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Clinical Effectiveness Bulletin No. 53 June 2011
Clinical Effectiveness Bulletin No. 53 June 2011
Clinical Effectiveness Bulletin No. 53 June 2011
About this Bulletin: It aims to draw attention to some of the key documents and reviews on clinical effectiveness that have been published in the previous month. Where possible, links to the full text documents are included. If the article is in a journal, you can contact the Health Library for a copy. Link to request form: http://www.keele.ac.uk/healthlibrary/usingthehealthlibrary/interlibraryloans/#d.en.27437 [Please note - a charge of 2 per request is payable for most copies] If you need further assistance, please contact the Health Library or the NHS Outreach Librarians, details below. The bulletin can be e-mailed to colleagues who may also find it useful. A list of websites that are checked in the production of this bulletin are listed on the first page. Please suggest further useful sites. Feedback is always welcomed to inform future issues of the bulletin.
Contact information
Bulletin produced by NHS Outreach Librarians Tel: FeatureNet 8429 (External calls 0300 123 1535 ext 8429) E-mail: lindsay.snell@northstaffs.nhs.uk clareh.powell@northstaffs.nhs.uk
North Staffs Health Library Tel: 01782 679500 Fax: 01782 556582 E-mail: health.library@keele.ac.uk
NHS Library and Information Service North Staffordshire Contents in this issue
Alcohol Cancer Cardiovascular Diseases Children and Young People Commissioning Dementia Diabetes Emergency Care Evidence and Information Gastroenterology General Practice Guidance Health Reforms IVF Learning Disabilities Maternal and Infant Health Mental Health Nursing Neurology Obesity Older People Patient Care and Safety Pharmacy Prescribing Public Health Research Respiratory Safeguarding Children and Vulnerable Adults Service Management Sexual and Reproductive Health Substance Misuse Vaccination and Immunisation Workforce
Websites
Cochrane Library http://www.thecochranelibrary.com/ CRD Centre for Reviews and Dissemination http://www.crd.york.ac.uk/crdweb/ - DARE (Database of Abstracts of Reviews of Effects) - NHS Economic Evaluation Database Health Technology Assessment (HTA) Database http://www.hta.ac.uk Daily Health Bulletin http://www.sheffield.nhs.uk/healthbulletin/ Department of Health http://www.dh.gov.uk/en/index.htm Kings Fund http://www.kingsfund.org.uk/ NeLM (National Electronic Library for Medicines) news bulletin http://www.nelm.nhs.uk/en/ NICE http://www.nice.org.uk/ SIGN http://www.sign.ac.uk/new.html
Cancer
Anticoagulation for the long-term treatment of venous thromboembolism (VTE) in patients with cancer Akl, E et al. For the long-term treatment of VTE in patients with cancer, low molecular weight heparin compared to vitamin K antagonist reduces venous thromboembolic events but not death. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD006650/frame.html Association between time to initiation of adjuvant chemotherapy and survival in colorectal cancer: a systematic review and meta-analysis Biagi, J et al The authors concluded that a longer time to adjuvant chemotherapy was associated with worse survival among patients with resected colorectal cancer. JAMA. 2011; v.305(22) p.2335-2342. doi: 10.1001/jama.2011.749 3
Cardiovascular Diseases
Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis Priess, D et al. In an analysis of data from 5 trials, intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose statin therapy. JAMA. 2011;305(24) p.2556-2564. doi: 10.1001/jama.2011.860 Naftidrofuryl for intermittent claudication de Backer, T et al. The authors of this Cochrane Review concluded that naftidrofuryl has a statistically significant and clinically meaningful effect of improving walking distance in the six months after initiation of therapy for people with intermittent claudication. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD001368/frame.html Structured telephone support or telemonitoring programmes for patients with chronic heart failure (CHF) Inglis, S et al. The authors of this Cochrane review concluded that structured telephone support and telemonitoring are effective in reducing the risk of all-cause mortality and CHF-related hospitalisations in patients with CHF; and that they improve quality of life, reduce costs, and evidence-based prescribing. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD007228/frame.html
Items in the Cancer and Diabetes sections may also be of interest. [back to topics]
NHS Library and Information Service North Staffordshire Children and Young People
