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Salazar-M. BALANI (Final)
Salazar-M. BALANI (Final)
Salazar-M. BALANI (Final)
Cellular Reproduction
Compare mitosis and meiosis, and their role in the cell division cycle.
(S8LT-IVd-16)
Marilou C. Salazar
Teacher III
Bislig City National High School
Cellular Reproduction
Compare mitosis and meiosis, and their role in the cell division cycle
(MELC Week 2 S8LT-IVd-16)
Unpacked Competencies:
1. Describe the cell cycle;
2. Explain mitosis and meiosis; and
3. Compare mitosis and meiosis, and their role in the cell division
cycle.
This instructional material was collaboratively developed and reviewed by educators from
the Department of Education - Bislig City Division. We encourage teachers and other
stakeholders to email their feedback, comments, and recommendations at
bcdlrmds@gmail.com. We value your feedback and recommendations.
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Cellular Reproduction
Compare mitosis and meiosis, and their role in the cell division
cycle. (S8LT-IVd-16)
First Edition,2021
Republic Act 8293, Section 176 indicates that: No copyright shall subsist in any work of the
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Borrowed materials (i.e., stories, selections, poems, songs, pictures, photos, brand names,
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over them.
Preface
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This contextualized learning material is developed in support of the K to 12
Science Curriculum. It is designed as an intervention material of the least-learned
competency to help students enrich their learning experiences by answering activities
that are meaningful to their lives which can be done by themselves or with minimal
assistance from the teacher. A variety of tasks deemed suitable for students are provided
to deepen students’ knowledge and skills.
This Learning Material contains Activities, Rubrics, References, and Answer Keys.
It follows the 7E Instructional Model – Elicit, Engage, Explore, Explain, Elaborate Evaluate,
and Extend which was developed by Lawson in 1995 and narrated by Kanli in 2007, and is
adapted by the science curriculum. Activities are provided in each model as a formative
assessment to check from time-to-time students’ understanding of the lesson. Apart
from identifying and describing, this Learning Material also provides activities that would
allow the students to give insights and personal responses and explore the meanings of
science words. Given the range of learning activities in this package, teachers are
encouraged to freely adapt them to suit their school contexts and students’ needs,
interests, and abilities. The readings found in the References are limited so the teacher is
advised to look for more supplemental readings. The answer key pages may be separated
from the material during the actual implementation of the lesson.
In answer to localization, most of the photos used were taken from Bislig City and
were personally photographed by the authors. Most Illustrations were drawn by local
illustrators and those taken from the internet were properly cited.
The suggested time in the implementation of the Learning Material follows the
regular schedule of the class however, teachers should use their professional judgment
to gauge appropriate timings with a particular group of learners in mind.
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It’s My Day!
Directions: Observe the pictures below on how living things reproduce. Answer
the guide questions that follow and write your answer on a separate
sheet of paper.
Spores Eggs
Guide questions:
1. What is reproduction?
2. Why is reproduction important to living things?
Activity 1. Follow Me
Directions:
A. Choose the correct sequence of the stages of mitosis as shown in the
A B C D
Illustrated by: Rosa Mia L. Pontillo
A.) A B C D C.) C A D B
B.) D B A C D.) B C D A
B. Identify the stages of mitosis shown in each diagram below. Choose the
letter of the correct answer inside the box and write it on a separate
sheet of paper.
A. Anaphase C. Metaphase
B. Prophase D. Telophase
1. 2. 3. 4.
Activity
Column2.A Much Me Up Column B
Stages 2 Cellular Activities
Directions: Match the stages in Column A with their cellular activities in
1. Interphase A. Synapsis occurs.
Column B. Write the letter of your answers on a separate sheet
B. Two nuclear membrane dissolves and nucleolus
of paper.
2. Synthesis disappears.
3. Prophase I C. Chromatids move to opposite poles.
4. Metaphase I D. Homologous chromosomes separate.
5. Anaphase I E. The cell merely grows.
6. Telophase I F. Daughter cells divide forming four haploid cells.
7. Prophase II G. Two daughter cells are created.
8. Metaphase II H. DNA replication occurs.
9. Anaphase II I. Spindle fibers attach to chromatids at the kinetochores.
10. Telophase II J. Spindle fibers attach to tetrads through their kinetochores.
Activity 3. Observing Mitosis
Directions: Identify and differentiate the stages of mitosis in animal cells. Write
your answers on a separate sheet of paper.
Materials:
illustrations of the different stages of mitosis in animal cells
pencil and eraser
bond paper
crayons
Procedure:
1. Examine and observe the illustrations of the different stages of mitosis.
Based on your observations, identify, and draw from each illustration the
following: prophase, metaphase, anaphase, and telophase.
Figure 2 shows the cell in the interphase period. The interphase is divided into
three sub-stages, namely:
Cell Division
The cell division phase happens every after interphase. In eukaryotic
cells, these types of cell division occur, mitosis and meiosis.
