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SKELETAL SYSTEM ● Red BM - blood

Anatomy and Physiology Lecture, 09/14/2022


Instructor: Ma’am Catherine Gem Villareal Bone Shapes
● Long
Skeletal System ○ More long than wide
● Organ system that provides an internal ○ Located in the upper and lower
framework for the human body limbs
● Came from the Greek word “skeleton” ○ Examples: tibia, fibula, femur
which means “dried up body”
● Consists of BTCL (bones, tendons, ● Short
ligaments, cartilages) ○ More wide than long
● Osteology - study of bones ○ Located in the wrist and ankle
○ An adult has 206 bones ○ Examples: tarsal, carpal, phalange
○ An infant has 300+ bones
● Flat
Functions of the Skeletal System ○ Usually encloses and protects the
● Protection - protects organs (examples: organs
skull - brain, vertebrae - spinal cord, rib ○ Examples: ribs, skull, sternum
cage - lungs and heart)
● Movement - tendons attach bone to ● Irregular
muscle, ligaments attach bone to bone ○ Has special functions
● Storage - stores CPL (calcium, ○ Examples: vertebrae and facial
phosphorus, lipids) bones
● Blood cell production - hematopoiesis
(blood cell formation or origin of RBC, Structure of a Long Bone
WBC, and platelets) ● Epiphysis - “growing upon”, site of growth,
● Support - bears body weight, supports spongy bone tissue
tissues ○ Articular Cartilage - dark part,
covers the end of epiphysis
Tendons ● Medullary Cavity - center of diaphysis,
● Attaches a bone to a muscle usually contains YBM or RBM
● Made up of collagen ● Periosteum - membrane around the outer
surface of the bone
Ligaments ● Endosteum - membrane that lines the
● Attaches a bone to another bone medullary cavity
● Made up of collagen ● Diaphysis - shaft or middle part of bone,
compact bone tissue
Cartilage
● Made up of collagen and proteoglycans Histology of a Bone
● Reduces friction ● Osteoblasts - bone-forming cell,
● Model for bone formation responsible for bone formation, repair, and
remodeling
Extracellular Matrix ● Osteocytes - bone cell, maintains bone
● Collagen - rope-like tissue
● Proteoglycans - can attract and retain ● Osteoclasts - bone-destroying cell,
large amounts of water between resorbs bone
polysaccharides, responsible for ● Osteogenic Cells - stem cell
smoothness and resilience of the bone
Bone and Calcium Homeostasis
Bone Marrow ● Involves 3 hormones (PVC): PTH, Vitamin
● Yellow BM - fats D in Active Form, and Calcitonin
● PTH (parathyroid hormones) is secreted Axial Skeleton (80 BONES)
when blood calcium levels are too low ● Cranial Bones - 8, PESTOF
○ Stimulates osteoclasts to break ○ Parietal (2) - sides and roof of
down bones and releases calcium cranium
to blood ○ Ethmoid (1) - anterior portion of
● Active Vitamin D is secreted when blood cranium, including medial surface
calcium levels are too low of eye orbit and roof of nasal cavity
● Calcitonin is secreted when blood calcium ■ Resembles a honeycomb
levels are high ○ Sphenoid (1) - forms part of
○ Secreted by thyroid gland, inhibit cranium floor, lateral posterior
osteoclasts and promote portions of eye orbits, lateral
osteoblasts portions of cranium anterior to
temporal bones
Bone Formation ■ Resembles a butterfly
● Bone Ossification - formation of bone by ○ Temporal (2) - inferior to parietal
osteoblasts bones on each side of the cranium
○ Intramembranous Ossification - ○ Occipital (1) - posterior portion and
bone formation that occurs within floor of cranium
connective tissue membranes ○ Frontal (1) - anterior part of
(skull), happens to a 12-week fetus cranium
○ Endochondral Ossification - bone
formation that occurs inside the ● Facial Bones - 14, VAIN MM PLZ
hyaline cartilage (all bones except ○ Vomer (1) - midline of nasal cavity,
the skull) nasal septum
● Primary Formation - diaphysis formation ○ Inferior Nasal Conchae (2) - nasal
● Secondary Formation - epiphysis cavity
formation ○ Nasal (2) - nose bridge
○ Mandible (1) - lower jaw
Bone Repair ○ Maxillae (2) - upper jaw
● Clot formation / hematoma ○ Palatine (2) - hard palate
● Formation of callus ○ Lacrimal (2) - medial surfaces of
● Callus ossification eye orbits
● Bone remodeling ○ Zygomatic (2) - cheekbone

