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A Word of Caution Against Excessive Protein Intake
A Word of Caution Against Excessive Protein Intake
DOI: 10.1111/ijpo.12612
ORIGINAL RESEARCH
1
Department of Pediatrics, Duke Center for
Childhood Obesity Research, Duke University, Summary
Durham, North Carolina Background: The relationship between milk fat content and body mass index (BMI)
2
Department of Pediatrics, Community and
remains unclear. The objective of this study was to determine if milk fat content is
Family Medicine, Duke Clinical Research
Institute, Duke Center for Childhood Obesity associated with obesity in children, adolescents and young adults.
Research, Duke University, Durham, North
Methods: We used repeated cross sections of National Health and Nutrition Exami-
Carolina
3
Duke Global Health Institute, Global Digital nation Survey (NHANES), 1999 to 2016. Using logistic regression, we measured
Health Science Center, Duke University, associations between first milk consumed after formula/breast milk (whole, 2%, 1%,
Durham, North Carolina
4
or fat-free) and weight status (≥85th to <95th BMI percentile, overweight; ≥95th
Department of Population Health Sciences,
Duke Clinical Research Institute, Duke Center BMI percentile, obesity) among children 2 to 6 years (n = 8367). We also assessed
for Childhood Obesity Research, Duke
associations between current milk type and weight status among those 2 to 20 years
University, Durham, North Carolina
of age (n = 26 750).
Correspondence
Results: Children 2 to 6 years with obesity were less likely to have been weaned to
Michelle J. White, MD, MPH, Department of
Pediatrics, Duke Center for Childhood Obesity whole milk versus healthy weight children (adjusted odds ratio [aOR], 0.77; 95% CI,
Research, Duke University, 2301 Erwin
0.60-0.98; P = .031). Individuals 2 to 20 years with overweight or obesity were less
Rd. Durham, NC 27705.
Email: michelle.white@duke.edu likely to drink whole milk as their current milk and more likely to drink fat-free or 1%
milk compared with healthy weight children.
Conclusions: Whole milk consumers are less likely to have obesity. It is unclear
whether this relationship is causal or a reflection of United States Department of
Agriculture recommendations. Further examination of the factors that influence milk
choice among diverse cohorts would lend clarity to this important issue.
KEYWORDS
preserving its nutritional benefits as a source of protein, calcium, and testing, and a detailed in-home interview. Two populations in the
vitamin D.6,7 In March 2014, the Special Supplemental Nutrition Pro- NHANES sample were used for this study, based on ages at which
gram for Women, Infants, and Children (WIC), a US federal assistance specific questions are included in the NHANES interview. To deter-
programme for low-income women and children, aligned their food mine the relationship between a child's first milk fat content after
packages with the Dietary Guidelines for Americans and made 1% and weaning and weight status, we included only children aged 2 to
fat-free milk the standard issue for women and for children older than 6 years reflecting the target age range for this question. To determine
8
2 years of age. Whole and 2% milk are available by physician the relationship between current milk fat content and weight status,
recommendation only. we included children, adolescents, and young adults aged 2 to
Research indicates beverage type, such as sugar-sweetened bev- 20 years.
