Professional Documents
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Muguni Brandan Proposal
Muguni Brandan Proposal
SCHOOL OF MEDICINE
BMS/2021/81368
RESEARCH TITLE:
i
DECLARATION
The work contained herein is original and has been done under the general supervision of the
undersigned supervisor.
This work has not been submitted to this institution for the award of a degree before.
The guidelines provided for by the university in developing research project proposals have been duly
followed
Whenever the contribution of others has been involved, every effort has been made to indicate them
clearly in the text in respect of various references and quotations.
BMS/2022/81368
This research project proposal has been submitted with my approval as the university supervisor.
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Table of Contents
DECLARATION............................................................................................................................................ii
LIST OF ABBREVIATIONS.......................................................................................................................iii
ABSTRACT...................................................................................................................................................iv
1.0 CHAPTER ONE: INTRODUCTION.....................................................................................................1
1.1 BACKGROUND INFORMATION........................................................................................................1
1.2 STATEMENT OF THE PROBLEM......................................................................................................2
1.3 JUSTIFICATION....................................................................................................................................2
1.4 RESEARCH QUESTION........................................................................................................................2
1.5 RESEARCH OBJECTIVES....................................................................................................................2
1.5.1 Broad objective......................................................................................................................................2
1.5.2 Specific objectives..................................................................................................................................2
1.6 CONCEPTUAL FRAMEWORK...........................................................................................................4
2.0 CHAPTER TWO: LITERATURE REVIEW........................................................................................5
2.1 Causes associated with antibiotic self – medication...............................................................................5
2.2 Level of knowledge of antibiotic self- medicating students...................................................................5
2.3 Attitudes of antibiotic self- medication...................................................................................................6
2.4 Practices associated with antibiotic self- medication.............................................................................6
3.0 CHAPTER 3: MATERIALS AND METHODS....................................................................................8
3.1STUDY DESIGN.......................................................................................................................................8
3.2STUDY AREA...........................................................................................................................................8
3.3TARGET POPULATION........................................................................................................................8
3.4 STUDY POPULATION...........................................................................................................................8
3.5 INCLUSION/EXCLUSION CRITERIA................................................................................................8
3.5.1 Inclusion criteria...................................................................................................................................8
3.5.2 Exclusion criteria..................................................................................................................................8
3.6 VARIABLES............................................................................................................................................8
3.6.1Independent............................................................................................................................................8
3.6.2 Dependent..............................................................................................................................................8
3.7 SAMPLING PROCEDURE....................................................................................................................8
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3.8 SAMPLE SIZE DETERMINATION.....................................................................................................9
3.9 SAMPLING TECHNIQUE.....................................................................................................................9
3.10 DATA COLLECTION...........................................................................................................................9
3.11 DATA MANAGEMENT.......................................................................................................................9
3.12 ETHICAL CONSIDERATION...........................................................................................................10
3.13 REFERENCE.......................................................................................................................................10
3.14 APPENDICES......................................................................................................................................18
3.14.1 WORK PLAN....................................................................................................................................18
3.14.2BUDGET.............................................................................................................................................18
3.14.3CONSENT FORM.............................................................................................................................19
3.14.4 QUESTIONAIRE..............................................................................................................................19
iv
LIST OF ABBREVIATIONS
M.K.U- Mount Kenya University.
MS - Microsoft
IV- Intravenous
v
ABSTRACT
Antibiotic self-medication is defined as the selection and use of non-prescription antibiotics by an
individuals’ own initiatives to treat self-recognized illnesses or symptoms. Self -medication is a
global- phenomena with antibiotic self-medication becoming widespread with one of the greatest risks
being antimicrobial resistance. However, it has being reported that this risk has being gradually rising
as the use of over the counter medication in developing countries is becoming more frequent. This
study therefore seeks to determine the knowledge, attitude and practices associated with antibiotic
self- medication among Mount Kenya University students. The study will employ a descriptive cross-
sectional study, with data being collected at a single point in time and assessing the population as
represented by the study sample at a single point in time. The study population will be sampled by
simple random sampling. Data will be primarily collected by use of interviewer administered semi-
structured questionnaires to subjects who will meet the inclusion criteria. Data will then be entered
into the MS Access database with inbuilt consistency and validation checks. Analysis will be done
using the SPSS analytical package. Presentation will be in form of tables and graphs.
