6.

0 GAVIMETRIC ANALYSIS
Ms. Melissa Calambro || October 2022 PHARCHEM3
Transcribers: Navarro
Editors: Montepio

the substance taken, the second weighing following an

GRAVIMETRIC ANALYSIS additional 15-minute ignition period.
It is the measurement of the weight of a substance in a sample
 Loss on drying
or calculation of the weight of substance in a sample from the
o It determines the amount of volatile matter of any kind
weight of a chemically equivalent amount of some other
that is driven off under the conditions specified.
substance.

w final product of GF
%P = x 100  Digestion
w sample o It is a process where a finely divided crystalline
precipitate is allowed to stand in contact with the hot
MW of sample
GF or Gavimetric factor = supernatant solution for a considerable period of time
MW of product before filtration.
o This method permits the smaller particles to
Sample assays: sodium chloride, sodium phosphate solution, increase in size thus be retained by the filter.
magnesium citrate oral solution for MgO, Milk of bismuth, o Co-precipitation effects are lessened and the precipitate
Sodium sulfate becomes correspondingly purer.

If a 0.46 g sample of KI yielded 0.7215 g of AgI precipitate by  Gasometric analysis

gravimetric assay. What would be the %P of KI? o Assay procedures for the medicinally important gases.
o Instrument use: Nitrometer (see Figure 1)
Given: mw of AgI: 234.7745 o Sample Assay: Ethyl nitrite spirit
mw of KI: 166.0045

STEP 1: Identify the Sample and the Product

Sample →KI
Product in the form of precipitate → AgI

STEP 2: Calculate the Molecular Weight of the sample and

product (if MW are given, proceed to Step 3)

STEP 3: Calculate the Gravimetric factor using

MW of sample
GF or Gavimetric factor =
MW of product

166.0045
GF or Gavimetric factor =
234.7746

GF or Gravimetric factor = 0.7071

STEP 4: Calculate the Percentage purity

w final product of GF
%P = x 100
w sample

0.7215 x 0.7071
%P = x 100
0.46

%P = 110.91 %

 Dried to Constant Weight

o The term dried to constant weight means that two
consecutive weighing do not differ by more than 0.5
mg/g of substance taken for the determination, the
second weighing following an additional hour of drying.
o An object is said to be at constant weight when two
consecutive weighing after heating and cooling do not
differ by more than 0.2 mg

 Ignite to constant weight

o The ignition shall be continued at 800 degree Celsius
unless otherwise indicated until two consecutive
weighing do not differ by more than 0.5 mg per gram of

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