Bone Remodeling ● Auditory Ossicles - 6 (one in each ear),


● Removal of existing bone by osteoclasts, MIS
deposition of new bone by osteoblasts ○ Malleus - hammer-shaped
● Responsible for changes in bone shape, ○ Incus - anvil-shaped
repair, adjustment of bone to stress, and ○ Stapes - smallest bone in the body
calcium ion regulation
● Occurs in all bones ● Hyoid Bone - 1
○ U-shaped
Bone Anatomy ○ Only bone that does not articulate
● Axial Skeleton with another bone
○ Upper part of the body ○ Point of attachment to the tongue
○ Consists of the skull, vertebral and several other muscles
column, and bony thorax
● Appendicular Skeleton ● Vertebral Column - 26, 7AM Breakfast,
○ Lower part of the body 12PM Lunch, 5PM Dinner
○ Consists of the girdles, arms, legs ○ Cervical Vertebra (7)
■ C1 is the atlas, which holds ● Each finger has
the head three phalange
■ C2 is the axis, which bones, except for
rotates the head the pollex which
○ Thoracic Vertebra (12) only has two
○ Lumbar Vertebra (5)
○ Sacrum (1) ● Pelvic Girdle - 2
○ Coccyx (1) - tailbone ○ Attaches lower limbs to the body
■ Coxal (2) - hip bones
● Sternum - 1, MBX ● The ilium, ischium,
○ Resembles a sword and pubis unite in
○ Manubrium - “handle” early adulthood to
○ Body - “blade” form the coxal
○ Xiphoid Process - “tip” bones
● Ilium - fan-shaped
● Rib Cage - 24 bone
○ True Ribs (pairs 1-7) - connected ○ Male pelvic girdle is narrow and
to the sternum deeper; angle of pubic arch is less
○ False Ribs (pairs 8-12) - not than 90°
connected to the sternum, ○ Female pelvic girdle is larger and
connected by cartilages wider because of childbirth; angle
■ Floating Ribs (pairs 10-12) of pubic arch is greater than 90°
- at the back of the rib
cage, connected to the ● Lower Limb - 60
spine ○ Consists of the thigh, leg, ankle,
and foot
Appendicular Skeleton (126 BONES) ■ Femur (2) - longest bone in
● Pectoral Girdle - 4 the body, thigh
○ Attaches upper limbs to the body ■ Patella (2) - knee cap
■ Scapula / Shoulder Blade ■ Tibia (2) - large lower leg
(2) ■ Fibula (2) - small lower leg
■ Clavicle / Collar Bone (2) ■ Tarsals (14) - bones of the
ankle, “cally called nate that
● Upper Limb - 60 milk is like cream”
○ Consists of the bones of the arm, ■ Metatarsals (10) - bones of
forearm, wrist, and hand the foot
■ Humerus (2) - longest bone ■ Phalanges (28) - bones of
in the arm / upper limb the toes
■ Radius (2) - runs parallel to ● Each toe has three
the ulna, on the thumb side phalange bones,
of the forearm except for the hallux
■ Ulna (2) - medial bone of which only has two
the forearm, on the pinky
side of the forearm Joints / Articulations
■ Carpals (16) - bones of the ● Named according to the bones or portion
wrist, “so long to pinky, of bones that join together
here comes the thumb” ○ Functional - according to degree of
■ Metacarpals (10) - bones of motion (SAD)
the palm ■ Synarthrosis - non-movable
■ Phalanges (28) - distal and joint (example: skull)
proximal, “holding a sword”
■ Amphiarthrosis - slightly
movable joint (example:
vertebral column)
■ Diarthrosis - movable joint
(examples: wrist, knee,
elbow)
○ Structural - according to the type of
connective tissue (FCS)
■ Fibrous Joint - fibrous
tissue
■ Cartilaginous - cartilage
■ Synovial - synovial fluid