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1.0 CHAPTER ONE: INTRODUCTION
1.1 BACKGROUND INFORMATION
Self-medication is defined as the selection and use of non-prescription medicines by individuals’ own
initiatives to treat self-recognized illnesses or symptoms. It is also obtaining and consuming
medication without professional supervision regarding indication, dosage, and duration of treatment
(Gutema et al., 2011).
Self-medication is a global phenomenon that most individuals practice throughout their daily life. The
world health organization reports that self-medication with antibiotics is becoming widespread with
one of the greatest risks being antibiotic resistance through limiting uptake of drug, modifying drug
target, inactivating a drug and active efflux. It has been reported that this risk has being gradually
rising as the use of over-the-counter medication in developing countries is becoming more
unregulated hence becoming more frequent due to accessibility to the drugs, poor polices on drug
control, under qualified practitioners, cultural customs and a perceived saving of time and money
compared to see a doctor. (Ali, et al., 2016).
Antibiotics are considered as one of the greatest inventions of the 20th century by Alexander flaming
who discovered penicillin which greatly contributed to decreased morbidity and mortality in many
infectious diseases. Improvements in knowledge levels, socioeconomic status and education may
provide the foundation for successful self-medication. However, inappropriate self-medication wastes
resources, increases the likelihood of adverse drug reactions and may also be involved in
antimicrobial resistance. (James H, et al.,2006).
Antibiotic resistance is one of the world’s most pressing public health problems. We are at the dawn
of a post-antibiotic era (CDC 2013). This resistance may result in longer-lasting illnesses, more
hospital stays, the need for more expensive and toxic medications, and even death (Holmberg et al.
1987; Davies 1994; Magee et al. 1999; Fischbach & Evans 2007).
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1.2 STATEMENT OF THE PROBLEM
Inadequate knowledge of medication use may directly lead to misuse by community and/or patients,
noncompliance with a drug regimen and results in serious outcomes like adverse drug reaction and
reduction of the quality of treatment. It is also thought that there is not enough attention focused on
the use of antibiotics. Moreover, health personnel and the community have insufficient information
about the adverse consequences, resulting from improper antibiotic use. (Celik, S. et al., 2010).
Antibiotic resistance has recently become an increasing problem worldwide due antibiotic abuse or
overuse. (Agarwal, S. et al., 2015). Furthermore, inappropriate antibiotic use may increase the
incidence of adverse, including allergic reactions, and may lead to negative results, such as
unrecoverable financial burden. (Ayalew, M. B, et al., 2017 and Fredricks, I. et al., 2017). At an
individual level, knowledge and beliefs affect health-related behavior, including behavior concerning
antibiotics use (Sawalha 2008; Widayati et al. 2011). Misconceptions about antibiotics among
students potentially cause antibiotic abuse. This subject remains understudied in Kenya and hence
presents a knowledge gap.
1.3 JUSTIFICATION
Given that abuse of antibiotics in undergraduate students in learning institutions continues to be a
significant problem in both developed and developing countries (Zafar et al. 2008), reducing
misconceptions regarding antibiotic use among this population is imperative. The results of this study
will provide epidemiological information that will serve as an essential input for policy makers to
design proper strategies to address antibiotic self -medication. Moreover, knowledge of the local self-
medication patterns and outcomes may raise the index of suspicion, for antimicrobial resistant bugs
and reduce morbidity and mortality. The study will bridge the gap in knowledge in this given subject
and also serve as future references for those who want to undertake research on the level of
knowledge, practices and attitude of antibiotic self -medication in Kenya and other countries
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1.5.2 Specific objectives.
i. To assess causes associated with antibiotic self- medication among Mount Kenya University
students.
ii. To assess the level of knowledge of antibiotic self- medication among Mount Kenya
University students.
iii. To determine the attitude and beliefs of antibiotic self- medication among Mount Kenya
University students.
iv. To determine practices associated with antibiotic self-medication among Mount Kenya
University students.