Adolescent health in the UK today: where next? Association for Young People's Health This report looks at why adolescent health matters. It also covers key trends in adolescent health and issues for service delivery. The report makes recommendations and gives supporting data about young people's health and well-being. http://www.chimat.org.uk/youngpeople/AHUK Grommets (ventilation tubes) for recurrent acute otitis media in children McDonald, S et al. The authors of this Cochrane Review concluded that grommets have a significant role in maintaining a 'disease-free' state in the first six months after insertion, but that clinicians should consider the possible adverse effects of grommet insertion before surgery is undertaken. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD004741/frame.html Place of Death for Children, Teenagers and Young Adults with Cancer in England National Cancer Intelligence Network (NCIN) This briefing explores patterns of place of death among children, teenagers and young adults with cancer in England who died during 2000-2009. http://www.ncin.org.uk/publications/data_briefings/place_of_death_for_ctya_with_cancer.aspx PREview Planning Resources Child and Maternal Health Observatory PREview is intended to help commissioners, managers and professionals to target preventive resources, in particular around the Healthy Child Programme, where they are most needed. PREview is based on evidence for the factors in pregnancy and infancy that are associated with outcomes for children at five years. http://www.chimat.org.uk/preview You are not on your own: A booklet to help children and adults talk about a parents drinking Childrens Commissioner This booklet helps children to have frank discussions with teachers, professionals or an adult who they trust. http://www.childrenscommissioner.gov.uk/force_download.php?fp=%2Fclient_assets%2Fcp %2Fpublication%2F498%2FYou_are_not_on_your_own__A_booklet_to_help_children_and_adults_talk_about_a_parents_drinking.pdf
Items in the Maternal and Infant Health, Mental Health and Obesity sections may also be of interest. [back to topics]
Dementia
A call to action on the use of antipsychotic drugs for people with dementia Dementia Action Alliance This call aims to improve the quality of life of people with dementia and their carers by reducing the inappropriate use of antipsychotics. http://www.institute.nhs.uk/qipp/calls_to_action/Dementia_and_antipsychotic_drugs.html Common core principles for supporting people with dementia: a guide to training the social care and health workforce Department of Health These principles can be used to support workforce development for any member of staff, in any health or social care setting, working with people at any stage of dementia. They can also be used to inform the content of curricula and training courses. http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidanc e/DH_127442
Diabetes
Blood pressure targets in subjects with type 2 diabetes mellitus/impaired fasting glucose: observations from traditional and Bayesian random-effects meta-analyses of randomized trials Bangalore, S et al. The authors concluded that the evidence suggests that in patients with type 2 diabetes mellitus/ impaired fasting glucose/ impaired glucose tolerance, a systolic BP treatment goal of 130 to 135 mm Hg is acceptable. With more aggressive goals (<130 mm Hg), the risk of stroke continued to fall, but there was no benefit regarding the risk of other macrovascular or microvascular (cardiac, renal and retinal) events, and the risk of serious adverse events increased. Circulation. Published online before print May 31, 2011, doi: 10.1161/CIRCULATIONAHA.110.016337 National Diabetes Audit: Key findings about the quality of care for people with diabetes in England and Wales 2009-10. Executive Summary NHS Information Centre The NDA includes data from both primary and secondary care participants. It currently covers four core care components of the National Service Framework (NSF) for Diabetes: Is everyone with diabetes recorded on a practice diabetes register? What percentage of people registered with diabetes received the nine key processes of diabetes care (Measure: Weight, Blood Pressure, HbA1c, Urine Albumin Creatinine Ratio (UACR), Serum Creatinine, Serum Cholesterol; Assess: Eyes, Feet, Smoking)? What percentage of registered diabetics achieved NICE defined treatment targets for glucose control, blood pressure and blood cholesterol? For people with registered diabetes what are the rates of acute and long term complications? http://www.ic.nhs.uk/services/national-clinical-audit-support-programme-ncasp/auditreports/diabetes Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus Hemmingsen, B et al. The authors of this Cochrane Review concluded trials did not show significant differences for all-cause mortality and cardiovascular mortality when targeting intensive glycaemic control compared with conventional glycaemic control. Targeting intensive glycaemic control reduced the risk of microvascular complications while increasing the risk of hypoglycaemia. Further, 8