Types of Movement
● Flexion - bending
● Extension - straightening
● Abduction - movement away from midline
● Adduction - movement toward the midline
● Pronation - rotation of the forearm with
palms down
● Supination - rotation of the forearm with
palms up
● Rotation - movement of a structure about
the long axis

Abnormalities in the Curvature of the Spine


● Kyphosis - abnormal posterior curvature of
the spine; hunchback
● Lordosis - abnormal anterior curvature of
the spine; swayback
● Scoliosis - abnormal lateral curvature of
the spine; letter “S”

Types of Sutures
● Lambdoid - between occipital and parietal
bones
● Coronal - between the frontal and parietal
bones
● Sagittal - between two parietal bones
● Squamous - between temporal and
parietal bones

Types of Fontanels
● Anterior
● Posterior
● Anterolateral
● Posterolateral
MUSCULAR SYSTEM ■ Belly - fleshy part of a
Anatomy and Physiology Lecture, 09/24/2022 muscle between tendons of
Instructor: Ma’am Catherine Gem Villareal origin and insertion

Muscular System Major Functional Characteristics of Muscle


● Has four functions: ● Irritability - ability to receive and respond
○ Body Movement - contraction of to stimulus
the muscles is responsible for the ● Contractility - ability to shorten when an
overall movement of the body adequate stimulus is received
○ Posture and Muscle Tone - skeletal ● Extensibility - ability to extend / stretch
muscles constantly maintain ● Elasticity - ability to recoil / return to
posture and tone, which allow us to normal shape when tension is released
stand erect or sit down
○ Stabilization of Joints - muscles Smooth Muscle
contribute to the overall support ● Located in various internal structures
and stability of joints including the digestive tract, uterus and
○ Heat Generation - when muscles blood vessels such as arteries
contract, heat is given off as a ● Movement is involuntary
byproduct
● Can be classified into three: skeletal, Cardiac Muscle
smooth, and cardiac (refer to slide 3 - ● Muscle specific to the heart
table comparing and contrasting the three ● Contracts and relaxes involuntarily
types of muscles) ● When viewed under the microscope, it
resembles a piece of steak
Trivia
● Longest muscle: Sartorius Skeletal / Striated Muscle
● Smallest muscle: Stapedius ● Specialized tissue attached to bones
● Biggest muscle: Gluteus Maximus ● Allows movement
● There are 640 muscles in the body ● Movement is voluntary
○ Muscles comprise 40% of a male’s
body mass Microscopic Anatomy of a Skeletal Muscle
○ Muscles comprise 32% of a ● Sarcolemma - specialized plasma
female’s body mass membrane
● Sarcoplasmic Reticulum - specialized
Characteristics of Muscles smooth ER, stores calcium in the muscle
● Muscles have myofilaments (muscle cell ● Myofibril - bundles of myofilaments, has
equivalent to the microfilaments of the two types
cytoskeleton) that are elongated ○ Thick / Myosin / I Band - 2 globular
○ Muscle Fiber - single muscle cell ends (cross bridges), has enzyme
○ Fiber - made up of fibrils called ATPase
○ Myofibrils - made up of thin and ■ Z Disc - in the middle of I
thick filaments band
● Prefixes “myo-“ and “mys-“ refer to ○ Thin / Actin / A Band - 2 strands of
muscle, while the prefix “sarco-” refers to globular actin molecules twisted
flesh into a helix, have binding sites for
● Muscles are attached to at least two myosin cross bridges
points: ■ Sarcomere - contractile unit
○ Origin - stationary bone of muscle fiber
○ Insertion - movable bones
Fascicle Arrangement of Skeletal Muscles
● Parallel - strap-like (example: sartorius)
● Fusiform - spindle-shaped (example: ● Shape of the muscle (example: deltoid -
biceps) triangular)