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1.6 CONCEPTUAL FRAMEWORK
INDEPENDENT VARIABLES
DEPENDENT VARIABLES
Gastrointestinal, respiratory
and UTIs
Level of knowledge of
antibiotic self -medicating
students. Self- medication with
antibiotics.
Antimicrobial resistance.
Positive or negative
attitude on antibiotic
misuse
Underdoing, overdosing
and antibiotic misuse
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2.0 CHAPTER TWO: LITERATURE REVIEW
2.1 Causes associated with antibiotic self – medication.
According to a study at Ahmadu Bello university the major reasons given for antibiotic self-
medication included assumed knowledge on antibiotics (34.98%), prior experience on use (28.27%),
lack of time to go for consultation (14.49%) and the attitude of the school sickbay staff (14.49%).
Only 11.31% reported that the nature of the illnesses was not serious enough for consultation.
Majority of the students 238 (84.10%) reported that they self- medicated for gastrointestinal infections
(GIT), 119 (42.08%) for genitourinary infections, 49 (17.30%) and 43 (15.15%) for respiratory tract
infections (RTI) and skin infections respectively. (O.J. Olayemi, B.O. Olayinka and A.I. Musa., et al
2010).
In another study it was identified that 31.1% started using antibiotics on their own. The reasons for
starting use being; flu 62.1%, sore throat 41.2%, toothache/ swelling 23.7%, headache 18.1% fever
16.9% cough 15.8%, abdominal pain 13.0%, weakness 10.7%, urinary burning 7.3% and skin
infection 6.2%. (Sergul Donmez, et al., 2018). In the same study 22.6% of antibiotic self- medicating
students did not have time to visit a doctor. 16.9% of those using antibiotics were advised by close
friends and relatives. (Sergul Donmez, et al., 2018).
In 2019, 536 students from a school in Medellin, Colombia composed of about two thirds’ females
43.5% of the students considered that the university had not sufficiently prepared them to interpret
anti-biograms. Furthermore, close to half of the respondents considered that they had received
insufficient clinical training with regard to switching from intravenous (IV) to oral antibiotics, and
21.4% of the students considered themselves inadequately trained to find reliable sources of
information. Typically, 29.6% of the students considered that the quality of information received on
the subject at their university ranged from regular to poor which poses a significant gap for these
students to discharge their responsibilities (Higuita-Gutiérrez et al., 2020).
A study carried out in Rwanda in 2019 evaluating the knowledge of 228 students reported satisfactory
knowledge scores on antibiotic use and antibiotic resistance. 95% of the respondents revealed that
unnecessary use of antibiotics drives antibiotic resistance and 96% reported to have heard about
antibiotics resistance. Moreover, 49% of the students acquired antibiotics from private pharmacies or
hospitals without a prescription and 83% revealed that they never heard about antibiotic stewardship.
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Despite their good knowledge lack of awareness on antibiotic stewardship dents proper antibiotic use
(Nisabwe et al., 2020).
In another study carried out in Nigeria in the first half of 2019, with to two-thirds of the respondents
(62.5%) being males, 126 (68.5%) aged between 25–29 years and about being 60.9% (112) in their
final year of undergraduate studies, 96.2% respondents correctly linked indiscriminate use of
antimicrobial drugs to the development of antimicrobial resistance. Worryingly, 39.1% of the
students did not know that common cold and influenza are caused by viruses and do not warrant the
use of antibiotics. Most (98.4%) of the respondents knew that antimicrobial resistance was an
important global public health issue and 87.0% of them wanted more education on antimicrobial use
and resistance (Alex, 2019)
From the above studies the general knowledge on antibiotic use is very low. This hinders the proper
use and prescribing of antibiotics and may play a significant role in driving the rates of antimicrobial
resistance.
