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Anemia
Anemia
Etiology
Chronic blood loss
Inadequate dietary intake
Faulty iron absorption
Increased requirements for iron- infancy, childhood, pregnancy.
CAUSES
Decreased iron stores
Decreased intake
Increase losses
Increased Demands
CLINICAL MANIFESTATIONS
Chronic fatigue
Pallor of the conjunctiva, lips, and oral mucosa;
Brittle nails with spooning, cracking,
Splitting of nail beds, koilonychia
Palmar creases
Palpitations
Shortness of breath, numbness
Bone pain
ORAL MANIFESTATIONS
Angular cheilitis,
Glossitis with different degrees of atrophy of fungiform and filliform papillae
Pale oral mucosa
Oral candidiasis
Recurrent aphthous stomatitis
Erythematous mucositis
Burning mouth
LABORATORY FINDINGS
• Microcytic hypochromic anemia due to inadequate supply of iron for normal hemoglobin synthesis.
• RBC-3.000.000-4.000.000/cubic mm
• Low hemoglobin
• Low serum iron and ferritin with an elevated total iron
binding capacity (TIBC)
MANAGEMENT
ORAL IRON THERAPY
PARENTERAL IRON THERAPY
DIET THERAPY
Aplastic Anemia
This rare, lite-threatening anemia occurs
when your body doesn’t produce enough
red blood cells.
Marrow failure may be initial presenting
reature.
Causes of aplastic anemia include:
-Infections,
-Bleeding
-Certain medicines,
-Autoimmune diseases
-and exposure to toxic chemicals.
Pharynx
PARYNGEAL TONSILS. Situated superior-posteriorly to the tors tubaris (elevation around the
pharyngeal opening of the Eustachian tube). In the roof of the NASOPHARYNX, the pharyngeal tonsil
is primarily responsible for"screening the air that enters through the nostrils.
The PALATINE TONSILS are the ones that are located near the opening of the oral cavity into the
pharynx.
LINGUAL TONSILS pre located Do the posterior surface of the tongue, which also places them near
the opening of the oral cavity into the pharynx.
The function of the palatine tonsils is thought to be associated with preventing infection in the respiratory and
digestive tracts by producing antibodies that help kill infective agents.
LARYNX
Your larynx is a hollow tube that connects your throat (pharynx) to the rest of your
respiratory system. It helps you swallow safely and contains the vocal cords, so it's often called the voice box,
What does the larynx do?
Your larynx has three main functions in your body:
-Breathing,
-Creating vocal sounds.
-Preventing food and other particles from getting into your trachea, lungs and the rest of your respiratory
system.
Acute laryngitis: Laryngitis is inflammation of the larynx. Short-term laryngitis may involve a sore
throat, hoarse voice, pain, coughing and sometimes fever. It can be caused by an infection or overuse
of the vocal cords. It usually lasts for one or two weeks.
Chronic laryngitis: Long-term laryngitis lasts longer than three weeks. It can be caused by allergies or
dust.
Laryngeal cancer: Laryngeal cancer may require surgery to remove part or all of the larynx
(laryngectomy)
Trauma or injury: The larynx can be injured like any other part of the body. A common injury is
damage from overuse (for example, someone who speaks, sings or shouts a lot).
Vocal cord dysfunction: Vocal cord dysfunction occurs when the vocal cords don't act or work
normally.
Vocal cord lesions: The vocal cords can develop noncancerous lesions, nodules, polyps or cyst,
especially with overuse of the voice.
Vocal fold paralysis: is when one or both vocal folds do no move properly.
ACCESSORIES INSPIRATION
1. DIAPHRAGM -Primary or main muscle of respiration. Muscle that helps your lungs pull in air and push
it out.
2. INTERCOSTAL
A. Internal
Forced expiration and coughing muscles
Decreases the diameter of the chest wall
B. External
Inspiration
Increases the diameter of the chest wall
3. PECTORALIS MAJOR AND MINOR- both increase the work of breathing.
4. Rectus Abdominis
-Forced expiration and coughing
5. Scalene
Stabilizes the upper chest wall.
Elevates the 19 and the 2nd ribs during inspiration, increases
the size of the thorax
6. Sternocleidomastoid-
Stabilizes upper chest wall. Assist in elevating the rib cage
Elevates stemum
7. PARASTERNAL - Inspiratory muscle, increases work of breathing.
8. Trapezius - Inspiratory muscles, starts at the base of your neck, goes across your shoulders and extends to
the middle of your bac.
