Generic Name: Propanolol (Inderal)

Classification: Beta-Adrenergic Blocker/Antianginal Drugs

Dosage: The dose is dependent on weight, clinical condition, laboratory results and should be determined by the doctor.
Mechanism of Action: Nonselective beta-adrenoreceptor antagonist
INDICATION CONTRAINDICATION
Propanolol is a competitive
beta-adrenergic receptor
antagonist devoid of
agonist activity, making it
the prototype for
comparison to other beta-
antagonists. It is indicated
for treatment of angina and
syncope.
SIDE EFFECTS ADVERSE REACTIONS NURSING
RESPONSIBILITIES
 Since the main Common side effects of Emotional depression,  Monitor signs of
effect of propranolol include: slower dizziness, fatigue, sleep peripheral
propranolol is to heart rate, diarrhea, dry disturbances, gastric pain, vasoconstriction,
decrease heart rate, eyes nausea, vomiting, colitis, such as extreme
it is contraindicated hair loss, nausea, and diarrhea, heart failure, coldness in the
in those who have weakness or tiredness. reduced cardiac output, hands and feet,
bradycardia (less arrhythmia, dyspnea, cyanosis, and
than 60 beats per cough, bronchospasm muscle cramping.
minute) Notify physician of
 Propranolol is also severe or prolonged
contraindicated in signs of
those with any lung vasoconstriction.
pathologies, such as  Give drug as
COPD, asthma, or ordered following
emphysema. safe and
 It is also appropriate
contraindicated on administration to
pregnant and ensure therapeutic
lactating women as effects.
it can have harmful  Provide comfort
effects on the fetus measures:
or neonates. ambulation
assistance, raised
siderails,
appropriate room
light and
temperature, and
rest periods.
 Generic Name: Isoniazid
Classification: Antituberculosis Agents
Dosage: 10 mg/kg P.O. or I.M. daily in a single dose
Mechanism of Action: Interferes with lipid and DNA synthesis, thus inhibiting bacterial cell wall synthesis.
INDICATION CONTRAINDICATION SIDE EFFECTS ADVERSE REACTIONS NURSING
RESPONSIBILITIES
Isoniazid is an antibiotic  Isoniazid is Common side effects may Peripheral neuropathy,  Be alert for signs of
that fights bacteria. It is contraindicated in include: numbness, memory impairment, optic drug-induced
indicated for prophylaxis patients who tingling, or burning pain in neuritis and atrophy, toxic hepatitis, including
and treatment of develop severe your hands or feet; nausea, encephalopathy, anorexia,
tuberculosis. hypersensitivity vomiting, upset stomach; convulsions, toxic abdominal pain,
reactions, including or abnormal liver function psychosis, elevated serum severe nausea and
drug induced tests. transaminase (SGOT, vomiting, yellow
hepatitis; previous SGPT), jaundice, skin or eyes, fever,
isoniazid-associated hyperbilirubinemia, sore throat, malaise,
hepatic injury; nausea, vomiting, weakness, facial
severe adverse epigastric distress, edema, lethargy,
reactions to thrombocytopenia, and unusual
isoniazid such as agranulocytosis, bleeding or
drug fever, chills, sideroblastic, hemolytic or bruising. Report
arthritis; and acute aplastic anemia, these signs to the
liver disease of any eosinophilia, systemic physician or
etiology. Lupus Erythematosus, nursing staff
fever, lymphadenopathy, immediately.
skin eruptions, vasculitis,  Watch for seizures;
pyridoxine deficiency, notify physician
metabolic acidosis, immediately if
hyperglycemia, pellagra patient develops or
and gynecomastia. increases seizure
activity.
References:
F. A Davis PT Collection. (n.d.). Retrieved from F. A Davis PT Collection: https://fadavispt.mhmedical.com/content.aspx?
bookid=1873&sectionid=139014893
glowm. (n.d.). Retrieved from glowm: https://glowm.com/resources/glowm/cd/pages/drugs/ij027.html
Pediatric Oncall. (n.d.). Retrieved from Pediatric Oncall: https://www.pediatriconcall.com/drugs/isoniazid/679
RxList. (2021, April 12). Retrieved from RxList: https://www.rxlist.com/isoniazid-drug.htm#description
Tabangcora, I. D. (2021, Aprl 22). Nurseslabs. Retrieved from Nurseslabs: https://nurseslabs.com/antianginal-drugs/
University of Michigan Health. (2017, October 16). Retrieved from University of Michigan Health:
https://www.uofmhealth.org/health-library/d00101a1