02770 | 02770 Clinical characteristics and outcomes of hospitalized patients with

COVID-19 in Argentina: results from the ECCOVID multicenter prospective study

12. COVID-19
12c. Clinical features, case management, outcome
Ezequiel Cordova 1, Analia Mykietiuk 2, Lautaro De Vedia 3, Natalia Pacifico 3, Matias H Garcia
Hernandez 4, Natalia M Baeza 4, Franco Garibaldi 1, Maria Fernanda Alzogaray 2, Rosa
Contreras 5, Lucrecia Soler Puy 6, Pablo G. Scapellato 7, Laura Barcelona 8, Mariana L Golikow
9, Maria Florencia Piñeiro 10, Hugo J Miño 11, Maria Fernanda Consalvo 12, Corina Nemirovsky
13, Virginia Azar 14, Lucia Lamponi Tapatta 15, Mariano Blasco 16, Jamile Ballivian 17, Gustavo

Lopardo 8, Omar Sued 18, Martin E Stryjewski 4

1Hospital Cosme Argerich - Buenos Aires (Argentina), 2Instituto Medico Platense - La Plata
(Argentina), 3Hospital FJ Muñiz - Buenos Aires (Argentina), 4CEMIC - Buenos Aires (Argentina),
5Hospital Dr. Marcial V. Quiroga - San Juan (Argentina), 6Hospital Julio C Perrando -

Resistencia (Argentina), 7Hospital Santojanni - Buenos Aires (Argentina), 8Hospital Prof. Dr

Bernardo A. Houssay - Vicente Lopez (Argentina), 9Hospital Nacional Posadas - El Palomar
(Argentina), 10Hospital Fernandez - Buenos Aires (Argentina), 11Hospital Iturraspe - Santa Fe
(Argentina), 12Hospital Penna - Buenos Aires (Argentina), 13Hospital Italiano - Buenos Aires
(Argentina), 14Hospital Centenario - Gualeguaychu (Argentina), 15Hospital Leonidas Lucero -
Bahia Blanca (Argentina), 16Sanatorio Agote - Buenos Aires (Argentina), 17Helios Salud -
Buenos Aires (Argentina), 18Fundación Huesped - Buenos Aires (Argentina)

Please add any third party affiliations (research group, study group etc.) for your abstract
here On behalf of the ECCOVID trial investigators. This study was supported by Sociedad
Argentina de Infectología (SADI).

Background Clinical features and outcomes of SARS-CoV-2 disease 2019 (COVID-19) may
differ across different countries and populations. In Latin-America data on clinical characteristics
and outcomes of patients hospitalized with COVID-19 is scarce. The aim of our study was to
describe clinical characteristics and to identify factors associated with severity and mortality in a
cohort of hospitalized COVID-19 patients in Argentina.

Methods Multicenter prospective cohort study of ≥18 years old patients with confirmed COVID-
19 admitted to 19 hospitals in Argentina from March to October 2020. Factors associated with
risk of intensive care unit admission and 30-day mortality were identified using a multivariable
logistic regression.

Results We prospectively enrolled 809 consecutive patients. The median age was 53 years
(IQR 38-67); 56% were males and 71% had at least one comorbidity. The most common
comorbidities were hypertension (32%), obesity (23%) and diabetes (17%). Disease severity at
admission was classified as mild, moderate, severe, and critical in 25%, 51%, 17%, and 7% of
the patients, respectively. Patients with severe/critical COVID-19 at admission had lower
lymphocyte count (1100 vs 1400 cells/mL; p<0.001), higher C-reactive protein (CRP) (27.5 mg/L
vs. 6 p<0.001), D-dimer (0.9 vs. 0.5 µg/ml; p<0.001) and ferritin levels (780 vs. 344 ng/mL;
p<0.001), respectively. During hospitalization 49% of the patients required oxygen
supplementation, 18% ICU, and 12% invasive mechanical ventilation. Overall, 30-day mortality
was 11%. Factors independently associated with ICU admission were male gender (OR 1.81
;95% CI 1.16 - 2.81), hypertension (OR 3.21; 95% CI 2.08 – 4.95), obesity (OR 2.38; 95%CI
1.51-3.7), oxygen saturation ≤93% (OR 6.45; 95% CI 4.20 – 9.92) and lymphopenia (OR 3.21;
95%CI 2.08 – 4.95). Factors independently associated with 30-day mortality included age ≥60
years-old (OR 2.68; 95% CI 1.63- 4.43), oxygen saturation ≤93% (OR 3.19; 95%CI 1.97 – 5.16)
and lymphocyte count <1000 cell/mL (OR 2.65; 95%CI 1.64 – 4.27).
Conclusions This study provides epidemiological and clinical data on patients hospitalized with
COVID-19 in Argentina. The identification of factors associated with severity and mortality will
contribute to better stratification of individual patient’s risk in our population.

Keyword 1
SARS-COV2
Keyword 2
COVID-19
Keyword 3
Coronavirus

Conflicts of interest