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Diabetes en México Costo y Manejo de La Diabetes y Sus Complicaciones y Desafíos para La Política de Salud
Diabetes en México Costo y Manejo de La Diabetes y Sus Complicaciones y Desafíos para La Política de Salud
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Diabetes in Mexico: cost and management of diabetes and its complications and
challenges for health policy
Globalization and Health 2013, 9:3 doi:10.1186/1744-8603-9-3
ISSN 1744-8603
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Ismael Campos-Nonato1*
*
Corresponding author
Email: icampos@insp.mx
Carlos Aguilar-Salinas2
Email: caguilarsalinas@yahoo.com
Ruy Lopez-Ridaura1
Email: rlridaura@insp.mx
Armando Arredondo1
Email: armando.arredondo@insp.mx
Juan Rivera-Dommarco1
Email: jrivera@correo.insp.mx
1
Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud
Pública, Av. Universidad No. 655. Col. Sta. Ma. Ahuacatitlán, Cuernavaca, Mor,
Mexico CP. 62508, Mexico
2
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México,
D.F, Mexico
Abstract
Background
Mexico has been experiencing some of the most rapid shifts ever recorded in dietary and
physical activity patterns leading to obesity. Diabetes mellitus has played a crucial role
causing nearly 14% of all deaths. We wanted to make a comprehensive study of the role of
diabetes in terms of burden of disease, prevalence, cost of diabetes, cost of complications and
health policy.
Method
In this paper we review the quantitative data that provides evidence of the extent to which the
Mexican health economy is affected by the disease and its complications. We then discuss the
current situation of diabetes in Mexico with experts in the field.
Results
There was a significant increase in the prevalence of diabetes from 1994 to 2006 with rising
direct costs (2006: outpatient USD$ 717,764,787, inpatient USD$ 223,581,099) and indirect
costs (2005: USD$ 177,220,390), and rising costs of complications (2010: Retinopathy USD$
10,323,421; Cardiovascular disease USD$ 12,843,134; Nephropathy USD$ 81,814,501;
Neuropathy USD$ 2,760,271; Peripheral vascular disease USD$ 2,042,601). The health
policy focused on screening and the creation of self-support groups across the country.
Conclusions
The increasing diabetes mortality and lack of control among diagnosed patients make quality
of treatment a major concern in Mexico. The growing prevalence of childhood and adult
obesity and the metabolic syndrome suggest that the situation could be even worse in the
coming years. The government has reacted strongly with national actions to address the
growing burden posed by diabetes. However our research suggests that the prevalence and
mortality of diabetes will continue to rise in the future.
Keywords
Diabetes, Costs, Mexico, Prevalence, Diabetes management
Background
Mexico has been the subject of an epidemiological transition: in two decades, Mexico’s
disease profile has transformed from malnutrition, communicable infectious and parasitic
diseases to a country dominated by obesity, diabetes and other nutrition-related non-
communicable diseases (NR-NCDs) [1-3]. Mexico has experienced some of the most rapid
shifts in dietary and physical inactivity patterns--and ultimately obesity--ever recorded [4-7].
Between 1988 and 2006, Mexico’s annual prevalence rate of obesity (body mass index [BMI]
≥ 30 kg/m2) increased among adults by approximately 2% per year, the largest increase
documented worldwide. From 1980 to 2000 researchers documented an alarming 47%
increase in diabetes mellitus mortality rates: in 1980 diabetes mellitus was the ninth cause of
mortality and ascended to the third by 1997 [2]. Based on national mortality statistics, after
disaggregating cardiovascular disease, diabetes has been the primary cause of death among
women and men since 2000 followed by coronary heart disease. In 2009, diabetes was
responsible for 77,699 deaths, representing 13.76% of all deaths [8].
Methods
In this paper we review the quantitative data that provides evidence of the extent to which the
Mexican health economy is affected by the disease and its complications. We then examine
and discuss the current situation of diabetes in Mexico with experts in the field. Our research
does not involve human intervention or collection biological samples. This paper only
describes information of secondary databases and studies that have been ed by Ethics,
Research and Biosecurity Committees of the National Institute of Public Health.