Similarly, a survey subjected to students in Zambia evaluated students’ attitudes on the abuse of
antibiotics becoming the main cause of bacterial resistance, need for more education on antibiotics
and the need for carrying out large scale antibiotics campaign promotion to promote their rational use.
Results from this study revealed that majority of the participants 252 of 260 (96.9%) exhibited a
positive attitude and only 8 of 260 (3.1%) had a poor attitude score on antibiotic resistance (Zulu et
al., 2020)
In 2019, a follow up survey evaluated the practices of 609 medical students on consulting a doctor
before starting an antibiotic, buying antibiotics from drug stores/pharmacies directly, using antibiotics
after suggestions from friends/neighbor and stopping to take a complete dose of antibiotics once
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symptoms of infection abate. The practice level of the first-year students and last-year students could
be described in two groups. First-year students showed a lower practice level than final-year students.
This therefore showed that drug knowledge was a positive predictor of the use of antibiotics among
medical students (Shah et al., 2019).
From the above studies the general knowledge, attitudes and practices related to the use antibiotic use
is very low. This hinders the proper use and prescribing of antibiotics and may play a significant role
in driving the rates of antimicrobial resistance. Therefore, it sounds sensible to lay down strategies
that preserve the current pool of antibiotics. Globally a number of studies have shown that appropriate
use of antibiotics decreases the risk of antimicrobial resistance and these practices can be translated to
Kenyan settings (Llor & Bjerrum, 2014). This study therefore aimed to evaluate the baseline
knowledge, attitudes and practices related to antibiotic use and resistance among students in Mount
Kenya University. Information accrued from this study might be important in shaping education
interventions in Kenya.
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3.0 CHAPTER 3: MATERIALS AND METHODS
3.1STUDY DESIGN
This will be a descriptive cross-sectional study.
3.2STUDY AREA
Mount Kenya University located in Kenya, Kiambu County, Thika constituency in Thika town. It is a
private university with a college of health sciences that oversees the graduation of about 600 medical
students every year. They are students in various medical specialties including medicine, pharmacy,
nursing, medical laboratory science as well as public health.
3.3TARGET POPULATION
Mount Kenya University students
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3.4 STUDY POPULATION
3.5 INCLUSION/EXCLUSION CRITERIA
3.5.1 Inclusion criteria
All Mount Kenya University students including College of health sciences students taking a
bachelor’s degree in Pharmacy, MBChB, Clinical medicine, Nursing, Physiotherapy and Public health
and other courses offered within the institution.
3.6 VARIABLES
3.6.1Independent.
Causes of antibiotic self-medication such as Gastrointestinal, respiratory and UTIs.
Attitude & Practices of self- medicating students. Such as Positive or negative attitude on antibiotic
misuse or Underdoing, overdosing and antibiotic misuse
3.6.2 Dependent.
Self- medication with antibiotics.
Antimicrobial resistance.
n = Z² x P (1-P)
d2
(0.05) ²
= 385 students
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Since the target population will be less than 10,000, the sample size will be adjusted based on the
number of students at Mount Kenya University.
nf = n
(1+n/N)
= 385
1.266
= 304 students
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3.13 REFERENCE
1. O’Neill, J. (2019). Review on Antimicrobial Resistance Antimicrobial Resistance: Tackling
a crisis for the health and wealth of nations. London: Review on Antimicrobial
Resistance. 2014.
46(3-4), 257-271.
11
4. Boolchandani, M., D’Souza, A. W., & Dantas, G. (2019). Sequencing-based
Genetics, 1.
