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PINKY MARIEL ANDREA REGISTOS LACABA

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Out of 50 points Time for this attempt

Your Answers:
1 1 / 1 point

Absorption in the rectum depends mainly on the following, except:

Drug’s degree of ionization

Drug’s lipid solubility

Drug’s molecular weight

None of these choices

2 1 / 1 point

This type of suppository base can leak from the rectal opening but are regarded as less irritating.

Oleaginous base

Water- washable base

Water-soluble base

Premixed fatty base

0 / 1 point
3
3
True about Vaginal Creams, Ointments and Foams, except:

None of these choices

Formulations can be washed away by vaginal fluids

Can be used as a spermicide

Correct Answer: None of these choices

May tend to leak out from the vagina 

4 1 / 1 point

Eye drops are effective in delivering drugs into the vitreous chamber, retina, choroid, and sclera. 

True

False

5 1 / 1 point

The nasal mucosa has higher enzymatic activity than the gastrointestinal tract. 

True

False

6 1 / 1 point

Which of the following ophthalmic preparations offer a longer duration of action because drugs are
retained in the cul-de-sac increasing the contact time?

Ophthalmic solution

Ophthalmic gel 

Ophthalmic ointment

Ophthalmic suspension

7 1 / 1 point
 One of the rectal drug delivery system that has better drug retention than enemas.

Rectal foam

Rectal ointment 

Rectal gel

Rectal suppository

8 1 / 1 point

Large surface area and the highly vascular surface of the mucosa, enables slow absorption of the
drug. 

True

False

9 1 / 1 point

Unionized drug will permeate the corneal membrane. 

True

False

10 1 / 1 point

Ketoconazole needs a __________ pH to become non-ionized and to be able to cross the membranes
of the vagina. 

Acidic

Neutral

Slightly basic

11 1 / 1 point

Vaginal mucosa is similar to the _____ mucosa.

Nasal
 Intestinal

Buccal

Rectal

12 5 / 5 points

Match the route of administration with its appropriate characteristics.

Solid drug inserted at the

Rectal drug administration
rectum that dissolves at body
temperature and spreads
over the lining of the lower
bowel, where it is absorbed in
the bloodstream

injecting the drug in the

Intratympanic drug administration
middle ear cavity, and the
drug substances then diffuse
from the middle ear cavity
into the cochlea.

simplest method for drug

Intracochlear drug administration
delivery to the inner ear is
the direct injection of drugs
into the cochlea using a
syringe.

Injecting the drug within the

Intravitreal drug administration
vitreous body of the eye

drug diffusion from the ear

Transtympanic drug delivery
canal into the middle and
inner ear. This process can be
facilitated by permeation
enhancers.

13 1 / 1 point

Nasal, ophthalmic, otic and vaginal drug delivery system bypasses first-pass hepatic metabolism. 

True
 False

14 1 / 1 point

The optimal size range of particles to be deposited in the respiratory region of the nasal cavity.

5-7 µm

8-10 µm

<0.5 µm

10-15 µm

15 1 / 1 point

Which of the following is true about using powders and ointments in Otic Delivery?

Powdered otic preparations have greater surface area, improving therapeutic effect in the ear
 

Ointments and powder otic preparations can cause conductive hearing loss

Ointments provide a longer residence time in the ear therefore promoting longer action to the
target site

Ointments and powder otic preparations can provide longer duration of action compared to
drops and solutions

16 1 / 1 point

Which of the following is true about using PEG as suppository base?

Does not melt at body temperature but dissolve slowly in body fluids. 

All of these choices

Different ratios of low and high molecular weight PEGs can be used to alter the hardness of the
suppository

Dipping PEG suppository prior to insertion reduces the stinging effect

17 1 / 1 point
 Vaginal mucosa is acidic and the acidity is maintained by a lactobacilli, which converts glycogen to
_________.

Acetic acid

Hydrochloric acid

Citric acid

Lactic acid

18 1 / 1 point

This type of suppository base does not melt at body temperature but dissolves slowly in body
fluids.

Fattibase

PEG

Wecobee

Cocoa butter

19 1 / 1 point

This type of vaginal drug delivery system is commonly used to deliver estrogen and progesterone
and it has the ability to control the release of the drug.

Rings

Suppositories

Tablets

Creams

20 1 / 1 point

In vaginal drug delivery, lipophilic drugs primarily occurs by ___________.

