MADE IN FRANCE

BREAKTHROUGH MICROBIOME-BASED SOLUTIONS

TargEDys
FROM PROBIOTICS TO PRECIBIOMICS
OUR FOCUS
Breakthrough microbiome-based solutions
« The human microbiome Recent studies have To utilize and optimize this
in its diversity will be the described the key role of potential, TargEDys
Amazon rainforest of the the microbiome in health, concentrates its efforts on
21st century and will be the and its potential to face research and development
supplier of new active global health issues such as of breakthrough microbiome-
molecules produced by overweight, undernutrition, based technologies and
bacteria. » stress and anxiety. products.

OUR ORIGIN
Rooted in science
3
technology
platforms, delivering
FRENCH both therapeutic and
nutraceutical solutions IP :
BIOTECH Stemming from 6 PATENT
based in Paris & families
more than
Rouen, Normandy

15 YEARS
of research
coming from Inserm /
University-hospital of
2
scientific founders
experts in their field:
Rouen collaboration.
Pr. Pierre Déchelotte &
Pr. Serguei Fetissov

OUR KNOW-HOW
Precibiomic strains
Patrick Veiga, in Nature in 2021(1), describes TargEDys
technologies as examples of "precision probiotics".
The term PreciBiomic is then born, from "precision" and
"microbiome". The particularity of PreciBiomic Strains:
• A detailed mechanism of action at the molecular level PreciBiomic
Strain
• Proofs of efficacy in-vivo
These two characteristics make PreciBiomic Strains unique
solutions in the world of probiotics.
(1) Veiga, P., Suez, J., Derrien, M. et al. Moving from probiotics to precision probiotics. Nat Microbiol 5, 878–880 (2020).
https://doi.org/10.1038/s41564-020-0721-1

Property of TargEDys SA - Documentation intended for healthcare professionals only

1. REGULATE THE APPETITE WITH HAFNIA ALVEI HA4597®
Molecular
mimetism
MECHANISM OF ACTION a-MSH
Molecular mimetism of ClpB
Satiety
hormone

a satiety hormone by HAFIA

Protein

a bacterial protein ALVEI

HA4597®
Bacteria
Sergueï O. Fetissov Satiety

Nature Reviews Endocrinology (2016)

ClpB

PROOF OF EFFICACY
In-vivo PRIMARY 2
ENDPOINT SECONDARY
Pre-clinical proofs of efficacy: ENDPOINT
1
Legrand R. et al.
International Journal of Obesity (2020)
Weight Loss
Lucas N. et al. Decrease Increased
Microorganisms (2020) in hip fullness
circumference
3
Clinical proof of efficacy – pharmaceutical
OTHERS
standard: OBSERVATIONS
Déchelotte P. et al.
Nutrients (2021) Results: Improvements
• Multicentric, randomized double-blind placebo- of weight loss, appetite
Decrease in total Decrease
controlled clinical trial on 236 overweight Cholesterol and Glycemia
regulation, glucose,
subjects subjected to a hypocaloric diet and LDL cholesterol and overall
taking either Hafnia alvei HA4597® or a placebo satisfaction were
Overall
for 3 months. benefit
significantly stronger
assessment in the probiotic group
than in the placebo.

ENTEROSATYS®
The clinically proven microbiome-based
solution to regulate the appetite

Property of TargEDys SA - Documentation intended for healthcare professionals only

 2. NUTRITION OPTIMISATION WITH
LACTIPLANTIBACILLUS PLANTARUM WJL
L. plantarum WJL Enterocytes IGF1
production & Growth
Hormone stimulation
Cell wall
Increased peptidase
MECHANISM OF
compound sensing
production

ACTION retio
n Amino

IGF-1 growth hormone Proteins

Sec acids
Increased
anabolism
Bone
growth
production by a stimulation
of peptidase expression and Protein
Amino
acids Amino acids absorption

amino-acids absorption cleavage into

amino acids and
dipeptides
Promote weight
gain & length gain

PROOF OF EFFICACY
In-vivo
Pre-clinical proofs of efficacy:

Erkosar et al.
Cell Host and Microbe 2015

Schwarzer et al
Science 2016

Matos et al.
Nature Microbiology 2017

CRESCYLIA®
The microbiome based solution
to promote growth for children

3. STRESS AND ANXIETY MANAGEMENT THROUGH

THE SYNERGY OF PRECIBIOMIC STRAINS®
Molecular
mimetism
Oxytocin
MECHANISM OF ACTION Hormone of
attachment

Molecular mimicry of oxytocin Postbiotic

Protein
by bacterial protein PreciBiomic
strains

Bacteria
PROOF OF EFFICACY
Ongoing preclinical studies Stress &
on animals Anxiety

TargEDys SA: Parc Nativelle, Bâtiment 4bis

MD053-V1

1 chemin de Saulxier, 91160 Longjumeau - France

contact@targedys.com • nvinot@targedys.com
www.targedys.com
Property of TargEDys SA - Documentation intended for healthcare professionals only