1. Mitosis
Mitosis is a cellular process wherein two nuclei and two cells are
produced due to the division of the original nucleus, each of which contains the
same chromosome number as the parent cell. Mitosis is divided into four stages
namely: prophase, metaphase, anaphase, and telophase. Figure 3 shows the
different stages of mitosis.
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Metaphase Stage
Chromosomes align at the equatorial plane.
Each spindle fiber from both centrosomes connects to each
chromosome through its kinetochore.
Anaphase Stage
Spindle fibers begin to contract and become shorter. The continued
contraction causes the separation of the genetically identical sister
chromatids.
Centromeres divide.
The single chromatids move towards the opposite poles.
Telophase Stage
The chromosomes are now at the opposing poles of the spindle.
The microtubules disappear.
Two sets of chromosomes are surrounded by new nuclear
membranes, completing the nuclear division process known as
karyokinesis.
Cytoplasmic division called cytokinesis occurs concurrently,
splitting the cell into two.
In telophase, the cell plate continues to grow and attaches to the cell membrane.
This results in the formation of two6daughter cells. Each cell is bounded by a cell
membrane. New cell walls form between the two cell membranes at the area
where the cell plate was formed earlier.
How are sex cells, the sperms, and eggs, formed? Another form of cell
division known as meiosis produces sex cells. In meiosis, the nucleus will
undergo two divisions: Meiosis I and Meiosis II. The cell divides twice in these
processes.
All human somatic cells have forty-six chromosomes. When human cells
reproduce through mitosis, each new cell will also have forty-six chromosomes.
But in reproductive cells or gametes, each of these cells produced has only
twenty-three chromosomes. Thus, meiosis decreases the chromosome number
by half.
Why must meiosis take place to produce sperm and egg?
When a sperm unites with an egg, each of them contributes only one-half
of the total number of chromosomes (twenty-three chromosomes) to the new
zygote which is diploid in the number of chromosomes (forty-six chromosomes).
Meiosis creates cells that are destined to become gametes (or reproductive cells),
this reduction in chromosome number is critical — without it, the union of two
gametes during fertilization would result in offspring with twice the normal
number of chromosomes.
Thus, in humans, a new life originates with the normal diploid number
(2N) of forty-six chromosomes. Then the zygote undergoes the process of mitosis,
producing cells with forty-six chromosomes each.
Meiosis involves two divisions, Meiosis I and Meiosis II. Each follows
similar stages as mitosis (prophase, metaphase, anaphase, and telophase).
Before meiosis, the reproductive cell is in the interphase stage whereby DNA
replicates to produce chromosomes having two sister chromatids. Then, the cell
will undergo a second growth phase called interkinesis. This stage happens
between Meiosis I and II, however, DNA does not replicate in this stage.
Meiosis I. 7
The first meiotic division, also known as Meiosis I, is a reduction division
phase (diploid - haploid). There are two daughter cells produced after Meiosis 1,
each daughter cell is carrying a haploid number of chromosomes. This consists
of four stages, namely, prophase I, metaphase I, anaphase I, and telophase I.
Prophase I Stage
Meiosis starts
with this stage and
includes the following
substages: leptotene,
zygotene, pachytene,
diplotene, and diaki-
nesis. Figure 6
shows the different
sub-stages of
prophase I.
Substage 2: Zygotene
The homologous chromosomes start to pair off through the
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the process known as synapsis. Pairs of chromosomes that are similar in
size and shape are called homologous chromosomes or tetrads.
Substage 3: Pachytene
The repeated coiling of chromosomes occurs resulting to its
contraction and thickening making the homologous pair of
chromosomes to be very close to each other. At this stage, the process
called crossing over happens. Here, the exchange of segments
between the sister chromatids of the homologous chromosomes
occurs. The exchanging process form a cross-linkage called a chiasma. After
crossing over, the sister chromatids of each chromosome may
not be identical with each other based on the genetic material they
contain. Crossing-over is a complicated process that results in genetic
variability.
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Substage 5: Diakinesis
This is the last stage of meiosis prophase 1. Diakinesis stage is
characterized by chiasmata terminalization. After diakinesis, the
dividing cell enters metaphase.
At this stage, bivalents, or homologous pair chromosomes
distribute them evenly in the nucleus. The nuclear membrane breaks
down and the nucleolus disappears. Chiasma moves towards the end,
which is called terminalization. Chromatids remain attached only at the
terminal chiasmata and enter the metaphase stage.
Metaphase I Stage
Spindle fibers from the centrosomes of each pole connect to bivalents or
tetrads through the kinetochores. Homologous chromosomes line up at
the equatorial plane. There is a double alignment of the chromosomes.
Anaphase I Stage
Spindle fibers begin to contract and separate the bivalent or tetrads.
Homologous chromosomes separate and migrate to each pole of the cell.
Telophase I Stage
Chromosomes decondense.
Nuclear membranes reform.
