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DRUG STUDY Ft. Ranitidine
DRUG STUDY Ft. Ranitidine
CLASSIFICATION / NURSING
DRUG NAME INDICATION CONTRAINDICATIONS SIDE EFFECTS/ADVERSE
MECHANISM OF EFFECTS RESPONSIBILITY
ACTION
October 11 ,2021 .
6:00 am Drug Class: Histamine FDA-Approved Ranitidine SIDE EFFECTS: Assess heart rate, ECG,
H2 Antagonists Indications Ranitidine is and heart sounds,
BRAND NAME: Ranitidine is a competitive contraindicated in patients especially during
-headache
Zantac inhibitor of histamine H2- Benign gastric ulcer disease, who have previously exercise (See
receptors. The reversible short-term, and maintenance abdominal pain Appendices G, H).
experienced a
inhibition of H2-receptors Duodenal ulcer disease, short- agitation Report any rhythm
GENERIC: in gastric parietal cells term, and maintenance hypersensitivity reaction to disturbances or
hair loss
Ranitidine results in a reduction in Erosive esophagitis ranitidine or any of the symptoms of increased
both gastric acid volume Hypersecretory conditions (e.g., confusion arrhythmias, including
product components.
and concentration. Zollinger-Ellison, systemic constipation palpitations, chest
Ranitidine’s acid-lowering mastocytosis, multiple endocrine Small case series and discomfort, shortness of
DOSAGE: diarrhea
150 mg Tab effect is more pronounced adenoma syndrome) analyses demonstrate breath, fainting, and
for basal and nocturnal Gastroesophageal reflux
dizziness
conflicting results fatigue/weakness.
ROUTE: acid secretion than it is for disease (GERD) hypersensitivity Report signs of
food-stimulated acid Non-ulcer dyspepsia, regarding cross-sensitivity
PO reaction agranulocytosis and
secretion. Additional indigestion, heartburn, and sour among H2-receptor neutropenia (fever, sore
nausea
FREQUENCY: indirect effects of ranitidine stomach antagonists; caution is throat, mucosal lesions,
are decreased pepsin Non-FDA-Approved Ranitidine vomiting signs of infection,
BID, PO advised. Due to
secretion and increased Indications anemia bruising), aplastic anemia
nitrate-reducing bacterial differences and similarities (unusual fatigue,
flora. Anaphylaxis[1][2] between the chemical weakness), or
NSAID-induced ulcer thrombocytopenia
structures, there is
prophylaxis[3] . (bruising, bleeding gums,
Stress ulcer prophylaxis[4] speculation that some H2 nose bleeds).
Taxane-related urticaria blockers have less risk of ADVERSE EFFECTS: Monitor signs of
prophylaxis[5] cross-reactivity than hypersensitivity
Aspiration prophylaxis during reactions, including
obstetric anesthesia[6] others.
Central nervous pulmonary symptoms
system (tightness in the throat or
chest, wheezing, cough,
(CNS): Malaise, dyspnea) or skin
dizziness, reactions (rash, pruritus,
somnolence, urticaria). Notify
insomnia, vertigo, physician or nursing staff
mental confusion, immediately if these
reactions occur.
agitation, and
Be alert for signs of
hallucinations. vasculitis, including
Cardiovascular: Ta fatigue, weakness,
chycardia, muscle pain, joint pain,
bradycardia, numbness, fever, loss of
asystole, appetite, and weight loss.
Report these signs to the
atrioventricular physician.
block, and Assess dizziness and
drowsiness that might
premature affect gait, balance, and
ventricular beats. other functional activities
Bradycardia may (See Appendix C).
be more frequent Report balance problems
with rapid and functional limitations
to the physician and
intravenous nursing staff, and caution
administration and the patient and
in patients with family/caregivers to
cardiac rhythm guard against falls and
disturbances. trauma.
Monitor other CNS
Gastrointestinal
symptoms such as
(GI): Constipation, confusion, hallucinations,
diarrhea, nausea, and headache.
vomiting, Excessive or prolonged
abdominal CNS symptoms may
discomfort, require a reduction in
dose.
pancreatitis. Monitor IM injection site
Hepatic: Hepatocel for pain, swelling, and
lular, cholestatic, or irritation. Report
mixed hepatitis; prolonged or excessive
hepatic failure injection site reactions to
the physician.
Musculoskeletal: M
yalgia, arthralgia
Hematologic: Leuk
openia,
granulocytopenia,
thrombocytopenia,
pancytopenia,
agranulocytosis
Endocrine: Decreas
ed libido,
impotence,
galactorrhea,
gynecomastia
Integumentary: Ras
h, alopecia,
vasculitis
Respiratory: Pneu
monia
Renal: Increased
serum creatinine,
acute interstitial
nephritis
Other: Hypersensiti
vity reactions,
anaphylaxis
REFERENCE:
https://www.rxlist.com/consumer_ranitidine_zantac/drugs-
https://www.ncbi.nlm.nih.gov/books/NBK532989/
https://fadavispt.mhmedical.com/content.aspx?
bookid=1873§ionid=139024156