erages (SSBs), is associated with child weight status; but when it
comes to milk, results are mixed. Some studies demonstrate low con-
sumption of milk in childhood is a risk factor for obesity,9-12 while 2.2 | Weight status
others indicate the opposite.13,14 A recent comprehensive review
found no evidence that milk consumption contributes to obesity risk Weight status was defined using body mass index (BMI) percentiles
among adolescents; however, the authors note less evidence to sup- calculated from measured height and weight using age and sex-
port this conclusion among children less than 8 years of age.15 A specific percentile ranges. We defined weight categories for children
study of the association of dairy and adiposity in China, one of the aged 2 to 17 according to the recommended cut-points from the
few non-Western nations represented in this literature, similarly Centers for Disease Control as follows: <5th percentile, under-
found no association between dairy consumption and weight status weight; 5th to <85th percentile, healthy weight; ≥85th to <95th
among adolescents.16 However, heterogeneity in study design, popu- percentile, overweight; ≥95th to <120% of the 95th percentile, class
lation, and definition of exposures and outcomes make comparisons I obesity; ≥120% to 140% of the 95th percentile, class II obesity;
difficult. Of concern, trends in beverage consumption in the United and ≥140% of the 95th percentile, class III obesity.27 For adults
States show that many children are not consuming milk regularly, aged 18 to 20, adult BMI cut-offs were used as follows: <18.5,
while approximately two-thirds of children consume SSBs.17 underweight; 18.5 to <25.0, healthy weight; 25.0 to <30.0, over-
Replacing SSBs with milk has positive effects on weight status.18 weight; 30.0 to <35.0, class I obesity; 35.0 to <40, class II obesity;
However, recent results suggest consumption of milk decreases with and >40, class III obesity.27
19
age, while SSB consumption increases.
Among young children who drink milk, the association between
milk fat content and later risk of obesity is important yet unclear. A 2.3 | Milk fat content
small number of studies have examined the association between milk
fat content and weight in children with mixed results; some report no Milk fat content and milk consumption frequency are asked as part
association between whole milk and weight, while others report an of the diet behaviour and nutrition interview component within the
inverse association.20-26 The dearth of evidence, particularly among NHANES survey. We defined milk fat content as whole (4%), 2%,
young children, and the heterogeneity in how milk intake is assessed 1%, fat free, and “other.” “Other” may include flavoured milk of vari-
and obesity risk is defined make it difficult to draw definitive conclu- able milk fat content as NHANES does not distinguish between
sions regarding the effects of milk fat content on childhood obesity these; thus, we excluded “other” milk type from our analyses. First
risk. Furthermore, the effect of the first milk fat content introduced milk fat content was defined as the first type of milk offered after
after formula or breast milk on subsequent risk of obesity is unknown. weaning from breast milk or formula. First milk fat content is asked
The goals of this study were to use a nationally representative sample retrospectively to parents of children aged 2 to 6 (“What type of
to investigate the association between (a) first milk fat content and milk was [subject] first fed on a daily basis?”). Current milk fat con-
weight status in early childhood and (b) current milk fat content and tent was defined as the primary type of milk consumed over the
weight status among children, adolescents, and young adults. past 30 days among children, adolescents, and young adults aged
2 to 20. We excluded individuals who consumed no milk (approxi-
mately 4% of the survey population) in order to allow appropriate
2 | P A T I E NT S A N D M E TH O D S comparisons among milk fat levels. The frequency of milk consump-
tion, daily or less than once per day, was also included in our analy-
2.1 | Data source sis of current milk fat content among children, adolescents, and
young adults aged 2 to 20. Parents responded for children aged
We examined data from repeated cross sections of the National 2 to 11; children 12 and older responded for themselves. Categories
Health and Nutrition Examination Survey (NHANES), 1999 to 2016. for comparison among milk types were selected based on current
NHANES is a stratified, multistage probability sample of the US popu- dietary recommendations.4 Thus, we compare whole milk to all
lation, conducted throughout the year at 15 geographic sites selected reduced fat milk types (fat-free, 1%, and 2%) and whole and 2% to
annually. It includes data from a physical examination, laboratory lower fat milk types (1% and fat-free).4
WHITE ET AL. 3 of 8
(Table 4). Compared with non-Hispanic White children, non-Hispanic also differences in first milk and current milk consumption by race/
Black, Hispanic, and non-Hispanic other children were more likely to ethnicity and income. These findings expand the evidence base of
drink whole milk and less likely to drink 1% or fat-free milk. Compared previous studies describing an inverse relationship between milk fat
with individuals below the FPL, individuals from all other income consumption and weight status using a large, nationally representa-
groups were less likely to drink whole milk. tive sample.
