Cal Misbah Test 2016 Qa PDF

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Calculation Test
1) How many grams of chemical are required to make 120 ml of a 20% w/w of solution of a
sp. gravity 1.15?
a) 120 g B) 28 g C) 138 g D) 20 g E) 18 g
Ans. B
Solving.
How many grams of chemical are required to make 120 ml x 1.15 = 138 g of a 20% w/w
(means 20 g in 100 ml) of solution of a sp. gravity 1.15?
Tips. Wt of solution= sp. gravity x wt of volume of water
=1.15 ml/g x 120 ml =138 g
so
20 g------>100 g solution
x g………>138 g of solution
x= 138 (20/100) =27.6 g
2) Given a Rx and the signature is start 40 mg and decrease 5 mg every day until finish. How
many days the patient will take to finish this Rx.
A) 8 days B) 7 days C) 6 days D) 5 days E) 4 days
Ans. A
8+7+6+5+4+3+2+1 = 8days
day 1 = 8 tab
day 2 = 7 tab
day 3 = 6 tab
day 4 = 5 tab
day 5 = 4 tab
day 6 = 3 tab
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day 7 = 2 tab
day 8 = 1 tab
3) Pharmacy manager provides a stock solution of 1:750 and would like you to prepare 60 mls
of 1:10,000, how much you need to use of the stock solution?
A) 2.4 mls B) 4.6 mls C) 1.3 mls D) 46 mls E) 0.46 mls
Ans: B 1:750 = 0.13% C1 x V 1 = C2 x V 2
1:10.000 = 0.01%
V= 4.6ml
0.13 x V 1 = 0.01 x 60
0.13V = 0.6 = 4.6 ml
4) Pharmacy manager provided alcohol 95% and asked to prepare 60 ml of alcohol 12%. How
much of alcohol 95% you should used to make this new concentration of alcohol?
a) 4.32 ml b) 7.57 ml c) 8.64 ml d) 6 ml e) 6.57 ml
Ans. B C 1 x V 1 = C 2 x V 2 → 95 x V 1 = 12 x 60 → V 1 = 7.57ml
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5) Pharmacy manager provided you ZnCl 2 0.7%, phenylephrine 0.1% and boric acid 1.1% with
E values 0.16, 0.32 and 0.5 respectively. This solution will be:
a) Isotonic b) Hypertonic c) Hypotonic d) Iso-osmotic e) Isotonicity cannot be finding.
Ans. C
(0.7 x 0.16) = 0.112 g
(0.1 x 0.32) =0.032 g
(1.1) x 0.5) = 0.55 g
0.112 g+0.32 g+ 0.55 g = 0.69 g
Isotonic is 0.9 of NaCl. Therefore it is hypotonic prep.
6) A patient brought a prescription with the following signature. Start with double dose of 5
ml, than take 2.5 ml BID for 7 days. How many ml of azithromycin suspension should be dis-
pensed to this patient.
a) 30 ml b) 35 ml c) 40 ml d) 45 ml e) 50 ml
Ans. C
10 ml-start dose + (5ml/day x 6days) = 10 + 30 = 40 ml
explained;
day 1 = 10 ml
day 2 = 5 ml
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day 3 = 5 ml
day 4 = 5 ml
day 5 = 5 ml
day 6 = 5 ml
day 7 = 5 ml
Day1 Day 2 Day 3 Day4 Day5 Day6 Day7
10 ml 5ml 5ml 5ml 5ml 5ml 5ml
Start take 2 tablet and one tablet daily till finish
Mitte; 6 tab
7) Rx; Prednisone 5 mg
Start 40 mg and decrease 5 mg every day until finish. How many tablets should be dispensed?
a) 30 tablets b) 35 tablets c) 36 tablets d) 40 tablets e) 12 tablets
Ans. C
Tips: 8+7+6+5+4+3+2+1 = 36 tab
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8) A metered dose inhaler contains 120 doses. How many days the patient will take to finish
the entire inhaler with this signature: “Use 2 inhalers in each nostril every morning and at
bedtime”
a) 7 days b) 10 days c) 20 days d) 15 days e) 30 days
Ans. D
“Two inhalers in each nostril (4x2=8) every morning and at bedtime”
2x2 nostril x 2 (morning + night) = 8 doses daily
120 doses ÷ 8 doses daily = 15 days supply
9) What is the minimum quantity that can be weight on a balance with sensitivity require-
ments of 15 mg of a 5% error is permissible
a) 100 mg b) 200 mg c) 300 mg d) 400 mg e) 500 mg
Ans: C
SR = Weight x Error → 15 = weight x 5/100= 300 mg
10) What is the sensitivity of a balance that can weight 120 mg of a substance and has a per-
missible error of 5%?
a) 6 mg b) 16 mg c) 66 mg d) 26 mg e) 1.6 mg
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Ans: A
SR = Weight x Error → SR = 120 mg x(5/100) = 6 mg
11) You receive the following order to be prepared in the hospital pharmacy. Metoclo-
pramide 12 mg in 50 mL D5W. How many milliliters of metoclopramide injection with a con-
centration of 5 mg/mL would you need to prepare this solution?
A) 25 ml B) 2.4 ml C) 12 ml D) 5 ml E) 1 ml
Ans: B
Tips: 12/5 = 2.4 ml
or
5 mg ..........1 ml
12 mg...........?
(12 mg x 1 mL)/5 mg = 2.4 mL
12) You receive the following order for an IV infusion. Famotidine 25 mg in 100 mL of D5W.
How many mL of famotidine injection (10 mg/mL) should be used for this preparation?
A) 25 ml B) 2.5 ml C) 12 ml D) 5 ml E) 1 ml
Ans. B
Tips
10 mg ............1 ml
25 mg .............?
(25 mg x 1 mL)/10 mg = 2.5 mL
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13) Which of the following preparation are using trans tretinoin is an isomer of carotenes.
A) oral tretinoin B) topical tretinoin C) oral and topical both preparations D) all of the
above
Ans. B
Tips: Trans topical tretinoin (TTT) has cream and gel preparation available, and cis-isomers
are oral products.
14) A nurse brings a prescription to the hospital pharmacy asking the pharmacist how to pre-
pare the following prescription for a 155 lb patient:
Rx: Dopamine 200 mg in 500 ml solution
Inject 5 mcg/kg/min
The nurse needs to know the rate/ml in which she should infuse the medication. Which of the
following concentration of the drug/ml should be infused?
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a) 100 mcg/ml b) 200 mcg/ml c) 300 mcg /ml d) 400 mcg /ml e) 500 mcg
/ml
Ans. D
Final concentration 200 mg-----500 ml
mg to mcg, 200 x 1000 = 200 000 mcg in 500 ml
200, 000 mcg ......…. 500 ml
? ..................... 1 ml = 400 mcg/ml
or
200 mg/ 500 ml = 0.4 mg/mL
= 400 mcg/ml
How much drug is administered?
body weight 155/2.2 = 70 kg
5 mcg ........ 1kg
?................70 kg
350 mcg
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15) We receive the following prescription:
Rx. Tetracaine 1 %
Boric acid 0.5%
Water qs 100% dispense 60 ml ophthalmic solution.
How many mg of NaCl is needed to adjust the isotonicity of this solution?
(E values are 0.18 for tetracaine and 0.5 for boric acid)
a) 108 mg b) 77 mg c) 128 mg d) 718 mg e) 282 mg
Ans: E
Isotonicity is 0.9 g of NaCl
Calculate the wt of tetracaine →
60 ml x 0.01 (because is 1%) = 0.6g = 600 mg
Wt of tetracaine is equivalent to
600 mg x 0.18 = 108 mg of NaCl.
wt of boric 60 ml x 0.005 = 0.3 g = 300 mg
boric acid 300 mg x 0.5 = 150 mg
108 mg + 150 mg = 258 mg for 60 ml
60 ml x 0.9 g = 540 mg
540 - 258 = 282 mg of NaCl
16) The dose of morphine that a patient is receiving daily is 30 mg (1 tablet of 15 mg BID). If
switch to liquid morphine 5 mg/ml, and dose is Q4 hours, how much morphine should be
supplied for 20 days period, to provide the same relief regimen?
a) 6 ml b) 60 ml c) 120 ml d) 180 ml e) 200 ml
Ans: C
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Daily dose 30 mg
Liquid morphine comes in 30 mg/5 ml so 6 ml is needed daily
20 days supply, 20 x 6 ml = 120 ml
17) How many milliliters of a 1:1500 solution dissolving 4.8 g of NaCl in water can make?
A) 1000 mL B) 1500 mL C) 3500 mL D) 7200mL
Ans. D
Tips:
We have 1 gram for every 1500 ml of solution
So for 4.8 g we will give x ml of solution
X ml = 4.8 (1500/1) = 7200 ml
18) 100 ml of 5% w/v of Diclofenac in ethanol was added to 150 ml of ethanol. Density of
ethanol is 0.8. The % w/w of Diclofenac gel in alcohol will be:
a) 4.76 %w/w
b) 1.96 %w/w
c) 3.92 %w/w
d) 2.44 %w/w
Ans. D
Thus % w/w=[wt of solute/Wt of solute + wt of solvent]
= [5 g/5 g + wt of solvent]
100 ml of ethanol= 100 x 0.8 = 80 g
150 ml of ethanol= 150 x 0.8 = 120 g
total grams of solvent is 80 + 120 = 200 g
[5 g/(5 g+ 200 g)] x 100% = 500 g/205 g = 2.44% W/W
19) 5 ml of 10% w/v of a drug was diluted five times with glycerine
(D of glycerine is 1.25 g/ml). The concentration w/w of the drug is:
a) 2.42 % w/w B) 1.57 % w/w c) 1.96 % w/w d) None of the above
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Ans. (B)
10 g.............100 ml
X..................5 ml
X = 50÷100 = 0.5 g of solute
%w/w = [(wt of solute/(wt of solute + wt of solvent)]x100%
[0.5 g/ 0.5 g + (1.25) x (25 ml)] x 100%
[0.5/0.5 + 31.25] = (0.5 g/31.75 g) x 100% = 1.57%
20) How many milliliters of a heparin sodium injection containing 200,000 heparin units in 10
mL should be used to obtain 5,000 heparin units?
A) 0.50mL B) 0.25mL C) 0.10mL D-0.75mL E-250mL
Ans: B
200,000 ---- 10 ml
5000 ---- ?
5000 x 10/200,000 = 0.25 ml
21) 5 ml of 10% w/v of a drug was diluted five times with Glycerine ( Density of Glycerine is 1.25
g/ml). The concentration w/w of the drug is:
A. 2.42% w/w
B. 1.57% w/w
C. 1.96% w/w
D. None of the above
Ans. B
10 g______100 ml
X_________5 ml
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X = 50/100 =0.5 g of solute
%w/w = [(wt of solute wt of solute + wt of solvent)] x 100%
0.5g/0.5 g+ (1.25)(25 ml) x 100%
0.5/ (0.5 + 31.25) = 0.5/31.75 x 100% = 1.57%
22) A physician requests that an elixir containing 32% alcohol be prepared, how much low al-
cohol elixir (10% alcohol) and high alcohol elixir 78% must be mixed to prepare 1 pint of re-
quested elixir.
A. 320 ml and 153 ml
B. 153 ml and 320 ml
C. 320 ml and 320 ml
D. 153 ml and 153 ml
22 parts of 78%
78%
32
10 46 parts of 10%
473 x 46
Low alcohol = 320 ml
68
High alcohol 473 x 22

