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A Critical Review On Balachaturbhadra CH d1690d03
A Critical Review On Balachaturbhadra CH d1690d03
A CRITICAL REVIEW ON
BALACHATURBHADRA CHURNA: AN
EFFECTIVE AYURVEDA FORMULATION FOR
THE PEDIATRIC AGE
Abhishek Joshi1*, Shrikrishna Rajagopala2, and Patel Kalpana S.3
1
Universitas Hindu Indonesia, Denpasar, Bali, Republic of Indonesia
2
Department of Bala Roga, All India Institute of Ayurveda, New Delhi
3
Department of Kaumarbhritya, IPGT & RA, Gujarat Ayurved University, Jamnagar, Gujarat
*
<dr_abhishekjoshi@yahoo.com>
Abstract
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poapular prescription by Kaumarbhritya practioners of Ayurveda. It is a combination of four
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Chakradatta and has been in practice since a millennium. Many queries have been raised
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WLOO QRZ 7KH DLP RI WKH SUHVHQW VWXG\ ZDV WR FRPSLOH DQG UHYLHZ VXFK DYDLODEOH UHIHUHQFHV IURP
FODVVLFV DQG UHVHDUFK ZRUNV SXEOLVKHG RQ %DODFKDWXUEKDGUD &KXUQD 7RWDO ¿YH VWXGLHV DUH
SXEOLVKHG RQ %DODFKDWXUEKDGUD &KXUQD ZKLFK UHYDOLGDWHG WKH LPSDFW RI FODVVLFDO JXLGHOLQHV
7KH UHVHDUFK SDSHUV UHYHDOHG VWDQGDUGV RI 4XDOLW\ &RQWURO DQG SKDUPDFRORJLFDO HI¿FDF\ RI
the drug. All the experimental studies revealed that Balachaturbhadra Churna is having no
toxic hazards at very higher Dose levels, proving it safe for therapeutic use. Though certain
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Abhishek Joshi, Shrikrishna Rajagopala, and Patel Kalpana S.
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2.226) of formulation depict that alcohol it had a pleasant odour and bitter taste
LV D EHWWHU VROYHQW IRU H[WUDFWLRQ 7KUHH for both the formulations. Quantitative
laboratory batches of formulation and Analysis of microscopic constituent of
Piper longum powder were estimated VWDQGDUG DQG PDUNHW IRUPXODWLRQV RI
for their piperine content against Balachaturbhadra Churna observed
standard piperine solution on double were 3.43 and 3.24 for Starch Grains,
beam UV-Visible spectrophotometer at 55.12 and 52.56 for Xylem vessels and
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Shahebaz et.al. in 2012 made (length). Screening of phytoconstituents
an attempt to evaluate and compare LQ VWDQGDUG DQG PDUNHW IRUPXODWLRQV
PDUNHW IRUPXODWLRQ ZLWK LQ KRXVH of Balachaturbhadra Churna showed
sample of Balchaturbhadra Churna SUHVHQFH RI DONDORLGV ÀDYRQRLGV
by performing physico-chemical phenolics, carbohydrates, tannins,
screening, phytochemical screening, Sterols and triterpenoids whereas
microscopic characterization and coumarins and saponins were absent.
ÀXRUHVFHQFH DQDO\VLV *KDGL\DOL Estimation of phytoconstituents
et.al., 2012). Respective physical LQ VWDQGDUG DQG PDUNHW IRUPXODWLRQV
parameters observed for standard and of Balachaturbhadra Churna were
PDUNHW SUHSDUDWLRQ RI Balchaturbhadra respectively 0.107% and 0.096% for
Churna ZHUH %XON 'HQVLW\ JP Flavonoids, 0.84% and 0.76% for Na+
ml.) 0.5882 and 0.434, Tap Density ion salts, 0.62% and 0.38% for K+ ion
JP PO DQG &DUU¶V ,QGH[ salts, 2.91 % and 3.74 % for Tannins
26.47 and 30.43, Hausner’s Ratio DQG IRU &UXGH ¿EUH FRQWHQW LW ZDV
1.36 and 1.43 and Angle of Repose 15.5% and 13%. Fluorescence analysis
32.32 and 34.43. Morphological was performed by observing the powder
study of Balachaturbhadra Churna RI WKH VWDQGDUG DQG PDUNHW IRUPXODWLRQ
VKRZHG ¿QH FRQVLVWHQF\ IRU VWDQGDUG of Balachaturbhadra Churna with 1N
IRUPXODWLRQV DQG YHU\ ¿QH IRU PDUNHW HCL, 1N H2SO4, 1N HNO3, aquous
formulations; colour was brown for and alcoholic NaOH, Iodine solution,
standard formulations and greyish .2+ DQG 1+ DQG WKH ÀXRUHVFHQFH LQ
EURZQ IRU PDUNHW IRUPXODWLRQ ZKLOH day light and in UV light was compared
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Abhishek Joshi, Shrikrishna Rajagopala, and Patel Kalpana S.