There are at least two possible interpretations for our findings on
the relationship between weight status and milk consumption. The
4 | DISCUSSION first is that children and families are following AAP and AHA recom-
mendations to consume lower fat varieties of milk when at risk for
Both first and current milk fat content were associated with weight overweight and obesity. Similar to previous cross-sectional analyses
status. Children aged 2 to 6 years of age who had class I obesity were of milk fat content and weight status, associations between milk fat
less likely to have been weaned to whole milk. Among those 2 to content and subsequent weight status may be a result of physician or
20 years old, individuals with overweight or obesity were less likely parent concern for the child's weight status, which may influence the
to consume whole milk and more likely to consume milk with lower decision to consume whole versus reduced fat varieties of milk.20,23,28
fat content compared with those with a healthy weight. There were Greater concern for overweight or obesity is associated with a change
WHITE ET AL. 5 of 8
T A B L E 3 Demographic characteristics of children and adolescents consumption and the rising obesity prevalence in the latter decades of
2 to 20 years from National Health and Nutrition Examination Survey the 20th century.29,30 Prior longitudinal research indicates that high pro-
(NHANES), 1999 to 2016 (n = 26 750)
tein, low-fat intake in early childhood may lead to higher BMI; however,
Percentage, it remains unclear whether the relationship between a specific food or
% beverage, such as reduced fat milk and obesity is truly causal.31,32 Longi-
Age in years tudinal assessment of dietary patterns, weight, and the motivations
2-5 20.8 behind dietary choices among large, diverse cohorts of children are nec-
6-11 32.4 essary to disentangle the relationship between milk and weight status.
12-20 46.8 First milk content after weaning may be important in obesity pre-
Male 51.5 vention because early dietary practices influence subsequent dietary
Underweight/healthy weight 65.9 content are different from those of current milk fat content indicating
that racial/ethnic and socio-economic differences in milk fat consump-
Overweight 16.7
tion evolve throughout childhood.42,43 Furthermore, our finding that
Class I obesity 11.6
children from wealthier homes were more likely to be weaned to whole
Class II obesity 4.0
milk compared with children from lower income homes may speak to
Class III obesity 2.1
the role WIC plays in determining milk selection. Lower income families
Milk consumption frequency
may have less access to whole milk as WIC is more likely to provide
Never 4.0 reduced fat milk in accordance with United States Department of Agri-
Less than once per week 6.0 culture recommendations. Notably, the relationship between milk fat
More than once per week but less than once per 16.8 content and income is reversed in our analysis of current milk fat con-
day
tent among children, adolescent, and young adults 2 to 20. In this popu-
Once a day or more 72.9 lation, increased income was associated with increased likelihood of
Varied 0.3 drinking reduced fat milk, similar to prior studies.40 One might hypothe-
Current milk consumed among those who drink milk size that the difference in these findings relates to the differing influ-
Whole 32.4 ences present in infancy compared with later life stages. Choice of milk
2% 41.8 fat content for older children, adolescents, and young adults likely
1% 11.8 reflects their own preferences and the availability of milk at school and
Fat free 10.3 home. Further examination of the role of milk fat consumption in deter-
mining the weight status of non-Hispanic Blacks, Hispanics, and lower
Other 3.8
socio-economic status individuals is warranted as they bear a dispropor-
a
Adjusted for age, race/ethnicity, income, and NHANES cycle.
tionate burden of child and adult overweight and obesity.44,45
This study has several limitations. Because of the structure of the
in dietary patterns in children, although it is unknown whether this NHANES survey, we were unable to account for flavoured (sugar-
change is a result of physician or parent weight perceptions.28 sweetened) reduced fat milk consumption, which may contribute to
Alternatively, our findings may indicate that the consumption of the association between overweight and obesity and consumption of
low-fat milk may actually contribute to overweight and obesity, con- reduced fat milk. Our analysis also does not account for other aspects
tradicting the rationale for AAP and AHA recommendations regarding of a child's diet beyond milk, which may contribute to child weight
the consumption of reduced fat milk for obesity prevention. US dietary status. NHANES relies on self-reported parent data that may not be
studies have noted the coincidental occurrence of changes in milk accurate for children attending day care or school and is vulnerable to
6 of 8 WHITE ET AL.