Emergency Care
NHS 111 Minimum Data Set Department of Health The 111 number will provide a new easy to remember route into the NHS for all those who are unclear about which service is best placed to meet their needs. The 111 service was rolled out to four pilot sites in 2010. This publication supplies data to help assess the efficiency and effectiveness of the different 111 models. http://www.dh.gov.uk/en/Publicationsandstatistics/Statistics/Performancedataandstatistics/NH S111MinimumDataSet/index.htm Transforming NHS ambulance services National Audit Office The report concludes that the Department of Health has until recently focused on speed of response as a measure of ambulance service performance, rather than clinical outcomes. The ambulance service achieves high levels of public satisfaction but there are wide variations in efficiency. The report identifies possible savings for the NHS of 165 million a year. Improving ambulance trusts performance has been hampered by a lack of comparative information to benchmark performance. The new clinical quality indicators introduced from April offer the potential for measurement of performance based on outcomes. http://www.nao.org.uk/publications/1012/nhs_ambulance_services.aspx
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General Practice
GP Patient Survey, April 2010 to March 2011 Department of Health Responses from around 5 million patients, providing timely and valuable information for Primary Care Trusts, GP practices and other patients about patients' experiences of local services. http://www.dh.gov.uk/en/Publicationsandstatistics/PublishedSurvey/GPpatientsurvey2007/ind ex.htm National survey of GP opinion 2011 BMA This interim analysis of some key questions in the National Survey of GP Opinion 2011 covers data from the first 10,000 UK postal respondents. It describes in more detail responses according to GP status where appropriate. http://www.bma.org.uk/images/gpopinionsurvey2011_tcm41-207092.pdf Promoting Continuity of Care in General Practice RCGP This paper outlines the evidence of the cost-effectiveness of general practice. It also makes the important link between access and continuity of care and suggests ways of helping patients achieve effective therapeutic relationships. The report identifies two specific types of Continuity of care: Relationship Continuity (the doctor-patient relationship in its most basic sense), and Management Continuity (co-ordination and co-operation between service providers to enable the patient to navigate the healthcare system). The report makes 30 recommendations to policy-makers, managers and commissioners, and practices. http://www.rcgp.org.uk//news/press_releases_and_statements/greater_continuity_of_care.as px
Items in the Commissioning sections may also be of interest. [back to topics]
Guidance
Annual Review 2010/2011 NICE http://review2010-2011.nice.org.uk/ 10
NICE Technology Appraisals Golimumab for the treatment of rheumatoid arthritis after the failure of previous disease-modifying anti-rheumatic drugs TA225 http://guidance.nice.org.uk/TA225 Lung cancer (non-small-cell, advanced or metastatic maintenance treatment): erlotinib (monotherapy) TA227 http://guidance.nice.org.uk/TA227 Rheumatoid arthritis (methotrexate-nave) - golimumab (terminated appraisal) TA224 http://guidance.nice.org.uk/TA224 Rituximab for the treatment of follicular non-Hodgkins lymphoma (maintenance treatment following response to first-line chemotherapy) TA226 http://guidance.nice.org.uk/TA226
[back to topics]
NICE Consultation Documents Acute coronary syndromes: ticagrelor Closing date for comments: 21 July 2011 http://guidance.nice.org.uk/TA/Wave20/70/Consultation/DraftGuidance Anaphylaxis To comment, contact the registered stakeholder organisation that most closely represents your interests. http://www.nice.org.uk/guidance/index.jsp?action=folder&o=55280 NICE advice on healthcare-associated infections To comment, contact the registered stakeholder organisation that most closely represents your interests. Closing date for comments: 9 August 2011 http://www.nice.org.uk/guidance/phg/advicehealthcareassociatedinfectionsconsultation.jsp 11
