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Clinical Feature

Journal of Perioperative Practice


2019, Vol. 29(1 & 2) 10–17
Assessing pain in children in the ! The Author(s) 2018
Article reuse guidelines:

perioperative setting sagepub.com/journals-permissions


DOI: 10.1177/1750458918780109
journals.sagepub.com/home/ppj

Michelle Bennett

Abstract
Pain assessment and management in children is challenging for a number of reasons. This paper aims to identify these
challenges and highlight strategies for effective pain assessment and management in children in the perioperative setting.

Keywords
Pain / Neonate / Infant / Child / Young person / Paediatric / Perioperative / Pain assessment / Pain management

Provenance and Peer review: Unsolicited contribution; Peer reviewed; Accepted for publication 2 March 2018.

Introduction have access to extensive resources, information and


advanced techniques such as patient-controlled
Pain assessment is widely recognised as a complicated
analgesia (PCA) and nurse-controlled analgesia (NCA)
and challenging aspect of caring for children of all ages,
and regional analgesia (Wong et al 2012). The reasons
from neonates to young people, in any clinical setting.
for this have been extensively examined in the literature
Numerous publications and textbooks are available
and key barriers to effective pain assessment and
encompassing the complexities of this topic (APAGBI
management have emerged (summarised in Box 1)
2008, 2012, Brahmbhatt et al 2012, DH 2003, RCN
(Asadi-Noghabi et al 2014, De Freitas et al 2014,
2009, Twycross & Williams 2014). If pain is not assessed
Stinson & Jibb 2014).
and managed promptly and effectively the child may go
on to develop long-term psychological as well as physical
consequences (Bentley 2014, Wong et al 2012). Cognitive development of the child and its
influence on their pain experience
This paper aims to identify some of the challenges of
Children are not miniature versions of adults. The
pain assessment in the perioperative setting, review
different stages of their physical and cognitive
pain assessment tools available to help address these
development will influence how neonates, infants,
challenges and explore current pain management
children and young people respond and interpret painful
strategies. For the purposes of this paper the term 'child'
experiences (Wong et al 2012). It is important to handle
will encompass the age range of neonate to adolescents
these situations appropriately as this might be the
(young people).
child's first contact with healthcare professionals. A
positive experience in childhood may prevent fear and
Children are different: Pain perception and anxiety associated with pain into their adult life.
cognitive development
Pain is a very personal experience and each individual's Neonates and infants
physical, emotional, cognitive and behavioural For many years it was believed that infants did not feel
experiences will influence their perception of pain pain, as their nerve sheaths are immature and not
(Twycross & Williams 2014). Therefore, a holistic
approach is needed when planning pain management
strategies. This is particularly the case for children, as Nottingham Children’s Hospital, Nottingham University Hospitals NHS
psychological and environmental factors can have a Trust, Queen’s Medical Centre, Nottingham, UK
more significant effect on a child's perception of pain Corresponding author:
(Twycross & Williams 2014, Wong et al 2012). Michelle Bennett, Clinical Nurse Specialist Children’s Pain Management,
Children’s Pain Team, Nottingham Children’s Hospital, Room EE1836,
E floor East Block, Nottingham University Hospitals NHS Trust, Queen’s
Poor assessment of children's pain is a real cause for Medical Centre, Nottingham NG7 2UH, UK.
concern, especially as healthcare professionals today Email: michelle.bennett2@nuh.nhs.uk
10 Journal of Perioperative Practice 29(1 & 2)

