AKANE SHIMIZU

HEY! SO,
WE MEET
AGAIN.

Chapters Food Poisoning

Chapter6é Heat Stress /

Chapter 7
Erythroblasts and
Myelocytes
 GASTRIC
ig VHICES.
MELTING
DOWN
CLUMPS OF
NUTRIENTS.
White Blood Cell
(Neutrophil)
His main job is to destroy
foreign substances that enter
the body from the outside,
Red Blood Cell
such as bacteria and viruses.
She transports oxygen and
carbon dioxide through
blood circulation.
 Vv : Stomach a

SOTHIS 2H Beare
A eae ( rea eee P
oOo
DIGESTED!

on, WELL:
rvs NOT
aL THAT & I'VE BEEN
\MPORTANT AR” WORKING SO HARD
JUST TO LEARN MY
WAY AROUND THE BODY
youl. RED THAT I NEVER REALLY
HAVE BLOOD STOPPED TO LOOK AT
TO TELL CELL! HOW THE DIFFERENT
ME THE ORGANS WORK!
REST
LATER!

THIS IS MY
FIRST TIME
SEEING FOOD
MELTED DOWN
LIKE THIS—
}: 7
i if 4
i VN
ity Wf gma
/ Af i]

HA-HA-HAL
WHAT A WIMPY
WHITE BLOOD

f-
ean Receptor
Works like radar to detect
bacteria and other bodies.
 WANT TO

GERM!
L WON'T
LET YOU
LAY ONE
FINGER ON
A SINGLE
BLOOD
CELL OR
NUTRIENT!

Eosinophil
Atype of white blood cell. Said to
make up a few percent ofall white
blood cells. Multiplies during allergic
reactions and parasitic infections.
Weaker than other w hite blood cells,
but is capable of phagocytosis.
 IS THAT
SUPPOSED
TO BE AN
AN ATTACK?

BUT I RAN YOU WERE

INTO THIS A MACRO-
PUNY EXCUSE PHAGE, I
FOR A WHITE MIGHT BE IN
BLOOD CELL = TROUBLE.
INSTEAD...
 H-HI
THERE,
ARE
YOU ALL PHEW... 1%
RIGHT?! TARGET f
ELIMI-
NATED.

T'M FINE... = (Ns | i Ba

T CAN ee
STAND ON s ee
 THAT WAS
CLOSE... !
THANKS, wee
etna
AN
Wl
Veneer
NEUTROPHIL.

OH? YOU
TWO KNOW
EACH
OTHER?

“41 IS THAT ONE

IN PIGTAILS
SHE WAS REALLY A
LOSING TO A i WHITE BLOOD
CELL?
GERM...
 AND SHE'S
GOT SUCH
A BIG
WEAPON.

IT WAS JUST
A BACTERIUM,
7 en HAVE
EVEN Lae
IT SHOULD'VE WHITE BLOOD
BEEN NO CELLS LIKE
PROBLEM. THAT? I DON'T
RECOGNIZE

/ JUST 60
/ I'S FINE, YOU KNOW,
NEUTRO- ELIMINATING
PHIL. BACTERIA ISN’T
THE ONLY JOB
OF A WHITE
BLOOD CELL.

EVERYTHING
THEY'RE
SAYING IS
TRUE.
 CAN YOU oll
HEAR IT...7
CAN YOU
me
| A
ie
ARN
hey
Y
Woe
==
en
2
\| BACTERIA
ae
GAH!
:
EMER-
HEAR THIS op ; : —
 THE GEARS OF
DESTINY HAVE
ALREADY BEGUN
TO TURN...CAN
: YOU STOP THIS
Ue RHAPSODY OF
BE “i RUINATION?
OU, YE WRETCHED
a WARRIORS
ops
BEARING THE
WEIGHT OF THE
CROSS CALLED
"PEACE"...

1 Basophil
Atype of white blood cell making up less
J than 1% ofall white blood cells. Basophils
| encountering specific antigens are said to trigger
4 the release of histamines, as well as allergic
@ reactions. They manufacture chemicals that
draw neutrophils and eosinophils to where they
are needed. The role that basophils play in the
immune system is not yet fully understood,
PENI

BECAUSE OF THE
ee BRITALITY OF ONE WHO
DOES NOT KNOW LOVE, OUR
BETTER | | THAT THERE PARADISE HAS BECOME A
LAND OF CARI ‘OND
EVERYONE, GET aerean Due CONTROL..-THE
ONLY
PLEASE | GOING. THAN CAN WAY WE CAN
EVACUATE. J: BE KILLED oe
BACTERIA WITH WITH YOUR
ARE HERE. | STOMACH
ACIDS?!
 WE ARE
DEALING WITH
AN APPARENT CASE
OF BACTERIAL
FOOD POISONING.
CELLS IN THE
AFFECTED AREAS
SHOULD EVACUATE
IMMEDIATELY.

Vibrio parahaemolyticus
A bacterium that livesin
seawater. Ingesting seafood
contaminated with this
bacterium can cause infective
food poisoning with symptoms
such as severe stomach pain. g

7IME TO
PARTY, MY \
MINIONS!

A BACTERIAL
COLONY WAS
ATTACHED TO
THERE'S AN THE RAW FISH/
AWFUL LOT INVADER
OF DAMAGE TO POPULATION
THE STOMACH IS HIGHS
LINING FOR
INFECTIVE FOOD
POISONING.
DOES THAT
MATTER?!
SOUND THE
ALARM, NOW!
 WE'RE ON
OUR OWN
UNTIL REIN-
2 FORCEMENTS &
ARRIVE!

IT’S GOING
TO EAT ME!

WEAKLING!
HELP ME
WITH THIS
p>\ONE!
Loan j

NESEEE
 YOU'RE
A COCKY
ONE! I'l
EAT YOU

ol Mey
Wey
&

inte

ae4 *
PS UR
 ABOUT THE
OTHERS? ARE
THEY ALL
RIGHT?
I’M SORRY,
NEUTROPHIL...

YES, THE
BASOPHIL
CALLED
IN REIN-
FORCE-
MENTS.

I
YOU HAD SHOULDN'T
TO PUT
HAVE
YOURSELF JUMPED
AT RISK... OUT ON
I'M
MY OWN...
ASHAMED BECAUSE
TO CALL
MYSELF CYTOSIS
WHAT =— A WHITE
GOOV ARE \y BLOOD
EOSINOPHILS, § CELL.
ANYWAY? Phagocytosis
When cells (phagocytes) like

We WERE
INA JAM, 1; no, rm THE
AND T DIDN'T
ONE WHO
CHOOSE ee
APOLOGIZE.

IT'S FINE.
T KNOW
THAT I'M

li
\
WH-WHAT I-IT KNEW
IS THIS? THAT
r SOMETHING

THERE'S WAY
TOO MUCH
DAMAGE TO THE
STOMACH LINING
FOR THIS TO BE
INFECTIVE FOOD
POISONING.
 THAT'S NO
__.) BACTERIUM—!

Wy Zs
aZ
ae

Zz Ris,
 IT'S EATING
, THROUGH
) THE STOMACH
LINING!

OUT! IT'S
TRYING TO
GET INSIDE
THE BODY!

WHAT- Md
ever it [JN
TAKES! |

EVEN IF
WE CAN'T
BEAT IT,
STAND
YOUR

Anisakis
A parasitic nematode that lives
A in marine animals. Eating raw
seafood containing anisakis
can cause food poisoning
(ansakiasis) with intense
stomach pain and vomiting that
is caused by invasion of the
stomach orintestinal lining.

IT'S THE
PARASITE
AN/ISAK/S!

AWAY JUST
BY THAT
ROAR!
AH

AUGH, IT'S
SO SCARY!
SOMEONE
STOP THAT
THINGH!

