LAMPIRAN 1

SAFETY DATA SHEET

Creation Date 16-Jan-2009 Revision Date 26-Dec-2021 Revision Number 7

1. Identification
Product Name Methyl formate

Cat No. : AC414340000, AC414340025; AC414340050, AC414345000;

CAS No 107-31-3
Synonyms Formic acid methyl ester; Methyl methanoate

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Company
Fisher Scientific Company Acros Organics
One Reagent Lane One Reagent Lane
Fair Lawn, NJ 07410 Fair Lawn, NJ 07410
Tel: (201) 796-7100

Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11
Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99
CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887

2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Flammable liquids Category 1

Acute oral toxicity Category 4
Acute Inhalation Toxicity - Vapors Category 3
Skin Corrosion/Irritation Category 2
Serious Eye Damage/Eye Irritation Category 2
Specific target organ toxicity (single exposure) Category 3
Target Organs - Respiratory system, Central nervous system (CNS), Optic nerve.

Label Elements

Signal Word
Danger

Hazard Statements
Extremely flammable liquid and vapor

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Toxic if inhaled
Harmful if swallowed
Causes serious eye irritation
Causes skin irritation
May cause respiratory irritation

Precautionary Statements
Prevention
Wear protective gloves/protective clothing/eye protection/face protection
Wash face, hands and any exposed skin thoroughly after handling
Do not eat, drink or smoke when using this product
Avoid breathing dust/fume/gas/mist/vapors/spray
Use only outdoors or in a well-ventilated area
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Take precautionary measures against static discharge
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Call a POISON CENTER or doctor/physician
Skin
IF ON SKIN: Wash with plenty of soap and water
Take off contaminated clothing and wash before reuse
If skin irritation occurs: Get medical advice/attention
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
If eye irritation persists: Get medical advice/attention
Ingestion
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
Rinse mouth
Fire
Explosion risk in case of fire
Fight fire with normal precautions from a reasonable distance
Evacuate area
Storage
Store in a well-ventilated place. Keep container tightly closed
Store locked up
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)

WARNING. Reproductive Harm - https://www.p65warnings.ca.gov/.

3. Composition/Information on Ingredients
Component CAS No Weight %
Methyl formate 107-31-3 >97
Methyl alcohol 67-56-1 <3

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4. First-aid measures
General Advice If symptoms persist, call a physician.

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention.

Inhalation Remove to fresh air. Do not use mouth-to-mouth method if victim ingested or inhaled the
substance; give artificial respiration with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device. Immediate medical attention is required. If
not breathing, give artificial respiration.

Ingestion Do NOT induce vomiting. Get medical attention.

Most important symptoms and Difficulty in breathing. Inhalation of high vapor concentrations may cause symptoms like
effects headache, dizziness, tiredness, nausea and vomiting
Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may
be used to cool closed containers.

Unsuitable Extinguishing Media No information available

Flash Point -32 °C / -25 °F

Method - No information available

Autoignition Temperature 440 °C / 824 °F

Explosion Limits
Upper 23%
Lower 4.5%
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical

Thermal decomposition can lead to release of irritating gases and vapors. Extremely flammable. Containers may explode when
heated. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back.

Hazardous Combustion Products

Carbon monoxide (CO). Carbon dioxide (CO2). Methanol.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.

NFPA
Health Flammability Instability Physical hazards
2 4 0 N/A

6. Accidental release measures

Personal Precautions Use personal protective equipment as required. Ensure adequate ventilation. Remove all
sources of ignition. Take precautionary measures against static discharges.
Environmental Precautions Should not be released into the environment. Do not flush into surface water or sanitary
sewer system.

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Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.

7. Handling and storage

Handling Ensure adequate ventilation. Wear personal protective equipment/face protection. Do not
get in eyes, on skin, or on clothing. Avoid ingestion and inhalation. Keep away from open
flames, hot surfaces and sources of ignition. Use spark-proof tools and explosion-proof
equipment. Use only non-sparking tools. To avoid ignition of vapors by static electricity
discharge, all metal parts of the equipment must be grounded. Take precautionary
measures against static discharges.

Storage. Flammables area. Keep container tightly closed in a dry and well-ventilated place. Keep
away from heat, sparks and flame. Incompatible Materials. Strong oxidizing agents. .

