Drug

ANTIBIOTICS
amikcin
Aciclovir

ceftazidime

ceftriaxone

ciprofloxacin

gentamicin

imipenem & cilastatin

levofloxacin

linezolid

meropenem

pipracillin with
tazobactam
(tazocin)

Teicoplanin
(targocid)
tigecycline

Vancomycin

metronidazole
(flagyl)

ANTIFUNGALS
amphotericin B
(liposomal)

amphotericin B
(conventional)

caspofungin

voriconazole

Antiepeliptics
levetiracetam
(keppra)
diazepam

phenobarbital

phenytoin

electrolytes
KCL potassium
chloride

magnesium sulfate
calcium gluconate

Mixed
aminophylline

desferrioxamine
mesilate

heparin

iron sucrose
(venofer)

methyl prednisolone
sodium succinate
metoclopramide
(plasil)

ondansetron
(zofran)

omeprazole

phytomenadione
(vit K1)

tramadol

tranexamic acid
(cyclokapron)
Dose compatible IV fluid route of administration

7.5mg/kg q.12 hr N/S , G/W &hartmanns iv direct , iv infusion , im

treatment of herpes simplex in N/S,G/W/ Hartmanns intermittent iv infusion & via
immunocompromised pts. syringe pump
&varicella zoster& severe initial
genital herpes:(5mg\kg by iv
infusion q.8hrs , usually for 5
days.

1 g q. 8 hrs …to a miximum of N/S, G/W /hartmanns, Ringer iv injection , iv infusion , im (max.
3 g q. 12 hrs. dose 1g)

1 g q 12 hr…to a max. of 2g q. N/S,G/W. im, iv injection and infusion

12 hr .

200-400mg twice daily N/S , G/W iv infusion .

&hartmanns ,ringer
total daily dose of 3-5mg/kg N/S, G/W im, iv injection and infusion

for sever infections(500mg q. N/S, g/w iv infusion.

6hrs)to a max. of 1 g q. 6-8 hrs
(for life threatening infections)

500 mg once or twice daily . N/S, G/W. iv infusion only!!

600mg twice daily for 10-14 N/S, G/W, Hartmanns, iv infusion

days ringer .

in sever infections 1 g iv q. 8 N/S, G/W iv inj, iv infusion

hrs.

2.25-4.5 g every 6-8 hrs . N/S, G/W ,WFI iv inj & infusion.

for severe infections (400 mg iv N/S,G/W, Hartmanns, also iv inj. ,iv infusion, im .,continuous
inj, or infusion q. 12 hrs for 3 peritoneal dialysis containing ambulatory peritoneal dialysis..
doses followed by 400mg daily glucose 1.36% or 3.86
either im or iv inj or iv
infusion )for pts whose wt.
more than 85 kg (dose
6mg/kg).in some cases (severe
burns, endocarditis, doses up
to 12mg/kg has been given )
initially 100 mg followed by 50 N/S, G/W iv infusion ..
mg every 12 hr. for 5-14 days

1 g iv infusion every 12 hrs. N/S, G/W/ Hartmanns. intermitant & continuous infusion

for anaerobic infections : 500 N/S ,G/W 5% iv infusion

mg iv infusion q. 8 hrs for 7
days (10 days if antibiotic-
assciated colitis)

3mg/kg to a max. of 5 mg/kg ONLY G/W!!! iv infusion only!!

0.250 mg/kg then increase G/W ONLY!!! iv infusion only!!

dose (if tolerated )to 1mg/kg .

70 mg iv infusion on 1st day N/S ,Hartmanns as iv infusion only!!

then 50 mg iv infusion once
daily.

loading dose 6mg/kg iv infusion N/S ,G/W, Hartmanns just intravenous infusion
every 12 hrs for 2 doses . ..
Maintenance 4mg/kg q.12 hr

monotherapy for partial N/S, G/W , Hartmanns iv infusion only!!

seizures (initially 250 mg iv
infusion twice daily (increased
according to response q. 2
weeks)
status epilepticus(10mg by N/S, G/W iv injection,,continuous iv infusion
slow iv injection,repeated if
necessary after 10 mins. Once
seizure is
controlled ,recurrence may be
prevented by slow iv infusion
(max total dose 3mg/kg over
24 hrs )reduce dose on
prolonged use to avoid cns
depression

for status epilepticus: 10mg/kg N/S, G/W /hartmanns, Ringer iv inj +im(avoid if possible,
iv inj. Up to max. 1g. Up to 30 , WFI absorption delayed & injection
mins may be required for site reactions are likely)
maximum effect.
for status epilepticus :loading N/S im (not recommended ), iv inj, iv
dose (in pts not on infusion .
oral )18mg/kg by slow iv inj. Or
infusion . Maintenance:(up to
100 mg every 6-8hrs,& adjust
according to plasma levels.

for sever hypokalemia (less N/S, G/W, Hartmanns, continuous iv infusion

than 2.5 mmol/L): 20-40 mmol ringer .
by iv infusion at a max. rate of
20mmol/hr ...for acute
deficiency ,a single dose of 20-
40 mmol iv infusion over 6-8
hrs may be enough .