T A B L E 4 Adjusted oddsa of current milk Fat content for children and adolescents 2 to 20 years from National Health and Nutrition
Examination Survey (NHANES), 1999 to 2016 (n = 29 039)
recall bias and social desirability bias. Additionally, NHANES repre- provision guidelines have shifted milk consumption in US children
sents repeated cross-sectional data, limiting our ability to speak to from whole milk to reduced fat milk. Our study highlights an associa-
causation. Strengths of our study include the use of a nationally repre- tion between low-fat milk consumption and overweight/obesity in
sentative sample with measured height and weight data. Also, the use children, adolescents, and young adults. We also demonstrate racial/
of multiple cycles of NHANES data reduces the likelihood of our find- ethnic and socio-economic differences in milk consumption. Because
ings being the result of brief historical dietary trends. concern for risk of overweight or obesity may lead to a decision to
consume reduced fat milk, future studies should utilize a prospective
longitudinal design with a racially and socio-economically diverse
5 | C O N CL U S I O N S cohort to determine whether the relationship between milk fat con-
tent and weight status is causal. Cumulatively, our data demonstrate
Current AAP and AHA recommendations promote consumption of that guidelines for milk consumption may be effective in promoting
reduced fat milk after 2 years of age to prevent obesity. Existing food reduced fat varieties of milk among those at risk of obesity. However,
WHITE ET AL. 7 of 8
our data also underscore the need for further examination of the rela- 10. Barba G, Troiano E, Russo P, Venezia A, Siani A. Inverse association
tionship between milk fat content and weight status to inform dietary between body mass and frequency of milk consumption in children. Br
J Nutr. 2005;93(01):15-19. https://doi.org/10.1079/BJN20041300.
recommendations.
11. Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and
weight gain in children and adults: a systematic review and meta-
CONF LICT OF IN TE RE ST analysis. Am J Clin Nutr. 2013;98(4):1084-1102. https://doi.org/10.
Dr. Sarah Armstrong has received a research grant from Astra Zeneca, 3945/ajcn.113.058362.
12. Hasnain SR, Singer MR, Bradlee ML, Moore LL. Beverage intake in
has a data safety monitor for Novo Nordisk, and has received a
early childhood and change in body fat from preschool to adoles-
speaker honorarium from Rhythm Pharmaceuticals. cence. Child Obes. 2014;10(1):42-49. https://doi.org/10.1089/chi.
2013.0004.
AUTHORS C ON TRIBUTION 13. Dubois L, Diasparra M, Bogl L-H, et al. Dietary intake at 9 years and
subsequent body mass index in adolescent boys and girls: a study of
Dr White interpreted the analyses, drafted the initial manuscript, and
monozygotic twin pairs. Twin Res Hum Genet. 2016;19(1):47-59.
reviewed and revised the manuscript. Drs Armstrong and Perrin con- https://doi.org/10.1017/thg.2015.97.
ceptualized and designed the study and reviewed and revised the 14. DeBoer MD, Agard HE, Scharf RJ. Milk intake, height and body mass
manuscript. Dr Kay helped design the study, interpreted the data, index in preschool children. Arch Dis Child. 2015;100(5):460-465.
https://doi.org/10.1136/archdischild-2014-306958.
and reviewed and revised the manuscript. Dr Skinner conceptualized
15. Dougkas A, Barr S, Reddy S, Summerbell CD. A critical review of the
and designed the study, performed and interpreted the analyses, and
role of milk and other dairy products in the development of obesity in
reviewed and revised the manuscript. All authors approved the final children and adolescents. Nutr Res Rev. 2019;32(1):106-127. https://
manuscript as submitted and agreed to be accountable for all aspects doi.org/10.1017/S0954422418000227.
of the work. 16. Lin SL, Tarrant M, Hui LL, Kwok MK, Lam TH, Leung GM,
Schooling CM The role of dairy products and milk in adolescent obe-
sity: evidence from Hong Kong's “Children of 1997” birth cohort.
