Abnormal RBC What is it?

Associated with
morphology/inclusion
Sickle cell RBC Sickle shaped cell due to Sickle cell
beta globin point mutation
Heinz bodies Inclusions can only be Post splenectomy, G6PD
visualized with supravital deficiency, toxins,
stains. They appear Unstable hemoglobin's
Purple, blue large single or Their
multiple inclusions presence indicates an
attached to the inner increase in hemoglobin
surface of the red blood denaturation and
cells. precipitation,
Mechanism : Heinz
bodies are usually not
seen, as they are normally
removed by splenic
macrophages. Their
presence indicates an
increase in hemoglobin
denaturation and
precipitation,
Pappenhaimer stipplings presence of small sinle or This could be seen in
multiple peripheral angular Sideroblastic anemia, MDS
basophilic granules, which
is smaller than Howell
bodies composed of
Hemosiderin.
.

Basophilic stipplings presence of irregular This could be seen in lead

basophilic granules (RNA and heavy metal
remnant) within the RBCs, poisoning, megaloblastic
might be fine medium or anemia, thalassemia,
coarse granules. infection

Howell-jolly bodies presence of smooth single This could be seen in

large round inclusions Megaloblastic anemia,
which are remnant of DNA post splenectomy,
abnormal eryhtropiesis.

Cabots ring
Butt cell
Target cell hemoglobin is Liver Disease, iron
concentrated in the center deficiency anemia,
and on the periphery with a haemoglobinopathies,
 colorless zone in between artifacts as PBS is made in
the two areas humid environment.

Haemoglobin c cystals
Bite cell
Acanthocytes variation in red blood cell Liver disease, abeta-
size in a peripheral blood. lipoproteinaemia,
RBCs appear small and renal failure , post
dense, lacking an area of splenectomy, inherited
central pallor with multiple hyperlipidemia, pyruvate
spiky projections. kinase membrane
Acanthocyte formation deficiency.
occurs as a result of either
hereditary or acquired
membrane defects.
Defects that cause an
imbalance between the
membrane cholesterol and
lipid content affect the
RBC’s ability to deform
resulting in more rigid
plasma membrane. Red
blood cells are then
remodeled in circulation,
resulting in an
acanthocytes associated
with
Helmer cell
Stomatocyte RBCs cells with central Liver disease, alcoholism
biconcave area appears
slit like. Cell formation: is
due to a membrane
defects (acquired or
inherited) that results
alterations in cell volume.
Could be due to artifacts,
Hereditary, Liver diseases,
alcoholism.