5. Genilloud, O. (2019). Natural products discovery and potential for new antibiotics.
9. Muloi, Dishon, Eric M. Fevre, Judy Bettridge, Robert Rono, Daniel Ong'are
12
10. Horton, R. (2019). Offline: AMR—the end of modern medicine?. The Lancet,
393(10172), 624.
12. Unemo, M., Golparian, D., & Eyre, D. W. (2019). Antimicrobial resistance in
14. Guo, Y., Song, G., Sun, M., Wang, J., & Wang, Y. (2020). Prevalence and
kenya. 2011
13
17. Almohammed, R. A., & Bird, E. L. (2019). Public knowledge and behaviours
18. Jairoun, A., Hassan, N., Ali, A., Jairoun, O., & Shahwan, M. (2019). Knowledge,
attitude and practice of antibiotic use among university students: a cross sectional
20. Nisabwe, L., Brice, H., Umuhire, M. C., Gwira, O., Harelimana, J. D. D.,
Nzeyimana, Z., ... & Muvunyi, C. M. (2020). Knowledge and attitudes towards
21. Alex, I. O. (2019). Knowledge of antibiotic use and resistance among students of a
22. Rusic, D., Bozic, J., Vilovic, M., Bukic, J., Zivkovic, P. M., Leskur, D., Seselja
Perisin, A., Tomic, S., & Modun, D. (2018). Attitudes and Knowledge Regarding
Antimicrobial Use and Resistance Among Pharmacy and Medical Students at the
1521–1528. https://doi.org/10.1089/mdr.2018.0010
14
23. Zulu, A., Matafwali, S. K., Banda, M., & Mudenda, S. (2020). Assessment of
24. Shrestha R. (2019). Knowledge, Attitude and Practice on Antibiotics Use and its
25. Shah, P., Shrestha, R., Mao, Z., Chen, Y., Chen, Y., Koju, P., Liu, X., & Li, H.
(2019).Knowledge, Attitude, and Practice Associated with Antibiotic Use among
University Students: A Survey in Nepal. International journal of environmental
research and public health, 16(20), 3996. https://doi.org/10.3390/ijerph16203996
26. Llor, C., & Bjerrum, L. (2014). Antimicrobial resistance: risk associated with
27. Gary S., Shehadeh M., Darwish D.A. et al. A cross-sectional study on knowledge,
attitude and behavior related to antibiotic use and resistance among medical and
abstract/A777AD433806
28. Huttner, A., Harbarth, S., Carlet, J. et al. Antimicrobial resistance; a global view
29. Deye, N., Vincent, F., Michel, P., Ehrmann, S., Da Silva, D., Piagnerelli, M., …
15
30. Gaarslev, C., Yee, M., Chan, G., Fletcher-Lartey, S., & Khan, R. (2016). A
31. Gajdács, M., Paulik, E., & Szabó, A. (2020). Knowledge, attitude and practice
https://doi.org/10.3390/antibiotics9020041
https://doi.org/10.5897/ajpp12.080
33. Gulliford, M. C., Moore, M. V., Little, P., Hay, A. D., Fox, R., Prevost, A. T.,
Juszczyk, D., Charlton, J., & Ashworth, M. (2016). Safety of reduced antibiotic
prescribing for self limiting respiratory tract infections in primary care: Cohort