8. Exposure controls / personal protection

Exposure Guidelines

Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA)
Methyl formate TWA: 50 ppm (Vacated) TWA: 100 ppm IDLH: 4500 ppm TWA: 100 ppm
STEL: 100 ppm (Vacated) TWA: 250 mg/m3 TWA: 100 ppm STEL: 150 ppm
Skin (Vacated) STEL: 150 ppm TWA: 250 mg/m3
(Vacated) STEL: 375 mg/m3 STEL: 150 ppm
TWA: 100 ppm STEL: 375 mg/m3
TWA: 250 mg/m3
Methyl alcohol TWA: 200 ppm (Vacated) TWA: 200 ppm IDLH: 6000 ppm TWA: 200 ppm
STEL: 250 ppm (Vacated) TWA: 260 mg/m3 TWA: 200 ppm STEL: 250 ppm
Skin (Vacated) STEL: 250 ppm TWA: 260 mg/m3
(Vacated) STEL: 325 mg/m3 STEL: 250 ppm
Skin STEL: 325 mg/m3
TWA: 200 ppm
TWA: 260 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists

OSHA - Occupational Safety and Health Administration
NIOSH IDLH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures Use only under a chemical fume hood. Ensure that eyewash stations and safety showers
are close to the workstation location. Use explosion-proof electrical/ventilating/lighting
equipment. Ensure adequate ventilation, especially in confined areas.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166. Tight sealing safety goggles. Face protection shield.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

9. Physical and chemical properties

Physical State Liquid

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Appearance Colorless
Odor Organic
Odor Threshold No information available
pH 4-5 @ 20°C (20 %)
Melting Point/Range -100 °C / -148 °F
Boiling Point/Range 31 - 33 °C / 88 - 91 °F
Flash Point -32 °C / -25 °F
Evaporation Rate No information available
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper 23%
Lower 4.5%
Vapor Pressure 644 mbar @ 20 °C
Vapor Density 2.07
Specific Gravity 0.968
Solubility Soluble in water
Partition coefficient; n-octanol/water No data available
Autoignition Temperature 440 °C / 824 °F
Decomposition Temperature No information available
Viscosity 0.35 mPa.s at 20 °C
Molecular Formula C2 H4 O2
Molecular Weight 60.05

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Incompatible products. Excess heat. Keep away from open flames, hot surfaces and
sources of ignition.

Incompatible Materials Strong oxidizing agents,

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), Methanol

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information

Acute Toxicity

Product Information
Oral LD50 Category 4. ATE = 300 - 2000 mg/kg.
Dermal LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.
Vapor LC50 Category 3. ATE = 2 - 10 mg/l.
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Methyl formate LD50 = 475 mg/kg ( Rat ) LD50 > 5 g/kg ( Rabbit ) LC50 > 21 mg/L ( Rat ) 4 h

Methyl alcohol LD50=1187–2769mg/

kg(
Rat
) LD50 = 17100 mg/kg ( Rabbit ) LC50 = 128.2 mg/L ( Rat ) 4 h
Toxicologically Synergistic No information available
Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Irritating to eyes, respiratory system and skin

Sensitization No information available

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Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

Methyl formate 107-31-3 Not listed Not listed Not listed Not listed Not listed
Methyl alcohol 67-56-1 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure Respiratory system Central nervous system (CNS) Optic nerve
STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute and Inhalation of high vapor concentrations may cause symptoms like headache, dizziness,
delayed tiredness, nausea and vomiting

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information

Ecotoxicity
Do not empty into drains.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Methyl formate EC50: = 240 mg/L, 72h Not listed EC50 > 10000 mg/L 17 h EC50: > 500 mg/L, 48h
(Desmodesmus (Daphnia magna)
subspicatus)
EC50: = 190 mg/L, 96h
(Desmodesmus
subspicatus)

Methyl alcohol Not listed Pimephales promelas: LC50 EC50 = 39000 mg/L 25 min EC50 > 10000 mg/L 24h
> 10000 mg/L 96h EC50 = 40000 mg/L 15 min
EC50 = 43000 mg/L 5 min
Persistence and Degradability Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its volatility.

Component log Pow

Methyl formate -0.21
Methyl alcohol -0.74

13. Disposal considerations

Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.

Component RCRA - U Series Wastes RCRA - P Series Wastes

Methyl alcohol - 67-56-1 U154 -

14. Transport information

DOT

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UN-No UN1243
Proper Shipping Name METHYL FORMATE
Hazard Class 3
Packing Group I
TDG
UN-No UN1243
Proper Shipping Name METHYL FORMATE
Hazard Class 3
Packing Group I
IATA
UN-No UN1243
Proper Shipping Name Methyl formate
Hazard Class 3
Packing Group I
IMDG/IMO
UN-No UN1243
Proper Shipping Name Methyl formate
Hazard Class 3
Packing Group I
15. Regulatory information
United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory

Active-Inactive Flags
Methyl formate 107-31-3 X ACTIVE -
Methyl alcohol 67-56-1 X ACTIVE -

Legend:
TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
X - Listed
'-' - Not Listed

TSCA 12(b) - Notices of Export Not applicable

International Inventories
Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
Methyl formate 107-31-3 X - 203-481-7 X X X X X KE-17243
Methyl alcohol 67-56-1 X - 200-659-6 X X X X X KE-23193

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

SARA 313
Component CAS No Weight % SARA 313 - Threshold
Values %
Methyl alcohol 67-56-1 <3 1.0

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Not applicable

Clean Air Act

Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors
Methyl alcohol X -

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OSHA - Occupational Safety and Not applicable

Health Administration

CERCLA

Component Hazardous Substances RQs CERCLA EHS RQs

Methyl alcohol 5000 lb -

California Proposition 65 This product contains the following Proposition 65 chemicals.