Results
Burden
In México, it was estimated in 2004 that NR-NCDs caused 75% of the total deaths and 68%
of total disability-adjusted life years (DALYs). The leading causes of death were ischemic
heart disease, diabetes mellitus and cerebrovascular disease. High body mass index (BMI),
high blood glucose and alcohol consumption are responsible for a larger burden of disease
than other non-communicable disease risks; diabetes mellitus accounted for 9.7% of total
deaths, with higher percentages in women (12.1%) than men (9.7%) and 3.5% of total
DALYs. High blood glucose and high BMI together accounted for 25.3% of total deaths and
10.1% of total DALYs [9].
The country shows very heterogeneous levels of transition by region, a condition that has
been called the polarization of the nutrition/epidemiological transition; the southern region of
Mexico, which is less developed, showed an increase of diabetes mortality rates from 1980–
2000 of 128% compared to the more developed northern region, where mortality increased
only 32.5% [2]. The southern region also faces higher prevalence of undernutrition and
infectious diseases making this region the one with the largest burden of ill health in the
country [9].
Although there have been some efforts to develop a national registry of diabetes, this has not
been accomplished yet. The prevalence of diabetes and other diseases at the national, regional
and state level have been obtained from diverse national surveys (the National Chronic
Disease Survey 1994, the National Nutrition Survey II and National Health Survey 2000)
which recently have been consolidated into the Mexican National Nutrition Survey
(ENSANUT 2006 and 2012) collected every six years. A representative subsample of fasting
serum, blood sugar, blood lipids, and other biochemical indicators [10] is obtained from
participants 20-years and older. These surveys also collect HbA1c from participants that have
been previously diagnosed to evaluate control. It also has a section on access to health
services. Data on expenditure on medications for diabetes, high blood pressure and obesity
and treatments is collected by the National Income and Expenditure Surveys every two years
in Mexico by INEGI [11]. Incidence data has been collected from diverse cohorts such as the
Mexico City diabetes study, but how representative it is of the entire country is uncertain
[12]. Overall, the health statistical system in Mexico has been recognized as one of high
quality, mostly due to the Mexican Health and Nutrition Survey. However, as in many other
countries, incidence information is scarce [13].
Finally, together with the launch of the medical specialties systems (UNEMES), there was an
effort to establish an information system for diabetes outcomes, especially related to quality
of care indicators. However this system is still in its development. Besides this, other local
efforts have been developed in the Mexican institute of social security (IMSS) and within the
certification of diabetic groups, that also might be a reliable source in the near future [14].
Prevalence
There was a significant increase in the prevalence of diabetes from 1994 to 2006 (the time
frame covered by the National Health Surveys). In the ENEC-1994 survey, the prevalence of
diabetes mellitus type 2 was 6.7% (previously diagnosed [PD] 4.6% and newly diagnosed
[ND] 2.1% or didn’t know who they had diabetes). In the ENSA-2000 study, the overall
prevalence was 7.5% (5.8% previously diagnosed and 1.7% newly diagnosed). In the
ENSANUT-2006 survey, the prevalence reached 14.4% (7.3% PD and 7.1% ND) (Table 1)
[15]. The prevalence increased in both genders. For women, the prevalence was 6.8%, 7.8%
and 13.2% in the 1993, 2000 and 2006 surveys respectively. The corresponding percentages
were 6.6%, 7.2% and 15.8% in men.
In both the ENSA-2000 and ENSANUT-2006 surveys (the only two surveys with
representation within rural and urban areas), the prevalence was higher in urban (8.2 vs.
15.5% respectively) populations compared to rural ones (5.6 and 10.4% respectively). The
estimated overall prevalence of type 2 diabetes between 1993 and 2006 increased by two-fold
(7.4 percentage points [pp]), resulting in a rate of 0.56 pp/year. Considering only the PD
cases, the prevalence increased from 4.6% in 1993 to 7.3% in 2006. This is an overall
increment of 2.7 pp over a 13 year time period (0.2 pp/year).
There is limited information on the incidence of diabetes available in Mexico; the Mexico
City study conducted in a low-income population reported a cumulative incidence of 9.12%
and 7.22% in males and females respectively, from 35–64 years of age in a 6.3 year follow-
up [16]. A study in Mexican-Americans showed a similar diabetes incidence of 6.5% after a
8-year follow-up, with higher rates for males than females [17].