● Pennate - feather-shaped ● Action (examples: flexor, extensor)
○ Unipennate - (example: extensor
digitorum longus) Nerve Stimulus to Muscle
○ Bipennate - (example: rectus ● Muscle tissue is innervated
femoris) ● Synaptic Cleft - gap between the nerve
○ Multipennate - (example: deltoid) and muscle, separates axonal ending of
● Convergent - (example pectoralis major the motor nerve and sarcolemma of
and pectoralis minor) muscle fiber
● Circular - (example: orbicularis oris) ● Axon Ending - contains vesicle of
neurotransmitter, produces acetylcholine
Connective Tissue Wrappings of Skeletal (Ach)
Muscles ○ Once the nerve ending is
● Endomysium - CT around a single muscle stimulated, Ach is released
fiber ○ Ach travels along the synaptic cleft
● Perimysium - CT around a fascicle and brings receptor on the motor
● Epimysium - CT that covers an entire end plate
skeletal muscle ● Muscle contracts
● Fascia - CT outside the epimysium,
extends beyond the end of the muscle to Sliding Filament Theory of Muscle Contraction
become a tendon 1. ATP Hydrolysis - myosin heads hydrolyze
ATP, which become reoriented and
Types of Muscles energized
● Prime Mover - a muscle with a major 2. Attachment - myosin head binds to actin,
responsibility for a certain movement forms cross bridges
● Antagonist - a muscle that reverses a 3. Power Stroke - myosin cross bridges
prime mover rotate towards the center of the sarcomere
● Synergist - a muscle that aids a prime 4. Detachment - myosin head binds to ATP,
mover, prevents rotation or unwanted cross bridges detach from actin
movement *Cycle repeats if ATP and calcium are
● Fixator - a muscle that stabilizes the origin present
of a prime mover in order to use all
tension to move the insertion bone Muscle Relaxation Mechanism
● Levator - a muscle that raises a body part 1. HCH is present in NMJ (neuromuscular
junction), preventing continual stimulation
Naming of Skeletal Muscles 2. Calcium ions are transported from
● Direction of muscle fibers (examples: sarcoplasm back into the sarcoplasmic
rectus - straight, oblique - slanted) reticulum
● Relative size of the muscle (examples: 3. Linkages between myosin and actin are
maximus - large, minimus - short, longus - broken because of the absence of ATP
long) 4. Muscle fiber relaxes
● Location of the muscle (example: ○ When contraction occurs:
temporalis - near the temporal bone) ■ I band becomes smaller
● Number of origins (examples: biceps - two ■ A band stays the same
origins, triceps - three origins, quadriceps - ■ H zone becomes smaller
four origins) ■ Sarcomere shortens
● Location of muscle’s origins and insertion
(examples: sterno - sternum, cleido - Derivation of ATP for Muscle Contraction
clavicle) 1. Aerobic production during exercise, in
normal conditions
2. Anaerobic production during extensive, ● Rotation
short-term work ● Abduction
3. Conversion of a molecule called creatine ● Adduction
phosphate (male creatinine level is higher ● Circumduction - combination of all
than that of females) ordinary body movements, except for
4. Conversion of two ADP (adenosine rotation
diphosphate) to one ATP (adenosine
triphosphate) and one AMP (adenosine Special Body Movements
monophosphate) ● Dorsiflexion - lifting the foot
● Plantar Flexion - depressing the foot
Muscle Response to Stimuli ● Inversion - turning the foot inward
● Muscles can continue to contract unless ● Eversion - turning the foot outward
they run out of energy ● Supination - upward
○ ATP is stored in the muscle for ● Pronation - downward
contraction for only 4-6 seconds ● Opposition - touching thumb to other
● Muscle force depends upon the number of fingers
fibers stimulated