Cytokinesis or the cytoplasmic division occurs and two haploid (N)
daughter cells with chromosomes with two sister chromatids are formed.
Meiosis II.
The second meiotic division forms four daughter cells, each carrying a
haploid number of chromosomes. This consists of the following stages, namely:
prophase II, metaphase II, Anaphase II, and telophase II.
Prophase II Stage
Chromosomes (chromatids) condense to form metaphase chromosomes.
Nuclear membrane dissolves and the nucleolus disappears.
Centrosomes move towards each pole of the cell.
Metaphase II Stage
Spindle fibers attach to chromatids at the kinetochores.
Chromosomes line up at the equatorial plane. (Single alignment of
chromosomes).
Anaphase II Stage
Spindle fibers shortened and separated the sister chromatids.
Chromatids that are now called chromosomes move towards each pole of
the cell.
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Telophase II Stage
Single-stranded chromosomes decondense.
Nuclear membrane and nucleolus reforms.
Cytoplasm divides (cytokinesis).
Four haploid (N) daughter cells are formed.
Figure 8 shows the stages in Meiosis I and Meiosis II. In meiosis I, the
two homologous chromosomes separate which results in two haploid (N)
daughter cells with chromosomes with two chromatids each. In meiosis II, four
haploid (N) daughter cells are formed. Each cell is carrying a haploid number of
chromosomes.
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Activity 4. Comparing Mitosis and Meiosis
Directions: Identify whether each phrase describes the characteristics and roles
of mitosis, meiosis, or both. Write your answers on a separate sheet
of paper.
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Directions: Choose the letter of the correct answer. Write your answers on a
separate sheet of paper.
1. Which description about cellular interphase is FALSE?
A. The cell is growing.
B. The cell is dividing.
C. The chromosome replicates itself.
D. The chromosome produces a precise copy of itself.
2. Which phase of the cell cycle does the synthesis of protein and RNA occur?
A. G1 phase C. S phase
B. G2 phase D. M phase
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13. If the zygotene substage in prophase I is absent, what cellular activity will
not take place?
A. synapsis C. replication of DNA
B. cytokinesis D. pulling apart of chromosomes
14. In what stage of meiosis II wherein four haploid (N) daughter cells are
formed?
A. anaphase II C. prophase II
B. metaphase II D. telophase II
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Activity 7. Arrange Me Up
Directions: Arrange the illustrations showing the stages of meiosis by writing
numbers from 1 to 8 beside each letter. Write your answers on a
separate sheet of paper.
t appropriate actions can we
A. _____
E. _____
B. _____ F. _____
C. _____ G. _____
D. _____ H. _____
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ANSWER KEY
Elicit Engage: Engage:
Activity 1 Activity 2
1. Reproduction – is a
process by which organisms A. B 1. E 6. G
produce its own kind. B. 1. A 4. B 2. H 7. B
2. It enables and ensures the 2. C 3. A 8. I
continuity of life on earth. 3. D 4. J 9. C
5. D 10. F
Explore: Activity 3
1. 2.
Centriol
e
Prophase Metaphase
3. 4.
Elaborate: Elaborate:
Activity 4 Activity 5
1. Mitosis 9. Meiosis 1. B
2. Mitosis 10. Meiosis 2. F
3. Mitosis 11. Mitosis 3. H
4. Meiosis 12. Mitosis 4. A
5. Meiosis 13. Meiosis 5. E
6. Meiosis 14. Both 6. G
7. Meiosis 15. Mitosis 7. D
8. Mitosis 8. C
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Elaborate: Evaluate: Extend:
Activity 6 1. B 11. C Activity 7
1. Nucleus 9. Forty-six 2. A 12. B
A. 1
2. Cell plate 10. Synthesis 3. D 13. A
B. 7
3. Interphase 4. D 14. D
C. 3
4. Haploid 5. A 15. D
D. 6
5. Diploid 6. C
E. 2
6. Cytokinesis 7. B
F. 4
7. Centriole 8. A
G. 5
REFERENCE
19 PAGE
Books:
Pia C. Campo, Science Learner’s Module Philippines: Abiva Publishing House,
Inc., 1997, 320 – 327.
Zonia M. Gerona, Science and Technology SEDP Quezon City: Abiva Publishing
House, Inc., 1997, 73 – 82.
Website:
“Life Birth Foal Horse,” Pixabay, accessed date August 12, 2021, https://
pixabay. com/images /search/reproduction/?pagi=2&
“Spring Seeds Sprout,” Pixabay, accessed date August 12, 2020,https://pixabay.
com/photos/spring-seeds-sprout-garden-soil-3424708/
“Plant Fern Macro,” Pixabay, accessed date August 12, 2021, https:// pixabay.
com/photos/plant- fern-macro-spore-1853731/
“Chick Egg Hatched,” Pixabay, accessed date August 12, 2021, https:// pixabay.
com/photos/chick-egg-hatched-eggs hell-chicken-1280732/
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