Diabetes mellitus prevalence has reached 14.4% of the population (representing 7.31 million
adults) [18] and at the same time it has become the number one general cause of mortality,
with 14% of total deaths; in 2008 a total of 75,572 Mexicans died from this cause (un-
adjusted mortality rate 70.8/100,000 inhabitants) [19,20].
The Mexican health care system is formed by diverse public institutions that offer health care
services to both the uninsured population (Ministry of Health Medical Services) and salaried
workers from the tax-paying formal economy (Mexican Institute of Social Security (IMSS)
and the Institute for Social Security and Services for State Workers (ISSSTE)). In 2001,
Seguro Popular (People’s Insurance) was created by the federal government as a major effort
to protect the uninsured population against steep health care costs. Enrolment in Seguro
Popular is voluntary and is not dependent on health status or pre-existing illness. There is no
co-payment and contributions are determined solely by ability to pay [15], with a predefined
quote based on income deciles (the poorest 4 deciles of income without any payments and
from the 5th to the top income deciles a quote of USD $152.00 to USD $834 per family per
year) [21]. The rest of the population with purchasing power receives medical attention from
the private sector [22]. In its last report from 2010, the Seguro Popular had already enrolled
43.5 millions of previously uninsured Mexicans reaching 88.5% of the final goal of universal
coverage. The total contributions from family quotes was USD$ 15.5 million, only covering a
0.2% of the total financial sources that for the year 2010 resulted in USD$ 8,043 million [21].
Diabetes mellitus is among the many diseases covered by this insurance, however this
coverage includes mainly ambulatory primary care and urgent care, but major costs of
chronic complications such as substitution of renal failure and acute coronary syndrome was
not covered in 2010. In 2011, myocardial infarction was added to the catalogue of major
diseases covered, but only among adults younger than 60 years old [23].
Several estimates have been published about the economic burden imposed to the health
system by this condition. In the most recent published report, Avila et al. estimated the total
national expenditure on diabetes mellitus, cardiovascular disease and obesity in 2006 came to
USD$ 2,869.6 million representing 7% of the national health expenditure and 0.4% of the
Gross National Product (GNP). From this amount 73% was financed by the state and 27% by
the private sector. A total of 40.7% of this estimate was allocated solely to diabetes mellitus
[11,24]. In addition to this estimation, which is based on expenditure rather than costs, many
other cost estimates have been published in the last two decades (Table 2).
In a report published in 2006, the total cost for Diabetes Mellitus in the country was USD$
1,164.8 million dollars, this amount includes the concepts described in Table 3 [11].
These estimates are higher than the ones reported by Arredondo et al. (2005) using different
methodology [22], where the total direct and indirect cost amounted to USD$ 317,631,206
(see III. Discussion). A recent update by this group found total costs for 2010 came to USD$
343,226,541 reflecting an increase of approximately 8% in a 5-year period [25].
In 2005 indirect costs were estimated at USD$ 177,220,390 (at an exchange rate
corresponding to January 2003). From these costs, a major part was the cost of permanently
disabled patients (USD$ 166,693,502), followed by the cost of mortality (USD$ 8,010,360),
and the cost of temporarily disabled patients (USD$ 2,516, 528) [22].
Based on data from the 2006 health survey and with the use of a predictive model, it is
estimated that the 53.8% of people currently living with diabetes will die in the following 20
years. The average life expectancy is 10.9 years (95%CI 10.7-11.2). It is expected that over
the next 20 years, 889,443 new cases of patients with heart failure (95% CI 509, 638–1, 269,
248), 2,048,996 with myocardial infarctions (95% CI 1,699,743-2,398,248), 798,188 with
strokes (95% 544, 809–1, 051, 568) and 491,236 with lower-limb amputations (95% CI 313,
900–668, 572) will occur if the quality of care has not been improved (Table 4).
Trends revealed by comparing incremental costs for complications from 2005 to 2010 can be
explained by three main reasons:
Prevention
Since 2001, there have been explicit national diabetes action programmes and the National
Health Plan had an important focus on NCDs [26]. During the 2007–2012 federal
administration, NCDs became a top priority in the National Health Plan [27], and efforts in
prevention, treatment and control were intensified based on a specific action programme for
diabetes mellitus [28]. Some of the important achievements in diabetes prevention and
control developed by the Ministry of Health (MOH) and the public health services since 2000
are described in Table 5.