= 153 ml
68
1 pint = 473 ml
Ans: A
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23) A hospital clinic requests 2 lb of 2% hydrocortisone ointment. How many grams of 5% hy-
drocortisone ointment would be diluted with white petroleum to prepare this order.
A. 363 g
B. 400 g
C. 463 g
Ans. A
C1 V 1 = C2 V 2
1 kg = 2.2 lb
2lb = 908 g
908 x 2% = ? x 5%
x = 363.2 g
24) What is weight of KCl in mg is needed to provide 109 mEq of K+? (MW 74.5).
A. 2.12 g
B. 4.06 g
C. 4.25 g
D. 8.12 g
ANS. (D)
Tips. mg = [mEq x MW]/valence
Valence of K is 1 and MW of KCl is 74.5
thus [109 x 74.5 mg]/ 1 = 8.12 g
Note. valency Na, K, Li = 1, Ca, Mg = 2 and Al = 3
Memorize.
mg = [mEq x MW]/valence
mEq = [(mg x valence)/MW]
mmol = Dose in mg/ Molecular weight
25) Ringer’s Injection contains 806 g of sodium chloride per liter. How many mEq’s sodium
does this represent? NaCl [MW 58.5 g/l)
A. 14.7
B. 73.5
C. 13.7
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D. 198
ANS. (C)
Tips: mEq = [mg x valence]/ MW
Thus [806 g x 1]/58.5
or
806,000 mg x 1/58.500
26) How many mEq of calcium are there in 10 ml of 10% calcium gluconate solution? (MW of
Ca gluconate is 448).
A. 0.45 mEq
B. 2.23 mEq
C. 4.46 mEq
D. 25.0 mEq
ANS. C
Tips. mEq = [mg x valence]/MW
10 ml of 10% is 1 g
[(1000 mg x 2)/448 mg] = 4.46 mEq
27) How many mEq’s of sodium ion (NaHCO 3 ) are there in a liter of a 5% solution of sodium
bicarbonate? Atomic numbers are Na 23, H 1, C 12, O 16. (MW 84)
A) 59 mEq B) 217 mEq c) 298 mEq d) 595 mEq
ANS. (D)
Tips: mEq = [mg x valence]/MW
NaHCO 3 MW = 23+1+12+48 = 84
5% of 1 Liter is 50 g
thus
[50,000 mg x 1]/84 mg = 595 mEq
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28) 50 milliequivalent of CaCl 2 injection to be given to a patient admitted to the ward. Calcu-
late the number of mg of elemental calcium in that injection. [Ca atomic weight 40].
A. 1000 mg
B. 500 mg
C. 100 mg
Ans: A
Tips. mg = [mEq x atomic weight]/valence
thus
Mg = [50 x 40]/2 = 1000 mg
29) The milliequivalent of a magnesium phosphate injection (10 ml) is 330. The mmole of
that injection is expected to be?
A. Higher
B. Lower
C. Same
Ans. B
Sol.
Tips: Since the valence of magnesium is 2, then the mEq. is double the mmol. Hence mmol of
magnesium phosphate is lower. If valence is 1 than mmol and mEq are the same.
potassium 40 mEq/L = 40 mmol/L