Passive diffusion

Active transport
 Transcellular

Paracellular

21 1 / 1 point

Tympanic membrane is the first major barrier to drug delivery to the ear.  

True

False

22 1 / 1 point

An example of a vaginal tablet lubricant.

Polyethylene glycol

Lactose

Silicone

Magnesium stearate

23 1 / 1 point

Drugs absorbed from the lower rectum do not undergo first-pass effect. 

True

False

24 1 / 1 point

Delivery of drugs into the posterior segment of the eye is achieved primarily by ___________.

Vitreal injections 

Orally administered medications

Eye patch

Ophthalmic drops
25 1 / 1 point

High volume of drug can be administered through nasal drug delivery system. 

True

False

26 1 / 1 point

Which of the following diseases/conditions may be relieved/treated with Otic Drug Delivery
systems?

Inflammation

Ear infection

All of these choices

Cerumen accumulation

27 1 / 1 point

Which of the following excipients will decrease MCC and prolong drug residence time in nasal
cavity?

Buffer 

Glycerol

Bile salts

Alginates

28 1 / 1 point

Limitation of otic topical drug delivery is ototoxicity. 

True

False
29 1 / 1 point

Which of the following excipients used in Vaginal Drug Delivery systems is a tablet disintegrant?

Magensium Stearate

Which of the following excipients used in Vaginal Drug Delivery systems is a tablet
disintegrant?

Lactose

Polyvinylpyrrolidone

30 1 / 1 point

Superior hemorrhoidal veins (lower rectum) drains directly into the portal circulation. 

True

False

31 1 / 1 point

Olfactory nerve is the 3rd cranial nerve and conveys special sensory information related to smell.  

True

False

32 1 / 1 point

Rectal delivery system should be placed too high to have a maximum absorption of the drug
locally. 

True

False

33 1 / 1 point

Local drug delivery for otic preparations, maximizes concentration in the ______ while minimizing
systemic exposure.
 Middle ear

Inner ear

Pinna

Outer ear

34 1 / 1 point

Which of the following solvents used in Rectal Drug delivery is found both in Rectal Gels and
Rectal Enemas?

Xantham Gum

Ethyl Alcohol

Propane

Glycerinated Gelatin

35 1 / 1 point

Increasing the MCC will prolong drug residence time. 

True

False

36 1 / 1 point

The following are properties of the nasal cavity, except _____________

Absorbed directly into portal vein facilitating hepatic metabolism.

A site of drug application for both local and systemic effects.

A site beneficial for the treatment of acute diseases and in emergency care.

It has lower enzymatic activity than the gastrointestinal tract, therefore, a route for the
administration of proteins.

37 1 / 1 point
 Drugs that permeate the mucous membrane of the cul-de-sac are 

Absorbed systemically

Drained out from the conjunctiva

Absorbed by the posterior segment of the eye

Absorbed by the anterior segment of the eye

38 1 / 1 point

Which of the following pH range levels reflect a healthy ear canal?

5.0-5.7

5.0-7

5.0-6

3.5-7.5

39 1 / 1 point

The drug is easily absorbed from the rectum, because _______.

It dissolves at body temperature.

It is accessible to administer the drug.

It minimizes hepatic-first pass metabolism. 

The area is rich in blood vessels

40 1 / 1 point

Which of the following excipients in otic preparations can act as a solvent and also a viscosity-
increasing agent?

Diluted alcohol 

Propylene Glycol

Water
 Sodium Hyaluronate

41 1 / 1 point

Ionization of weakly acidic and basic drugs can be altered by changes in vaginal pH. 

True

False

42 1 / 1 point

It is a physical and biochemical barrier between systemic circulation and the cochlea. 

 Round window membrane

Blood-perilymph barrier

 Oval window

Tympanic membrane

43 1 / 1 point

_____________drugs are absorbed through cell membranes of the epithelial layer.

Amphiphilic 

Lipophilic

Hydrophilic

44 1 / 1 point

Ophthalmic suspensions result to minimal side effects. 

True

False

45 1 / 1 point
 Systemically administered medications for ophthalmic purposes have low bioavailability due to
__________.
 

Blinking

Tear dilution 

Blood-eye barrier

Drainage

46 1 / 1 point

Which of the following is true when administering Otic Preparations to children younger than 3
years of age?

None these choices

Push the tip of the ear drop inside the ear canal for optimum administration

Which of the following is true when administering Otic Preparations to children younger than
3 years of age?

Pull the ear backward and downward