1. Formulate P-I-C-O-M based on the case.

P Middle aged patients who are diagnosed with DM Type 2

I DPP4 Inhibitors particularly sitagliptin and linagliptin
C Metformin
O 1. DPP4 inhibitors alone is better than metformin alone as initial
therapy for lowering blood sugar?
2. Metformin monotherapy and DPP4 inhibitors monotherapy cause
significant weight change?
M Meta-analysis of treatment and intervention as well as RCT of
treatment or intervention

2. Conduct a Pubmed search (enumerate the steps you used. Include

screenshots if feasible)

I first tried free text searching:

Then is tried free text searching with truncated search:

This lead me to narrow down articles to 13 articles

And on the narrowed list of articles, I found the an article which answers both concerns
regarding lowering the blood sugar AND weight changes while using monotherapies of
DPP4 inhibitors and Metformin.

3. Retrieve the title and abstract of your chosen article.