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Pathogenesis Stunting

Dr. rer. nat. Ikhwan R. Sudji, M.Si


Stunting Have Unbroken Cycle If We Don’t
End It
What is Stunting and Why We should Worried
with Stunting
Stunting Prevalence Worldwide

Indonesia
30,8%
Stunting Prevalence in Indonesia No.5

Source:  Global  Nutri0on  Report,  2018  


Child Nutritional Problems in Indonesia

Sources:  Riskesdas  &  Dir.  Gizi  Kemenkes  


The Nutrition Intervention Programs Result
Was Not Optimal In Reducing Stunting
•  IFA  supplementa0on   •  Counseling-­‐  EBF  
•  Calcium  supplementa0on   •  Ins0tu0onal  birth   •  Counseling  Complementary  
•  Food  supplementa0on   •  Birth  conducted  by  skill   feeding  
• Iron  and  folic  acid   •  Counseling  on  nutri0on   health  personnel   •  Immuniza0on  
• (IFA)  supplementa0on   during  pregnancy   •  Delayed  cord  clamping   •  Vitamin  A  supplementa0on   Healthy    
Deworming   •  Counseling  on  EIBF   •  Counseling-­‐  EIBF   •  IFA  supplementa0on  
•  IFA  supplementa0on    
Childrren  
• For0fica0on  (Iodized   •  Malaria  preven0on   •  ORS  with  zinc  during  diarrhea  
•  Deworming   •  Calcium  supplementa0on   •  Growth  monitoring  
salt)  
•  Maternity  benefits   • Food  supplementa0on   •  Food  supplementa0on  
•  Management  of  SAM  
•  Management  of  MAM  
•  Deworming  in  children  
•  Sanita0on  

30,8%  
StunBng  

WHY???

Indonesian  Nutri0on  Interven0on  Programs  


We Need Increase Understanding Pathophysiology
of Stunting To Decrease Prevalence
Poorly  Understood  
The Lower Concentration Of Amino Acids
Failed In Activated mTORC1, mTORC2, IGF1
Lower  concentraBon    
in  serum  

Survey  said  
Protein  intake    
adequate  
Why The Protein Consumed Does Not Become an Amino Acid
Needed For Children Growth?
Alterated Gut Microbiome
Gut Microbiome Induced Bone Formation
Evidence of stunting genes in Asian
countries
Recomendation

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