Li 2 CO 3 40 mEq/L = 40 mmol/L
CaCO3 40 mEq/L = 20 mmol/L
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30) How many grams of opium containing 15% of morphine, and how many grams of lactose
should be used to prepare 150 g of powder containing 10% w/w morphine?
A) 10 g opium and 140 g lactose
B) 15 g opium and 135 g lactose
C) 50 g opium and 100 g lactose
D) 100 g opium and 50 g lactose
Ans. D
C1V1=C2V2
15xV1 = 10x150
V1 = (10x150)/15] =100 g of opium
or
Step 1: 150 grams of powder to be produced (containing 10% morphine) are equivalent to
(10/100) x 150 = 15 g morphine.
Step 2: Since the original opium contains 15% morphine, 100 grams of the original opium
powder are required to give the 15 g of morphine required for the final product. The rest of
the weight (150g –100g) = 50 g should be derived from lactose.
31) Patient was admitted to ER and was given KCl injections as 60 mg every 12 hours for 3
days. The patient was taking 3 ml in each injection. The label of the injection is 60 mg. The
number of injections the patient received is:
A) 3 B) 4 C) 5 D) 6
Ans. D
Tips:
60 mg x 2 = 120 mg since the injection is 60 mg/3 ml.
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Patient was using 2 injections per day.
For 3 days 2x3 = 6
32) Nurse wants to give TPN 250 ml IV. 4 times daily for 5 days to cancer patient. The bottle
has 500 ml size. The number of bottles used were:
A) 5 B) 10 C) 20 D) 7.5
Ans. B
250 ml x 4 = 1000 ml
1000 ml x 5 days = 5000 ml
5000 ml/500 ml size = 10 bottles
33) The physician orders calcium gluceptate 540 mg to be added to IV fluids. You have avail-
able 5 mL ampoules, each containing 90 mg of calcium gluceptate. How many milliliters
would you add to the IV fluids to fill this order?
A) 25 ml B) 50 ml C) 30ml D) 75 ml E) 10 ml
Ans: C
90 mg .............5 ml
540 mg ...............?
[540 mg x 5 mL/90 mg] = 30 mL
34) A pharmacist gets the following physician’s order. Add 1 g of lidocaine to 250 mL IV solu-
tion. How much 2% lidocaine solution should be added?
A) 25 ml B) 50 ml C) 12 ml D) 75 ml E) 10 ml
Ans. B
Tips
2% = 2 g/100 mL
(1g x 100 mL)/2 g = 50 mL
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35) Doctor prescribed ferrous sulphate 20 mg/kg/day for a patient weighing 20 lbs. You have
ferrous sulphate 300 mg/5ml solution in stock. How much ml stock solution you need?
A) 1 ml B) 3 ml C) 2 ml D) 4 ml
Ans. B
20 lbs = 9.09 kg
9.09 kg x 20 mg/kg/day = 181.82 mg/day = 3.03 ml = 3 ml
36) Plot of log of concentration against time produces a straight line with a:
A) Slope of –K/2.303
B) Slope of –K/t 1/2
C) Slope of –K o
D) slope of K/2.303
E) slope of K/0.693
Ans. A
37) How many ml of camphor you need to prepare 60 ml of 2% camphor. Your pharmacy has
stock solution of 89%?
A) 2 ml B) 1.35 ml C) 5 ml D) 10 ml E) 6ml
Ans: B
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C1 V 1 = C2 V 2
89 x V 1 = 2 x 60
V 1 = [2x60]/89 = 1.35 ml
38) How many ml of 2% iodine solution must be mixed with a 7% iodine solution to obtain 1
liter of a 5% strength?
a) 50 ml B) 400 ml C) 200 ml D) 2 ml E) 20 ml
Ans. B
7% 3%
5%
2% 2%
(2%/5%) x 1L = 400 ml
39) A patient is to receive 1 L of 0.9 sodium chloride injection over 24 hours to keep his vein
open in case IV medications need to be administered. What would be the flow rate (mL/hr)
for this solution?
A) 15 ml/hr B) 42 ml/hr C) 45 ml/hr D) 60 ml/hr E) 75 ml/h
Ans. B
1000 mL/24 hr = 41.6 mL/hr
Formulas.
IV flow rate (gtt/min)=[volume (mL)/time (min)]x drop factor (gtt/ml)
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40) A physician asks the pharmacist to compound codeine sulfate tablet triturates containing
10 mg of codeine. The patient needs a 5-day supply and may take 1-2 q4-6h prn. How much
codeine is needed to fill this prescription?
A) 300 mg B) 400 mg C) 600 mg D) 1200 mg E) 1500 mg
Ans: C
2 tab q 4 h = 12 tab/day
5 day x 12 tab/day = 60 tab
10 mg x 60 tab = 600 mg
41) If a prescription order requires 25 g of concentrated HCI (density 1.18 g/ml), what volume
should the pharmacist measure?
A) 29.50 ml B) 0.02 ml C) 23.0 ml D) 21.2 ml
Ans: D
W= 25 g
D= 1.18 g/ml
V= W/D = 25/ 1.18= 21.2 ml
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42) How many grams of 10% (w/w) ammonia solution can be made from 1800 g of 28% (w/w)
strong ammonia solution?
A) 6428 g B) 5040 g C) 50,400 g D) 642 g
Ans: B
C1V1 = C2V2
(10) X = (1800)(28)
X = 5040 g
43) A Pharmacy tech adds 75 mL of strong iodine solution USP (5.0% w/v) to 1 litre of sterile
water for irrigation. What is the % w/v of iodine present?
A) 0.35% B) 0.37% C) 0.53% D) 0.60% E. 30%

