Department of Pharmacy, Comilla University

Things we need
to know about
Pyridazine
Presented By Benzene Research Centre
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ID No: 11715016

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(1) What is Pyridazine?

Pyridazine is a heterocyclic organic compound with

the molecular formula (CH)4N2. It contains a six-
membered ring with two adjacent nitrogen atoms
and is aromatic.
Pyridazines are heterocyclic compounds with an N-
N bond in their ring structure. that are structurally
important in several biologically active substances
with a broad range of biological and
pharmaceutical activities.
Atomic Image of Pyridazine

Exact Mass: 80.037448136

Systematic IUPAC name: 1,2-Diazabenzene
Other names:
1,2-Diazine
Orthodiazine
Oizine
Melting point: −8 °C
Boiling point: 208 °C
 Synthesis of
Pyridazine
Historically, pyridazines were first named by Knorr
, while Fischer
prepared the first substituted compounds but Tauber was
the first to synthesize the
unsubstituted pyridazine.
Synthesis: The strategy adopted in the synthesis is the reaction of
hydrazine with the 1,4-diketone to give dihydropyridine. Oxidation of
the dihydropyridine then gives the pyridazine. Carrying out oxidation at
this point avoids a cis double bond problem.
 Pyridazine Synthesis Reaction

Hydrazine 1,4- diketone

Mechanism of Action
Other Synthesis Reactions
Reactions of Pyridazine

Reactions of Pyridazine

 Pharmaceutical Applications
Pyridazine Drugs

Anticancer Drugs Antihistamine Drugs Antiarryhthmic Drugs

Vatalanib Azelastine Hydralazine
Olaparib Cilazapril
Talazoparib
Taladegib
 Non- Pharmaceutical
Applications
Pyridazine Drugs

Pyridafol 3- aminopyridazine Credazine

Fungicide Agents Herbicide Agents

3- aminopyridazine Credazine
Pyridafol
Pyridate
 Pyridazine Drugs

Here are some most used pyridazine

drugs' structures.

Azelastine
Olaparib
A histamine H1-receptor
A pyridazine anticancer antagonist used intranasally
drugs to treat allergic and
vasomotor rhinitis
Hydralazine
An antihypertensive agent
used for the management of
essential hypertension
How does pyridazine
work against cancer?
Pyridazine derivatives like pyridopyridazine inhibit the scar
cell proliferation. The cancer cells have their own system of
cell reproduction, it's quist different from healthy cells. So,
Pyridaizine inhibit the signals which is associated with
cancer cell proliferation. Thus, pyridazine works.
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