Ne 4,.2013' IIbKIIMNIIESIND NS 820608960 JIR0G069 Experimental & Clinical MEDICINE kcnepumenmanouaa u KuUHUYeCKaAa MEJMWHHA Abstracts of articles are published in “Georgian Ref, Journal” (www.tech.caucasus.net)¥I66I30 CONTENTS COMEPKAHNE BDORIS, B.N6B0GSdI. R.6II6I0 93080, ©. IRON VOGHEBLOL 362d3L M3990 JIGGIGOL 3963009GI30b SLISTEBS SUIdMIHNBO LSHBISTGHS JMOL 339LIGOSTO OKROPIRIDZE T,, PIRTSKHALAVA M., KAPANADZE R,, MOTSONELIDZE N. EXPERIMENTAL USAGE OF PLASMATIC IRRADIATION FOR OSTEOGENESIS STIMULATION ‘H.C TIABIIMALLIBHIIN, B.A.KUTIHAHH, T-TIETP HALIBUT, MLILTOIYPHIBE. HAHA B.KHITHAHH, HLTAMKPBSIMIBE- — a 3MEHEHIA PEC HOHAPHOT 0 KPOBOOBPALLIEHH(A H MHKPOTEMOLMPKSULALAM TPH BOCTIAJIEHHH Y KHBOTHBIX C KAPLIMHOMOI BPOYHA-TIHPC IL. DSSROS, 6.6, 23SBOBIIS, ©. %, 3006030360 B3L0b VOILOTEIMO LSOSEIZON BIICGIIILD GsOSOLO LS 8I3I9IEO8 0600 GMO B.38Ib3AI, 6. RISIOEISI, B.IOCIOII. 3.933L03. 2. 800680130360, 8.198030 930220, W.PIWILOSED. 3.33 VOS60dI IGMEDIIE GdVBOLOY ISHS - 8dIC03I3IZO VS adM0 WsaLasOv BoId0 4N3MGOLBON0 bOIGOS EBIEKORSISORD » 27 S8N80LI30560 LORLOSEIIOL IBONIBONLMBOS LS IML MBNIHD BITGOGIZ0 16 GONGADZEN, KEZELIT, MIRSIASHVILI M, MAKHARADZE T,, ABULASHVILID., GOGOLAURI M. ‘THERAPEUTIC TARGETS FOR PREVENTIONAND TREATMENT ‘THE PROGRESSION OF DILATED CARDIOMIOPATHY E.I60IR33, IRIEL, IITIKISI, IISIHIGOS, 3.830 20360 ~ 36G03SIGIGIILO VIIGIMHIL WITISLIBIBOL 3DISSMSMIVOIISMOV IONIVOGLMOS LI IGE BOLIIGOSOY B%I30 D-IDBICOII. I.MbSd3dI, 6.63900 05IE6 09. 3.8363b83IS00, 0.8080? 5d, L.BOISdd - IMLIMGIGOILO 36IIGOS. E.6IVDCSIGOdI. O.4TI3 I60II. 6.896349. 6 PILSIIOLD, O. GSD. S.I6DSIIORD - BWOVMESLOL B5HN8S BIHIIGIOIL LIGIWIETLIBIBGD — 31 bd LI BSHISGISHIBL BOHOL KVIZHINADZE N, —~ KVIZHINADZE N,, MIRVELASHVILL [vee ‘THEROLE OF PHARMACIST IN HIGH SCHOOLS 6.608 3GSd9 ~ BNGNGNHOGSO BsGassmaz0aONLI30Im 63593530 UBOISdI. F-BIRGOXSE0S60, 3.336334S09, 3.303303, 6.9 I6R0S60. 383d TG 00d BNL IGO SLIGO SYMPHYTUMASPERUM-0b 23609302S6 JOLIBIL WBIISINGI SHO VIBICMHIZILO SLIT BIVIYISBIZS 6. BSIOIBIORD, 0.9 T6 03US BIOL, 8.830 T6009. 0.°I6EBI03, 6.838690 980820, 3.33dI60d9, V.3I6SB80L0 SBOIENS ORO L3ISH NIL 898H3ILIFILO LIBICIZOD BGILS HGOMIVOLIEGIG SIGVIGMISGI 8§.BI3dI, *d-DIRGOKSEOSEY, Bagaasasds. 18.303303, '6.dIGR0S60, ORM AE TRI ee ea TONS F BLING SHB Se ‘wdoggalids Wye dager Vole poz hogy ab GrBogob grandad aggoongeoaddh goed gojodad Bio ydx odosoclia, bajoconggeve !GOKADZE S., *MULKUANYAN K,, *BARBAKADZE 'BAKURIDZE A. ELABORATION OF WOUND HEALING OINTMENT BASED ON PHENOLIC POLYMER: FROM STEMS OF SYMPHYTUM ASPERUM \Tpilisi State Medical University, Faculty of Pharmacy; I-Kutateladze Institute of Pharmacochemistry, Tbilisi, Georgia | MIKAIA G., 'KURDIANIN., SUMMARY ‘The results of the development of wound healing ointment based on phenolic polymer from comfrey PDGA are presented. The optimal ointment formulation has been justified on the basis of experimental studies carried out. The colloidal stability of PDGA containing ointment has been studied. The ointment remains stable both right after manufacturing and during storage at different temperatures for 24 hours with following centrifugation. Biopharmaceutical studies established that the maximal release of PDGA from the ointment was achieved when sodium alginatis was used for an ointment base, Animal studies revealed that the ointment exhibits pronounced wound healing action, Jeoqedghd IpqGapeddborgd goGone godneyghgh> ySgioge FyemraaRae® Re hngtiyso byabgsGgapdowss Bangdyee Wplasoazia. 