CELLS?
. j 0 SOME-
W\ SAX THING!
ARE YOU | :
KIDDING? \..
WE DON'T
STAND A
2g CHANCE! if | ze i:
 YOU CAN'T
EVEN BEATA WHAT...?!
BACTERIUM! DO You HEAR
YOU HAVEN'T YOURSELF,
GOTA EOSINOPHIL?!
PRAYER!!

|Oow~ mall i

WH-WHY
WON'T
YOU SAY
SOME-
THING?!
SHE'S NOT
THROWING
 WHO CAN
BEAT THAT
THING!

AS A WHITE
BLOOD CELL,
I HAVE A DUTY
TO ELIMINATE
BACTERIA...
The Role of Eosinophils
When parasites enter the body,
Eosinophils work to damage it
and defend against infection.

set
TO K/tl
FARA-
SITES!!
i
Lh
|

| /
Hd nt g; 4
be
EOSINO-
PHIL

U
FOUGHT IT
OFF!! THANK
You!
 YOU WERE
50 COOL.
YEAH! JUST
AWESOME.

DOING?!

THANKS TO
E0SINOPHIL'S
HARD WORK,
THE WORLD WAS
SAVED FROM
THE PERIL OF
THE ANISAK/S.

ps a=
PP Vel
wre \
(We b

TO THINK—
THAT THE HOLE
OPENED BY
ANISAKIS, THE
UNINVITED GUEST,
WOULD LET IN
«80, IN THE LIGHT
== tue RK TO SHINE LIPON
==|
=|
WORD6...
"CASE
Aff THE HEARTS OF
Ty ! ‘ig ws THE MASSES...
==] close’? | AN os — OUR FATE
== ae ;) CHAPTER 5: END ABOUNDS WITH
zis IRONY...
 = DAMN

WE DON’T
HAVE MUCH
WATER
LEFT... |

THERE ANOTHER
ANYTHING... EMPTY WATER
ANYTHING \ TANK...!/
WE CAN A
DO.
 »» ABOUT
THIS
GLOEAL
WARMING

IT’S ALL
DRIED UP
BECAUSE OF
THIS HEAT.
THERE USED
TO BE MORE
WATERWAYS
AND SUCH.

Thermo-
regulation
One way the IS THE
THAT'S body maintains AREA
WHY WE'RE its temperature NEAR THE

niaodne ‘Scions |)Sees is

MARCHING is to increase EPIDERMIS

10 LOSE HEAT | skin, better TO LOOK carbon dioxide through

: : radiating LIKE THIS? blood circulation.
heat away.
pOESN'T LOOK
ANYTHING
LIKE THE
BROCHURES...
\PTER-G:
HEAT STRESS
/

Li Ce Lae.
C:.77\
nal ia
aie

IT'LL BE
ALL RIGHT.
ANY TIME = IT'LL COOL
NOW, THE DOWN AS
SWEAT SOON AS
GLANDS THE BODY
WILL... SWEATS!
 DAMMIT!
\) tuis Guy
) JUST WON'T

ROGER
THAT. |
NO. 146
foes HERE. JUST
ELIMINATED
THE LAST
BACTERIUM.

White Blood Cell (Neutrophil)

His main job is to destroy
foreign substances that enter
the body from the outside, such
as bacteria and viruses.
 CAN'T
BELIEVE
HE HAS
THE ENERGY,
TO RUN
AROUND
IN THIS
HEAT...

IS SOME-
THING THE

THEY'RE
GOING TO AREN'T YOU
START THE HOT WEARING
ALL THAT,
WHITE BLOOD
CELLFJ =

IF I TAKE
ANY OF IT
OFF, I CAN'T
RESPOND |
PROPERLY
IN AN EMER-

FINALLY...
THAT SHOULD
COOL THINGS
DOWN.
Sweat Glands
These glands secrete the sweat |
stored in the skin. There are
two types: apocrine glands
and eccrine glands. Sweat
removes heat by evaporating
(the heat of vaporization),
and plays an important role in
regulating body temperature.

WHAT'S GOING
ON? YOU'VE I'S JUST
b GOTTA BE
STAYING
KIDDING. IT'S LIQUID.
BUT SOME-
THING'S |
NOT RIGHT.

NO GOOD,
SIR!
THE WE'RE
SWEAT PER-
ISN'T SPIRING
VAPOR- SUCCESS-
IZING?! stout
«BUT
17'S NOT
IT MUST COOLING SWEAT IS
BE TOO THE BODY SUPPOSED
HUMID SURFACE! TO TURN INTO
OUTSIDE MIST AND COOL
THE THE SKIN BY
BODY! REMOVING THE
HEAT OF
VAPORIZATION.
 THE BODY
TEMPERA-
TURE 1S
GOING TO
KEEP
RISING!

WE WALKED ALL
THE WAY HERE IN
THIS HEAT TO MAKE
THE BODY SWEAT—
ALL BECAUSE YOU
TOLD US IT WOULD
COOL THINGS DOWN!!
 THAT'S
ALL THAT
WE BLOOD
CELLS CAN

WE HAVE TO
RELEASE MORE
HEAT FROM THE
EPIDERMIS... !/

GIVE IT
EVERYTHING EVERYONE
YOU'VE GOT | MARCH
TO REGULATE THROUGH THE
CAPILLARIES
TO RELEASE

THIS
BE...77

BUT THIS
INCREASE ISN’T
NORMAL.../ AND
SWEATING ISN'T
COOLING DOWN INCREASED
THE BODY CIRCULATION...
LIKE IT SHOULD... ON THE SURFACE, §
THE BODY IT'S JUST ONE COG
TEMPERATURE IN THE BODY'S
KEEPS RISING... THERMOREGLULATION
SYSTEM...
Heat Stress
Ageneral term for health disorders resulting from
the malfunction of thermoregulatory processes,
or from the breakdown in the balance of water or
electrolytes in the body. It is divided into three levels
based on severity. Heat syncope, characterized by
symptoms such as dizziness, lightheadedness and
numbness in the lips, is considered the lightest level
of heat stress. It is caused when blood vessels near
the skin dilate to increase blood flow, leading to low
blood pressure and reduced circulation to the brain.

TH-THIS
 IT’S
THE END
OF THE

WHOA! THE
GROUND IS
TIPPING—?!

QUICK!
GRAB
ONTO
SOME-
THING!
 LOSING
YOUR
HEADS OVER
A LITTLE
HEAT...

Bacillus cerus YOU DON'T

A bacterium commonly found DESERVE
in soil, water, and other parts
of the natural environment.
I, BACHLUS THIS BODY.
It can form heat-resistant CEREUS,
spores that can survive thirty
minutes at temperatures of WILL TAKE IT
210°F. Itcan cause two types
of food poisoning, inducing FROM YOU!
either vomiting or diarrhea.

"HEAT STRESS DOES NOT

INCREASE THE RISK OF
INFECTION BY B, CEREUS,
 $0, YOU'RE
HERE TO
KICK US
WHEN WE'RE

AAI TR ie
i

ie
SOMEWHERE
UNTIL IT

YOU GERM |
BASTARDI!! |.
 BWA HA HAL!
don ie EVERYONE
ie ae HERE LOOKS
VESSELS LIKE THEY
AROUND CAN'T TAKE
HERE ARE THE HEAT.
FLOWING NICE
AND FAST!

ALMOST
LIKE THEY'RE
TELLING ME, Gu...
"HEY MR. HE'S GOING
CEREUS, PLEASE) TO GET AWAY
GET AWAY AND BY HITCHING
TAKE OVER A RIDE WITH
THIS BODY!” THE BLOOD
CELLS!

OBSTACLES
SURE ARE
CONVE-
NIENT!
 PLEASE,
LET ME
THROUGH!

I'M
CHASING
A BACTE-
RIUM!
OUT OF
MY WAYI!