ORCID Nerurkar P V., ed. PLoS One 2012;7(12):e52575. doi:https://doi.org/
Michelle J. White https://orcid.org/0000-0002-1944-1995 10.1371/journal.pone.0052575
Melissa C. Kay https://orcid.org/0000-0002-9695-3126 17. Bleich SN, Vercammen KA, Koma JW, Li Z. Trends in beverage con-
sumption among children and adults, 2003-2014. Obesity. 2018;26
(2):432-441. https://doi.org/10.1002/oby.22056.
RE FE R ENC E S 18. Zheng M, Rangan A, Olsen NJ, et al. Substituting sugar-sweetened
1. Herrick KA, Terry AL, Afful J. 2016 Key findings data from the beverages with water or milk is inversely associated with body fat-
National Health and Nutrition Examination Survey, 2013. https:// ness development from childhood to adolescence. Nutrition. 2015;31
www.cdc.gov/nchs/data/databriefs/db320_table.pdf#2. Accessed (1):38-44. https://doi.org/10.1016/j.nut.2014.04.017.
July 12, 2019. 19. Moshfegh AJ, Garceau AO, Parker EA, Clemens JC. Highlights what
2. Ballew C, Kuester S, Gillespie C. Beverage choices affect adequacy of beverages did children consume? Figure 1. Percentage of children
children's nutrient intakes. Arch Pediatr Adolesc Med. 2000;154(11): who consumed beverages* on any given day, WWEIA, NHANES
1148-1152. https://doi.org/10.1001/archpedi.154.11.1148. 2015–2016; 2019. www.ars.usda.gov/nea/bhnrc/fsrg. Accessed July
3. Marshall TA, Eichenberger Gilmore JM, Broffitt B, Stumbo PJ, 12, 2019.
Levy SM. Diet quality in young children is influenced by beverage 20. O'Connor TM, Yang S-J, Nicklas TA. Beverage intake among pre-
consumption. J Am Coll Nutr. 2005;24(1):65-75. http://www.ncbi.nlm. school children and its effect on weight status. Pediatrics. 2006;118
nih.gov/pubmed/15670987 Accessed July 12, 2019. (4):e1010-e1018. https://doi.org/10.1542/peds.2005-2348.
4. U.S. Department of Agriculture and U.S. Department of Health and 21. Berkey CS, Rockett HRH, Willett WC, Colditz GA. Milk, dairy fat, die-
Human Services. Dietary Guidelines for Americans, 2010. 7th Edition, tary calcium, and weight gain. Arch Pediatr Adolesc Med. 2005;159(6):
Washington, DC: U.S. Government Printing Office, December 2010. 543-550. https://doi.org/10.1001/archpedi.159.6.543.
5. Gidding SS, Dennison B a, Birch LL, et al. Dietary recommendations 22. Noel SE, Ness AR, Northstone K, Emmett P, Newby PK. Milk intakes
for children and adolescents: a guide for practitioners (American are not associated with percent body fat in children from ages 10 to
Heart Association). Pediatrics. 2006;117(2):544-559. https://doi.org/ 13 years. J Nutr. 2011;141(11):2035-2041. https://doi.org/10.3945/
10.1542/peds.2005-2565. jn.111.143420.