Muscle Tension
● A condition wherein muscles remain
semi-contracted for an extended period of
time
● Usually a cause of stress (examples: back
pain, shooting pain, etc.)

Graded Responses
● Twitch - abnormal single or brief
contraction
● Tetanus - one contraction is immediately
followed by another; summing all
contractions
● Fused / Complete Tetanus - no evident
relaxation before the following contraction,
muscle contraction is sustained
● Unfused / Incomplete Tetanus - relaxation
appears between contraction

Types of Twitches in Skeletal Muscle Fibers

● Slow - slow oxidative


● Fast - fast oxidative / fast glycolytic

Phases of Muscle Twitch


1. Lag Phase - beginning of contraction
2. Contraction Phase - muscles are
contracting
3. Relaxation Phase - muscles are relaxing

Ordinary Body Movements


● Flexion
● Extension
NERVOUS SYSTEM ● Autonomic - cardiac muscles, smooth
Anatomy and Physiology Lecture, 10/01/2022 muscles, and glands are involved
Instructor: Ma’am Catherine Gem Villareal (involuntary)

Nervous System Subdivisions of the Autonomic Motor System


● Neurology / Neurologists ● Sympathetic - fight or flight
● The control center of the body ● Parasympathetic - resting and digesting
● Has five functions (CRIME)
○ Controlling - muscles and glands Cells of the Nervous System
○ Receiving - receiving sensory input ● Neuron - conducts impulses
(vision, hearing, sense, touch, etc.) ○ Dendrites - receives information
○ Integrating - integrating information from other neurons, transmits
(brain and spinal cord processes electrical signals towards the cell
sensory input and initiates body
responses) ○ Soma / Cell Body - site of protein
○ Maintaining - homeostasis (CNS) synthesis, surrounds nucleus
○ Establishing - establishing and ○ Axon - transmits signals away from
maintaining mental activity the cell body
(consciousness, memory, and ■ Clusters of axons in PNS -
thinking) nerves
■ Clusters of axons in CNS -
Central Nervous System tracts
● Consists of the brain and the spinal cord ■ Axon Hillock - site of action,
● Detects, interprets, and responds to the potential, generation; also
stimuli from internal and external the area where axons leave
environment the neurocell body
○ Axon terminal - responsible for
Peripheral Nervous System transmitting signals to other
● Consists of all nerves that conduct neurons; releases
impulses (peripheral nerves) neurotransmitters
● Divided into two: sensory and motor ○ Myelin Sheath - insulates one
nerve cell to another, responsible
Sensory / Afferent for speeding up nerve impulses
● Nerves leading towards CNS along the axon
● Receptor which monitors responses from ○ Node of Ranvier - gap in the
internal and external environment myelin sheath
● Two types of stimuli ● Glial / Neuroglial - helper cells, gives
○ Conscious - five senses support to axons
○ Unconscious - blood pressure,
heart rate Types of Neurons
● Unipolar
Motor / Efferent ○ One axon
● Nerves leading away from the CNS ● Bipolar
● Responsible in controlling actions of ○ One axon and one dendrite
receptor organs (muscle and glands) ○ Usually seen in the retina of the
● Brings information from CNS to the eyes
periphery ● Multipolar
○ Many projections
Subdivisions of the Motor Division ○ One axon and two or more
● Somatic - skeletal muscles are involved dendrites
(voluntary) ○ Most common form of neurons
● Purkinje ● Presynaptic Terminal - located at the end
○ Inhibitory neuron of the axon
○ Many dendrites ● Postsynaptic Terminal - located at the
● Pyramidal membrane of the second neuron
○ Pyramid-shaped (dendrites)
○ Largest neuron cell seen in the ● Synaptic Cleft - spaces between axon and
cortex (responsible for conscious the next neuron
thought) ● Synaptic Vesicles - contains
neurotransmitters that are responsible for
Types of Glials inhibiting or causing action potential
● Astrocytes - responsible for limiting ● Neurotransmitters
damage in neural tissues (example: BBB - ○ Excitatory Neurotransmitters
blood brain barrier) ■ Acetylcholine - activates
○ Star-shaped cell muscle stimulation
○ Most abundant type of glial ■ Glutamate - most common
● Microglial - phagocytic cells neurotransmitter in the
● Oligodendrocytes - forms myelin sheaths CNS
● Schwann Cells - provide myelin to ■ Histamine - inflammatory
neurons in the PNS response
● Ependymal Cells ■ Dopamine - motivation
■ Epinephrine - fight and
Neural Signaling flight response
1. Stimuli ■ Norepinephrine - controls
2. Information is sent to the CNS blood pressure and heart
3. Information is received and processed rate
4. Information is interpreted ○ Inhibitory Neurotransmitters
5. Response is produced ■ GABA (gamma
aminobutyric acid) -
Electrical Signals and Neural Pathways reduces neuronal
● Resting Membrane Potential - uneven excitability
distribution of charges when no more ■ Serotonin - cravings, pain
potassium can diffuse out of the cell control
(PISO)
● Local Current - area where sodium Reflexes
channels briefly opens, start of ● An involuntary reaction in response to a
depolarization stimulus applied to the periphery and
● Depolarization - cell membrane becomes transmitted to the CNS
more positive ● Reflexes allow a person to react to stimuli
● Local Potential more quickly than possible, if the patient is
○ When threshold is not met, conscious
repolarization occurs
○ When threshold is met, action Reflex Arc (example: person touches a hot
potential occurs object)
● Action Potential ● Stimulus - hot object
○ Unmyelinated Axons - no myelin ● Receptor - pain and heat detected by skin
sheaths, action potential is slow ● Sensory Neuron - carry signals to relay to
○ Myelinated Axons - has myelin the relay neuron
sheaths, action potentials are ● Relay Neuron - transmits signals from
conducted quickly sensory neuron to other neurons,
including the motor neuron
Synapses
● Motor Neuron - receives signals, brings Spinal Cord Reflexes
signals to the arm muscles ● Stretch Flex- muscle contracts in
● Effector - arm pulls away / withdraws from responses to stretching force
the hot object ● Knee Jerk Flex - patellar reflex
● Response ● Withdrawal Flex - flexor reflex, removes a
limb from a painful stimulus
Reflexes Showing Abnormal Reactions
● Patellar Reflex Spinal Nerves
● Triceps Reflex ● Cervical - from spinal nerves C1-C4
● Plantar Reflex ● Brachial - from spinal nerves C5-T1
● Pupillary Reflex ● Lumbosacral - from spinal nerves L1-S4