for symptomatic N/S, G/W iv infusion (preferred), iv inj. , im

hypomagnesaemia (1-2
mmol/kg by iv infusion . Up to a
total of 160 mmol may be
reqiured over 5 days). Other
regimen is to give 0.5 mmol /kg
iv infusion on day 1 ,then 0.25
mmol/kg on days 2-5.
for acute hypocalcaemia(2.25 N/S , G/W &hartmanns iv injection, iv infusion
mmol 10 ml of 10% ) by slow iv
injection.in tetany this is
followed by 9 mmol(40 ml of
10%injection)in 500 ml over 8-
24 hr with monitoring serum CA
. Or as an alternative giving
22.5 mmol ca (100ml of
10%inj.)in 1 L ,at initial rate of
50ml/hr.

250-500 mg(5 mg/kg)IBW. As a N/S , G/W &hartmanns im, but not recommended !!..iv
laoding dose , for at least 20 via a syringe pump or iv infusion .
mins with close monitoring then
maintenance infusion (for
normal pt. 5mg/kg IBW /hr)

for acute iron poisoning (15mg\ N/S, G/W, WFI iv injection, iv infusion ,
kg\hr by continuous iv im ,sc ,intraperitoneal .
infusion ,reduced after 4-
6hrs ,max . Dose is 80mg\kg in
24 hrs. *chronic iron
overload (20-60mg/kg/day)

for prophylaxis of VTE(5000 N/S IV infusion (syringe pump) , sc ,

unit q. 8-12hr) , for general iv inj.
surgery with high risk of VTE
(5000ui 2 hrs pre-operative &
then q.8-12 hrs till the pt. is
mobile…. Treatment(by iv
infusion) (5000 ui iv (for PE
10000ui)followed by 18
unit/kg/hr infusion adjusting to
APTT ratio.

standard dose(100-200mg iv N/S iv inj. ,iv infusion

inj. Or infusion 2-3 times a
week ) , dose calculation
for IDA :total dose required(mg
iron)=(body weight (kg)*(target
HB -actual HB)*2.4)+500

for acute graft rejection N/S, G/W, Hartmanns. im, iv inj.(up to 250 mg only), iv
reactions(1 g daily for up to 3 infusion
days)
for N & V with cytotoxic N/S, G/W/ Hartmanns, ringer im, iv inj, iv infusion (both
chemotherapy : (2-4 mg/kg by intermitant & continuous)
iv infusion bef.chemotherapy
followed by continuous infusion
of 3-5mg/kg over 8-12hrs . Or
alternatively give up to 2 mg/kg
iv infusion bef. Starting chemo
and repeat q. 2hrs as
necessary. Max dose (10
mg/kg in 24hrs)

for chemothrapy N&V (8 mg im N/S, G/W/ Hartmanns, ringer IM, IV inj& infusion
or iv inj. Immediately before
treatment.
prophylaxis (40 mg iv inj.),,, for N/S , G/W iv inj., iv infusion (intermittent &
gastrointestinal hemorrhage continuous)
(80 mg iv inj. Followed by
continuous infusion of 8mg/hr
for 72 hrs)

as an antidote to warfarin N/S , G/W iv inj, iv infusion

(major bleeding): stop warfarin .
Give k1 5-10mg by slow iv inj.
Larger doses of up to 40 mg in
24hrs have been given .if
anticoagulation is needed after
overdosage of vit k1 , heparin
may be used).

for pain (50-100mg im or iv inj. N/S,G/W,Hartmanns im, iv inj. Iv infusion(continuous &

Every 4-6hrs). For Post intermitant)
operative pain (100mg initially
then 50 mg every 10-
20minwhen needed during the
first hr(to a max. total 250 mg
including initial dose ,then 50-
100 mg q. 4-6 to max 600mg
daily)

for local fibrinolysis 500mg-1g N/S, G/W / Ringer iv inj. & infusion
by iv inj. Three times daily .if iv
treatment is likely to be
required for more than 3
days ,25-50mg/kg /day may be
given by continuous iv
infusion .
preparation and administration notes

dilute in 100ml N/S and give in about 30 mins.need dosage adjusment in renal impairment.
reconstitute each 250mg vial with 10ml WFI pt should be adequately hydrated bef.
to make a solution of 25mg/ml .doses less Taking aciclovir.
than 500mg should be diluted in 100 ml N/S ;
doses >500 diluted in 250 ml and give by iv
infusion over a minimum of 1hr.

reconstitute with 10 ml then dilute in 100 ml only third generation cephalosporin used
of a compatible fluid. in treatment of pseudomonas spp.

reconstitue 1 g vial with 10ml d.w then add to it is incompatible with CA containing
50-100ml of fluid. Then infuse over at least solutions (hartmanns, ringer).
30 mins.
given over 30 mins for 200mg ..

dilute the required dose in 100 ml ..
reconstitute each 500 mg vial in 10 ml nacl
then add to 100ml .dose of 1 g should be
given over 40-60 mins.
nephrotoxic and ototoxic drug with high
rate of resistance.
could provoke seizures . Need dosage
adjusment in renal impairment.