negative impact on relationships with healthcare


Box 1 Barriers to effective pain assessment professionals (WHO 1998). Therefore, it is important to
and management
know the child's pain history, which may also have some
influence on the anxiety expressed by the parents.
• Limitations in drug licensing for children (challenges with
obtaining ethical approval, safeguarding the child’s rights
and safety and effective communication when recruiting Preschool children
for drug trials). Preschool children are one of the most difficult groups to
• The influence of the different cognitive stages of devel- manage. They may see pain as a punishment and 'hate'
opment on the child’s perception of pain.
the healthcare professional who appears to be inflicting
• The difficulty in accurately assessing pain in preverbal and
non-verbal children (eg infants and children with spe- pain by hitting out or biting (Twycross & Williams 2014).
cial needs). Toddlers will not be able to see the connection between
• Healthcare professionals’ own beliefs and attitudes treatment and relief of pain, for example giving an
towards pain. unpleasant tasting medicine that will make the pain in
• The lack of research and training undertaken in their arm better. These children need their parents to be
this population. present, but parents also need to be supported in the
• Myths and misconceptions that still surround children’s
perioperative setting as they can be anxious and
pain including:
– Infants cannot feel pain because of their immature distressed themselves.
nervous system.
– Active children are not in pain. School-aged children
– Sleeping children cannot be in pain.
– Opioids cause respiratory depression and addiction. These children have vivid imaginations which can be
– A child’s pain can always be detected by behavioural used to distract them for short periods of time. How they
and physiological signs. react to painful situations and the pain words used are
(APAGBI 2008, RCN 2009, Twycross & Williams 2014) learned behaviours from their family, which are
influenced by culture, society or religious beliefs. It is
important to find out the pain words for each child. For
insulated with myelin, resulting in slow impulse example, a 'headache' can become a pain word applied
transmission. However, substantial evidence has now to any part of the child's body as they may have heard
demonstrated that an infant's pain impulses are still adults say they have a headache and need a pain relief
present but pass more slowly up to the brain (Wong et al tablet. School-aged children are able to describe how
2012). Infants (aged less than one year) have also been they feel, relate to pain physically and specify location in
found to have a full complement of neurons in the cortex terms of body parts and internal organs (Twycross &
by 20 weeks' gestation and can therefore perceive pain. Williams 2014).
They may even perceive pain more acutely because the
descending mechanism, present in adults, that Adolescents (now commonly referred to as
dampens down pain transmission, is immature (Asadi-
young people)
Noghabi et al 2014).
A young person, like younger children, needs time to
Pain inflicted on a neonate (aged less than 28 days) may gain the healthcare professional's trust and
increase sensitivity to pain and have potentially opportunities to discuss fears preoperatively. Young
damaging effects on brain development (Asadi-Noghabi people need information about their condition and to be
et al 2014, Carter & Simons 2014, Walker 2014). given treatment choices where applicable, especially if
Research has also demonstrated that neonates exposed they have chronic conditions (Twycross & Williams
to frequent painful procedures become sensitised over 2014). Young people may revert back to a previous
time, developing a lower pain threshold and heightened cognitive level and want their parents with them. They
pain behaviours and responses during subsequent also need to know that it is 'O.K.' to be cross or cry and
painful events, even years later (Bentley 2014, Walker that they do not need to put on a brave face, but to tell
2014, Wong et al 2012). you if it hurts.

These data indicate that children have pain memory and


Children with communication difficulties
that inadequately treated pain can result in detrimental
long-term effects throughout childhood and perhaps into Most children can communicate in some way, whether it
adulthood (Carter & Simons 2014). If pain is poorly is through sign language or behavioural cues. Each child
managed during a first admission to hospital, even in will need individual assessment preoperatively,
the neonatal period, this can increase the pain documenting their normal responses to pain and the
perceived by the child in the future, reduce their usual interventions that the parent or carer may use to
compliance with medical advice and potentially have a relieve pain (Stinson & Jibb 2014).
Bennett 11

Children with complex disabilities are sometimes


hypersensitive to bright lights and noise and may Box 2 Physiological indicators of pain
become very agitated, so the environment may need to
be adjusted. The involvement of the parent or carer is • tachycardia
vital in this group of children. • bradycardia (neonates and infants)
• hypertension
• tachypnoea
Pain assessment • apnoea (neonates and infants)
• desaturation (neonates and infants)
Key practice points • palmar sweating (neonates)
• elevated blood glucose
The key points to keep in mind when dealing with • pallor.
children in pain are as follows:

• Wherever possible, self-reporting should be used to


promote most accurate pain assessment.
• Use an appropriate validated and reliable pain Box 3 Behavioural indicators of pain
assessment tool in conjunction with observing
behavioural and physiological signs of pain. Changed behaviour Irritability
• Treat every child and family individually and remem- Unusual posture Screaming
Reluctance to move Aggressiveness
ber that the family are partners in the pain assess-
Disturbed sleep Crying
ment process and their involvement should Grimacing Increased clinging
be secured. Loss of appetite Restlessness
• Document pain assessment and management Sobbing Lethargy
measures taken. Lying 'scared stiff’ Guarding the area
• Reassess regularly and liaise with colleagues regard- Pulling away Withdrawal
ing further options (eg anaesthetist, children's pain
team and medical staff).
combination with other methods of assessment (APAGBI
(Based on Baker and Wong QUESTT principles of pain
2012, RCN 2009).
assessment (1987))
Pain behaviours which are used by nurses to assess
Without accurate pain assessment and evaluation, pain
pain in children include restlessness, grimacing, head
cannot be managed effectively. Whilst self-report of pain
shaking, drawing up knees, generalised restless body
is the gold standard of pain assessment, many children,
movements and withdrawing limbs from painful stimuli
including premature infants, neonates, toddlers with
(see Box 3). Combining behavioural assessment with
limited vocabulary, the critically ill and children with a
changes in vital signs is more indicative than using one
cognitive impairment, are unable to verbally
method alone. However, it is important to note that pain
communicate their pain (Brahmbhatt et al 2012,
behaviours may not always be evident. A child's pain
Verghese & Hannallah 2010). Therefore, physiological behaviours can be modified by several factors including
and behavioural indicators of pain are often used to fear, sleep deprivation, cultural background and the
supplement self-report. environment. A child may also react to pain by becoming
quiet and withdrawn.
Physiological indicators
Changes such as increased heart rate and blood Each child's behaviour needs to be assessed individually
pressure, tachypnoea, reduced oxygen saturation levels as they may behave differently when recovering from a
and palmar sweating would all be considered to be general anaesthetic for example. The initial assessment
physiological indicators of pain (see Box 2) (RCN 2009, can be carried out with their family as part of their
Stinson & Jibb 2014). However, it is important to admission to hospital and documented at this point.
remember that these indicators must be seen in context
as changes can also be signs of fear and anxiety and Pain assessment tools
can have many other causes, for example pyrexia, There are numerous different pain assessment tools
dehydration, medication. available for children of different ages and cognitive
ability. The APAGBI (2008), RCN (2009) and Royal
Even if the physiological indicators of pain diminish, pain College of Paediatrics and Child Health (RCPCH 2001)
may still be present as the body's response to pain have made evidence-based recommendations.
adapts after a period of time. For all these reasons, Behavioural and physiological scales are used for infants
physiological indicators should always be used in and children who are unable to verbally communicate.
12 Journal of Perioperative Practice 29(1 & 2)

There are many visual scales for school-aged children to Best practice when considering any pharmacological
assess quality and quantity of pain experienced. Young pain management strategy is a combination of
people often prefer the visual analogue scale of 1–10. medications as recommended by the World Health
Organization analgesic pain ladder (1998) (see Box 6).
As there are so many tools available, a small selection of Combining analgesics (multi-modal analgesia) blocks
tools should be chosen for the perioperative setting so pain transmission at several points of the pain pathway.
that the children can choose from them and the This method of management has a synergistic effect
healthcare professional can become familiar (see Box 4 whereby the overall analgesic effect can be superior to
for examples). Local policies and guidelines should be in
place to guide clinical practice and to identify the tools to
be used to ensure consistency in pain assessment
Box 5 Pharmacological pain management. Summary taken
throughout the institution. from APAGBI 2008