SUMMARY:
-Muscle responsible for supraclavicular retraction
Sterocleidomastoid
Scalene
Trapezius
-Inspiratory muscle
Parasternal
Trapezius
Pectoralis
EXPIRATION MUSCLES
IC- internal
Rectus abdorinis
ACCESSORIES: BONES (skeletal system )
1. RIBS
7 pairs -true ribs (attached directly to sternum)
3 pairs - false ribs- 8th, 9th, and 10th ribs (attached to one another by costal cartilages but not directly to
the sternum.
2 pairs - floating ribs - 11' and 124 ribs ( not attached to other ribs and sternum
Allow full expansion of the chest.
Protect the kidneys
2. STERNUM
Manumbrium
Body
Xiploid
VERTEBRAE
T1-T7 True ribs
T8-T10 False Ribs
T11-T12 Floating ribs
Oxygenation
Respiratory Physiology: Most cells in the body obtain their energy
from chemical reactions involving oxygen and elimination of carbon
dioxide. The exchange of respiratory gases occurs between environmental air and the blood. There are 3 steps
in the process of oxygenation:
Ventilation,
Perfusion
Diffusion.
For the exchange of respiratory gases to occur, the organs, nerves and muscles of respiration must be intact
and the central nervous system able to regulate the respiratory cycle.
1. Ventilation:
Ventilation is the process of moving gases into and out of the lungs. Ventilation Requires coordination of the
muscular and elastic properties of the lung and thorax. The major inspiratory muscle of respiration is the
diaphragm. It is innervated by the phrenic nerve - the spinal cord at the fourth cervical vertebra.
Oxygenation Versus Ventilation
Oxygenation is how we get oxygen to the tissue. Oxygen is inhaled into the lungs where gas exchange
occurs at the capillary-alveolar membrane. Oxygen is transported to the tissues through the blood
stream. Pulse oximetry measures oxygenation.
Ventilation (the movement of air) is how we get and of carbon dioxide Carbon dioxide is cared back
through the blood and exhaled by the lungs through the alveoli Capnography measures ventilation.
A.
A.
A.
A.
A.
A.
A.
A. Inhalation. The intercostal muscles contract, lifting the rib cage up and out. At the same time, the
diaphragm contracts and pulls downward. As the lungs expand, air moves in.
B. Exhalation The intercostal muscles relax, allowing the rib cage to return to its normal position. The
diaphragm also moves upward, resuming its domed shape. As the lungs contract, air moves out.
Normal Inspiration Normal Expiration
Diaphragm - flattens and contracts relaxes and elevates
ICM-contracts relax
Rib cage - raised lowered
Thoracic - enlarged reduced
DIFFUSION
- is the process whereby gases move from an area of high pressure to low pressure. This includes during:
Internal respiration - this is the movement in the internal tissues between cells and capillaries, and
External respiration - when gas is exchanged between the alveoli and lung capillaries.
Once in the lungs, the air travels through a series of increasingly smaller structures called bronchioles. It
eventually reaches tiny sacs called alveoli. From the alveoli, the oxygen from the air you breathe enters your
blood in nearby blood vessels. This is a process called oxygen diffusion. Once your blood is oxygenated, it
carries oxygen throughout your body.
Another form of diffusion occurs when blood containing carbon dioxide
travels back to your lungs. The carbon dioxide moves from your blood to your alveoli. It's then expelled through
exhalation. This is a process called carbon dioxide diffusion.
Outcomes
Explain how diffusion happens in liquids and gases
Investigate the process of diffusion between two substances
Justify how the rate of diffusion can be affected by different factors
PERFUSION
- Is the actual blood flow through the pulmonary circulation.
Perfusion refers to the blood flow to tissues and organs. Alveoli are perfused by capillaries so the diffusion of
oxygen and carbon dioxide can take place
The main difference between perfusion and diffusion is that perfusion is the delivery of blood to the pulmonary
capillaries, whereas diffusion is the movement of gases from the alveoli to plasma and red blood cells.
COMPLIANCE
Is the elasticity and expandability of the lungs and
thoracic structures.
describes the expandability of the lungs and chest wall. There are two types of
compliance: dynamic and static.
DYNAMIC COMPLIANCE describes the compliance measured during breathing, which involves a combination
of lung compliance and airway resistance, decreases with increasing airflow and a faster respiratory cycle. This
is defined as he change in lung volume by the change in pressure, in the presence of flow
STATIC COMPLIANCE describes pulmonary compliance when there is no airflow, like an inspiratory pause.
This is defined as the change in lung volume by the change in pressure, in the absence of flow.
Rubber Band/Balloon Concept - A simple way to understand lung compliance is through the rubber band or
balloon concept.
A tighter rubber band, with more resistance, would be more difficult to stretch, and can readily recoil.
A loose rubber band, with less resistance, would easily stretch and wouldn't recoil as easily.