A GERM?!
\ REALLY?!
WHERE?!

/7'S 60 ANY-
HOT AND THING!
DARK!
WHAT'S
GOING
ON?!

HEH
STOPPED HEH
CHASING HEH,
ME...?
 THERE'S
A GERM
RIGHT
THERE!

THAT
WHITE
BLOOD
CELL

NOOOO T
CAN'T SEE
ANYTHING!
IT’S TOO
 IN THIS
BODY, EVEN
THE WHITE
BLOOD CELLS
HAVE HEAT
STRESS!

LOOKS
LIKE YOU
WORKED A
LITTLE TOO
HARD IN
THIS HEAT!
llny
A Poe fT 37 r y
Gott ft

a
Jw
 OH, BUT
GoOoD
YOu'RE FOR You!
WEARING
A HAT LIKE
; A GOOD
| Heat Stress#1: |.” a4 ¥ “ Boy!
Weara hat Poe
Avoid direct
sunlight to the
head to prevent
overheating.

BUT YOU
REALLY SHOULD
: Ry at HAVE HYDRATED
aad 4 BETTER.

I GUESS
| THERE
How to Prevent ‘| ISN'T ANY
Heat Stress #2: WATER
Hydrate
IN THIS
To avoid
dehydration, BODY...
take in fluids and
electrolytes often.

GATHER UP AS
MUCH SODIUM
AS YOU CAN!
USE OSMOTIC
PRESSURE TO
DRAW WATERI!
THERE'S
NOTHING
MORE
THAT THE

DON'T HAVE
ENOUGH FOR
PERSPIRATION!

OUR SODIUM
SUPPLIES
ARE ALSO
DRAINED
FROM
meant |
\
 RAAAIN/
RAAAIN/
COME TO
us! COME
TO Us!

HELP! THE
COMMANDER'S
LOST IT!

HEH HEH
THE THERMO- Rens
REGULATORY ,
FUNCTIONS ARE
COMPLETELY
SHOT NOW.

Now,
THEN!
THIS KIND
OF HEAT
DOESN'T
BOTHER
MEA

COULDN'T
SAVE
YOUR
FRIENDS.
SO SAD.

SHALL I
DO FIRST...?
MAYBE
T'LL GO UP
AROLIND
THE BRAIN,
SHOW OFF
MY POWER A |
LITTLE?
 YOU'RE
REALLY
GETTING
IT'S TIME ON MY
TO ACCEPT NERVES!!
REALITY, BUDDY! GIVE IT
you TRIED uP AL-
A BUNCH OF
THINGS LIKE
SWEATING AND
INCREASING
BLOOD FLOW.

IT'S THE
END FOR
THIS BODY os THERMO-
BODY'S tae
NOW!! REGULATORY rb
SYSTEM HAS NEVER...
FAILED! IT LOST . LET YOU
TO THE OUTSIDE ae
ONCE YOU TEMPERATURE!
REALIZE THAT,
YOU CAN GO
TAKE IT EASY
IN SOME COOL
CORNER AND
LOOSEN THOSE
CLOTHES!
 THIS
BODY

MY JO /
NO REASON
FOR ME TO
GIVE UP ON
f
Nant
1S STILL
aw
Uy

rt:

Cy
itiemes:
cA
mance

=,

— q*esTey
Se ga
apag e WwROSLELS
eg BST VE SR
VGRVS
gageee
esqCL
US SH
GTAEE S CR
: wESSESOG
>~IEy
ak
cs. 4
bis
 T CAN
HIDE IN THE
DARKNESS
AND
WHILE THe MULTIPLY.
CELLS ARE IN
A PANIC OVER
THE HIGH BODY
TEMPERATURE,
TLL TAKE OVER
THIS BODY!!
MINE!LLL

THERE'S
NO ONE
LEFT TO
STAND /N
MY WAY!!
 |
MT VLE

WHAT'S
THAT
RING OF
LIGHT...7
 SIR, THE
BODy'S
SURFACE
TEMPERATURE
IS DROPPING
RAPIDLY!
 Intravenous Rehydration
An injection into a vein, most
often administered to infuse
fluids, electrolytes, or nutrients.

THE HECK
1S THAT
PIPE?!

C-COULD
IT BE...7
 @ WATER-
7 RRRRII!<

IT'S GETTING
BRIGHTER...
COOLING IS THE BODY
OFF AND RECOVER-
TAKING ON ING?!
FLUIDS?!

YOUR RAIN
DANCE
REACHED
THE
HEAVENS!
 wooo.
NOW THAT'S
REFRESHING.
 Y \\Wcy ‘HoffNe
': \ r

BUT MAYBE
NOW'S NOT
THE BEST
TIME TO
SAY HI.

THANKS TO A
DID THE | MIRACULOUS
RAIN DANCE (A RAIN FROM THE
REALLY HEAVENS CP),
THE célg = MOVE THE
HAD NO WAY PEAVENS...?
THE BODY
ESCAPED THE
OF KNOWING PERILS OF
WHAT REALLY
HAPPENED TO
THIS BODY.
 IT'S REALLY
T DUNNO... COOL AROUND
BUT T DON’T THE NECK
CARE RIGHT AND ARMPITS,
NOW. NEAR BIG
BLOOD
VESSELS!

Cooling the Body CA nn oo eee Bes ste ias

Escaping to a cool spot, i :
then cooling down parts
of the body with large

NICE AND
blood vessels (around the
neck, armpits, and upper
thighs) is an effective
way to cool down.
COOL...

T HEARD
YOU HAD
HEAT
STRESS.
GOTTA BE MORE
CAREFUL.

WHITE
BLOOD CELL,
THE BLOOD YOU SHOULD
| REALLY DRESS
| | CELLS WERE LIGHTER FOR
|| | ABLE TO TAKE WORK.

A BREAK TO
4 ENJOY THE x
=| REFRESHING 3\4
Le COLD... :
3 Z| HAPTER 6: E
 THE DIFFERENTIATION
BONE OF BLOOD CELLS
MARROW ‘ in NBY) con!”Ue, 30 (ABBREVIATED)
WHY 00 Tey ATED)
¢-, HEMATOPOIETIC
STEM CELLS

LYMPHOID
STEM CELL

\ PROMEGA-
KARYOCYTE

PROERYTH-
ROBUAST

IMMATURE KARYOCYTE
BCELL

BAND.CELL

HELPER
TCELL MONOCYTE
“4 IT'S TOO
COMPLICATED
| INSIDE THE (=
CHAPTER 7
ERY THROBLASTS AND MYELOCYTES
 \ ors BOtHNEe \ efitPe ae aq ~ oS
1.) RED ! 200 8S
MARROW BAIT

Ae. Niagile ’ alti,

 THE RED BONE \\
CELLS ARE MARROW IS
BORN HERE THE HOME OF
AND SPEND BLOOD CELLS.
THEIR EARLY
CHILDHOOD
HERE.

Ey

WE'VE GOT
ANOTHER
PROGENITOR
CELL BORN!

Progenitor Cell
Acell that has not yet
differentiated from astem
cell to a specific cell type.

SHOULD
THIS ONE
BE...A RED
BLOOD
CELL?
SHE DOES HAVE
RED HAIR.

;,| Hematopoietic
“y Stem Cell
Makes blood cells
such as red blood
cells, white blood
cells, and platelets.
 DOESN'T LOOK
LIKE SHE COULD
DO ANY OTHER
WORK.
7 peT SHELL
GROW UP TO BE
a DUMMY.

BLOOD CELLS
ARE FORMED —
HERE BY
HEMATOPOIETIC yeete
STEM CELLS, ME ENOW
THEN SORTED IF YOU SEE
INTO VARIOUS
TYPES.