• The paediatric anaesthetist is responsible for initiating


Pharmacological pain management suitable postoperative analgesia and liaising with
patients and their families/carers, surgeons and other
The APAGBI (2008) Good practice in postoperative and members of the team providing postoperative care in
procedural pain guidelines provided evidence-based order to ensure that pain is assessed and appropriate
recommendations for numerous specific surgical ongoing analgesia is administered.
procedures in neonates and children and is an • Children should not be discharged from the recovery
invaluable resource. The guidelines include general area until satisfactory pain control is established and
principles and good practice points based on the ongoing analgesia is available.
• All health professionals caring for neonates and children
principles of pre-emptive, synergistic pharmacological
postoperatively should have appropriate educational
pain management (see Box 5) in combination with non- input including an awareness of the general principles of
pharmacological measures. This is supported by the pain assessment and pain management in children.
recent clinical practice guideline, Recommendation 6, • Postoperative analgesia should be appropriate to the
from the American Pain Society (Chou et al 2016). child’s developmental age, surgical procedure and clini-
cal setting in order to provide effective and safe, suffi-
ciently potent and flexible pain relief with minimal
side effects.
Box 4 Pain assessment tools suitable for the periopera- • Postoperative pain should be assessed frequently, the
tive setting frequency depending on the surgical procedure and the
child’s individual needs.
Premature infants and neonates • Analgesic prescribing and combination should be suffi-
Behavioural ciently flexible to allow for inter-individual differences in
Premature Infant Pain Profile (McNair et al 2004) the response to analgesics and the variation in the
Crying, Requires increased oxygen administration, requirement for pain relief that occurs during the
increased vital signs, Expression, sleeplessness (CRIES) postoperative period.
(Krechel & Bildner 1995) • Analgesics should be used in combination unless there
COMFORT scale (Ambuel et al 1992) are specific contraindications, for example: opioids,
local anaesthetics, non-steroidal anti-inflammatory
Children and young people without a cognitive impairment drugs (NSAIDs) and paracetamol can be given in con-
Self-report junction, not exceeding maximum recommended doses.
FACES Pain Scale (Wong & Baker 1988). Valid for 3–18
year olds
Faces Pain Scale-Revised (Hicks et al 2001) Valid for 4–12
year olds
Behavioural Box 6 Postoperative pharmacological pain management
Face, Legs, Activity, Cry and Consolability (FLACC)
(Merkel et al 1997). Valid for 1–18 year olds • local anaesthetics (epidural infusion, caudal block,
Children and young people with a cognitive impairment regional block, local wound infiltration, topical
Behavioural cream/gel)
Non-Communicating Children’s Pain Checklist- • neuraxial analgesics, for example ketamine and clonidine
Postoperative Version (Breau et al 2003). Valid for 3–19 (added to local anaesthetic blocks and epidural or
year olds intravenous infusions)
Paediatric Pain Profile (Hunt et al 2004). Valid for 1–18 • opioids, for example morphine, fentanyl (PCA and NCA
year olds and continuous infusions or added to local anaesthetic
Revised FLACC (Malviya et al 2006). Valid for 4–19 blocks and infusions)
year olds • NSAIDs
• paracetamol
(cited in APAGBI (2012) and Voepel-Lewis et al (2010)) (APAGBI 2008, 2012)
Bennett 13

