Buenviaje, Lorraine Tuesday Patient 603 Colon Cancer

BSN 3-01

Drugs Indication Action Side Effect & Adverse Nursing Considerations/ Health
Effect Teachings

a. Brand Name: ● Used in combination with ● ​The drug's platinum Side Effects: ● Do not use needles or infusion sets
Oxalee infused fluorouracil. complex attaches to DNA ● Nausea and vomiting containing aluminum parts. Flush infusion
b. Generic Name: ● It is indicated for advanced and creates cross-links. The ● Fatigue line with D5W before and after
Oxaliplatin
colorectal cancer treatment and cross-links stop DNA ● Diarrhea administration of any other concomitant
c. Classification
Cytotoxic for individuals with stage III replication, transcription, ● Mouth sores medication.
Chemotherapy colon cancer who have received and cell cycle arrest, which ● Loss of appetite ● Check IV site for any signs of thrombosis or
d. Route: complete resection of the main leads to cell death. ● Low blood count drug reaction
IV tumor. ● Verify correct IV concentration and rate of
Adverse Effects: infusion with physician Inspect skin daily
● Hypersensitivity especially for appearance of rashes
● Peripheral neuropathy ● Monitor patient for S&S for peripheral
● Dyspnea and cough neuropathy, hypersensitivity, and
● Abdominal pain coagulation disorders.
● Anemia ● Avoid drinking cold beverages, don't use
ice, and cover any exposed skin before
handling cold temperatures or cold things.
● Monitor I&O.

a. Brand Name: ● Together with 5-FU, folinic
Leucovorin acid is a drug used to treat a
b. Generic Name: number of cancers. It is
Folinic Acid
frequently used as a remedy for
c. Classification
Vitamins folic acid antagonists. like
d. Route: methotrexate. Commonly
IV indicated in advanced
colorectal cancer, often as
palliative treatment after
surgery and anemia.
● The two main roles of
folinic acid in
pharmacology are to
counteract the effects of
folic acid antagonists and to
enhance the effects of
fluoropyrimidines.
Side Effects: ● Monitor patient for signs and symptoms of
● Nausea neurological decline, gastrointestinal
● Diarrhea complications such as diarrhea/stomatitis,
● Loss of appetite and anemia.
● Feeling irritable ● Verify correct IV concentration and rate of
● Bloating infusion with physician Inspect skin daily
● Sleep problems especially for appearance of rashes.
● Monitor I&O.
Adverse Effects:
● Hypocalcemia
● Hypersensitivity
● Stomatitis
● Dehydration
 ● Anorexia

a. Brand Name: ● Chemotherapeutic drug ● The drug fluorouracil Side Effects: ● Ensure safe handling, double-glove with
Fluoroxil fluorouracil (5-FU) is used to inhibits an enzyme that ● Nausea latex gloves, and change the double set after
b. Generic Name: treat a variety of cancers. The changes cytosine nucleotide ● Diarrhea every 30 min of exposure. If a drug spill
5FU/Fluorouracil
FDA has approved the systemic into its deoxy derivative. ● Loss of appetite occurs, change gloves immediately after it is
c. Classification
Cytotoxic use of 5-FU for the treatment of Fluorouracil also prevents ● Sore throat cleaned up.
Chemotherapy colorectal, pancreatic, breast, the thymidine nucleotide ● ● Monitor and report signs of abnormal
d. Route: and gastric adenocarcinomas. from being incorporated bleeding from any source during
IV into the DNA strand, which Adverse Effects: thrombocytopenic period.
further inhibits DNA ● Chest pain ● Monitor and establish a reference data base
synthesis. ● Thrombophlebitis for body weight, I&O ratio and pattern.
● Gastrointestinal ulcer ● Inspect patient's mouth daily. Promptly
● Severe allergic reaction report cracked lips, xerostomia, white
● Hyperbilirubinemia patches, and erythema of buccal
● Inflammation of membranes.
esophagus ● Educate patient and family that it is very
important to report the first signs of
toxicity: Anorexia, vomiting, nausea,
stomatitis, diarrhea, GI bleeding.

a. Brand Name: ● It is indicated in cases of acute ● It boosts the expression of Side Effects: ● Inspect the abdomen, auscultate bowel
Mucopiod gastritis and acute exacerbation epidermal growth factor and ● Nausea sounds
b. Generic Name: of chronic gastritis, which both EGF receptors, rebamipide ● Diarrhea ● Assess mucous membrane status to evaluate
Rebamipide
involve bleeding, erosion, aids in replacing lost tissue. ● Vomiting potential problems with absorption and
c. Classification
Antacids redness, and edema which are These EGF promote ● Cold sweat hydration.
d. Route: all symptoms of gastric angiogenesis, more ● Monitor laboratory test results, including
PO mucosal lesions. granulation tissue Adverse Effects: serum electrolyte levels and renal function
formation, and ● Severe allergic reaction tests, to monitor for adverse effects of the
epithelization during ulcer ● Hypersensitivity drug and potential alterations in excretion
healing. ● Drowsiness that may necessitate dose adjustment.
● Thrombocytopenia

a. Brand Name: ● For the short-term management ● Tramadol is a centrally Side Effects: ● May be taken with or without food
Cetra of moderate to severe pain. acting opioid analgesic that ● Dizziness ● Monitor vital signs and assess for
b. Generic Name: binds to μ-opiate receptors ● Nausea orthostatic hypotension or signs of CNS
Tramadol +
 Paracetamol in the CNS, leading to
c. Classification: inhibited ascending pain
Opioids pathways and altered pain
d. Route:
perception and response. It
PO
also inhibits the reuptake of
norepinephrine and
enhances the release of
serotonin.
● Paracetamol is a
para-aminophenol
derivative with analgesic,
antipyretic and weak
anti-inflammatory activity.
● Vomiting depression
● Heartburn ● Assess bowel and bladder function; report
● Stomach pain urinary frequency or retention.Assess for
level of pain relief and administer prn dose
Adverse Effects: as needed but not to exceed the
● Flatulence, recommended total daily dose.
● hot flushes ● Do not take with other medications
● HTN containing acetaminophen without medical
● Hypoesthesia advice.Do not self-medicate patients for
● Pruritus pain for more than 10 days
● Trembling & vomiting

a. Brand Name: ● Temporary relief of painful ● Difflam Forte, a Side Effects: ● Prior to administering medication, evaluate
Difflam Forte conditions of the oral cavity prostaglandin synthetase ● Dizziness the pain's onset, type, location, and duration.
b. Generic Name: including tonsillitis, sore throat, inhibitor, specifically binds ● Nausea Withhold and call a doctor if your
Benzydamine
radiation mucositis, aphthous to inflamed tissues and acts ● Headache respirations are less than 12 per minute.
c. Classification:
NSAID ulcers, post-orosurgical & as an anti-inflammatory and ● Heartburn ● Analyze the effectiveness of the treatment
d. Route: periodontal procedures, analgesic by stabilizing ● Vomiting and clinical pain relief.
PO pharyngitis, swelling & cellular membranes and ● Ensure that patients report any adverse
inflammatory conditions. preventing prostaglandin Adverse Effects: effects.
synthesis. ● Dryness
● Tingling
● Warm feeling in the
mouth
● Altered sense of taste

REFERENCES
MIMS Pharmaceuticals, (n.d). Drug information. Retrieved from https://www.mims.com/philippines
Rob holland (n.d). Nursing Drug Guide. Retrieved from http://www.robholland.com/Nursing/Drug_Guide/data/monographframes/O004.html