RED BLOOD
CELLS ARE
BORN AS
PROGENITOR

.». GROW INTO

CELLS CALLED
ERYTHRO- Leo
BLASTS, AND ON
ARE RAISED BY ii
x §a
MACROPHAGES.
 _
OKAY! IS
EVERYONE
HERE?

TAKING CARE \\.=<4 a

OF YOU UNTIL }y Macrophage
In the bone marrow,
YOU GROW erythroblasts gather
INTO FULL- around macrophages.
| Erythroblasts
Acellstillin the midst of
FLEDGED RED Macrophages play a
BLOOD CELLS. large role in the differ- differentiation, before it
© entiation and matura- turns into a red blood cell.
tion of erythroblasts.
ES Ses

LET’S ALL
WORK HARD
$0 YOU CAN
BECOME
RED BLOOD
CELLS!

YAAY! GO,
EVERYONE,
GO! © CARRYING
 fil(0ws
i
LEARN YOUR
WAY AROLIND
SOON ENOUGH.
DON'T YOU
WORRY. 0
 sotopay, \Al irs Not ‘Pr
WE'RE GOING [Ee] ALWAYS ji Jp
TO PRACTICE PEACEFUL | |Z
RUNNING IN BL . 4
AWAY FROM Daas "A wz
BACTERIA. if

SOME-
a
TIMES,
SCAAARY
BACTERIUM art as
COMES ALONG, ALONG
TAKE COVER .
WHEREVER
YOU CAN.

MR,
GOING TO NEUTRO-
GET LOST PHIL
AND GET i / Wilk BE
EATEN FOR ’, PLAYING
SURE! oS THE ROLE
tT! OF A
BACTERI- |
umf

HEY!
YOU PAY
ATTENTION
TO YOUR
TEACHER,
you
HEAR?

White Blood Cell

<=] (Neutrophil)
iJ His main job isto destroy
foreign substances that enter
the body fram the outside,
such as bacteria and viruses.
 YOU'RE
ALL VERY
+190 YOUNG...
YOU CAN'T
LEAVE
THE BONE
MARROW

AS LONG AS
YOU'RE HERE
IN THE BONE
MARROW,
WE'LL ALWAYS
BE ABLE TO
FIND You.

Erythroblasts live in the \

bone marrow until they
mature and enucleate.

IF YOU'RE
SCARED, WE
COULD STICK
TOGETHER.

OH,
REALLY?

THANKS!!
 GRRRRI!!
BOW DOWN
70 YOUR
BACTERIA
1 OVERLORDS!

I WANT ME
SOME TASTY
RED BLOOD
CELLS!
 DON'T LET
THE SCARY ONE FIND A
BACTERIUM GOOD HIDING
CATCH YOU! PLACE?

TERIA
ARE SO
SCARY...
HERE'S AND
YOUR IT GET
OXYGEN LOST SO
DELIV- EASILY.
ERY!!
 CAN I GET
ONE OVER
HERE, TOO?

THANK
you, AS ff
ALWAYS.

\
NO
PROBLEM.
HAVE A
GOOD ONE.

COMING
RIGHT
uP!
 T CAN BE
YOU DOING LIKE THEM
IN A PLACE ONE DAY?
LIKE THIS? 43
j
 AREN'T HEH
HEH...
AHLELH ALONE,
YOU AN
ERYTHRT?O-
HUH? LUCKY
BLAS
A BABY D
RED BLOO

THIS IS
A DRILT?L,
RIGH

YOU AREN'T
TO CALL ISTER,” LA
MEONTHGAT. TAM “M
WR
R
TO YOU, AFTE
ALL...
 THIS
AIN'T NO
COSTUME!
(3 I'M PSEU-
Yi DOMONAS
by” AERUGINOSA,
| THE REAL
j DEALI!

Pseudomonas
aeruginosa
A bacterium that is
ubiquitous in the natural
world. Can cause
opportunistic infections.
 ERYTHRO-
BLASTS
CANNOT LEAVE
THE BONE
MARROW.

LE LL
NM wip
ELMYY,
yeliy LE.

/// I i,

pombe
LOOOVE TO

OWERLESS
LITTLE BLOOD at eames
CELLS LIKE ae x THING, LITTLE
vee BACTERIUM tae
WHO :
DOESN'T NEED
NUTRIENTS OR
OXYGEN TO
SURVIVE... |

| Pseudomonas
| aeruginosa@ .. BOTHER
4 Multiplies rampantly even TO COME
v without nutrients. Once in ALL THE
the human body, wreaks WAY HERE

SOOONN0S
i havoc on blood cells and INTO THIS
cellular tissues. BODY?
: THAT'S
BECAUSE...
 SEAARARS

SHALL
WE FINISH

HEH HEH HEH.

YOU POOR
THING. SO
YOU'RE YOUNG, TOO.
GOING TO
DIE HERE
WITHOUT EVER
GETTING A
CHANCE TO
GROW UP.

WELL,
THAT'S JUST
YOUR FATE.
NOTHING YOU
CAN DO!
 a

EPP
{==
{==
{==
 & :
aor
EVEN
WANT
BE AN E
SOM
AWE

Cell
fe

4
Sry,
A tM
a

OT
YOU'VKEINGG A
ATTAC
IN
BLOOD CELL
 A
BACTERILIM
i, DOESN'T
i /\\ DESERVE TO |
| KNOW MY
NAME.

—
Sl
WERE GONNA
BE ALIVE
THAT LONG,
ANYWAYIT!
 MAN, DO I
LOVE BEING
A BULLY. SHATTERING 44 HA HA,
THE DREAMS
OF LITTLE — ok
KIDS, BREAK- ‘
ING THEIR
PRIDE!

SPARE
YOUR
LIFE IF & WHAT'LL
YOU HAND fag” IT BE,
OVER Ox KID?
THAT s T LIKE
ERYTHRO- |" KIDS
BLAST. } WITH
WHAT SOME
D'you GUTS.

BLOOD CELLS
PROTECT
OTHER CELLS,
EVEN IF IT
COSTS THEM
THEIR OWN
LIVES. I’M
GOING TO BE A
THAT'S GREAT WHITE
THE SPIRIT, BLOOD CELL
YOUNG SOMEDAY/!
MYELOCYTE!
 THANK
GOODNESS!
WE WERE SO
WORRIED. :

YOU'RE
SAFE NOW,
BOTH OF
 WILL T
EVER
SEE YOU
AGAIN?

IF WE BOTH
GROW UP
AND WORK
IN BLOOD
VESSELS...
 I HAVETO
‘ +. AND GET TO
a DELIVER THE MAIN
THIS STREET...

SORRY!
I'M SO
SORRY!

The
a
i

eaLhe
N

NO..1
SHOULD
HAVE...
wu BEEN
PAYING
MORE
ATTEN-
TION...
ow!!
 WHITE
BLOOD
CE.LL eee
IT'S
YOU...

Vi4 s
beez a
we cor f apie
Ais
WHAT, ARE
Rp| some time } «|| pl00ict yourE'| YOU Lost
ON MY fe Ves NE AGAIN?
HANDS. ET Lee FINE... (wae 05t4
sory :
TLL =
ti fl WALK YOU <
; THERE.
THANK VA
youl! eH
j,
ENUCLEATION OF ERYTHROBLASTS

pre , 5 —
CAN { 7 CANNOT
CELL-DIVIDE. nye CELL-DIVIDE.

ve RED BLOOD
ERYTHROBLAST CELL
Erythroblasts ...but red blood cells
have nuclei... don’t need nuclei.

l@
This is called
enucleation.

This is a mark of
becoming
a full-fledged
red blood cell.
 IT SURE
HAS BEEN
PEACEFUL
LATELY.

> Agaanil! C
) HEEEELPIN &
White Blood Cell
(Neutrophil)
f His main
job is to destroy
OF. ‘CM foreign substances that enter
\ the body fram the outside,
A such as bacteria and viruses.
eh os
Z
Z
oe

CELLS (PART T.