Ans: A
C1 V 1 = C2 V 2
(5) 75 = C 2 X (1075)
X = 0.35%
44) 30 g of hydrocortisone cream 1%, prepare in 1/4 g menthol and 1/4 g camphor? What is
weight of menthol and camphor of each?
a) 1/4 = 0.25 g of each menthol and camphor; 29.5 g of hydrocortisone 1% cream
b) 2.5 g of each menthol and camphor; 5 g of hydrocortisone cream
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c) 5 g of each menthol and camphor; 20 g of hydrocortisone cream
D) 6.25 g each menthol and camphor; 17 g of hydrocortisone cream
Ans. A
Tips. 1/4 g menthol is 0.25 g, 1/4 g camphor is 0.25 g
45) In dosing the drug gentamicin in pediatric patients, for every 1 mg/kg of gentamicin ad-
ministered, serum drug concentrations are expected to increase by 2.5 µg/ml. What would
be the expected serum drug concentration following an administration of a 2.5 mg/kg dose of
gentamicin?
A) 5 µg/ml B) 6.25 µg/ml C) 10 µg/ml D) 2.5 µg/ml
Ans. B
(1 mg/kg/2.5 µg/ml)= (2.5 mg/kg)/X µg/ml
X = 6.25 µg /ml
46) An elixir is to contain 250 mg of an alkaloid in each teaspoonful dose. How many grams
of the alkaloid will be required to prepare 5 litres of the elixir?
A) 0.25 g B) 5 g C) 250 g D) 2.5 g
Ans: C
= (X g/5000 ml) x (0.25 g/5 ml)
X= 250 g
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47) A pediatric product contains 100 mg of erythromycin ethylsuccinate in each dropper (2.5
ml) of the product. How many kilograms of erythromycin ethylsuccinate would be re-
quired to prepare 5000 pint-size bottles?
A) 74.6 kg B) 84.6 kg C) 99.5 kg D) 94.6 kg
Ans. D
1 pint = 473 ml
480 ml x 5000 = 2, 365,000 ml
0.0001 kg /2.5 ml = X/2,365,000 ml
X = 94.6 kg
48) A physician places a patient on a daily dose of 48 units of U 80 insulin (80 units/mL). How
many ml should the patient inject each day?
A) 0.4 B) 0.5 C) 0.6 D) 0.25
Ans. C
U-80 INSULIN
80 U/1ml = 48 units/ X
X= 0.6 ml
49) A 20 ml vial of biologic solution is labelled “2 megaunits.” How many units of drug are
present in every ml of solution?
A) 2000 B) 1000 C) 100,000 D) 10,000
Ans. C
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I Megaunit = 1000,000 U
20 ml --- 2,000,000 units
1 ml ---- ?
X= [2 x 1000 x 1000]/20 = 100,000 units
or
1Megaunit = 1000KU
1KU = 1000 units
2.0 M units x 1000 KU_ x 1000 units = 1000,000 units
1M units 1KU
50) The usual initial dose of chlorambucil is 150 µg per kg of body weight once a day. How
many milligrams should be administered to a person weighing 154 lbs.?
A) 10.5 mg B) 18 mg C) 15 mg D) 8 mg
Ans. A
154 lbsx1 kg/2.2 lbs = 70 kg
150 mcg/1 kg = X/ 70 kg
X = 10, 500 mcg
= 10.5 mg
51) An initial heparin dose of not less than 150 units/kg of body weight has been recom-
mended of open-heart surgery. How many ml of an injection containing 5000 heparin
units per milliliter should be administered to a 300-pound patient?
A) 5.1 µl B) 4.1 µl C) 5.1 ml D) 4.1 ml
Ans: D
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300 lbs x 1kg/2.2 lbs = 136.36 kg
150 units /1 kg = X/136.36 kg = 20 454.54 units
5000 u/ 1 ml = 20454 u/ X
X= 4.1 ml
52) The pediatric dose of cefadroxil is 30 mg/kg/day. If a child is given a daily dose of 2 tea-
spoonful of a suspension containing 125 mg of cefadroxil per 5 ml, what is the weight in
lb. of the child?
A) 19.5 lbs. B) 18.8 lbs. C) 18.3 lbs. D) 18.1 lbs.
Ans: C
(125 mg x 2)/5 ml = 250 mg/ 5 ml
250 mg/ X = 30mg/1 kg
X = 8.33 kg
8.33 kg x 2.2 lbs = 18.33 lbs
53) If the loading dose of Kanamycin is 7 mg/kg of body weight, how many grams should be
administered to a patient weighing 130 lbs.?
A) 0.492 g B) 0.414 g C) 414 g D) 0.485 g
Ans. B
130 lbs x 1kg/ 2.2 lbs = 59.09 kg
7 mg/1 kg = X/59.90 kg
X= 413.63 mg
= 0.414 g
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54) The adult dose of a liquid medication is 0.1 ml/kg of body weight as single dose. How
many teaspoonfuls should be given to a patient weighing 220 lbs?
A) 2 tsp B) 2.5 tsp. C) 2 tbsp. D) 2.5 tbsp. E. 2 tbsp
Ans. A
220 lbs x 1 kg/2.2 lbs = 100 kg
0.1 mL/1 kg = X/100 kg
X = 10 ml or = 2 tsp
55) If the dose of a drug is 0.5mg/kg body weight/day, how many mg will a 35lb infant receive
per 24hours?
A) 7.9 mg
B) 7.1 mg
C) 7.2 mg
D) 7.4 mg
Ans. A
35 lbs x 1 kg/2.2 lbs = 15.9 kg
0.5 mg/ 1 kg = X/15.9 kg
X = 7.9 mg
56) What is the weight of 60 ml of oil whose density is 0.96 g/ml?
A) 5.77 g B) 57.7 g C) 6.0 g D) 0.57 g
Ans. B
V = 60 ml
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D = 0.9624 g/ml
D = M/v
M=DxV
= 0.9624 x 60 = 57.7
57) If a prescription order requires 25 g of concentrated HCI (density 1.18g/ml), what volume
should the pharmacist measure?
A) 29.50 ml B) 0.02 ml C) 23.0 ml D) 21.2 ml
Ans: D
W= 25 g
D= 1.18 g/ml
V= M/ D = 25/1.18 = 21.2 ml
58) A prescription calls for 0.3 g of phosphoric acid with a specific gravity of 1.71. How many
milliliters should be used in compounding the prescription?
A-0.5 B-0.7 C-0.18 D-0.3
Ans: C
D = M/V = g/ ml
V = M/D= 0.3 g
D = 1.71 g/ml
X = 0.18 ml
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59) How many mL of a syrup having a specific gravity of 1.350 should be mixed with 3000 mL
of a syrup having a specific gravity of 1.250 to obtain a product having a specific gravity of
1.310?
A) 3500 mL B) 4500 mL C) 4600 mL D) 5500 mL
Ans. B
1.35 .................... 0.06
1.31
1.25..................... 0.04
0.06/ X = 0.04/3000 ml
X = 4500 ml
60) A patient is determined to have 0.8 mg of glucose in each milliliter of blood. Express the
concentration of glucose in the blood as mg%.
A) 800 mg% B) 0.8 mg% C) 8 mg% D) 80 mg%
Ans:D
0.8 mg/1 ml = X/100 ml
X = 80 mg %
61) How many mL of a 1:400 (w/v) stock solution should be used to make 4 litres of a 1:2000
(w/v) solution?
28
cyPrep.
A) 1000mL B) 200 mL C) 800 mL D)1600mL
Ans. C
1 g/2000 ml = X/4000mL = 2 g
X mL/2g = 400mL/1g
= 800 mL
62) if a patient is determined to have 100 mg % of blood glucose, what is the equivalent con-
centration in terms of mg/dL?
A) 1 mg/dL B) 10 mg/dL C) 40 mg/dL D) 100 mg/dL
Ans: D
1 dL = 100 mL
mg/dL = mg/100 mL
=100 mg/dL
63) Strong Iodine Solution USP contains 5% w/v iodine. How many mg of iodine are con-
sumed daily if the usual dose is 0.3 mL tid.?
A) 15 mg
B) 90 mg
C) 22.5 mg
29
cyPrep.
D) 45 mg
Ans. D
5/100 = X/0.9
X = 0.045 g x 1000
= 45 mg
64) Express in percentage the fluoride concentration in drinking water given in 0.6 ppm.
A) 0.06% B) 0.00006% C) 0.0006% D) 0.006%
Ans. B
0.6 g/1,000,000 = X/100
X = 0.00006%
65) How many grams of dextrose are required to prepare 4 litres of a 5% solution?
A) 0.2g B) 200g C) 2g d) 20 g
Ans. B
(x/4000 mL) = (5 g/100mL)
30
cyPrep.
66) How many grams of petrolatum should be added to 250 g of a 25% sulphur ointment to
make a 5% ointment?
A) 1000 g B) 1250 g C) 500 g D) 100 g
Ans. A
Given: 250 g of 25 %
5 parts/250 g = 20 parts/ X
X = 1000 g
0 20
25 5
or
C1 V 1 = C2 V 2
5% x V 1 = 25% x 250
V 1 = 1250 g
1250 – 250g = 1000 g
67) How many grams of potassium citrate are needed to prepare 1 litre of 10%?
A) 1000 g B) 50 g C) 100 g D) 10 g
Ans. C
(X/1000) = (10/100)
X = 100
31
cyPrep.
68) How many grams of a drug is required to make 120 mL of a 25% solution?
A) 30 g B) 10 g C) 120 g D) 12 g
Ans: A
(X/120) = (25/100)
X = 30 g
69) Calcium Hydroxide Topical Solution contains 170 mg of calcium hydroxide per 100 mL at
15º C. Express this concentration as ratio strength.
A) 1: 688 B) 1: 888 C) 1: 588 D) 1: 788
Ans: C
(170 mg/100 ml) → (0.17 g/100 ml) = 1/ X
X = 588 ≈ 1:588
70) How many mg of isofluorophate are contained in 15 g of a 1: 10,000 ophthalmic solution