Component CAS No California Prop. 65 Prop 65 NSRL Category

Methyl alcohol 67-56-1 Developmental - Developmental
U.S. State Right-to-Know
Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Methyl formate X X X - X
Methyl alcohol X X X X X

U.S. Department of Transportation

Reportable Quantity (RQ): Y
DOT Marine Pollutant N
DOT Severe Marine Pollutant N

U.S. Department of Homeland This product contains the following DHS chemicals:
Security Legend - STQs = Screening Threshold Quantities, APA = A placarded amount

Component DHS Chemical Facility Anti-Terrorism Standard

Methyl formate Release STQs - 10000lb
Other International Regulations

Mexico - Grade Severe risk, Grade 4

Authorisation/Restrictions according to EU REACH

Component REACH (1907/2006) - Annex XIV - REACH (1907/2006) - Annex XVII - REACH Regulation (EC
Substances Subject to Restrictions on Certain Dangerous 1907/2006) article 59 - Candidate
Authorization Substances List of Substances of Very High
Concern (SVHC)
Methyl formate - Use restricted. See item 75. -
(see link for restriction details)
Methyl alcohol - Use restricted. See item 69. -
(see link for restriction details)

https://echa.europa.eu/substances-restricted-under-reach

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of

Pollutant Potential Hazardous
Substances (RoHS)
Methyl formate 107-31-3 Listed Not applicable Not applicable Not applicable
Methyl alcohol 67-56-1 Listed Not applicable Not applicable Not applicable

Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
Qualifying Quantities Qualifying Quantities
for Major Accident for Safety Report
Notification Requirements
Methyl formate 107-31-3 Not applicable Not applicable Not applicable Not applicable
Methyl alcohol 67-56-1 500 tonne 5000 tonne Not applicable Not applicable

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16. Other information

Prepared By Regulatory Affairs
Thermo Fisher Scientific
Email: EMSDS.RA@thermofisher.com

Creation Date 16-Jan-2009

Revision Date 26-Dec-2021
Print Date 26-Dec-2021
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of SDS

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LAMPIRAN 2
SAFETY DATA SHEET Version 8.0
Revision Date 30.09.2021
according to Regulation (EC) No. 1907/2006 Print Date 30.08.2022
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Methyl formate
Product Number : W519103
Brand : Aldrich
Index-No. : 607-014-00-1
REACH No. : A registration number is not available for this substance as the
substance or its uses are exempted from registration, the
annual tonnage does not require a registration or the
registration is envisaged for a later registration deadline.
CAS-No. : 107-31-3

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Pte Ltd
(Co. Registration No. 199403788W)
2 Science Park Drive
#05-01/12 Ascent Building
SINGAPORE 118222
SINGAPORE
Telephone : +65 6890 6633
Fax : +65 6890 6639
E-mail address : TechnicalService@merckgroup.com
1.4 Emergency telephone
Emergency Phone # : 1-800-262-8200

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 1), H224
Acute toxicity, Oral (Category 3), H301
Acute toxicity, Inhalation (Category 3), H331
Acute toxicity, Dermal (Category 3), H311
Eye irritation (Category 2), H319
Specific target organ toxicity - single exposure (Category 1), H370
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 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal word Danger

Hazard statement(s)
H224 Extremely flammable liquid and vapor.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H370 Causes damage to organs.
Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
P280 Wear protective gloves/ protective clothing.
P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
Rinse mouth.
P302 + P352 + P312 IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/
doctor if you feel unwell.
P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Call a POISON CENTER/ doctor.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
Supplemental Hazard none
Statements
Reduced Labeling (<= 125 ml)
Pictogram

Signal word Danger

Hazard statement(s)
H224 Extremely flammable liquid and vapor.
H370 Causes damage to organs.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.
Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
P280 Wear protective gloves/ protective clothing.
P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
Rinse mouth.
P302 + P352 + P312 IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/
doctor if you feel unwell.
P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Call a POISON CENTER/ doctor.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
Supplemental Hazard none
Statements

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2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Synonyms : Formic acid methyl ester