THAT CELL
IS BEING
CHASED BY
A WEIRD-
 a> \
HEY, CELL, JUST
THAT'S AN LIKE Us...!
UNUSUAL
KILL

A VIRUS-
INFECTED
CELL...7
NEVER SEEN
 HMM...
LOOKS LIKE
HE WAS
INFECTED BY
A VIRUS OR
SOMETHING.

POOR

IT'S BEEN A
WHILE SINCE
I SAW A
NEUTROPHIL
ELIMINATING
ANOTHER
CELL.

p |
Killer T Cells (Cytotoxic T Cells)
Deployed on the order of a Helper T
CELLS LIKE Cell. Professional killers who recognize
US GET and destroy foreign substances
such as transplanted cells, virus-
HURT... infected cells, and cancer cells.

THANKS
FOR
HELPING
OuT
NAIVE
THE
OTHER
DAY.
 : iff wel,
<— “ay THEN!
|| TROUBLE mee y ic =WE'RE
INVOLVING Pea NE) GOING
CELLS Is || ey AlN TO TAKE
OUR \ Mm VAC? custopy
PURVIEW. ~ BX ifs] or tuis
— BODY.
\
YOUR JOB
IS KILLING
BACTERIA.

TT
: 5 IT'S NOT
MAN. "i LIKE WE
I'VE BEEN AN | NEUTROPHILS
BORED r Le DON'T DO ANY
LATELY = fe hoe WORK WHEN
WITHOUT S. oe 2 CELLS ARE
ANYTHING | SSy 4 oy eS | INVOLVED.
TO DO. _ i
NK Cell (Natural
Killer Cell)
Patrols the whole
body for cancerous
or virus-infected
cells to attack.
 YOU...
I BET WHAT DO
THERE'S YOU WANT...
MORE OF
THEM. j

GUYS LIKE |
THIS CAN
MULTIPLY
LIKE CRAZY.
THIS IS NO
ORDINARY
VIRUS.

MAYBE
THIS Guy
HERE CAN
SHOW
us THE
WAY?

ub...
TH- (h
WHY DIDN'T THAT'S
YOU TELL RIGHT!
US SOONER, HEY, YOU.
DUMBASS?! THIS WASN'T
THE ONLY
THEBES: INFECTED
MORE LIKE
wae” ie
/ THEM NEAR
MY HOUSE...
ZA, 1 WAS TRYING
To SAY THAT
ALL ALONG.
 TAKE US

T'LL TAKE
apes YOU GUYS
OF els STAY OUT OF
THIS! T DON'T
WANT YOU
SLOWING ME
DOWN.

DON'T THIS
THINK /SN'T
YOu SOME
CANDO KID'S
EVERY- GAME!
THING
ON YOUR
OWN...
 SORRY,
MY HAND
SLIPPED.
 OOPS,
SORRY...

MY HAND
SLIPPED.
 you
SHOULD RUN
ON HOME,
LITTLE LADY.
WOULDN'T
WANT. YOU

Mo
(rag

YOU'RE
SLIPPIN’
Alt
N YOU'RE OVER THE
ONE TO PLACE!
WHAT
ARE YOU,
SENILE?!
Ay.
wa
oe
Y/
WHAT'RE |’
you
TALKING WHY'RE
ABOUT? ‘| You
2 WALKING [eZ
50 a
FAST?
PE
ay THIS
ISN'T A
—
wt
SPEED-
WALKING
COMPETI-
TION, YOU s
DOES THIS KNOW. -y
LOOK LIKE
COMPETING
TO YOU?!
EAREA
SE
EASES
PAL

im

WHERE’RE
YOU
GOING
HEY, WHAT
THE...7/ YOU ON YOUR
STOPPED OWN,
ALL OF A
SUDDEN...
DUMMY?!

GOINGI!
 INTO |THE

WHAT?!
YOU DIDN'T if

LET ME
MAKE THIS
CLEAR.
I'VE
GOT NO
INTENTION
OF
WORKING
WITH YOU
GUYS.
 T’LL
KILL
YOU!!!

THEY DON'T.

THEY'RE
KILLING

POINT US IN
THE RIGHT
DIRECTION.

N
Nove wit
\ geePetrsg eo
WE VS

BESIDES, ; Su WE'RE
YOU SAVED ME TM ABOUT TO KILL
EARLIER... GOING TO CELLS THAT
TAKE YOU MIGHT HAVE
THERE. BEEN YOLIR
FRIENDS OR
NEIGHBORS.

IT’S FOR
THIS BODY,
AFTER ALL!

T'M SURE
YOU DON'T
WANT TO
SEE THAT.
 SOMETIMES, 1 KNOW
CELLS HAVE
70 DIE TO
PRESERVE HELPED.
THE PEACE
FOR THE
WHOLE BODY.

yeeToRY
S
MINE! I CAN'T
TALK
| ABOUT it
MUCH, OUT
| OF CON-
| SIDERATION s

WHAT'S
WRONG?
AHEAD. TLL
CATCH UP.

M-MY
SHOELACE
BROKE.

YOU'RE
WALKING
UNDER A
LADDER iH
Red Blood Cell
She transports oxygen and
carbon dioxide through
blood circulation.

WHAT 1S
THIS....7
L’°VE GOT
A BAD
FEELING... DISHES!
HEH, T BET
A BUNCH OF
FRIENDS OF
THAT VIRUS
ARE HIDING
OUT WHERE
WE CAN'T
SEE. J
 al HOW ABOUT
THIS ISN'T A me nee / Ye WE CALL IT IN
FIGHT! IT'S | spur ZAe J TO H@ AND
A VISCERAL: . UP INTO fp > SS We oo Some
REACTION! iq | Pals SQ RECONNAIS-
T CAN'T hi f | . TAKE
CONCEN- N | :

COME ON,
NEUTRO- 4
PHIL? WE'LL
OF US?7I!
NO
FRICKIN’
WAYIL!
 HEY, YOU'RE
LETTING
PERSONAL
FEELINGS
COMPROMISE
OUR
POSITION!!
WE HAVE TO
GO BACKI!

WORKING
MAN, HE'S WITH HER
ANNOYING. IT'S A COMPRO-
MISES OUR
MATTER POSITION.
OF COM-
PATIBILITY,
OKAY?!
WHY DON'T
WE GET
STARTED?

OF
COURSE,
NO
IF YOU
PARTNERS
WANT TO
TO SLOW
DIE IN THAT
ME DOWN,
DISGUISE, NO CROWD
THAT'S UP
TO GET IN
TO YOU.
OUR WAY.
COME ON,
TLL TAKE
YOU ON.
 yOu HAD
THE MOST
ADVANCED
SYMPTOMS,
BUT YOu
DISGUISED
YOURSELF AS
A HARMLESS
: CELL.

“5
Pat

gi
ve
U
ia
~.+oe
Ss SS
=

AND You,
LADY—YOU
CAME DEEP
INTO ENEMY
TERRITORY...
GOT YOUR R
TWO
FRIENDS

YOU MUST
BE PRETTY
COMFIDENT...
 TAKE CARE
OF THE
THREE OF
| YOU AT
ONCE.
 THEY WOULD HEH...
HAVE SLOWED IT WASN’T
ME DOWN, GETTING
THAT'S ALL. THEY THEM OUT
DIDN'T EVEN OF HARM'S
REALIZE WHAT
YOU WERE.

YOU BUG-
RIDDEN,
DEFECTIVE

Cancer Cells
Cells that multiply uncontrol-
lably due to a genetic anomaly.
They overstep the boundaries
with neighboring cells ina
process called infiltration.
Advanced infiltration leadsto
metastasis, in which cancer
cells travel to other parts
of the body through the
bloodstream and lymphatic
system. This eventually leads
to the cancer spreading to
vital organs and endangering
the life of the organism.
 COULD
HAVE JUST
BUT you WREAKED
OPTED FOR HAVOC IN
THIS CHEAP SOME
ACT. PUBLIC
SPACE.