that of one drug alone (APAGBI 2012, Chou et al 2016, using an NCA rather than a continuous opioid infusion
Verghese & Hannallah 2010). are that the programme allows an analgesic regimen to
be prescribed which is more flexible and may provide a
For example, combining an oral or intravenous opioid better quality of analgesia.
with regular paracetamol and a NSAID such as ibuprofen
or diclofenac sodium is a common method of achieving The system is suitable for preverbal and non-verbal
balanced analgesia in the immediate postoperative children (ie neonates, infants, young children, those
period (APAGBI 2008, Chou et al 2016). Analgesics critically ill and cognitively impaired) and those without
should be prescribed and administered regularly, to the physical dexterity to press a PCA button.
prevent peaks and troughs in serum levels and potential
episodes of 'break-through' pain. In addition, PCA has been available for 20 years and has been used
combination therapy has been shown to have an opioid widely for postoperative pain management since its
sparing effect (APAGBI 2012). introduction. PCA is used to deliver self-demand boluses
of medication. PCA has a large range of applications for
Pre-emptive pain management managing moderate to severe pain postoperatively
(Chou et al 2016). The child or young person should be
As a general principle in pain management, anticipation
assessed preoperatively to ascertain whether they can
and prevention of pain is preferable to attempting to
understand the concept of PCA and that they have the
treat pain after a nociceptive insult has occurred and the
manual dexterity required to push the button.
pain pathway triggered. A recent study of the plasticity of
the nervous system and its ability to adapt its thresholds
PCA can engage the child or young person in feeling that
according to input would suggest that introducing
they are a participant in their treatment, giving them
analgesic agents prior to the first painful stimulus
occurring, such as surgery, can improve the overall pain control of their pain management which can empower
management (APAGBI 2008). them, increase their confidence and help to
reduce anxiety.
Opiate use in neonates and children
Epidural and regional local anaesthetics
Both the World Health Organization (1998) and the
National Service Framework for Children (DH 2003) Regional anaesthesia has become widely used and
highlight that many healthcare professionals are accepted for perioperative analgesia in children usually
reluctant to prescribe and administer opioid medications as an adjuvant to general anaesthesia (Verghese &
due to inherent fears regarding opioid side effects and Hannallah 2010). Techniques range from simple
addiction, and that this is the case in both adults and infiltration, blocks of single nerves or plexuses to
children. In fact, respiratory depression is uncommon neuraxial blocks like spinal and paravertebral blocks
(Morton & Arerra 2009). and epidural analgesia (Walker 2014). Regional
anaesthesia modifies the neuroendocrine stress
However, it must be noted that neonates have higher response, provides profound postoperative pain relief,
body water content than that of older children and insures a more rapid recovery and may shorten
adults, immature liver and kidneys, a large extracellular hospital stay.
fluid compartment, slower gastric emptying and less fat
and muscle as a per cent of body weight. All of these Peripheral nerve blocks can provide significant pain
factors contribute to delayed excretion of drugs and lead relief after many common paediatric procedures. They
to a greater degree of accumulation of some drugs, can be performed with ease in children and adolescents
including opiates (Verghese & Hannallah 2010). using similar equipment to that used in adults but small
Neonates and infants also have a naturally higher bore needles are required. Adequate knowledge of the
number of opioid receptors, with the potential to cause relevant anatomy is necessary along with appropriate
respiratory depression (Walker 2014). This does not indications and knowledge of complications that can
mean, however, that opioids should be withheld from occur. Techniques involving the use of ultrasound
this group of patients, just that they should be to be technology can facilitate better placement of nerve
administered with caution. blocks (Ivani & Mossetti 2010, Rapp et al 2005).

A continuous epidural infusion of a local anaesthetic, in


Analgesic techniques combination with low dose opiate, reversibly blocks pain
transmission along the pain pathway and offers unique
PCA and NCA benefits in the relief of acute and perioperative pain
A NCA infusion allows the child to receive an immediate (Bennett & Douglass 2012a). Additional training and
predetermined dose of analgesia to target increased monitoring is required to ensure that staff are
pain, or prior to painful procedures or episodes, in competent to manage patients with an epidural infusion
addition to the background infusion. The advantages of and this has implications for staffing and skill mix which
14 Journal of Perioperative Practice 29(1 & 2)

needs to be considered. An epidural infusion may not be


suitable, for example if the child is allergic to local Box 7 Non-pharmacological interventions for the periop-
anaesthetics, if they have abnormal anatomy of their erative setting
spine, local or systemic infection or if they or their
parents refuse consent. Used to its full potential it can • parental presence
offer children pain-free recovery post-surgery and is • distraction, for example toys, books, blowing bubbles,
known to reduce postoperative morbidity, particularly in children’s videos, relaxation music
• rocking, stroking, swaddling
high-risk patients (eg children with complex needs,
• non-nutritive sucking or feeding
respiratory disease or poor lung function) (APAGBI 2008, • information giving
Bennett & Douglass 2012a, Chou et al 2016). • choice.