of isoflurophate in peanut oil?
A) 1.7 mg B) 1.9 mg C) 1.8 mg D) 1.5 mg
Ans: D
X/15 g = 1 g/10,000 mg
32
cyPrep.
X = 1.5 mg
X = 500
71) A cupric chloride injection (0.4 mg Cu/mL) is used as an additive to IV solution for TPN.
What is the final ratio strength of copper in the TPN solution if 2.5 mL of the injection is
added to enough of the IV solution to prepare 500 mL?
A) 1: 500 B) 1:5000 C) 1: 500,000 D) 1: 50,000
Ans. C
X/ 2.5 ml = 0.4 mg/1 ml 0.001 g/500 ml = 1/ X
X = 1 mg ≈0.001 g X = 500,000
1: 500,000
72) How many millilitres of a 23.5% (w/v) concentrate of Sodium Chloride solution should be
used in preparing 650 mL of a stock solution such that 30 mL diluted to litre will yield a
1:5000 solution?
A) 0.2 mL B) 4.33 mL C) 18.44 mL D) 11.75 mL
Ans: C
X/5000= 1/ 100
X = 0.2 g
0.2 g/ 30 ml = X/650 ml
X = 4.33 g
23.5/100 = 4.33 g/ X
X = 18.44 ml
33
cyPrep.
73) You have a stock solution of 50% Sodium citrate and you were asked to prepare 300 mL of
a 10% solution. How many mL is needed?
A) 20 B) 15 C) 30 D) 60
Ans. D
C 1 V 1 =C 2 V 2
X (50) = 300(10)
X = 60
74) How many millilitres of 1:16 solution of sodium hypochlorite should be used in preparing
5,000 mL of a 5% solution of sodium hypochlorite for irrigation?
A) 800 ml B) 2500 ml C) 4000 ml D) 300 ml
Ans: C
C1 V 1 = C 2 V 2
(X) 6.25% = (5000)(5%)
X = (5% x 5000 mL)/6.25%
X = 4000 ml
75) Prepare 1000 ml of KMnO 4 1:12,000 compresses out of KMnO 4 1: 8,000.
A)Add 333.3 mL water to 1000 mL KMnO 4 1: 8,000
B)Add 666.6 mL water to 333.3 mL KMnO 4 1: 8,000
C) Add 333.3 mL KMnO 4 1: 8,000 and enough water to make final volume 1000 mL
D) Add 333.3 mL water to 666.6 mL KMnO 4 1: 8,000
Ans. D
34
cyPrep.
C1V1 = C2V2
1000 x1/12000 = 1/8000 x V 2
V 2 = 666.6 mL of KmnO 4
1000-666.6 = 333.4 ml
76) How many milliliters of 24% (w/v) concentrate of saline solution should be used in pre-
paring 600 mL of a solution such that 10 mL diluted to a litre will yield a 0.09% solution?
A) 300 ml B)150 ml C) 50 ml D) 225 ml