YOU MUST
HAVE SOME
REASON WHY.

NK Cell (Natural
Killer Cell)
Patrols the whole
body for cancerous
or virus-infected
cells to attack.

Cancer Cells
Cells that multiply
uncontrollably due to
a genetic anomaly.
 HEY!
WHAT'S

I WORKED
REALLY
HARD TO
KEEP FROM
LALIGHING
AT YOUR
LITTLE ACT!
 SOMETHING
ISN'T RIGHT.
LET'S HEAD
BACK AND
JOIN UP
WITH NK AND
THE OTHER
GUY.

WHAT'S
THIS
PIECE OF
PAPER
?

White Blood Cell

(Neutrophil)
His main job is to destroy
foreign substances that
enter the body fram
the outside, such as
bacteria and viruses.
 ® Killer T Cells
(Cytotoxic T Cells)
Deployed on the order of a
Helper T Cell. Professional
killers who recognize and
destroy foreign substances
such as transplanted
cells, virus-infected
cells, and cancer cells.

CELLS HERE
IGNORE THE Multiplication
MULTIPLICATION (76 Cancer cells
cannot control
PROTOCOL?! cell division, and
multiply endlessly.
=

2 i
NU

YEAH...
THERE MUST
BE TONS
OF THEM.
THIS ISN'T
NORMAL.
Quiet

Voices a
dawn

THEY
AND LOOK RIPPED
AT ALL THROUGH
THESE BOXES, THE
NEATLY WALLS,
PACKED FOR TOO.

Infiltration
Cancer cells
overstep the
Metastasis TISSUES 4 boundariesof
Cancer cells travel AROUND healthy neigh-
across the body in HERE ARE A boring cells.
the bloodstream and
MESS.
lymphatic system to
spread their activity.
 |
\N 4
' 0
: MULTIPLICATION, ?
THIS () INFILTRATION,
/S NO INC { AND
VIRUS!
: N \ METASTAS/S!

is " nna,
 —=x
NNN)

DAMN!
WHERE'D
THEY
COME
FROM?!

HEY, KILLER!
/ NK AND THAT
MORON!! OTHER CELL
DON'T WORRY : ARE IN
ABOUT HER! : DANGER!
THINK ABOUT
HOW WE'RE
GOING TO
GET OUT OF
 YOU TALKED
ALL THAT HEY,
4 THIS 1S HOW NKI
2 YOU END LIP?! ,

LIKE YOu
TWO ARE
LOOKING
$0 HOT!

GRAPES! I
TOLD YOu
GOING OFF
ON YOUR

YOUR FACE,
DUMBASS!
you TWO
BLOCKHEADS
COULDN'T
EVEN SPOT
THAT CANCER
TWO! THIS
CELL TAKING
ISN'T THE
A STROLL IN TIME OR
PUBLIC!
PLACE!!
 NOW IT’S
THREE HEH, SO
ON ONE, THE THREE
OF YOU ARE
TOGETHER

LADY, YOU $0 HE'S

WERE ASKING A CANCER
WHY I WENT
= me TELL THAT WAS
youl SoME-
THROUGH THING. AN ACT?
ALL THIS HE WAS /N
TROUBLE.
CAHOOTS
WITH
THE OTHER SO WHEN HE
WAS BEING
CHASED

CELLS TO
GETA
TASTE...

OF HOW
IT FEELS TO
BE GANGED
UP ON AND
KILLED//
 My <I]
i

a) Ty Ng4‘A
 ENGULFED
THE WHOLE
BUILDING... !!

WNesSs7)
Z
 o)
>ka7 THIS (S WHY
1 WANTED
TO DO THIS

YOU WIMPS
WOULD JUST
GET HURT
TRYING TO
FIGHT THIS
 OU, HELLO (ll \ OH HI, RED |
THERE, ‘ aa 3) BLOOD
LITTLE gt. a CELL LADY!
PLATELET!

Red Blood Cell oe A iS an

She transports oxygen and f aa Na DEANS :
carbon dioxide through | Platelets
blood circulation. When blood vessels are damaged,
aN they gatherto seal the wound
and stop the bleeding.

SURE IS
PEACEFUL,
SENPAI.

THAT BAD
FEELING
; I HAD
‘A EARLIER...
| WAS THAT
JUST MY
IMAGINA-

OH, NO
WORRIES.
 HE WAS wes DID you
HAVING SOME
TROUBLE. SEE THAT?
MAYBE WE HE WAS
COULD HELP CARRYING £
HIM CARRY A TON OF -
NUTRIENTS.

uH,
, WLS excuse Me!
= g - AW (WHAT'RE
ae \P ALL THESE
WE THINK = Na, NUTRIENTS
IT’S WEIRD, ; FOR?!
muerere |ML acraatig, |(Oro
A LOT oa é 4
OF HUGE “
ORDERS. ES 4
ONE AFTER e
ANOTHER.

THEY'RE ai
ALL FOR THIS ff
HOUSING
COMPLEX.
 Proinflammatory Cytokines
Cancer cells release an enormous
amount of these chemicals. By
doing so, nutrient-rich blood flows
preferentially to the cancer and
contributes to the multiplication
of cancer cells. If this situation
is prolonged, it upsets many
balances inside the body.

Sanna

DOES THIS
LOOK RIGHT TO
YOU? IF THEY
NO, USE UP SO MANY
PROBABLY NUTRIENTS, THERE
NOT... WON'T BE ENOUGH
BUT THEY FOR THE REST OF
TOLD US THE BODY.
TO KEEP
DELIVERING.

HEY, THIS
DOESN'T
LOOK GOOD
AT ALL...
LET'S STAY

“|if
:
 DIE, YOU
BUGGY
BASTARD!
 DIE, YOU
BUGGY
BASTARD!!

DAMN IT! 7wO

THOSE
BUGGY
BRATSI! CELLS
GOT
AWAY!!
 ERROR!

TEE HEE...
SORRY, IT j
WAS TIRED. The number of cancer cells made in a day
Cancer cells are made when normal cells make |
errors during cell division. Even in healthy A.
LAY people, thousands are made every day.

| YOU THINK
THEY'RE
GOING TO
KILL US?

De
Let's I DON'T
W aust Ger KNOW.
KS? “out oF
WHOA!!
 THERE'S
ONE LEFT...
FIND /T NO
MATTER
WHAT...AND
KILL IT!
 "BUGGY
BASTARD,”
HUH...7

TREATING
ME LIKE
SOME a
DEFECTIVE

DION'T 0O
ANYTHING
WRONG...
WE WERE
JUST
BORN LIKE tee

THIS!

aeAY a
 ~
yiY
(|) ne
AAALIGH! (os
|a
ae
 WE'LL MULTIPLY : 5
AND KILL EVERY LN
LAST ONE OF YOUR iN ede GONG
FRIENDS! AND THEN | !..- <p 7 ese TO SPREAD ALL |
YOU NORMAL CELLS \.5/ Se : wpe SS. OVER THE BODY
WILL KNOW HOW IT Yo gp 9 2 NR | = THROUGH THE
ee
FEELS AT THE VERY ae
Ae a Ge bes BLOOD AND
THE SLAUGHTERED, : 5 C ae Vee,
INSTEAD OF THE ABLE (Nee \ ;
BUTCHER.

DON'T BE STUPID!
THERE'S NO WAY
TI DON'T MALFUNCTIONING
CARE CELLS LIKE YOU
ABOUT CAN KEEP THIS
BODY RUNNING!