Formula : C2H4O2
Molecular weight : 60,05 g/mol
CAS-No. : 107-31-3
EC-No. : 203-481-7
Index-No. : 607-014-00-1
Component Classification Concentration
methyl formate
CAS-No. 107-31-3 Flam. Liq. 1; Acute Tox. 3; <= 100 %
EC-No. 203-481-7 Eye Irrit. 2; STOT SE 1;
Index-No. 607-014-00-1 STOT SE 3; H224, H301,
H331, H311, H319, H370,
H335
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a
physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse
mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

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SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Dry powder Dry sand
Unsuitable extinguishing media
Do NOT use water jet.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of
vapors accumulating to form explosive concentrations. Vapors can accumulate in low
areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand,
earth, diatomaceous earth, vermiculite) and place in container for disposal according to
local / national regulations (see section 13).
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Advice on safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.
Advice on protection against fire and explosion
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of
electrostatic charge.
Hygiene measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately
after handling the product.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions

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 Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage. Store in cool place.
Over time, pressure may increase causing containers to burst Refrigerate before opening.
Storage class
Storage class (TRGS 510): 3: Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
Ingredients with workplace control parameters
8.2 Exposure controls

Personal protective equipment

Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU)
2016/425 and the standard EN 374 derived from it.
Splash contact
Material: butyl-rubber
Minimum layer thickness: 0,3 mm
Break through time: 145 min
Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail
sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which
differ from EN 374, contact the supplier of the EC approved gloves. This
recommendation is advisory only and must be evaluated by an industrial hygienist
and safety officer familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use
scenario.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective
clothing., The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-
face respirator with multi-purpose combination (US) or type AXBEK (EN 14387)

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 respirator cartridges as a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator. Use respirators and
components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Color: colorless
b) Odor No data available
c) Odor Threshold No data available
d) pH 4,0 - 5,0 at 200 g/l at 20 °C

e) Melting Melting point/range: -100 °C - lit.

point/freezing point
f) Initial boiling point 32 - 34 °C - lit.
and boiling range
g) Flash point -19 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower Upper explosion limit: 23 %(V)
flammability or Lower explosion limit: 5 %(V)
explosive limits
k) Vapor pressure 634,9 hPa at 20 °C
2.261,5 hPa at 55 °C
l) Vapor density 2,07 - (Air = 1.0)
m) Density 0,974 g/cm3 at 20 °C - lit.
Relative density No data available
n) Water solubility soluble
o) Partition coefficient: log Pow: -0,21
n-octanol/water
p) Autoignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
s) Explosive properties No data available
t) Oxidizing properties No data available

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9.2 Other safety information
Relative vapor 2,07 - (Air = 1.0)
density

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
Oxidizing agents
10.6 Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
Acute toxicity estimate Oral - 100,1 mg/kg
(Expert judgment)
Acute toxicity estimate Inhalation - 3,1 mg/l
(Expert judgment)
Acute toxicity estimate Dermal - 300,1 mg/kg
(Expert judgment)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation
(OECD Test Guideline 404)
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Carcinogenicity
No data available
Reproductive toxicity

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 No data available
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation. - Respiratory Tract
Causes damage to organs.
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
RTECS: LQ8925000
Cough, Shortness of breath, Headache, Nausea, Vomiting, To the best of our knowledge,
the chemical, physical, and toxicological properties have not been thoroughly investigated.

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to fish LC50 - Leuciscus idus (Golden orfe) - 120 mg/l - 96 h
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 500 mg/l - 48 h
and other aquatic (OECD Test Guideline 202)
invertebrates
Toxicity to bacteria static test EC50 - Pseudomonas putida - > 10.000 mg/l - 17 h
(DIN 38421 TEIL 8)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 93 % - Readily biodegradable.
(OECD Test Guideline 310)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material
must be disposed of in accordance with the Directive on waste 2008/98/EC as well as
other national and local regulations. Leave chemicals in original containers. No mixing
with other waste. Handle uncleaned containers like the product itself.

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 Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 1243 IMDG: 1243 IATA: 1243
14.2 UN proper shipping name
ADR/RID: METHYL FORMATE
IMDG: METHYL FORMATE
IATA: Methyl formate
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: I IMDG: I IATA: I
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
National legislation
Seveso III: Directive 2012/18/EU of the European : FLAMMABLE LIQUIDS
Parliament and of the Council on the control of
major-accident hazards involving dangerous
substances.
: ACUTE TOXIC

15.2 Chemical Safety Assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H224 Extremely flammable liquid and vapor.
H301 Toxic if swallowed.
H301 + H311 + Toxic if swallowed, in contact with skin or if inhaled.
H331
H311 Toxic in contact with skin.
H319 Causes serious eye irritation.
H331 Toxic if inhaled.
H335 May cause respiratory irritation.
H370 Causes damage to organs.

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 Further information
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

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match the product purchased as we transition our branding. However, all of the
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