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Metodología Síntesis Sales Derivadas de Guanosina
Metodología Síntesis Sales Derivadas de Guanosina
Step 1
3. Add 25% ammonia solution in water dropwise to the mixture till pH value of the reaction
mixture reaches value 7.
4. Add acetone (250 mL) to the mixture continuously additional portions of 25% ammonia
solution in water dropwise to the mixture till pH value of the mixture stabilizes at value
7.
8. Dry the mixture overnight over P4O10 in a vacuum to obtain the product.
Scale gram
1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 7.49 - 7.45 (m, 2H), 7.42 - 7.33 (m, 3H), 6.98 (s, 2H),
5.83 (d, J = 4.1 Hz, 1H), 5.67 (s, 1H), 5.70 - 5.59 (m, 2H), 5.30 (s, 1H), 5.28 (s, 1H), 4.45
(t, J = 4.6, 4.1 Hz, 1H), 4.13 (t, J = 5.0, 4.6 Hz, 1H), 3.99 (q, J = 5.0, 3.3 Hz, 1H), 3.71 (dd,
J = 12.2, 3.3 Hz, 1H), 3.59 (dd, J = 12.2, 3.3 Hz, 1H)
HRMS ESI (+) calculated m/z for C17H20N5O5+ [M + H]+ 374.14590, found 374.14582
RT 9.0 min
State white solid
CAS Method Number 3-614-CAS-4645439
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John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Syntheses Inc. Reproduced
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