THE ONLY
THING
I'M GOING WAITING FOR
YOU AT THE |
END OF THIS
TO DIE ROAD...IS
ANYWAY.
I MISSED.
T WAS
AIMING
ARE YOU
FOR HIS GUYS ALL
RIGHT?!

THERE WHOA!
THEY ARE:
i CANCER =
BS< a ELLSY gp

OH! WHITE
BLOOD CELL, Aneta fe
YOU'RE HERE,
Wa you Sain,
TOO!! RED BLOODf
QUST WHEN CELL. LOTS
T THOUGHT T DIDNT OF STRANGE
EE YOU AROUND... CELLS HERE.
p ITLL BE SUCH a
FUN TO KILL
THEM ALL.

ae<
a “FE

iS Macrophage
(/ MV Atype of white blood cell.
They catch and kill bacteria
= and foreign substances, and :
= find information on antigens } 3
and immune response.
OVER NOW,
CANCER
CELLS!!! a

B Cell (Antibody-
7| producing cell)
Makes weapons called
antibodies to fight antigens.

CANCER
CELLS! YOU'RE
COMPLETELY
SURROLINDED
? SURRENDER BY US IMMUNE
PEACE-

Helper T Cell
Notifies other cells of foreign
enemies and their weaknesses.
 HEY, HOW
: LONG’RE
YOU GONNA
Ler's || sit THERE
. Go cet || LIke THAT?
THAT
a an GUY...
TOGETH-
ER!

WE HAVE
70 FIGHT
FOR THIS
BO0Y! or
a“; Ne i
 y KILLER,
DODGE

OKAY! [orshaa
TO MY
RIGHT!! wi
\

YOU,
STU-
PID?!
Har’s THE
SECOND TIME
you FELL
FOR THAT!
 ALL THIS
LAUGHING’S
GOT ME
GOOD AND
ENERGIZED

OH, THAT'S
RIGHT.
NK CELLS...
 Activation of NK Cells
Laughter stimulates the
diencephalon to trigger the rapid
production of neurotransmitters
called “neuropeptides.” These
chemicals attach to the surfaces
of NK cells, activating them.

.. ARE
TS) ACTIVATED BY
‘Vp’ LAUGHINGIT!
YYSS \
K
és
 wes 4 " cal

~~
mS
WHAT DO
YOU WANT
| WITH ME?

ARE YOU YOU'RE

GOING TO THAT
GUILT TRIP WHITE
ME FOR oe
LYING TO
YOU? FROM
BEFORE, /|

saw A HOW LONG'RE

HUMAN JOST... YOU GOING TO
SIDE OF STAY FROZEN UP
You. oo LIKE THAT?
YOU'RE A
I Guess CELL, TOO.
A) YOU CAN'T
MOVE BLIT
YOU STILL
HAVE THE
‘| ENERGY
1 TO TALK.

WHEN I WAS
PRETENDING TO BE
A NORMAL CELL AND
YOU SAVED ME, T
WAS ACTUALLY HAPPY!
THAT WAS THE
FIRST TIME IN MY
LIFE THAT ANYONE
HELPED ME...

ARE YOU
THERE ISN'T TRYING TO
A SINGLE CELL FEEL LESS
IN THIS BODY GUILTY?
WHO'LL GO LET'S GUYS LIKE
OUT OF THEIR SEE IF i CAN Yeu Get
WAY TO HELP ae
PANGS IN
Sly
NERVES.
SOMEONE LIKE
THAT PUNY
CONSCIENCE
OF YOURS!
 I'M JUST
ANOTHER
CELL...!

I WAS
SuP-
YOU MULTIPLY POSED

' RULES OF THIS PEACEFULLY

WE CAN'T BODY, AND WITH
LET YOU ROB IT OF ITS EVERYONE
LIVE, AND ELSE, AS A
: NUTRIENTS MEMBER
FIX CAN’T
WE YOU WHILE DESTROY- OF THIS
EITHER in ING NORMAL BODY...
- TISSUES. BUT LOOK
) AT Me!

’ wv WY
gr, PENT De
Beate OO

ITLL ALL AFTER TODAY,

BLOW AWAY EVERYONE
IN THE WIND WILL FORGET.
WITHOUT EVER
BEING HEARD...
AS IF IT NEVER
HAPPENED...

FORGET MY
HATRED, MY
ANGER, MY
SADNESS.
 I WAS BORN
DEFECTIVE BECAUSE
OF SOMEONE ELSE'S
MISTAKE...HUNTED BY
THE IMMUNE CELLS
THAT SHOULD'VE
BEEN MY FRIENDS...

AND I
FOUGHT...
AND LOST...
AND I'LL
DISAPPEAR
FROM THIS
WORLD
WITHOUT
TRACE.
 T'LL LET
YOU WIN... {; “
THIS TIME. [°c

BUT DON'T
FORGET...
 IS THAT...
IS HE OUR
ENEMY?

I INSP IS THAT
aa eS GE Re A CANCER
SRS a CELL...?
ALREADY. A as f! . SO SCARY.

AND I'll
KILL YOU...1
UNTIL THEN
JUST KEEP ON
BEING CARE-
LESS WITH S el iy = YN
YOUR HEALTH! . AN gS SOMEDAY...
SS : an S q I'LL COME
é BACK TO
att . . THIS BODY!
a i tf NO MATTER
Tore RST WHAT IT
COEMK cata | . TAKES...//
 You
MUST HAVE
BEEN THE
ONE WHO
THANKS. GATHERED
YOU'RE You
SAVED
ALL THE
OTHER
WEL- us. IMMUNE
CELLS.
COME!

COME BACK AS
MANY TIMES OH...
OH, WHAT

AS YOU WANT, IT WAS

DID You
TWO TALK
CANCER CELL! NOTHING. ABOUT
ANYWAY?
 YOU! STILL
YOU DO A NEWBIE
THAT NEXT AND YOU GO
TIME, AND STICKING
T'LL NEVER YOUR NECK
DELIVER IN OTHER
WITH YOU PEOPLE'S
FIM AGAIN! BUSINESS!
SOKRY... &
I JUST E&
WANTED To Do E&
SOMETHING Ki >C)
To HELP...

CELLS AT WORK! VOLUME 2: END

Medical Editor: Tomoyuki Harada
 TRANSLATION NOTES
Tally marks : < cannot control
Page 124 cell division, and
The Japanese character iE po Tultiply-endlessly.
(meaning "right,” “true,” or
"correct”) is commonly used
to count to five, just like tally
counts using four vertical lines
and one slash through them for THERE MUST
“five” Cif). oe BE TONS
at OF THEM.
THIS ISN'T

ies RETA cae LR

Buggy bastard
Page 140
In the Japanese edition, the
immune cells insult the cancer
cell by calling him baguri-yaro.
The term "baguri” comes from the
verb "baguru,” which a slang term
describing what software does
when it has bugs—an apt insult for
a renegade cancer cell. Baguri also
may echo the term pakuri, meaning
plagiarism, which would make
sense given that cancerous cells
are poor copies of the original.

DIE, YOU
BUGGY
BASTARDI!

Aw, crab
Page 156
In his final moments, the cancer
cell makes a terrible pun. He says
"Gaan,” which is an exclamation
expressing shock or dismay. "Gan"
is also the Japanese word for
cancer. In this version, he murmurs
"crab,” the Latin term for which
gives us the word "cancer” (and is
the namesake for the constellation).
KILLER
T CELL
 A WEIRD BACTERIUM
APPEARS!