Surface Tension
Alveolus- where gas exchange occurs (carbon dioxide with the blood)
The spherical alveoli formed clusters. Alveoli is also lined with mucus which create surface tension
Any factor that reduces the airway caliber (mucosal edema, inflammation, secretion, bronchospasm,
less surfactant) will raise the resistance to airflow and decrease the ventilation of the corresponding
alveoli similarly any area in which the local compliance has decreased (ie. That portion of the lung has
become more stiff) will receive less ventilation than the surrounding more expandable portion of the
lungs.
Lung Volumes: Normal lung volumes are measured through pulmonary function testing. Spirometry measures
the volume of air entering or leaving the lungs. Variations in lungs volumes may be associated with health
states such as pregnancy, exercise, obesity Or obstructive and restrictive conditions of the lung. The amount of
surfactant, degree of compliance, strength of respiratory muscles can affect pressures and volumes within the
lungs.
Pressure: Air Pressure variances- Air flows from a region of higher pressure to a region of lower pressure.
Pulmonary ventilation is the process of breathing, which is driven by pressure differences between the lungs
and the atmosphere. Atmospheric pressure is the force exerted by gases present in the atmosphere. The
force exerted by gases within the alveoli is called intra-alveolar (intrapulmonary) pressure, whereas the force
exerted by gases in the pleural cavity is called intrapleural pressure.
Typically, intrapleural pressure is lower, or negative to, intra-alveolar pressure. The difference in pressure
between intrapleural and intra-alveolar pressures is called transpulmonary pressure. In addition, intra
alveolar pressure will equalize with the atmospheric pressure.
Typically, for respiration, other pressure values are discussed in relation to atmospheric pressure. Therefore,
negative pressure is pressure lower than the atmospheric pressure, whereas positive pressure is the pressure
that it is greater than the atmospheric pressure. A pressure that is equal to the atmospheric pressure is
expressed as zero. Before entering the alveoli, inspired air mixes with gas that wasn't exhaled on the previous
expiration. Because this gas contains more CO2 and less 02 than inspired air, partial pressures change again.
The air that finally enters the alveoli for diffusion across the respiratory membrane goes to further partial
pressures changes. However it remains high in PO2 and low in PCO2. The differential in partial pressures of
02 and Co2 causes the two gases to cross the respiratory membrane toward the lower side of their respective
pressure gradients 02 diffuses into the blood, and CO2 diffuses outward, equalizing gas pressures on both
sides of the respiratory membrane
Intrapleural pressure is the pressure of the air within the pleural cavity, between the visceral and parietal
pleurae. Similar to intra-alveolar pressure, intrapleural pressure also changes during the different phases of
breathing. However, due to certain characteristics of the lungs, the intrapleural pressure is always lower than,
or negative to, the intra-alveolar pressure (and therefore also to atmospheric pressure). Although it fluctuates
during inspiration and expiration, intrapleural pressure remains approximately 4 mm Hg throughout the
breathing cycle.
OXYGEN CONTENT- Oxygen binding capacity is the is the maximum amount of oxygen that can be bound to
hemoglobin, abbreviated as Hgb, which is the main protein found inside of red blood cells, which is a main
component of blood.
1. Sa02 -is a measure of how much hemoglobin is currently bound to oxygen compared to how much
hemoglobin remains unbound.
2. Hgb. & Pa02 -Pa02 as the driving pressure for oxygen molecules entering the red blood cell and
chemically binding to hemoglobin; the higher the Pa02, the higher the Sa02.
Hbg- It is composed of a protein called heme, which binds oxygen. In the lungs, oxygen is exchanged for
carbon dioxide
Pa02- is determined solely by the pressure of inhaled oxygen (the PI02), the PaCO2, and the architecture of
the lungs.
Arterial 02- in healthy individuals breathing room air at sea level, Sao2 is between 96% and 98%. The
maximum volume of oxygen which the blood can carry when fully saturated is termed the oxygen carrying
capacity, which, with a normal hemoglobin concentration, is approximately 20 mL oxygen per 100 mL blood.
Mixed 02 -The normal mixed venous oxygen saturation is about 70%-75%. This value reflects the fact that the
body normally extracts only 25%-30% of oxygen carried in the blood.
Week 2: NCM113 Ma’am Tierra
People
Population variables that affect the health of the community include the size, density, composition, rate
growth or decline, cultural characteristics, mobility, social class and educational level.
System
A social system is the patterned series of interrelationships existing between individuals, groups, and
institutions and forming a coherent whole.
Social system components that affect health include the family, economic, educational, communication,
political, legal, religious, recreational, and health systems (Allender et al., 2009).