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A. gPByeayGigraee apsassFer oPersgerahg soesgioeor Gerd AmGorggdysy Soegodes 323809 Jogpebeh Bdsbeeryg gave BePsegh> $2969HIGIHS 1. Barbakadze V. et al. - Evaluation of immunomodulatory acti Georgian Acad. Sei. Biol. Ser. 1999, v25, #4-6, 207-216. ee AY. et al. =. Poy(3-G4-dinydroxyphenyDlveeric acid] from the Stems of Symplotum eperm Lepesh and S cawcasium Bib! Chem. Nat, Comes. 2005, vil, 374377 ae eetcindae'v et al.— Stature ofa new aiiomplementary dihydroxycinnamate~ derived polymer ftom Symphytum asperum (Boraginaceae)!/ Mendeleev Comm, 2000, v10, #4, 148-140 4. Bobabadee V.e¢ al Boly(3-G 4-dlhydroxyphenyl)lyeeric acid]: A new biologically setve poner pare omey species Symphytum asperum and S. caucasicum (Boraginaceae)/ Russian J. Bioorg Chem, 2002, v28, #4, 326-330. jty of some plant polysaccharides! Proc. 515, Barbakadze V. et al. - Poly(3-G,4-tihydroxypheny!)glyceric acid), a new biologically active polymer from Spmpltum asperum Lepech. and S.caucasicum Bieb. (Boraginaceae)/ Molecules, 2005, v10, #9, 1135-1144. 6, Barhomeuf C. et al. Evaluation of the dietetic and therapeutic potential of a high molecular weight Tydronicimnamate-derived polymer from Sympiyrum asperum Lepech. Regarding its antioxidant, wmuilipoperoxidant aninlammatory, and eytotoxi properties! J. Agric. Food Chem. 2001, v 49. #8 3942-3946. 7. Barbekadze V. et al. — Antioxidant and anticomplementary activity of | poly{3.(3.4" dlitydroxyphenyi)glyceric acid} from Symphytum asperum and S. caucasicumi! Pharm. Chem. 3. 2007, vl, #1, 14-16. CDOKAJGBE, B.BAPBAKAJISE, K MYJIKHIDKAHAH, P.MHKAWA, H.KYPIHAHH, ‘A. BAKYPHIBE. PA3PABOTKA PAHO3A2KMBJIAIOLUEM MA3H HA OCHOBE DEHOJIbHOTO TIOJIMMEPA V3. CTEBIE SYMPHYTUM ASPERUM “Toumicexnit rocyaapornennnit mexmuunickatl ynMBepcuTeT, PapmanesTuvecKiti axyoTeT, Vincruryt Oapwaxoxumun ms. W.Kyratenamse, Tommen, Tpysia PE3IOME B cratse mpencrassienst pesybTaTsI HecmeqOBaHHi no paspaboTKe parosaxuBamomelt Mani 1a ocHose detiomsHoro nomMepa PDGA 13 oxonmmka. Ontumaxbiili cocras Masi Ob YeTHOBNEH Ha OCHOBE SKCIIEPUMCHTATBHEIX wecrenoBannit. Buina nsysewa KonnowmHaa craSumwocts PDGA-conepxcanimnx maseli. Maab ocrapasiach craGwmbuioii Kax cpasy ocile WsrOTORNEHHA, TAK NocTe 24-vaconOTO XpaHeHHA pH pasmMuHOH Temmeparype ¢ Hocneayioms teHTpHpyTHpOBAHHEN. Buo(papaantesTHveckHMH —HCCTenOBAHAMH —YCTAHOBTEHO, TO MaKCHMALTBHO® pucnoGoxmenue PDGA ¥3 MasH JOCTHTaylocs B cHyaae MpHMeHeHMA aNbruNATa HATpHA B kavectse Ma3eBofi ocHosbi. VccnenonaHia Ha 2kHROTHEIC noKasanM, 9TO Masb oGnanaeT BHIP@KCHHBIM paHlOSaXHBIIATOMIMM eHCTBHEM. ~~