https://doi.org/10.1136/bmj.i3410
34. Lv, B., Zhou, Z., Xu, G., Yang, D., Wu, L., Shen, Q., Jiang, M., Wang, X.,
Zhao, G., Yang, S., & Fang, Y. (2014). Knowledge, attitudes and practices
https://doi.org/10.1111/tmi.12322
16
35. Nisabwe, L., Brice, H., Umuhire, M. C., Gwira, O., Harelimana, J. D. D.,
Nzeyimana, Z., Sebatunzi, O. R., Rusingiza, E. K., Hahirwa, I., & Muvunyi,
C. M. (2020).
37. Oh, A. L., Hassali, M. A., Al-Haddad, M. S., Sulaiman, S. A. S., Shafie, A.
A., & Awaisu, A. (2011). Public knowledge and attitudes towards antibiotic
https://doi.org/10.3855/jidc.1502
38. S., P., T., N., G., M., Savkar, M., & M., R. (2016). Knowledge, attitude and
2003.ijbcp20164100
39. Struzycka, I., Mazinska, B., Bachanek, T., Boltacz-Rzepkowska, E., Drozdzik,
40. Zollner-Schwetz, I., & Krause, R. (2015). Therapy of acute gastroenteritis: Role
of antibiotics.
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3.14 APPENDICES.
Proposal writing
Proposal presentation
Data collection
Data analysis
Report writing
Research
presentation.
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3.14.2BUDGET
TOTAL 6810
3.14.3CONSENT FORM
I acknowledge that I have read and understood the information about this study or it has been
read to me by the investigator. I have asked questions whose answers were satisfactory. I hereby
consent voluntarily to be a participant in this study without any coercion and I am aware I can
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3.14.4 QUESTIONAIRE
1. Gender
a) Female
b) Male
2. Age
a) 16-20
b) 21-24
c) Above 24
3. School
f) Other students
4. Year of Study
a) First year
b) Second year
c) Third year
d) Fourth year
e) Fifth year
f) Sixth year
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SECTION B: Knowledge on antibiotic use.
1. Choose antibiotics from this list (Pick more than one answer)
a) Azithromycin
b) Methotrexate
c) Gentamicin
d) Allopurinol
e) Omeprazole
f) Amoxillin / Augmentin
g) Metformin
h) Penicillin
i) Ceftriaxone
2. Antibiotics are a class of drugs that kill or inhibit the growth of bacteria
a) Strongly Agree
b) Agree
c) Neutral
d) Disagree
e) Strongly disagree
a) Changes in weather
b) Viruses
c) Bacteria
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4. Antibiotic are effective against viral infections
a) Strongly agree
b) Agree
c) Neutral
d) Disagree
e) Strongly disagree
a) Strongly agree
b) Agree
c) Neutral
d) Disagree
e) Strongly disagree
6. Use of antibiotics without proper guidance from a duly qualified medical practitioner
increases the risk of undesirable effects like diarrhea and anaphylactic reactions.
a) Strongly agree
b) Agree
c) Neutral
d) Disagree
e) Strongly Disagree
7. Misuse of antibiotics makes bacteria used to them and become difficult to treat
a) Strongly agree
b) Agree
c) Neutral
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d) Disagree
e) Strongly Disagree
1. Choose antibiotics that you have used/prescribed in the past three months (Pick more
a) Azithromycin /Azifred
b) Gentamicin
c) Amoxicillin/Amoxiclav
d) Penicillin
e) Ceftriaxone/Rocephin/Injxone
f) Erythromycin/
g) Metronidazole/Flagyl
i) Doxycycline/ Doxicip/Doxyspor
a) Strongly agree
b) Agree
c) Neutral
d) Disagree
e) Strongly Disagree
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3. I'd rather take an antibiotic that may not be needed than wait to see if I get better
without it.
a) Strongly disagree
b) Disagree
c) Neutral
d) Agree
e) Strongly agree
4. If I feel better after half treatment, I stop taking a prescribed dose of antibiotics.
a) Strongly disagree
b) Disagree
c) Neutral
d) Agree
e) Strongly agree
5. Sometimes I keep left-over antibiotics for future use or give them to someone else
a) Strongly agree
b) Agree
c) Neutral
d) Disagree
e) Strongly Disagree
a) Strongly agree
b) Agree
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c) Neutral
d) Disagree
e) Strongly disagree
antibiotics.
a) Strongly Agree
b) Agree
c) Neutral
d) Disagree
e) Strongly disagree
25