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    Med News+6 2017

    Uploaded by

    SopioGokadze

    Copyright:

    © All Rights Reserved
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    ISSN 1512-0112 TBILISI-NEW YORK GEORGIAN MEDICAL NEWS No 6 (267) Hom 2017 PSDSHOBILOL LIBILOGOEN LOS6FLIEO MEAUUNHCKME HOBOCTUTPY3MN sarin nomen rat Batipavon Bt. OMTHMABALIHA MATHOCTHH TIPH CHHIPOME ILIEBPAILHOTO BBITIOTA HESICHOM STHOLIOTHH. ‘Vashakidze N Mebonia N. Keresedze M.,Zhlzhilashyi FACTORS AFFECTING SURVIVAL OF WOMEN DIAGNOSED WITH BREAST CANCER IN GEORGIA. Wollina U, Hansel G, Zschuppe By Teherney G. PEMETREXED-INDUCED PSEUDOCELLULITIS — A RARE CUTANEOUS ADVERSE. REACTION 10 MULTI-TARGETED ANTIFOLATE THERAPY. Kynewon A.B. BAPHABEBHOCTS PHTMA CEPAUA ¥ JETEI C AHOMAJIBHO PACTIOMORXEHHEIMH XOP/IAMH B JIEBOM 2KEJIYIIONKE CEPAIUA. Chkhalze 1, Kapanadze N. (CYTOKINES AS THE PREDICTORS OF SEVERE MYCOPLASMA PNEUMONIAE PNEUMONIA IN CHILDREN (REVIEW). 3yfapeno A.B. Kouetien A.K., Kpasseuo T3O., Kosa J.HL, Type EA. (OCOBEAHOCTH BHEKOMIBHHTHOM IIHEBMOHMM Y AETEMI C HEBPONOTHYECKOA ATOIOTHER, ‘TkemaladzeT,, Molikishvil G., Kherkheulidze V, Melikishvill A, DavitaiaT. EXPANDED PHENOTYPE OF TMEM67 GENE MUTATION (CASE REPORT), Beneamer BB. POVTb TEKOMMPECCHH IIMINEBAPHTENISHOTO TPAKTA Y BOVIbHEIX ‘OCTPOM HENPOXONMMOCTHIO TOHKOM KMUKH, OLUABKH, (OCTOXHEHIA H UX IPEIYTIPERAERME. Muramse XK, JeaopGenaase TA. Anant M2 TATOMOPOO/IOT HYECKME H3MEHEHIGI IPH JIATEHTHOM MACTOMUTE, ‘Vasylyev D. Chernobay L., Vasyleva O., Olinyk M., Vashuk M. CLINICAL AND GENETIC PECULIARITIES OF VASCULAR MANIFESTATIONS. OF ANTIPHOSPHOLIPID SYNDROME (CASE REPORT) Gokadze &, Barbakadze V., Mulkijanyan K., Bakuridze A, Bakuridze FORMULATION AND TECHNOLOGY DEVELOPMENT OF HERBAL PHENOLIC BIOPOLYMER-CONTAINING FILMS FOR BURN TREATMENT, 16 39 9s 103 m na 19 gsonawn maoican News Nesey 3017 regabeges shogol docog6 ba. seob. Ugeaiegas%) Aobyyboliygeeday $29 ITGB3--o693¢060) p96al 1983669 JSorighimal Bygagngaeb so IB gobggotol Byeromnorgdob sestiegggabora6 stergodgiysea MTRR ggbol dadertngnaiyen Bgoegeeab. Bods Goal grsby, go8qgosee oes Golly golem. Fgos asimdderbo. eriergmo wenoBGMbgog> seo oberg peatoe BeVagqeyLo Ione IBghn FORMULATION AND TECHNOLOGY DE} BIOPOLYMER-CONTAINING FI ryisdos odgegge lageghsabsngol LsP%Bn ol ob gocnrgaegbgbals ogme®. sqaeegbob, sefhae SqooRGmns_ GhrgegBob beeobbob gsyBxeBghgBol WwBgemegish sggneigak Inge gadersbomnos seals Ge Ogle hg se Spagna geben ontesBberyoneos aingamant fopatgiod sygrmaanend thbtas abs sl > Mera Rn nde PORVE ABD endo seo BIRO IRL AGyEOnl HATE gM. VELOPMENT OF HERBAL PHENOLIC ILMS FOR BURN TREATMENT Gokadze S., Barbakadze :, Mulkijanyan K., Bakurldze A, Bakuridze L, isi State Medi The development of rational remedies for burn healings considered as one of the problems of dermalal- ‘ogy and pharmacy. In particu, protection of the burned sree asthe main task, proved tobe necessary for effec tive fighting against shock, los of plasma and preventing secondary infection The modem remedies, used curently for bara troatmont are not effective enough, deta inbility to main tain the drug concentration on the afeciod surfice, short contact timo and long-term treatment (1). Applicaton of plytolims based on biosolublepolymers is considered as ‘2 prospectivemethod for burn treatment] bal remedies contain biologically active substances, that re relatively Tess toxic, donot cause skin Imation or allergic reactions and, importantly afeetstrins ‘ofthe microorganisms and viruses resistant to antibiotics and synthetic drugs [11] Nowadays, the advantages are given such bum ‘eating drugs, which along with igh specific efleay, have analgesic, an-inflammalory and antimicrobial effects, and don’trtte the tissues. The mentioned peculiarities University, Georgia poly[3-3,-dihydroxyphenyl) glycerie acid](PDGA) 5.69,10,solaed from the roots and stems of diferent comiey species The aim of the study was the development of tho formulation and technology of biaoluble films far burn treatment onthe basis ofPDGA, “Materials and methods Sever film-forming ‘ytheticandnatural polymers such a: sodumcarboxymet y/eelulosetNaCMC), gelatin, polyviylpymolidone!PVP), Sodium alginate, polyvinyl spirit (PVS) and ethylene vinyl acetato(EVA), Wereised forthe development of the phytofln, ‘The study was conducted using biopharmacetical snd technological methods [2.38]. Six sample films for the treatment of burs with dierent composition (Table 1) were formulated forthe selection of most suitable one. Sample ile-formers were prepared in diferent ways. Sample 1: 3.5 g of sodium carboxy methyleel- lose (Na-CMC) was weighed onthe analytical scales mixed With 40m of distiled water, ested upto SS45°C, and left for 30 min for swelling; the remaining amount of cold arses fora new etal phenolic boplyne : Table 1. Composion of Semple Fim Composition of Sas Fims G2) ] roca | xecuc | N88 |geutin |evs|eve | eva |ctiorsorm | water | ciyeerot = - — a > fas a 5 [Ho [3s | : fae = [we | 3s] af a a as = wo | 25 19 econ nomseyrraay oe “Nietaaia] Fim cn averagemas | Thicknen dextran former | Composition ami ame, | comp On| Mam | PH | Humaine | deren | integrity | | dixie a=] + it 1 | MecMcnas | osaoo2 | 62] ssisn2s | sozsaor | Gbewol28 | jen Water—85.0 _ | r PDGA- 100 | Tf 2] Seems fo 7 i | cams) seam sois012 | ozasioos L water 85.0 I | 1 Pca 100 1 frat romecce saesois | oaissoon es 850, | PGA 100 fees P| sas | + | cheectzs | 1752000 | orsioon | 64 | szsou | aransom | Snares Pea t00 WP _3s s 7 rrasoom | oso | 6s | sssio4s | stsnen _sner ad Poca- ino 1 | | =a ‘ oes, | sesnoos | ornsoon | s0 seseions | Chiowiom 850 ! | J Water was added and mixed until an uniform soation was obtained. Then the solution wat processed in accordance with general scheme, Sample 2: 3.5 g of sodium alginate was weighed ‘on the analytical scales, mixed with cold distilled water and lef for 3 hours for swelling, After awhile, solution ‘as heated on the water bath, nixed with the resdvel ater, and mixture was thoroughly sired until a uniform solution was obtained: Then the solution was processed ‘naccordance with general scheme, Sample 3: 3.5 g of gelatin was weighed on the analytic sate, mixed with 40 eal of eold distilled water {and lef for 40 minutes for swelling. tera wile, soltion ‘washes on the waterbath mixed withthe residual water, afer which mixture was thoroughly sired until uniform Solation was obiined-Then the solution was processed in accordance with general scheme, Sample 4: 35 g of polyvinyl spirit (PVS) was weighed onthe analytic seals, mixed with 40 ml ofcald Aistiled water and the solution was heated the water bath adding th residual water, afler which mixture was thoroughly sired until a uniform solution was obtained Then the solution was processed in accordance with ‘general scheme. 120 ‘Semple :3.5 gofpolyvinylgyroldone (PVP) was weighed up on the snaytc sales, mixed with 40 ml of cold

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