One important success in this period was the creation of self-support groups across the
country. Currently there are more than 11,000 groups receiving orientation, guidelines and
certification from the MOH. Screening has also improved substantially; in 2000, 10% of
adults requested this service from the MOH. Six years later, one out of every five adults went
to public medical services for blood glucose screening [28].
Screening
Treatment
A recent report found that adequate control is very rare for members of the population that
participated in ENSAUT 2006 that were previously diagnosed with diabetes; only 6.6% of
those diagnosed had HbA1c <7%. One of the identified reasons for this increase in mortality
and lack of control has been the suboptimal efficacy of the current therapeutic model. In
addition, this report found that most of the known diabetes population in Mexico are in poor
control, regardless of access to care, type of institution, or insurance [30].
The majority of patients are under treatment (94.1%), which is based on the use of glucose
lowering drugs in most cases (84.8%). However, only a minority understands the importance
of life style modifications, e.g. the eating habits (24.1%) and exercise (1.8%) as part of its
management.
The use of insulin is delayed and it is indicated in a small number of cases (6.8%)
compared to international standards (> 20%)
The same phenomenon occurs with other clinical variables that should be modified for the
prevention of chronic complications.
Among those previously diagnosed cases, 80% received treatment. However, the majority
(76.7%) has blood pressure values above the recommended targets (130/85 mmHg). The
same phenomenon can be seen with the treatment of dyslipidemia (DM) and the use of
antiplatelet drugs.
Other NR-NCDs in Mexico follow the same pattern of DM; obesity is steadily increasing as
well as high blood pressure and other NR-NCD mortality causes such as ischemic heart
disease. Cardiovascular and liver diseases are on the increase too [7,31]. In terms of insulin
use, many potential barriers have been proposed by the attending physician, the patient and
the institution itself. However, recent efforts in public institutions are focusing on how to
increase insulin use among diabetics [32]. In Mexico, public health services are obliged to
provide all prescribed medications to patients if included in the basic medication scheme (a
list of generic drugs). When a prescribed medication is not on this list, it must be purchased
by direct payment by the patient in a drug store or with charge to the institution, when it is
justified according to specific criteria [33].
Some evidence of availability of drugs from the basic medication scheme (Table 6) in
primary health services has been documented [34].
The increasing diabetes mortality and lack of control among diagnosed patients make quality
of treatment a major concern in Mexico. The growing prevalence of childhood and adult
obesity and the metabolic syndrome suggest that the situation could be even worse in the
following years [1,8,35,36]. An analysis of diabetes care in the Mexican population using
data from ENSANUT 2006 reported that 25.6% of the previously diagnosed cases did not
have access to care; from this percentage 73.4% were females and this group had the highest
proportion of subjects speaking an aboriginal dialect and living in rural areas. This study
showed that 85.6% of diagnosed patients are treated with oral agents, 6.2% reported no
pharmacological therapy and a very small proportion of the population was using insulin (as a
single therapeutic agent or in combination). Only a small fraction of the participants had
adequate HbA1c levels and the group with no access to health care had similar values of
mean HbA1c compared to the rest of the groups. A total of 84% of the population with
HbA1c was poorly controlled and more than half of these had levels above 12% [30]. Among
the factors that were associated to a better control in this survey were: a medical consultation
within the last three months, and access to social security. The participation of a dietitian in
the medical attention of the participant decreased the odds of being severely uncontrolled
(RM = 61, 95%CI = 0.38-0.97) [37].
There are different sets of guidelines and norms in Mexico, however recently an attempt to
unify criteria has been made. The NOM (Mexican Official Norm) NOM-015-SSA2-1994
described the general treatment for diabetes in medical practice. A new norm has been
released with more updated criteria in 2010 (NOM-015-SSA2-2010). The UNEMES-
Crónicas (previously described), have protocols for interdisciplinary treatment of diabetes
mellitus and other diseases [38]. IMSS, ISSSTE and other public health services have their
own guidelines. There is also consensus in publications from medical societies promoting
recommendations for DM treatment as well as position papers [39,40].
Diabetes outcome
Each Mexican health system has his own set of diabetes-related outcomes. However, their
databases are not integrated into a national registry. Outcomes are recorded for all
hospitalized patients by the attending physicians; data is sent to a central office. However,
outcomes are not recorded in the majority of the outpatient clinics (except for the UNEMES
chronic units). Process indicators are recorded in some but not in all health systems. Their
recollection started in the last five years.