Neural Pathway (see: slide 23) Brain


● Converging Pathway - two or more neuron ● Has three major areas: cerebrum,
synapses having the same neuron cerebellum, and brain stem
● Diverging Pathway - one neuron with ● Cerebrum - most prominent feature of the
branching axon synapses, having two or brain
more neurons ● Cerebellum - smallest part of the brain
● Brain Stem - located in the inferior part of
Spinal Cord the brain
● Has two main functions
● Has two layers of protective or nourishing Brain Stem
tissue ● Controls heart rate, blood pressure
○ Vertebral Column - bony covering ● Once damaged, a person will die
○ Meninges - membranous covering ● Cranial nerves 3-12
● Contains three columns ● Composed of medulla oblongata, pons,
○ Dorsal / Posterior midbrain
○ Ventral / Interior ○ Medulla Oblongata - swallowing,
○ Lateral vomiting, coughing, sneezing,
● Has two types of nerve tracts balance, and coordination
○ Ascending - consists of axons that ○ Pons - resembles a footbridge,
conduct action potentials toward controls facial expressions and
the brain body equilibrium, posture,
○ Descending - consists of axons regulates respiration and sleep
that conduct action potentials away ○ Midbrain - involved in eye
from the brain movement coordination

Center of Spinal Cord (see: slide 30) Diencephalon


● Anterior Horns - receives info from brain to ● Thalamus - largest part, registers
motor cortex unfamiliar or unlocalized or uncomfortable
● Posterior Horns - takes sensory perceptions of pain
information and sends it to the brain ● Epithalamus - involved in emotional and
● Lateral Horns - regulates urination, visceral responses to odor
digestion, and heart rate ● Hypothalamus - controls body temp,
● Central Canal - fluid-filled space in center hunger, thirst, sexual pleasure
of spinal cord
● Grey Matter - looks like letter H or a Cerebrum
butterfly, allows communication between ● Prosencephalon - controls body temp,
horns reproductive function, eating, sleeping
● White Matter - ● Corpus Callosum - connects left side of
the brain to the right side
● Cerebral Cortex - outer layer, on top of the
cerebrum
● Gyri (folds) and Sulci (grooves) - between
the two clefts of the cerebral surface of the
brain, increases surface area of the
cerebral cortex
● Frontal Lobe - responsible for smell,
motivation, aggression, and mood
● Temporal Lobe - responsible for smell and
hearing reception
● Occipital Lobe - responsible for visual
● Parietal Lobe - center for touch, pain, and
taste

Cerebellum
● Initiates movement such as walking,
posture, balance, and speech
● Once cerebellum is damaged, a person
might have tremors, lack of balance, or
shaking of hands

Cranial Nerves
● OOOTTAFVGVAH
● “Oh, Oh, Oh, To Touch And Feel Virgin
Girl’s Vagina, Ah Heaven”

NOTES:
● The contents of this document are solely
based on the lectures. Kindly refer to the
Anatomy and Physiology textbook for any
details I might have missed.
● These lecture notes are compiled by
Christienne Marcelino from BSMT-139 :)
● Good luck and padayon, future RMT!

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