6. Rehm CD, Drewnowski A, Monsivais P. Potential population-level 23. Vanderhout SM, Birken CS, Parkin PC, et al. Relation between milk-
nutritional impact of replacing whole and reduced-fat milk with low- fat percentage, vitamin D, and BMI z score in early childhood1,2.
fat and skim milk among US children aged 2–19 years. J Nutr Educ Am J Clin Nutr. 2016;104(6):1657-1664. https://doi.org/10.3945/
Behav. 2015;47(1):61-68.e1. https://doi.org/10.1016/j.jneb.2014. ajcn.116.139675.
11.001. 24. Bigornia SJ, LaValley MP, Moore LL, et al. Dairy intakes at age
7. Thompson FE, Dennison BA. Dietary sources of fats and cholesterol 10 years do not adversely affect risk of excess adiposity at 13 years.
in US children Aged 2 through 5 years. https://www.ncbi.nlm.nih. J Nutr. 2014;144(7):1081-1090. https://doi.org/10.3945/jn.113.
gov/pmc/articles/PMC1615046/pdf/amjph00456-0097.pdf. 183640.
Accessed February 22, 2018. 25. Huh SY, Rifas-Shiman SL, Rich-Edwards JW, Taveras EM,
8. Oliveira, V. and Frazao, E. The WIC Program: Background, Trends, and Gillman MW. Prospective association between milk intake and adi-
Economic Issues, 2015 Edition (January 1, 2015). USDA-ERS Economic posity in preschool-aged children. J Am Diet Assoc. 2010;110(4):563-
Information Bulletin Number 134. Available at SSRN: https://ssrn.com/ 570. https://doi.org/10.1016/j.jada.2009.12.025.
abstract=2709086 or http://dx.doi.org/10.2139/ssrn.2709086 26. Scharf RJ, Demmer RT, DeBoer MD. Longitudinal evaluation of milk
9. Moore LL, Bradlee ML, Gao D, Singer MR. Low dairy intake in early type consumed and weight status in preschoolers. Arch Dis Child.
childhood predicts excess body fat gain. Obesity. 2006;14(6):1010- 2013;98(5):335-340. https://doi.org/10.1136/archdischild-2012-
1018. https://doi.org/10.1038/oby.2006.116. 302941.
8 of 8 WHITE ET AL.
27. Kuczmarski RJ, Ogden CL, Guo SS, et al. 2000 CDC Growth Charts hormones in children. Appl Physiol Nutr Metab. 2017;42(3):302-310.
for the United States: methods and development. Vital Health Stat https://doi.org/10.1139/apnm-2016-0251.
11. 2002;(246):1-190. 39. Mesirow MSC, Welsh JA. Changing beverage consumption patterns
28. Willett WC. Is dietary fat a major determinant of body fat? Am J Clin have resulted in fewer liquid calories in the diets of US children:
Nutr. 1998;67(3 Suppl):556S-562S. http://www.ncbi.nlm.nih.gov/ National Health and Nutrition Examination Survey 2001-2010.
entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_ J Acad Nutr Diet. 2015;115(4):559-566.e4. https://doi.org/10.1016/j.
uids=9497170. jand.2014.09.004.
29. Nielsen SJ, Popkin BM. Changes in beverage intake between 1977 40. Kit BK, Carroll MD, Ogden CL. Low-fat milk consumption among chil-
and 2001. Am J Prev Med Am J Prev Med. 2004;27(3):205-210. dren and adolescents in the United States, 2007-2008. NCHS Data
https://doi.org/10.1016/j.amepre.2004.05.005. Brief 2011;(75):1–8. http://www.ncbi.nlm.nih.gov/pubmed/
30. Cavadini C, Siega-Riz AM, Popkin BM. US adolescent food intake 22617139. Accessed March 15, 2018.
trends from 1965 to 1996. Arch Dis Child. 2000;83(1):18-24. http:// 41. Dodd AH, Briefel R, Cabili C, Wilson A, Crepinsek MK. Disparities in
www.ncbi.nlm.nih.gov/pubmed/10868993 Accessed April 18, 2018. consumption of sugar-sweetened and other beverages by race/-
31. Rolland-Cachera M, Akrout M, Péneau S, Rolland-Cachera MF, ethnicity and obesity status among United States schoolchildren.