Ans. D
X/1000=0.09/100
X = 0.9 g
0.9 g/10 ml = X/600 ml X = 54 g
24 /100 = 54/ X
X = 225 ml
77) The only source of Sodium Chloride is in the form of tablets, each containing 5 g. How
many tablets should be used in preparing 3000 litres of a solution of such strength that 20 mL
diluted to 100 mL with water will yield a 0.9% (w/v) solution?
A) 60,000 tablets B) 27,000 tablets C) 12,000 tablets D) 9,000 tablets
Ans. B
X/100 = 0.9/100 X = 0.9 g
0.9 g/20 ml = X /3,000,000 ml X = 135,000 g
135,000 g/5 g = 27,000 tabs
78) Prepare a mixture of progesterone 0.05% in glaxal base. So that the total amount of the
compound is 90 g with glaxal base. The weight of glaxal base should be
a) 90 g b) 89.96g C) 95g D)80.5g
Ans. B
0.05% means 0.5 g in 100 g

?...........90 g
35
cyPrep.
0.05 x (90/100) = 0.04 g of progesterone

90-0.04=89.96 g glaxal base
79) How many ml of 0.9% (w/v) NaCl solution should be prepared from 250 ml of 25% (w/v)
solution?
A) 3750 ml B) 2500 ml C) 6944 ml D) 9 ml
Ans. C
C1 V 1 = C 2 V 2
(X)(0.9)= 250(25)
X = 6944 ml
80) A 40 year old patient who weighs 70 kg, needs intravenous infusion of amoxicillin. The
desired C ss of drug is 15 mg/dL. The physician ordered antibiotic infused for 10 hours. Amoxi-
cillin has t 1/2 = 1 hour and V d = 9L. What rate of iv is recommended for this patient? (no load-
ing dose was given);
A) 135 mg/hr
B) 936 mg/hr
C) 1000 mg/hr
D) 333 mg/hr
E) 400 mg/hr
Ans. B
36
cyPrep.
Tips:
C ss = R/K x V d
R = Rate of infusion
K = first order elimination constant
V d = volume of distribution
R = C ss x k x V d
T 1/2 = 0.693/k
or
k = 0.693/t 1/2
R = 15/100 [(0.693/ 1 hour) x 9000] = 935 mg/hr
37
cyPrep.
81) How many mL of a 1:500 (w/v) stock solution should be used to make 4 liters of 1:2000
(w/v) solution?
A) 50 ml B) 100 ml c) 500 ml d) 1000 ml
Ans. D
Working: 1:500 = 0.2%
4 liters = 4000 mL
1:2000 = 0.05%
(0.2% /0.05%) x (4000 mL/ x mL) = 1000 mL
82) What is the concentration in mg/ml of a solution containing 2 mEq of KCl per milli-
liters: (MW. 74.5 g) K= 39.1
A) 74.5 mg/ml B) 149 mg/ml c) 0.74 mg/ml d) 0.148 mg/ml
Ans. B
M. wt. Of KCl = 74.5 g
1 mEq. of KCl = (1/1000) x 74.5 = 0.0745 g = 74.5 mg
2 mEq. Of KCl= 74.5 mg x 2 = 149 mg/ml
1 mol of KCl = 74.5 g
mmol = 1/1000 mol
1mmol of KCl = 74.5 mg
1mEq of KCl = 74.5 mg
1 micromol = 74.4 mcg
10 mEq of KCl is (74.5 x 10) = 746 mg of KCL
38
cyPrep.
10 mEq of KCl is equal to how many mg of elemental K+?
10 x 39.1 = 391 mg
OR
mg/ml = 2 (mEq/ml) x 74.5 = 149 mg/ml
83) What is the concentration, in mg per milliliter of a solution containing 4 mEq. Of