Other Guidance Evidence-based guideline: Treatment of painful diabetic neuropathy American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation Neurology May 17, 2011 v.76(20) p.1758-1765. Published online before print April 11, 2011, doi: 10.1212/WNL.0b013e3182166ebe Guidelines on oral anticoagulation with warfarin: 4th edition British Committee for Standards in Haematology http://www.bcshguidelines.com/documents/warfarin_4th_ed.pdf 12
Health Reforms
Accountability in the NHS: Implications of the government's reform programme Kings Fund The authors identify five types of accountability most relevant to health care by scrutiny, management, regulation, contract and election. Current accountability relationships, of both providers and commissioners, are considered, and compared and contrasted with the proposed new forms. The authors then assess whether the reforms will meet the governments policy aims and whether the new system is workable. http://www.kingsfund.org.uk/publications/nhs_accountability.html Establishing social enterprises under the Right to Request Programme National Audit Office This report highlights risks to value for money associated with the Department of Health's programme for enabling its staff to take the lead in leaving the NHS to set up health social enterprises. http://www.nao.org.uk/publications/1012/the_right_to_request_programme.aspx Government response to the NHS Future Forum report Department of Health This document sets out the Government's detailed response to the Forum's report. It explains how the government will make significant changes in line with the Forum's recommendations. http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidanc e/DH_127444 Government's response to forum report: briefing NHS Confederation This briefing gives commentary and analysis on the governments response to the NHS Future Forum. http://www.nhsconfed.org/OurWork/latestnews/Pages/member-briefing-on-Governmentsresponse.aspx
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Learning Disabilities
Information for people with learning disability and their carers Royal College of Psychiatrists This is a new series of very accessible information for people with mental health problems who also have learning disabilities. All these materials have been written and tested with people with learning disabilities and their carers. http://www.rcpsych.ac.uk/mentalhealthinfo/problems/learningdisabilities.aspx
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Mental Health
Attitudes to Mental Illness: 2011 survey report NHS Information Centre This report presents the findings of a survey of attitudes towards mental illness among adults in England undertaken in 2011. Questions on this topic have been asked since 1994. http://www.ic.nhs.uk/statistics-and-data-collections/mental-health/mental-health-act/attitudesto-mental-illness--2011-survey-report-ns Clinical relevance of findings in trials of antipsychotics: systematic review Lepping, P et al. A systematic review identified studies of antipsychotics that used the Brief Psychiatric Rating Scale (BPRS) and Positive and Negative Syndrome Scale (PANSS). A published method of translating these into Clinical Global Impression Change scale (CGIC) scores was used to measure clinical relevance. The findings show improvements of limited clinical relevance. The British Journal of Psychiatry (2011) 198: 341-345. doi: 10.1192/bjp.bp.109.075366
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Nursing
Making nursing visible: valuing our contribution to high quality patient-centred care RCN This guidance covers the use of standardised terminologies in electronic patient records. It describes the value of ensuring that nursing concepts can be captured within electronic patient records to make nursing visible and valued. http://www.rcn.org.uk/__data/assets/pdf_file/0003/372990/003877.pdf
Items in the Research sections may also be of interest. [back to topics]
Neurology
Local adult neurology services for the next decade Royal College of Physicians This new report makes three proposals: expansion and improvement of local services with a shift in emphasis from scheduled to emergency care better organised care for patients with long-term neurological conditions, partly through an enhanced role for specialist nurses and GPs with a special interest in neurology better local planning with increased clinical involvement in a commissioner/ provider forum, creating a neurological network to improve clinical and financial outcomes. http://bookshop.rcplondon.ac.uk/details.aspx?e=354 (Scroll to the bottom of the page to download the report)
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Obesity
Obesity Epidemic, Paranoia or Evidence Based? The Bow Group This paper assesses current predictions indicating that 60% of the UK population will be classified as clinically obese by 2050 and recommends action to reduce this risk. http://www.bowgroup.org/content/target-paper-obesity-epidemic-paranoia-or-evidence-based 18