for both the samples. After analysis Qualitative test for various functional
LW ZDV REVHUYHG WKDW PDUNHW VDPSOHV groups revealed the presence of
PDWFKHG H[DFWO\ ZLWK WKDW RI DXWKHQWLF carbohydrates, steroids, cardiac
standards of in-house formulation after JO\FRVLGHV ÀDYDQRLGV DONDORLGV DQG
performing the standardization. tannins in the formulations. Saponin
$EKLVKHN -RVKL et.al. in was absent in Churna. On performing
2013 made an attempt to develop HPTLC, the chromatogram showed 17
Pharmacognostical, Pharmaceutical and SHDNV ZLWK 5I YDOXHV DW QP ZKLOH
HPTLC standards for Balachaturbhadra at 366nm the chromatogram showed
Churna. Organoleptic characters 14 spots. Commonly seen Rf values at
observed for Balachaturbhadra Churna both 254nm and 366nm were 0.14, 0.18,
were light brown colour, spicy pungent 0.23, 0.29, 0.34, 0.35, 0.47, 0.53, and
odour, Kashaya - Tikta (astringent – 0.58.
ELWWHU WDVWH DQG ¿QH FRQVLVWHQF\ RI WKH 7R[LFLW\ VWXG\
powder. Powder microscopy shows Parmar Parag et.al., in 2011
VWULNLQJ FKDUDFWHUV RI DOO LQGLYLGXDO FRQGXFWHG VWXGLHV RQ DFXWH WR[LFLW\
constituents. Starch grains without VWXG\ RQ DOELQR UDWV $FXWH WR[LFLW\
KLOXP GDUN EURZQ FRORXULQJ PDWWHU study was carried out as per WHO
DQQXODU YHVVHOV DQG OLJQL¿HG ¿EUHV RI JXLGHOLQH IRU DFXWH WR[LFLW\ WHVW DQG
Musta, starch grains without hilum, PRGL¿HG DV SHU H[SHULPHQWDO QHHG
stone cells and oil globules form (Anonymous, 1993). The rats were
Pippali, simple and compound starch observed closely for behavioural
JUDLQV FRUN FHOOV SULVPDWLF FU\VWDOV RI FKDQJHV VLJQ DQG V\PSWRPV RI WR[LFLW\
calcium oxalate and parenchyma cells DQG PRUWDOLW\ FRQWLQXRXVO\ IRU WKH ¿UVW
from Ativisha, tannin content material, four hours and thereafter periodically
fragments of pitted vessels, vascular up to 14 days. Balacaturbhadrika
bundles along with tannin cells and Churna did not produce any signs and
epidermal cells from Karkatashringi. V\PSWRPV RI WR[LFLW\ DQG PRUWDOLW\ XS
Loss on drying, ash value, WR D GRVDJH RI PJ NJ LQ UDWV
ZDWHU VROXEOH H[WUDFW Z Z DOFRKRO Nariya M. et.al., in 2011 published
VROXEOH H[WUDFWV Z Z S+ YDOXH GDWD UHODWHG WR[LFRORJLFDO VWXG\ RI
of Balachaturbhadra Churna were Balachaturbhadrika Churna. The
4.7%w/w, 5.75%w/w, 29.3%w/w, study was carried out by administering
27.3%w/w and 6 respectively. Particle Balacaturbhadrika Churna in a dose
size of Churna was ranging from 60- XS WR PJ NJ RUDOO\ RQFH )RU
120 mesh. 3.209g, 2.345g, 1.360g, and ORQJ WHUP WR[LFLW\ Balacaturbhadrika
3.019g was obtained from >60, 61-85, Churna was administered in doses
86-120 and >120 mesh respectively. RI DQG PJ NJ RUDOO\ IRU
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Abhishek Joshi, Shrikrishna Rajagopala, and Patel Kalpana S.
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Abhishek Joshi, Shrikrishna Rajagopala, and Patel Kalpana S.
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