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Methcathinone: 1. Synonyms CFR: CAS #
Methcathinone: 1. Synonyms CFR: CAS #
CH3
HN
CH3
1. SYNONYMS
CFR: Methcathinone
2.2. SOLUBILITY
Form A C E H M W
Base SS FS SS I FS SS
Hydrochloride VSS FS I I FS FS
A = acetone, C = chloroform, E = ether, H = hexane, M = methanol and W = water, VS = very soluble, FS =
freely soluble, S = soluble, PS = sparingly soluble, SS = slightly soluble, VSS = very slightly soluble and I =
insoluble
3. SCREENING TECHNIQUE
Marquis No reaction
Method MCAT-GCS1
Method MCAT-CES1
Buffer Preparation:
Tris-phosphate buffer, pH 2.4 - Prepare by adding one drop H3PO4 per 50 mL of 25 mM
Tris(hydroxymethyl)aminomethane HCl buffer
Injection Solvent:
9:1 H20:Tris-phosphate buffer
Sample Preparation:
Accurately weigh an amount of sample and dilute with injection solvent to an approximate concentration of
0.05 mg/mL.
Voltage: 30 kV
Temperature: 30°C
4. EXTRACTION TECHNIQUES
Because Methcathinone is sensitive to strong base, it is preferred that saturated sodium carbonate (pH 11) be
used to basify aqueous mixtures prior to extraction.
Chloroform and methylene chloride are suitable extraction solvents. Shaking the basified aqueous solution with
one of these solvents will transfer the methcathinone as the free base into the organic solvent. The solvent
should then be passed through a layer of anhydrous sodium sulfate to remove any residual basic aqueous phase.
Addition of 2-propanol or ethanol:hydrochloric acid mixture (4:1) to the extracted base, and subsequent solvent
evaporation with a steam bath, is suitable to provide the hydrochloride salt.
5. QUANTITATIVE PROCEDURE
Method MCAT-GCQ
Sample Preparation:
Accurately weigh an amount of sample into an appropriately sized volumetric flask so the final concentration of
Methcathinone HCl is approximately equivalent to that of the standard solution. Dilute to volume with ISS.
COMPOUND RRT
methamphetamine 0.629
methcathinone 1.00
pseudoephedrine 1.158
tetradecane 1.421
The adulterants guaifenesin, diphenhydramine, dextromethorphan and chlorpheniramine had retention times
greater than 5 min.
6. QUALITATIVE DATA
Both sample and standard should be subjected to the same procedures, using either KBr pellet or ATR
accessory.
No sample preparation is needed unless two or more active substances are in a sample.
7. REFERENCES
Clarke, E.G.C. ed., Isolation and Identification of Drugs, 2nd Edition, The Pharmaceutical Press, 1986.
Dal Cason, T., “The Identification of Cathinone and Methcathinone,”Microgram, December 1992, pp. 10-29
Moffat, A. C., Sr. ed., Clarke's Isolation and Identification of Drugs, The Pharmaceutical Press, Second
Edition, 1996.
O’Neil, M. ed., The Merck Index, 13th Edition, Merck and Co., Inc., 2001, p. 1067.