CaCl 2 .2H 2 O per millilitre. (M.Wt 147) ?
A) 74.5 mg/ml B) 149 mg/ml c) 0.294 mg/ml d) 294 mg/ml
Ans. d
Formula weight of CaCl 2 .2H 2 O = 147
Eq. wt. Of CaCl 2 .2H 2 O = 147/2 = 73.5g
1 mEq. CaCl 2 .2H 2 O = (1/1000)x 73.5 g = 0.0735 g
4 mEq. Of CaCl 2 .2H 2 O = (0.0735 g x 4 )= 0.294 g/ml or 294 mg/ml
OR
by mg/ml = [4 (mEq/ml)x 147]/2 = 294 mg/ml = 0.294 g/ml
84) How many teaspoonfuls would be prescribed in each dose of a drug of fluidounce VI con-
tained 16 dose?
39
cyPrep.
A) 2.25 tsp B) 5 tsp C) 6 tsp D) 10 tsp
Ans. A
6 x 30 = 180 ml
180 ÷ 5 = 36 teaspoonful
36 ÷ 16 = 2.25 ml teaspoonful in each dose
or
We know each teaspoonful equals 1/6 of a fluidounce therefore

= 29.5 ÷ 6 = 4.9 ml. In other words each fluidounce = 6 teaspoonful.
6 x 6 = 36 teaspoonful, and
36 ÷ 16 = 2.25 teaspoonful has to be taken
__________________________________________________________
85) How many drops would be prescribed in each dose of a drug if 15 ml contains 60 doses?
The dispensing dropper calibrates to 32 drops/ml
A) 8 drops per dose
B) 62 drops per dose
C) 15 drops per dose
D) 8 drops per day
E. 15 drops per day
Ans: A
15 ÷ 60 = 0.25 ml, and 0.25 x 32 = 8 drops per dose
86) How many mls of drug is needed to produce if 2 tablespoonfuls twice a day for 8 days
A) 16 ml B) 30 ml C) 60 ml D) 480 ml
40
cyPrep.
Ans. D
2 x 2 x 8 x 15 = 480 ml
__________________________________________________________
87) How many mgs of a drug are needed to prepare 72 doses of 1/12 gr.
A) 16 mg
B) 300 mg
C) 390 mg
D) 5000 mg
Ans: C
Each.
72 x 1 ÷ 12 = 72 ÷ 12 = 6 gr.,
we know each grain is 65 mg therefore,
6 x 65 mg = 390 mg is required
__________________________________________________________
88) If 125 tablets contain 0.05 gram of a drug. How much is contained in each tablet?
A) 0.6 mg B) 0.3 mg C) 0.4 mg D) 0.5 mg
Ans. C
0.05 g x 1000 = 50 mg, if 50/125 = 0.4 mg or 400 microgram

__________________________________________________________
41
cyPrep.
89) Given the following prescription

Codeine phosphate 0.6 g
Ammonium Chloride 6.0 g
Cherry syrup ad. 120 ml
SIG. 1 teaspoonful PRN cough
How much codeine is present in each dose?

A) 200 mg B) 250 mg C) 400 mg D) 500 mg E) 25 mg
Ans: E
0.6 x 5 ÷ 120 = 0.025 g or 25 mg of Codeine

6 x 5 ÷ 120 = 0.25 g or 250 mg of ammonium chloride
__________________________________________________________
90) A doctor writes a prescription:
Codeine PO 4 200 mg
Dimetapp qs 120 ml
Sig. 1 tsp tid and HS
How many mg Codeine received by the patient daily?
A) 20 mg/day B) 33 mg/day C) 40 mg/day D) 50 mg/day
Ans: B
Working. 4 tsp means 4 x 5 = 20 ml/day

if 120 ml contain 200 mg
so daily = 200 x 20/120 = 33 mg/day
91) A patient is currently taking 220 mg of anhydrous Zinc sulphate (MW. 161). To receive the
equivalent amount of elemental Zinc, how many mg of zinc sulphate heptahydrate (MW: 287)
would the patient have to take?
A)287 B) 392 C) 220 D) 161 E) 300
Ans. B
161-------287
42
cyPrep.
220 mg -----?
or
Mol Wt of Zinc = 65
Zinc Sulphate MW = 161
220 /161= 1.36 of Zinc
Zinc heptahydrate MW = 161 + 126 H20 = 287
ZnSO 4 (7H 2 O) ----- Zn2++ So 4 2+ +7H 2 O
1.36 = x /287
= 1.36 x 287 = 392
92) 120 grams of 15% urea cream is needed. We have 20% cream available. How much of the
base needed?
A)90 g base B) 120 g base C) 30 g base D) 20 g base E) 150 g base
Ans. C
(120) (15%) = X (20%)
43
cyPrep.
X= 90 g ointment
120 – 90 = 30 g base
93) What is the relative bioavailability of the drug from the generic tablet compared to the
reference tab?
Drug Products Dose (mg) C max (mcg/ml) T max (hour)

i.v. bolus inj 100
Oral solution 200 21.3 1.2
Generic tablet 200 17.0 2.1
Reference tab 200 16.5 1.9
a) 100% B) 103% C) 70% D) 88% E) 200%
Ans. B
Relative bioavailbility = AUC generic/AUC of reference
17/16.5= 103.9%
Although T max is an indication of rate of drug absorption, T max is a discrete measurement and
usually too variable to use for statistical comparisons in bioequivalent studies. Statistical
comparison used AUC and C max values from test and reference drug products as the basis of
bioequivalence
94) 1 g vancomycin was added to 1 liter 0.9% NS. Calculate the rate of infusion of Vancomy-
cin if the infusion was given for 12 hours.
A) 1.38 ml/min B) 2.5 ml/min C) 1 ml/min D) 0.9/min
Ans. A
1000ml /12hrx60mins/hr = 1000ml/720 = 1.388 ml/min
44
cyPrep.
95) Four family members want to use a Nix cream (Permethrin) volume of 60 ml/person. The
family consists of 2 adults and 2 kids. The volume of mix cream is 60 ml. The amount required
for the family considering all have existing lice.
a) 240 ml b) 180 ml c) 300 ml d) 150 ml E.400 mL
Ans. A
95) Two drugs to be pharmaceutical equivalent, the drugs must:

A) Contain different excipient
B) Contain different salts
C) Same therapeutic moiety
D) Same therapeutic use
E) Different dosage form
Ans. C
96) Only indomethacin 25 mg capsules are available in your pharmacy. How many capsules
are required to obtain the amount of indomethacin required to prepare the following Rx:
Rx
Indomethacin 2 mg/mL
Cherry syrup 150 mL
Sig 5 ml BID
A) 8 B) 10 C) 12 D) 15
Ans: C
Working:
Total indomethacin required = 2 mg/mL x 150 mL = 300 mg
1 capsule contains 25 mg. Therefore, number of caps required = 300/25 =12
97) A patient is receiving D5W/2NS, and you receive an order to add 30 mEq of potassium
chloride to the next 1 L bag of fluids. How much of a 14.9% KCl solution would you need to
use? (molecular weight of KCl = 74.5)
A) 15 ml B) 30 ml C) 45 ml D) 60 ml
Ans: A
mEq = Valence x mg/MW

30 = 1x mg/74.5
mg = 2235 mg
14.9 g........1000 ml
or
45
cyPrep.
14900..........1000 ml
2235 mg.........?
= 150 ml
150/10 = 15 ml
or
7.4 g KCl is equal to 1 mEq
so
14.9 g KCl is equal to 2 mEq
30 mEq x (1 mL/2 mEq) = 15 mL
98) Rx. Ventolin ( Salbutamol) inhaler 100 mg (200 doses)

2 puffs QID prn
Mitt: 3
The above puffers should last:
a) 100 days b) 90 days c) 75 days d) 85 days e) 100 days
Ans. C
200/8 = 25 days each puffer last
25 x 3 = 75 days.
99) Rx
Zithromax susp. 200 mg/5 ml
300 mg x 1 day
150 mg 2-5 days
What will be the total amount?
A) 5 ml
B) 22.5 ml (900 mg)
C) 30 ml
D) 4.5 ml
Ans: B
46
cyPrep.
100) How long would you infuse a phenytoin dose of 20 mg/kg in a 33 lb child at a rate of
0.5 mg/kg/min.
A) 20 min
B) 40 min
C) 60 min
D) 30 min
Ans: B
(33 lb/2.2 lb) x 1 kg = 15 kg x 20 = 300 mg dose
0.5 mg/kg/min x 15 kg = 7.5 mg/min
7.5 mg = 1 min
300 mg x
x = 300mg/ 7.5
= 40 mins
Correct answers 95 is excellent
Over 90 = good job
Less than 90 = need improvement
47
cyPrep.

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A) 8 days B) 7 days C) 6 days D) 5 days E) 4 days

A) 2.4 mls B) 4.6 mls C) 1.3 mls D) 46 mls E) 0.46 mls

Ans: B 1:750 = 0.13% C1 x V 1 = C2 x V 2

0.13V = 0.6 = 4.6 ml

a) 4.32 ml b) 7.57 ml c) 8.64 ml d) 6 ml e) 6.57 ml

a) Isotonic b) Hypertonic c) Hypotonic d) Iso-osmotic e) Isotonicity cannot be finding.

(0.7 x 0.16) = 0.112 g

(0.1 x 0.32) =0.032 g

(1.1) x 0.5) = 0.55 g

0.112 g+0.32 g+ 0.55 g = 0.69 g

Isotonic is 0.9 of NaCl. Therefore it is hypotonic prep.

10 ml-start dose + (5ml/day x 6days) = 10 + 30 = 40 ml

Day1 Day 2 Day 3 Day4 Day5 Day6 Day7

10 ml 5ml 5ml 5ml 5ml 5ml 5ml

Start take 2 tablet and one tablet daily till finish

a) 30 tablets b) 35 tablets c) 36 tablets d) 40 tablets e) 12 tablets

Tips: 8+7+6+5+4+3+2+1 = 36 tab

a) 7 days b) 10 days c) 20 days d) 15 days e) 30 days

“Two inhalers in each nostril (4x2=8) every morning and at bedtime”

2x2 nostril x 2 (morning + night) = 8 doses daily

120 doses ÷ 8 doses daily = 15 days supply

a) 100 mg b) 200 mg c) 300 mg d) 400 mg e) 500 mg

SR = Weight x Error → 15 = weight x 5/100= 300 mg

SR = Weight x Error → SR = 120 mg x(5/100) = 6 mg

Rx: Dopamine 200 mg in 500 ml solution

Final concentration 200 mg-----500 ml

mg to mcg, 200 x 1000 = 200 000 mcg in 500 ml

200, 000 mcg ......…. 500 ml

? ..................... 1 ml = 400 mcg/ml

200 mg/ 500 ml = 0.4 mg/mL

How much drug is administered?

body weight 155/2.2 = 70 kg

5 mcg ........ 1kg

Isotonicity is 0.9 g of NaCl

Calculate the wt of tetracaine →

60 ml x 0.01 (because is 1%) = 0.6g = 600 mg

600 mg x 0.18 = 108 mg of NaCl.

wt of boric 60 ml x 0.005 = 0.3 g = 300 mg

boric acid 300 mg x 0.5 = 150 mg

108 mg + 150 mg = 258 mg for 60 ml

540 - 258 = 282 mg of NaCl

a) 6 ml b) 60 ml c) 120 ml d) 180 ml e) 200 ml

Liquid morphine comes in 30 mg/5 ml so 6 ml is needed daily

20 days supply, 20 x 6 ml = 120 ml

A) 0.50mL B) 0.25mL C) 0.10mL D-0.75mL E-250mL

5000 x 10/200,000 = 0.25 ml

High alcohol 473 x 22

mmol = Dose in mg/ Molecular weight

potassium 40 mEq/L = 40 mmol/L

(1g x 100 mL)/2 g = 50 mL

9.09 kg x 20 mg/kg/day = 181.82 mg/day = 3.03 ml = 3 ml

B) Slope of –K/t 1/2

A) 15 ml/hr B) 42 ml/hr C) 45 ml/hr D) 60 ml/hr E) 75 ml/h

1000 mL/24 hr = 41.6 mL/hr

IV flow rate (gtt/min)=[volume (mL)/time (min)]x drop factor (gtt/ml)

A) 300 mg B) 400 mg C) 600 mg D) 1200 mg E) 1500 mg

5 day x 12 tab/day = 60 tab