Older People
Dignity and nutrition for older people CQC This review is a targeted inspection programme of NHS hospitals. It looks at whether older people are treated with respect and whether they get food and drink that meets their needs. CQC is adding reports to these pages as they are published. http://www.cqc.org.uk/reviewsandstudies/inspectionprogrammedignityandnutritionforolderpeople.cfm
Items in the Mental Health, Substance Misuse and Workforce sections may also be of interest. [back to topics]
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Prescribing
An organisational competency framework to ensure the effective delivery of medicines management functions and responsibilities: a guide for commissioning consortia boards. National Prescribing Centre The Framework and a supporting Self-assessment tool are available at: http://www.npc.nhs.uk/qipp/ PCT Prescribing for January to March 2011 NHS Information Centre The data includes PCT code and name; BNF section code; BNF section name; Items; Actual Cost and Net Ingredient Cost http://www.ic.nhs.uk/statistics-and-data-collections/primary-care/prescriptions/pct-prescribingfor-january-to-march-2011 Scopolamine (hyoscine) for preventing and treating motion sickness Spinks, A et al. The authors of this Cochrane Review concluded that the use of scopolamine versus placebo in preventing motion sickness has been shown to be effective but no conclusions can be made on the comparative effectiveness of scopolamine and other agents such as antihistamines and calcium channel antagonists. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD002851/frame.html
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Public Health
Analysis of controls on the marketing and promotion of food and drink to children Department of Health This report is based on: A mapping exercise of marketing practices, regulations, policies, commitments and proposals relating to food marketing to children; Consultations with corporate stakeholders; Consultations with children, young people and parents; An analysis of the Marine Stewardship Council as a case study. http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidanc e/DH_127778 20
Research
Informed consent in health and social care research RCN This document provides an overview of: the concept of informed consent for research; the ethical and legal framework; the process of gaining informed consent; the participants perspective; and obtaining informed consent in specific circumstances. http://www.rcn.org.uk/__data/assets/pdf_file/0010/78607/002267.pdf NIHR Research Support Services Framework National Institute for Health Research This framework of good practice and standard procedures is intended to facilitate consistent local research management and improve performance. http://www.nihr.ac.uk/systems/Pages/Research_Support_Services.aspx
Items in the Dementia section may also be of interest. [back to topics]
Respiratory
Epinephrine for bronchiolitis Hartling, L et al. This Cochrane review demonstrates the superiority of epinephrine compared to placebo for short-term outcomes for outpatients, particularly in the first 24 hours of care. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD003123/frame.html Immunostimulants for preventing respiratory tract infection in children Del-Rio-Navarro, B This review shows immunostimulants reduce the incidence of Acute Respiratory Tract Infections by 40% on average in susceptible children, and considers possible safety concerns. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD004974/frame.html
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Service Management
Implementing the Overseas Visitors Hospital Charging Regulations 2011 (Regulations come into force from 1 August 2011) Department of Health This guidance is for NHS bodies in carrying out their duties under the NHS (Charges to Overseas Visitors) Regulations 2011 to make and recover charges for NHS hospital treatment from overseas visitors not exempt from charge. It also includes guidance to safeguard the health of those not entitled to free hospital treatment. NB, the Regulations do not come into force until 1 August 2011 and aspects of this guidance that relate directly to those Regulations should not be implemented until then. http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidanc e/DH_127393 Collaboration between local health and local government agencies for health improvement Hayes, S et al. The authors of this Cochrane Review concluded that when comparing local collaborative partnerships between health and government agencies with standard working arrangements there is no difference in health outcomes. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD007825/frame.html