A BATTLE FOR INTESTINAL Wig \ Lin ye

SUPREMACY? NN
WHAT DOES THAT EVEN MEAN! Dae flex, \N i
A NEW COMPANION ew — Cas
APPEARS! diel aaa
#
BAD

KILLER “ayy <a

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MYSTE 4 ASLEEP...
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PAST! 4

VOLUME
3
COMING
. SOON!
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 KODANSHA
7 i)
4
—_
HS
4

y “The word
heartwarming
was made for

, and biting social

commentary... delivers Y very powerful
in its depth of char- / story about being
acter and emotional | different and the con-
strength.” -Comics P\sequences of childhood
Bulletin ), bullying... Read it.”
|\ -Anime News
Network ! |
| |

wast)J; Ig
Shoya isiibully. When S hoko, a girl w ho can't hear, enters his ele-
mentary school class, she becomes their favorite target, and Shoya
and his friends goad each other into devising new tortures for her.
But the children’s cruelty goes too far. Shoko is forced to leave the
school, and Shoya ends up shouldering all the blame. Six years lat-
er, the two meet again. Can Shoya make up for his past mistakes,
or is it too latee

© Yoshitoki Oima/Kedansha Ltd. All rights reserved.

 DON’T MISS THE MOST ACCLAIMED
ACTION MANGA OF 2013!
“Gripping doesn’t begin to describe Vinland Saga. “The art is gorgeous, a combination of beautiful
5 stars,” —ICv2 cartooning and realistic backgrounds, Yukimura
‘i ; . is also a master of pacing, both in frenetic battle
Deeply engrossing... If you have any interest at : of
scenes and charged emotional moments,
all in Vikings, the Medieval period, or pirates, this Faith Bin Hicks, Feels Wah Boys
is not a series you want to miss,”
—Anime News Network “For those who love Berserk, you'll love this too...
Worth the long wait.”
—A A CaseCase Suitable
Suitable forfor Treat
Treatmen t

“Tt will be impossible to stop watching this story

unfold.” —Japan Media Arts Awards jury

/
’ Kodansha
Yukimura
©Makoto
reserved.
All'fights
Ltd.
 Praise for the anime:

“The show provides a ple

on the highs andlows

the real thing.”

“Always it is smarter, more poetic,:

stiplain better than you

KC/
KODANSHA
COMICS}
Mei Tachibana has no friends — and says she doesn’t need them!
But everything changes when she accidentally roundhouse kicks the most
popular boy in school! However, Yamato Kurosawa isn’t angry in the slightest—
lala fs(eiem a=W lalial.comalccme)eellarclavmllicmerel0l(eMmUrcyomr-lamUlalUciUrcVmella MoM \Y(c) Amol UMuUlalaliare)
Mei’s trust will be a tough task. How long will she refuse to say, “I love you”?

© Kanae Hazuki / Kodansha Ltd. All rights reserved.

 PRAISE FOR THEFANIME!
“This series never fails to “A very funny look at what happens when
put a smile on my face.” two strange and strangely well-suited people
-Dramatic Reviews try to navigate the thorny path to true love
: together.”
) Anime News Network

OPPOSITES ATTRACT... MAYBE?

Haru Yoshida is feared as an unstable and violent “monster.”
Mizutani Shizuku is a grade-obsessed student with no friends.
Fate brings these two together to form the most unlikely pair. Haru
firmly believes he’s in love with Mizutani and she firmly believes
he's insane. KODANSHA
© Robico / Kodansha Ltd. All rights reserved. COMICS
 “Maria's brand of righteous
~ justice, passion and plain talking
make for one of the freshest
manga series of 2015. | dare any
other book to top it.”
—UK Anime Network

As a war to determine the rightful ruler of ¢

medieval France ravages the land, the witch’
Maria decides she will not stand idly by as
men kill each other in the name of God and /
glory. Using her powerful magic, she summons
various beasts and demons —even going as far 4
as using a succubus to seduce soldiers into sub- =~
mission under the veil of night— all to stop the
needless slaughter. However, alter the Arch- _
angel Michael puts an end to her meddling, he P
curses her to lose her powers if she ever gives NG 47
up her virginity. Will she forgo the forbidden —— ee Vg
fruit of adulthood in order to bring an end to Ws
P ; va Ady) ileRNA i
the merciless machine of war? Gone ea
. : : “8 | < ; oe —_
Available now in print and digitally! ©Mayasuki Ishikawa /Kodanska, Ltd. All rights reserved.
 ICHIRO INUYASHIKI IS DOWN ON HIS LUCK. HE LOOKS MUCH
OLDER THAN HIS 58 YEARS, HIS CHILDREN DESPISE HIM, AND
HIS WIFE THINKS HE’S A USELESS COWARD. SO WHEN HE’S
DIAGNOSED WITH STOMACH CANCER AND GIVEN THREE MONTHS
TO LIVE, IT SEEMS THE ONLY ONE WHO’LL MISS HIM IS HIS DOG.

THEN A BLINDING LIGHT FILLS THE SKY, AND THE OLD MAN
IS KILLED... ONLY TO WAKE UP LATER IN A BODY HE ALMOST
RECOGNIZES AS HIS OWN. CAN IT BE THAT ICHIRO INUYASHIKI
IS NO LONGER HUMAN?

COMES IN EXTRA-LARGE EDITIONS WITH COLOR PAGES!

 3FAa e
IRYTAIL!
OF
5 “NEARLY 1,000 PAGES!
“EXTRA LARGE 7°x10)5" TRIM SIZE!
hy QUALITY PAPER!

a wizard-in-training who wants to!joinee sit $0. that she can

become a full-fledged wizard. She dreams of joining the 1most famous Sb
known as Fairy Tail. One day she. meets Natsu, a boy raised by a dragon
4 which vanished when he was young. Natsu has devoted his life to finding |
his dragon father. When Natsu helps Lucy out of a tricky. situation, she he
discovers that he is a member of Fairy ea and our heroes, soy enrcure)$s

© Hiro Mashima/Kodansha Ltd. All nghts reserved. M ASTER'S ip) mate), |

Cells at Work! 2

KODANSHA COMICS Digital Edition

Cells at Work! volume 2 copyright © 2015 Akane Shimizu

English translation copyright © 2016 Akane Shimizu

All rights reserved.

First published in Japan in 2015 by Kodansha Ltd., Tokyo.

Electronic Publishing rights for this English edition arranged through
Kodansha Ltd., Tokyo.

No portion of this book may be reproduced or transmitted in any form or

by any means without written permission from the copyright holders.

English digital edition published by Kodansha Advanced Media, LLC,

San Francisco.

www.kodanshacomics.com

ISBN: 9781682335345
Digital Edition: 1.0.1

Translation: Yamato Tanaka

Lettering: Abigail Blackman
Editing: Paul Starr
Kodansha Comics edition cover design: Phil Balsman
 HOW TO READ MANGA
Japanese is written right to left and top to bottom. This
means that for a reader accustomed to Western languages,
Japanese books read “backwards.” Since most manga
published in English now keeps the Japanese page order,
it can take a little getting used to—but once you learn how,
it’s a snap. Here’s a handy guide!

Here you can see pages 10-11 from Volume 1 of Ce//s at

Work. The speech balloons have been numbered in the
order you should read them in.
Start here, at
Page 10—read this one first! the top right
corner of the
right hand
page.

Read right to
left, then top to
bottom. In this
panel, the leftmost
speech balloon
comes before the
one in the top left
corner.

Now continue on to
the top right corner : ~ ite
of Page 11. -
 Page fl
On this page,
the top two
panels are
read first.

This panel is the top

right-most after the
first two, so it’s next.

If you go to this
panel next, you
would have to
move backwards
Cright) to read
balloons 6 and 7.

Instead, after
reading balloon
5, you move
down to 6 and
7, then left...

..and then you

arrive at the end
of the page!

After a few pages, you’ll be reading manga

like a pro—Japanese-style!
(That
means
STOP)
You’re about to
read a manga—a
Japanese comic—
presented in its
original page order,
which means you
start at the other
end of the book. If
you need a quick
guide on how to
read manga the way
it was meant to be
read, flip to the next
page—otherwise,
turn the book over
and enjoy!