Discussion
Weak evidence base due to lack of solid data
Data basis
Currently the major registry is within each public institution, especially IMSS and ISSSTE,
and its primary use is administrative. Periodically the Minister of Health reports on the
number of diabetics registered as new cases and estimates of incidence rates. However, due to
the lack of a diabetes registry, these estimates are not often used for epidemiological or
administrative purposes. Moreover, since the year 2000, the MOH has started another
sentinel surveillance system for hospitalized cases of diabetes but similar to the periodic
surveillance reports, the data obtained lacks validity for any systematic use. The last report
from this system was in 2007 [41].
In addition to the information system, Mexico has a very well developed system for reporting
mortality and prevalence information based on national surveys. In Mexico, date on diabetes
mellitus mortality is obtained from the National Mortality Statistics Registry managed by the
National Institute of Statistics, Geography and Informatics (INEGI www.inegi.org.mx).
Prevalence data
There are multiple reasons for the observed changes in the prevalence of diabetes. These
include a shift in the age distribution of the population and a growing prevalence of obesity,
principally related to changes in lifestyle. However there are several methodological
differences between surveys that might explain part of the ascendant trend. The proportion of
subjects studied under fasting conditions was small in both the 1993 and 2000 surveys (≈5%).
As a result, most of the newly diagnosed cases were identified by the random blood glucose
criterion (200 mg/dl). This characteristic of the 1993 and 2000 studies may have led to an
underestimation of the true prevalence; random glucose measurements are the diagnostic
criterion with the lowest sensitivity. This was not the case for the ENSANUT-2006 survey.
Fasting was verified in all participants of the subsample in which the prevalence of diabetes
was estimated.
Another indicator of a possible underestimation of the type 2 diabetes prevalence in the two
earlier surveys is the proportion of previously diagnosed to newly diagnosed cases. This ratio
was 1:0.45 for ENEC-93, 1:0.26 for ENSA-2000 and 1:0.97 for ENSANUT-2006
respectively. The PD:ND ratio in the National Health and Nutrition Examination Survey of
North America (NHANES-III) was 1:0.5 [21]. The high prevalence of diabetes mellitus is
associated with an earlier age of onset in the majority of the population [9]. The prevalence of
type 2 diabetes diagnosed before the age of 40 increased progressively from 1.8% (PD =
0.95%, ND = 0.65%) in 1993 to 2.3% (PD = 1.19%, ND = 1.51%) in 2000 and to 5.7% (PD =
1.45%, ND = 4.26%) in 2006. The surge of early onset diabetes seen in ENSANUT-2006
corresponded predominantly to cases diagnosed during the survey.
Individuals diagnosed before the age of 40 will have a longer exposure to hyperglycemia and
other diabetes-related abnormalities, ultimately increasing the likelihood of chronic
complications. Also, this type 2 diabetes will require insulin therapy early on. Studying this
variant of the disease will render strategic information for health care planning in Mexico;
detection campaigns and preventive actions have to be targeted to subjects younger and older
than 40 years. However, this strategy has to be proven to be cost effective in order to
establish it as a public policy.
Large differences exist between reports on costs; inconsistencies arise due to the sources of
information used and the assumptions and models applied. Depending on the study referred
to, these differences can be further explained by one or more of the following reasons:
■ The population base and the method of costing may be based only on estimates and
probabilistic simulations without information on actual costs or actual cases from national
health system.
■ The population base and the method of costing may be based on actual costs and actual
cases by type of institution for the entire national health system.
■ The concept of costs and expenses are different; some studies are not explicit or clear in
regards to expenditure or cost depending on the sources of information and the type of
inputs and costs.
■ In the case of the methodology based on annual average cases, differences in the
amounts are explained by differences in the type and quantity of inputs used by each
institution depending on the production function in question and the quality standards
attention as intervening variable in the control or management cost average. This kind of
estimate is more related to the “ideal” cost, rather than the actual cost. For instance, the
differences in the total amounts of direct and indirect costs can also be explained by
differences in the sources of cost information. Furthermore, the cost of inputs varies
depending on social security institutions, for public assistance and private institutions and
users.