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NHS Library and Information Service North Staffordshire Sexual and Reproductive Health
Antioxidants for male subfertility Showell, M et al. The authors of this Cochrane Review concluded that the evidence suggests that antioxidant supplementation in subfertile males may improve the outcomes of live birth and pregnancy rate for subfertile couples undergoing ART cycles. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD007411/frame.html Provider training and experience for people living with HIV/AIDS Rackal, J et al. The authors of this Cochrane Review concluded that results demonstrate improved medical outcomes when treated by a provider with more training/expertise in HIV/AIDS care in the outpatient (clinic) setting. Practitioners who do not consider themselves 'experts' in HIV/AIDS care and care for few of these patients need to seriously consider this review which demonstrates a trend towards worse patient outcomes when receiving care by those with low caseloads/training in HIV/AIDS care. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD003938/frame.html STI Annual Data Tables Health Protection Agency Data for England is available on: STI diagnoses from both GUM and community-based settings 2008-2010 Diagnoses in GUM clinics by gender, age and sexual orientation 2001-2010 HIV testing uptake 2010 Patient's area of residence, ethnicity and continent of birth 2010 Report and tables are available at http://www.hpa.org.uk/web/HPAweb&Page&HPAwebAutoListName/Page/1201094610372
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Substance Misuse
Heroin maintenance for chronic heroin-dependent individuals Ferri, M et al. The available evidence suggests an added value of heroin prescribed alongside flexible doses of methadone for long-term, treatment refractory, opioid users, to reach a decrease in the use of illicit substances, involvement in criminal activity and incarceration, a possible reduction in mortality; and an increase in retention in treatment. Due to the higher rate of serious adverse events, heroin prescription should remain a treatment for people who are currently or have in the past failed maintenance treatment, and it should be provided in clinical settings where proper follow-up is ensured. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD003410/frame.html Our Invisible Addicts: First Report of the Older Persons Substance MisuseWorking Group Royal College of Psychiatrists The report warns that not enough is being done to tackle substance misuse in our aging population making them societys invisible addicts. It pulls together evidence to highlight 25
Workforce
Integrated care for older people: Examining workforce and implementation challenges Centre for Workforce Intelligence This report is the first in a series investigating the workforce implications of moving towards an integrated health and social care system. It considers eight different models of care, describing the service provided and assessing economic, quality of care and workforce implications. http://www.cfwi.org.uk/intelligence/projects/integrated-care-for-older-people-examiningworkforce-and-implementation-challenges NHS staff attitudes tracking survey Department of Health This survey provides an overview of NHS staff morale and engagement plus awareness of attitudes towards a range of DH and NHS initiatives. It includes NHS staff working in a range of primary, secondary and community settings. http://www.dh.gov.uk/en/Publicationsandstatistics/PublishedSurvey/ListOfSurveySince1990/D H_127666 NHS Staff Earnings January - March 2011 NHS Information Centre This data gives present estimates of annual basic pay and total earnings for NHS staff groups (excluding GPs and high street dentists). Pay data is taken from all NHS organisations using the Electronic Staff Record (ESR) during the period. http://www.ic.nhs.uk/statistics-and-data-collections/workforce/nhs-staff-earnings/nhs-staffearnings-january--march-2011 The support workforce in the NHS NHS Confederation This digest highlights recent research on support workers in health. This evidence can help managers understand the increasing importance of support staff and how they can best be used as part of a flexible modern workforce. http://www.nhsconfed.org/Publications/digests/Pages/SDO-Digest-1.aspx
Items in the Dementia and General Practice sections may also be of interest. [back to topics]
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