least of the variance in our study. Lykouras et al. [20] opmental deficits regardless of cultural attributes. The
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Factor Structure of Arabic PANSS Psychopathology 5


DOI: 10.1159/000472154
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Table 5. Comparison of the factor loadings of the Qatar population with other published studies

Present Kay and Sevy Lancon et al. Mass et al. Lykouras et al. Stefanovics et al. Wu et al.
study [9], 1990 [18], 2000 [19], 2000 [20], 2000 [21], 2014 [22], 2015

Population Qatar USA France Germany Greece USA, China, China


Brazil
Sample size 101 240 205 253 258 1,460, 1,020, 252 813
P2 conceptual disorganization cognitive disorganized cognitive disorganized disorganized disorganized cognitive
N5 difficulty in abstract thinking cognitive disorganized cognitive disorganized disorganized disorganized negative
N7 stereotyped thinking cognitive – – – disorganized – cognitive
G10 disorientation cognitive disorganized cognitive – disorganized/ – negative
negative
G11 poor attention cognitive negative cognitive disorganized disorganized disorganized cognitive
G13 disturbance of volition cognitive negative – – negative – cognitive
G15 preoccupation cognitive depressive/ – – negative – cognitive
anxiety
N1 blunted affect negative negative negative negative negative negative negative
N2 emotional withdrawal negative negative negative negative negative negative negative
N3 poor rapport negative negative negative negative negative negative negative
N4 passive apathetic social withdrawal negative negative negative negative negative negative negative
N6 lack of spontaneity and flow of
conversation negative negative negative negative negative negative negative
G12 lack of judgment and insight negative positive positive – positive/ – negative
depressive
G16 active social avoidance negative negative negative negative excited – negative
P4 excitement excited excited excitation excited excited excited excitement
P7 hostility excited excited excitation excited excited excited excitement
G4 tension excited depressive/ excitation excited depressive/ – excitement
anxiety anxiety
G5 mannerisms and posturing excited negative – excited negative/ – excitement
cognitive
G7 motor retardation excited negative negative – negative negative cognitive
G8 uncooperativeness excited excited – excited excited excited
G14 poor impulse control excited excited excitation excited excited excited excitement
G2 anxiety depressed depressive/ depression depressive/ depressive/ depressed depression
anxiety anxiety anxiety
G3 guilt feelings depressed depressive/ depression depressive/ depressive/ depressed depression
anxiety anxiety anxiety
G6 depression depressed depressive/ depression depressive/ depressive/ depressed depression
anxiety anxiety anxiety
P1 delusions positive positive positive positive positive positive positive
P3 hallucinatory behavior positive positive positive positive positive positive positive
P6 suspiciousness persecution positive – positive – positive – positive
G9 unusual thought content positive positive positive positive positive positive positive
P5 grandiosity – positive positive excited positive positive positive
G1 somatic concerns psychopathology – depressive/ – – excited – depression
anxiety
Percentage of variance explained 63.19% 64.7% 64.3% 68.9% 59.85% not reported 64.2%

items in the excited factor were similar to those reported same loading items as all the 6 studies reviewed in other
in the studies presented in Table 5, except for motor re- countries (Table 5).
tardation. This item is expected to load on the negative The 30 items were included into 5 factors with large
instead of excited factor. It is worth noting here that mo- loading (>0.40). The items on grandiosity and somatic
tor retardation had a negative loading (–0.46; Table  3) concern that loaded each on a separate factor had low
and thus ended with the excited factor in the Arab pa- contribution to the variance explained (less than 4%). In
tients. This could be related to the lack of significant mo- addition they did not cross-load on any other factor. The
tor retardation in this sample to correlate well with the grandiosity item generally loaded on the positive factor in
other negative features. It seems that the depressed and several other studies (Table 5). In the model presented by
positive factors are somewhat universal as they had the van der Gaag et al. [38, 39], somatic concerns was includ-
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6 Psychopathology Yehya/Ghuloum/Mahfoud/Opler/Khan/
DOI: 10.1159/000472154 Hammoudeh/Hani/Al-Amin
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ed into the positive factor. However, in the model of Wall- generalizable to other Arabic countries. Third, our com-
work et al. [40] this item did not load on any factor. It is parisons with other cultures have some limitations as not
possible that the somatic concerns of Arab patients with all studies used the same kinds of rotations or even PCA,
schizophrenia do not reach the delusional levels and the so more studies are needed to confirm these comparisons.
latter are not commonly associated with grandiose
themes. However, it is also plausible that the translation
of these items into Arabic did not capture the same con- Conclusions
struct provided in English versions or the raters showed
variability on some of these items. In a study on cross- In conclusion, the factor structure in this sample of
cultural validity of the PANSS [41] among different coun- Arab patients with schizophrenia was similar to that
tries, the authors suggested that differences in scoring, in found in the literature with minor differences. Items on
addition to culture and translation, could also contribute grandiosity and somatic concerns were different as they
to the differences in factor structures among cultures. did not add to any of the main factor clusters: positive,
Schizophrenia has been viewed initially to be very similar negative, cognition, excited and depression/anxiety. Fur-
across cultures where the degree of the overlap in the ill- ther evaluation of these items should provide either a spe-
ness definition and symptoms in many countries increas- cific cultural domain or a difference in the language of the
es with the illness severity [6]. On the other hand, mea- scale itself.
surements of psychiatric symptoms leading to a diagnosis
like schizophrenia have been criticized for their interna-
tional use without paying attention to the validation Acknowledgment
across cultures [42]. There is evidence that improper
The Qatar National Research Fund (QNRF) thankfully sup-
translation and adaptation of an instrument can affect the
ported this study (NPRP 4-268-3-086).
scale reliability compared with that of the same original
version [43]. For example, although several cultures be-
lieve in sorcery, religious and spiritual causes for the psy- Disclosure Statement
chosis, it had been reported that a large number of Arab
people commonly relate mental illness to possession by a All authors declare no commercial or financial conflicts of in-
supernatural force, such as demons, Jinn, the evil eye (Al- terest with regard to the submitted article. The QNRF did not have
Ein), or magic (Sihr) [44]. The strength and spread of any additional role in the study design, data collection and analy-
sis, decision to publish, or preparation of the manuscript.
such beliefs can have a differential cultural impact on how
patients from different cultures would present such be-
liefs and how the raters would score the corresponding
items from the PANSS. References 1 Saha S, Chant D, Welham J, McGrath J: A sys-
tematic review of the prevalence of schizo-
phrenia. PLoS Med 2005;2:e141.
Limitations 2 World Health Organization: Global Burden
Our study has much strength due to the proper train- of disease: 2004 update. http://www.who.int/
healthinfo/global_burden_disease/GBD_
ing of raters, the proper design and validation, and the report_2004update_full.pdf.
heterogeneity of the sample in terms of symptomatology 3 Kay SR, Fiszbein A, Opler LA: The Positive
and duration of illness. However, our results have a few and Negative Syndrome Scale (PANSS) for
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Mujalli A, Hani Y, Elsherbiny R, Al-Amin H:
this might prevent a generalizable conclusion of the factor Validity and reliability of the Arabic Version
structure across gender. Nevertheless, other studies sug- of the Positive and Negative Syndrome Scale.
gested that there are no such differences across gender Psychopathology 2016;49:181–187.
5 White L, Harvey PD, Opler L, Lindenmayer
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132.239.1.231 - 5/18/2017 9:44:53 AM
Univ. of California San Diego

8 Psychopathology Yehya/Ghuloum/Mahfoud/Opler/Khan/
DOI: 10.1159/000472154 Hammoudeh/Hani/Al-Amin
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