8. ADDITIONAL RESOURCES
Wikipedia
FTIR: Methcathinone hydrochloride, KBr pellet
16 Scans, resolution 4.0, 4.0 mg/100 mg
50
45
40
%Transmittance
35
13 60.72
15 97.20
30
97 5.99
14 69.31
12 44.90
24 54.76
25
20
27 08.62
70 0.19
15
16 91.62
10
100
95
90
85
80
29 74.27
75
%Trans mittanc e
70
30 58.22
65
96 1.47
12 35.23
60
16 82.97
14 46.89
55
10 23.81
13 71.61
50
45
16 37.06
10 67.74
40
14 01.27
70 3.68
35
15 95.41
15 51.08
30
76 3.29
25
20
3000 2000 1500 1000 500
W avenumbers (cm-1)
FTIR (ATR 1-bounce): Methcathinone hydrochloride
16 Scans, resolution 4.0
96
94
92
26 98.86
90
90 0.36
12 43.85
65 7.93
88
16 88.97
%Transmittance
97 4.97
86
84
52 8.14
82
53 2.42
80
78
54 1.79
76
69 8.58
74
72
3000 2000 1500 1000
W avenum bers (cm -1)
95
90
30 59.10
29 72.18
85
80
75
10 66.00
12 01.74
70
16 81.80
96 0.17
14 46.13
65
15 58.61
%Trans mittanc e
11 22.50
12 33.94
60
10 00.95
55
53 8.85
15 96.88
13 67.52
50
78 9.01
45
60 8.68
16 38.14
40
35
67 0.29
30
25
69 9.05
20
15
76 1.58
71 9.54
10
0.6 10 7.58
11 7.60
Normalized Inten...
12 7.62
Normalized Int...
0.5 0.15
0.15 13 7.72
0.10 14 7.74
0.10
0.4 15 8.05
0.05 0.05 16 8.05
17 8.07
0.3 5.1 5.0 4.9 4.8 18 8.07
8.00 7.75
Chemical Shift (ppm) Chemical Shift (ppm)
0.2
0.1
8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
Chemical Shift (ppm)
1.00 6 47.81
Normalized ...
0.6 10 59.46
129.5 128.5 49 48 47 46 11 128.79
Chemical Shift (ppm) Chemical Shift (ppm) 12 129.18
0.5 13 133.02
14 134.85
15 195.89
0.4
0.3
0.2
0.1
Normalized Intensity
6 5.05
7 5.05
Normalized Intensity
0.50
0.6 8 5.07
9 7.26
0.25 10 7.47
0.5
11 7.48
12 7.50
8.00 7.75 7.50 7.25 13 7.60
0.4
Chemical Shift (ppm) 14 7.62
15 7.64
0.3 16 7.92
17 7.93
18 7.93
0.2 19 7.95
0.1
8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5
Chemical Shift (ppm)
0.7 1.00
8 129.38
0.75 9 133.18
Normalized Intensity
0.5
135.0 132.5 130.0
Chemical Shift (ppm)
0.4
0.3
0.2
0.1
0.9
No. (ppm)
0.8
1 1.28
2 1.30
0.7 3 2.23
4 2.35
Normalized Intensity
5 2.67
0.6 0.10
Normalized Intensity
6 3.30
7 3.30
0.5 8 3.30
0.05 9 3.31
0.4 10 3.31
11 3.58
12 3.75
0.3 0 13 4.88
14 7.53
0.2 8.00 7.75 7.50 7.25 15 8.00
Chemical Shift (ppm ) 16 8.00
17 8.02
0.1
8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5
Chemical Shift (ppm )
13 7.26
14 7.32
0.25
15 7.33
16 7.34
17 7.35
0.20 18 7.44
19 7.46
20 7.51
21 7.52
0.15 22 7.52
23 7.52
24 7.53
25 7.53
0.10
26 7.55
27 8.05
28 8.06
0.05 29 8.07
8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5
Chemical Shift (ppm)
FT RAMAN: Methcathinone HCl
64 Scans, resolution 8.0
11
10 00.36
30 65.19
15 96.36
10
16 89.09
8
7
Rama n in te nsity
6
29 62.67
0
3000 2000 1500 1000 500
Ram an shift (c m -1)
10 00.75
3.4
10 28.67
3.2
3.0
2.8
16 40.28
2.6
30 62.89
2.4
15 97.75
2.2
Rama n in te nsity
2.0
1.8
1.6
1.4
29 29.71
14 48.50
1.2
1.0
15 41.14
61 6.91
11 75.73
13 69.18
0.8
0.6
0.4
0.2
0.0
3000 2000 1500 1000 500
Raman shift (c m-1)
MS: Methcathinone HCl in Chloroform