Treatment
Visits between doctor and patient are seldom programmed. The duration of individual
consultations is insufficient and the inclusion and participation of other health professionals
only occurs in a few instances.
At present, the training of health professionals does not adequately prepare them for the
realities of practice. Educational programmes provide a priority to combat degenerative
diseases in the medium term; however, many graduates have the knowledge but lack the
skills to promote an effective treatment. As a result, clinical inertia is a major contributor to
the inefficiency of the system.
Finally, public awareness of the disease is low. Patients often do not understand the treatment
goals and do not make the necessary lifestyle changes.
Programmes to improve the quality of diabetes treatment have been presented but poorly
implemented. The lack of infrastructure of the teams in charge of the programmes is the main
reason for the lack of success.
This model is based on experiences in Ireland, London, the US and Europe [43-46]. More
than 50 clinics are now operating in most states of the country. Information and evaluations
of this pilot programme would be useful to quantify the potential impact of these initiatives.
These clinics are able to treat 3,000 patients/year. There is at least one of the almost 100
UNEMES specialized health clinics in the majority of states in Mexico.
There are additional government initiatives that set out to complement the diabetes
programme. Primary care physicians and members of the “UNEMES cronicas” teams are
trained in virtual courses (diploma) in chronic diseases (including evaluation and prescription
of diet and physical activity, obesity, diabetes, dyslipidemias and high blood pressure
treatment and adherence, and motivational interviewing training coordinated by the National
Institute of Public Health for approximately 2,000 health professionals).
The MOH created a National Council for the Prevention and Control of Chronic Diseases and
promoted a nation-wide communication programme called “Five Steps for Your Health”
(“Cinco pasos por tu salud”). This programme included recommendations to consume water
(instead of soft drinks or other caloric beverages), increase physical activity, increase
consumption of fruits and vegetables, and regular weight checks. A total of six television
advertisements on 440 television channels and 750 radio stations are broadcasted daily
promoting this programme which reaches an audience of approximately 70 million people
[47].
During 2010, The president of Mexico announced that the MOH together with the National
Institute of Public Health had developed the first national policy to prevent obesity and
promote healthy nutrition [48]. In addition to these federal efforts, there are several state
programmes to prevent diabetes. IMSS, ISSSTE and other public health services have
developed their own national programmes based on common guidelines. In a propensity
score matching analysis, poor diabetic patients registered with Seguro Popular (part of the
social health protection system) showed in a preliminary analysis that they had improved
access to health care and blood glucose control [15].
Competing interests
In the past five years have you received reimbursements, fees, funding, or salary from an
organization that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future? Is such an organization financing this manuscript
(including the article-processing charge)? If so, please specify.
Authors’ contribution
SB Designed the structure of the paper, analyzed the information and wrote the paper with
co-authors. ICN Analyzed the information, reviewed the findings and wrote the paper with
co-authors. CAS Discussed the preliminary data, reviewed the findings and revised the
manuscript. RLR Analyzed the information and wrote the paper with co-authors. AA
Analyzed the information and wrote the paper with co-authors. JRD Reviewed the findings
and revised the manuscript. All authors read and approved the final manuscript.
Authors’ information
SB is Director of the Area of Nutrition Policies and Programmes, in the National Institute of
Public Health. He has not received any fees, reimbursement or honorary in relation to this
work.
ICN is Research of the Research Unit in Chronic Diseases and Diet, in the National Institute
of Public Health. He has not received any fees, reimbursement or honorary in relation to this
work.
CAS is Research of the Department of Endocrinology and Metabolism, in the National
Institute of Medical Sciences and Nutrition-Salvador Zubiran. He has not received any fees,
reimbursement or honorary in relation to this work.
RLR is Research of Center for Population Health: Chronic Disease Division, in the National
Institute of Public Health. He has not received any fees, reimbursement or honorary in
relation to this work.
AA is Research of Center for Research in Health Systems, in the National Institute of Public
Health. He has not received any fees, reimbursement or honorary in relation to this work.
JRD is Director of Center of Research in Nutrition and Health in the National Institute of
Public Health. He has not received any fees, reimbursement or honorary in relation to this
work.
Acknowledgment
This paper is part of a research project based at the London School of Economics and
Political Science (LSE) on Diabetes International which is funded with an unrestricted
educational grant by Novonordisk.
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