High-quality analgesia with minimal sedation allows


better lung expansion and increases the child's ability to should always be considered to be an essential part of
clear secretions by coughing. In older children and young pain management (DH 2003).
people there is a decrease in the risk of deep vein
thrombosis secondary to immobility. The reduced
quantity of opiate drugs required can decrease the Sensory methods
degree of ileus and nausea and vomiting after Sensory methods stimulate A-beta afferent fibres
abdominal surgery (Bennett & Douglass 2012b).
through pressure, thermoregulation, positioning and
Epidural analgesia in children does have associated
weak electrical currents. They inhibit nociceptive signals
risks but the incidence of serious complications is less
by directly blocking transmission of nociceptor input and
than 1%, as reported in a national paediatric epidural
at the same time, activate internal pain-inhibiting
audit of 10,000 children and young people over a five-
signals (Vessey & Carlson 1996).
year period (Llewellyn & Moriarty 2007).
Sensory pain management techniques useful in the
Adjuvant agents perioperative setting would include parental presence,
Ketamine has been demonstrated to be a useful careful positioning, use of a comforter and nursing with
adjuvant to opiates for acute postoperative pain boundaries (Bentley 2014, Carter & Simons 2014,
management (Chou et al 2016). Ketamine is an N- Twycross & Williams 2014) (see Box 7). Many babies are
methyl-D-aspartate (NMDA) antagonist: it opposes the very hungry postoperatively and can be comforted by
action of this chemical which is produced naturally in the non-nutritive sucking or a feed (Asadi-Noghabi et al
body. At sub-anaesthetic doses it has an analgesic effect 2014). Therefore, they should be fed as soon as possible
as it binds to the receptor sites of NMDA, which inhibits in recovery if surgery allows, ideally by the mother if
the transmission of pain impulses from the primary breast fed. Please note that some parents specifically do
afferent fibre to the NMDA receptor. It exerts strong not wish their babies to be given bottled water or milk if
adjuvant analgesic properties by inhibiting the binding of they breast feed, so consent should be obtained for this.
glutamate to the NMDA-R receptor. As this mode of
action is different from the action of opioid drugs, the
use of ketamine in combination with an opiate can Parental presence
improve pain relief (APAGBI 2008). Ketamine also has Parental presence and participation is of course a vital
an opioid-sparing effect which can result in less component of managing children's pain, especially when
escalation of the opiate dose and less incidence of considering psychosocial aspects, as they are familiar
opiate side effects (Laskowski et al 2011). with their child's likes and dislikes, hobbies, home
environment and level of cognition. The parents will
Ketamine has been used in the paediatric population for
usually also have well-established trusting relationships
some time in the form of caudal administration. More
with their child (Polkki et al 2001). However, nurses
recently, ketamine has been administered via
should not rely on parents too heavily, as they can be
continuous sub-anaesthetic infusion or in combination
under a great deal of stress themselves. Also, family
with a PCA or NCA for postoperative pain management
(Laskowski et al 2011). For more detailed information members' own experiences, perceptions of pain and
about analgesic agents, please refer to the APAGBI Good expectations will influence the child and this needs to be
practice in postoperative and procedural pain taken into consideration. Despite this, the presence of
management (2012). parents can provide emotional support and reassurance
and can play an important role in reducing their child's
level of anxiety; nurses have an important role in
Non-pharmacological measures supporting parental participation in non-
Any measures that help to treat pain and anxiety whilst pharmacological measures for pain relief (Carter &
reducing the need for pharmacological interventions Simons 2014, Twycross & Williams 2014).
Bennett 15

Cognitive behavioural therapies (CBTs) No competing interests declared


CBTs are combinations of physical and cognitive
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