Akrout M, Péneau S. Nutrient intakes in early life and risk of obesity. J Nutr Educ Behav. 2018;45(3):240-249. https://doi.org/10.1016/j.
Int J Environ Res Public Health. 2016;13(6):564. https://doi.org/10. jneb.2012.11.005.
3390/ijerph13060564. 42. Rimkus L, Isgor Z, Ohri-Vachaspati P, et al. Disparities in the availabil-
32. Alexy U, Sichert-Hellert W, Kersting M, Schultze-Pawlitschko V. Pat- ity and price of low-fat and higher-fat milk in US food stores by com-
tern of long-term fat intake and BMI during childhood and munity characteristics. J Acad Nutr Diet. 2015;115(12):1975-1985.
adolescence—results of the DONALD study. Int J Obes (Lond). 2004; https://doi.org/10.1016/j.jand.2015.04.002.
28(10):1203-1209. https://doi.org/10.1038/sj.ijo.0802708. 43. Black MM, Hurley KM, Oberlander SE, et al. Participants' comments
33. Birch LL, Daniels SR, Gilman MW, et al. Dietary recommendations for on changes in the revised special supplemental nutrition program for
children and adolescents: a guide for practitioners. Pediatrics. 2006; women, infants, and children food packages: the Maryland food pref-
117:544-559. https://doi.org/10.1542/peds.2005-2374. erence study. J Am Diet Assoc. 2009;109(1):116-123. https://doi.org/
34. de Lauzon-Guillain B, Jones L, Oliveira A, et al. The influence of early 10.1016/j.jada.2008.10.016.
feeding practices on fruit and vegetable intake among preschool chil- 44. Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity
dren in 4 European birth cohorts. Am J Clin Nutr. 2013;98(3):804- among adults and youth: United States, 2015–2016. Key findings
812. https://doi.org/10.3945/ajcn.112.057026. data from the National Health and Nutrition Examination Survey;
35. Ward ZJ, Long MW, Resch SC, Giles CM, Cradock AL, Gortmaker SL. 2015. https://www.cdc.gov/nchs/data/databriefs/db288_table.
Simulation of growth trajectories of childhood obesity into adulthood. pdf#1. Accessed July 13, 2019.
N Engl J Med. 2017;377(22):2145-2153. https://doi.org/10.1056/ 45. Isong IA, Rao SR, Bind M-A, Avendaño M, Kawachi I, Richmond TK.
NEJMoa1703860. Racial and ethnic disparities in early childhood obesity. Pediatrics. 2018;
36. Kerr JA, Long C, Clifford SA, et al. Early-life exposures predicting 141(1):e20170865. https://doi.org/10.1542/peds.2017-0865.
onset and resolution of childhood overweight or obesity. Arch Dis
Child. 2017;102(10):915-922. https://doi.org/10.1136/archdischild-
2016-311568.
37. Barr SI, McCarron DA, Heaney RP, et al. Effects of increased con-
sumption of fluid milk on energy and nutrient intake, body weight, How to cite this article: White MJ, Armstrong SC, Kay MC,
and cardiovascular risk factors in healthy older adults. J Am Diet Perrin EM, Skinner A. Associations between milk fat content
Assoc. 2000;100(7):810-817. https://doi.org/10.1016/S0002-8223 and obesity, 1999 to 2016. Pediatric Obesity. 2020;e12612.
(00)00236-4.
https://doi.org/10.1111/ijpo.12612
38. Vien S, Luhovyy BL, Patel BP, et al. Pre- and within-meal effects of
fluid dairy products on appetite, food intake, glycemia, and regulatory