given over at least 60 min. for 500 mg vial avoid in pts with history of tendinitis or
epilepsy or pregnant or breast feeding
women.
given over 30-120mins. require adjusment in renal impairment .
And if platelet count drops on a dose of
600 mg twice daily,consider reducing to
600 once.
each 1 g vial should be reconstituted with 20 in meningitis the dose could be 2g iv q.8
ml and diluted in 100-200 ml and infused hrs.
over 15-30 min .
reconstitute each 2.25 vial with 10ml WFI OR generic tazocin must not be mixed or co-
N/S and give (if iv injection over at least 3-5 administered with any aminoglycoside ,
min) &( if infusion dilute in 50-100 ml of and must not be reconstituted or diluted
compatible fluid and give over 20-30 min) with hartmanns.!!

reconstitute so to make a solution contains

400mg \3ml ,then dilute with 100 ml of fluid
and give over 30 min.
reconstitute each vial with 5.3 ml to make a require dosage adjusment in hepatic
solution contains 10mg /ml, then add to 100 impairment(according to child-pugh
ml for dilution and give over 30-60min. C)reduce to 25 mg every 12 hrs after the
100mg loading dose.
reconstitute each 1 g vial with 20 ml WFI to vancomycin could be administered orally
give a solution containing 50mg/ml .then in case of (antibiotic associated pseudo-
dilute in 200 ml of compatible fluid as a membranous colitis ,dose(125 mg orally
minimum and give by iv infusion over a q.6 hrs up to 2 g/day in sever cases
minimum of 2 hrs at a max. rate of 10mg/min (usually for 7-10 days ).
,to reduce risk of red man syndrome … for
continuous infusion give the total daily dose
over 24 hrs.

give by iv infusion at a rate of about 5ml/min it is incompatible with G/W10% and

(500mg over 20min) Hartmanns

each vial of 50 mg amphotericin should be it can cuase infusion related reactions so

reconstituted with ( water for injection)12 ml
and shake very well ,then after reconstituting
the whole dose for a patient (i.e 250mg)
should be filtered by a specific filter then add
to a 500 ml G/W solution .
should be preceeded by (h.c, allermin
and paracetol 1g).. It is not light
sensitive .

should dilute the vial with 10 ml(water for
injection)and shake immediately to make a
solution of (5mg/ml) then make the dilution in
a G/W pint to make a solu. Of
(10mg/100ml)or less.
it can cuase infusion related reactions so
should be preceeded by (h.c, allermin
and paracetol 1g).. It is light sensitive
and should be protected from light ..

reconstitute the vial with 10.8 or (10.5)water require dosage adjusment in hepatic
for injection to make a clear solution of 5 impairment (according to child- pugh
mg/ml then add to 250 ml of Nacl 0.9%then score).. 50 and 35 doses
give by infusion over 1-2 hrs. (not 70) could be diluted in 100 ml in fluid
restricted pts.

reconstitute with 19ml WFI to give a solution it has high oral bioavailability (96%) so
of 10mg/ml then add to a suitable volume of switch to oral as soon as possible .
fluid to give a solution containing 0.5-5 mg/ml
and give by iv infusion at a max. rate of
3mg/kg over 1-2 hrs.

diluted in at least 100 ml of N/S and given require dosage adjusment in renal
over 15 min. impairment.
for continuous infusion ,each 10mg should
be added to at least 200ml . For direct
injection should be given slow (max rate
5mg\min)

dilute each 1ml in 10ml WFI and give by iv

injection at a rate of not more than
100mg/min

for iv injection(give by slow iv inj, into a large the line should be flushed with Nacl
vein ,at a max. rate of 25mg/min (to avoid before & after administration to reduce
decreased BP) &the rate should be reduced risk of irritation since phynytoin is highly
in higher risk pts to 5-10 mg/min alkaline!!
(elderly ,heart disease, low wight)…. For
infusion : (the dose is diluted in 50-100 ml
N/S (max concentration 10mg/ml). give by iv
infusion using volumetric infusion device
&also the rate should not be more than
25mg/min )

given at a maximum rate of 10-20 mmol/hr.. normal range of K is 3.5-5 mmol/L .and
20 &40 mmol in NACL OR G/W in 500 ml KCL must (not) be injected undiluted as
and 1 L solutions. For more concentrated instant death may occur !!!..
solutions may be used in 100 ml of fluid.

the resulting solution should contain a max. each 50% vial contains 0.5 g /ml MG and
of 0.4 mmol/ml and given over 4-8 mmol/hr. 2mmol/ml
dilute in 500-1000 ml of a compatible iv fluid . each 10%ca gluconate inj. Contains: 225
The injection directly should be given over a micromol/ml (ca 8.4 mg/ml)…..
minimum of 3 mins!..
for 20min. Via a syringe pump & the rate
should never exceed 25mg/min(150ml /hr).
For infusion ,should be diluted in 500 mg of a
compalible fluid to make a solution of 1mg/ml
each 500mg vial dissolved in 5ml(wfi) to
make 10% solution .should be given at a rate
not exceeding 15mg/kg/hr reducing to
5mg/kg/hr
dilute into 50 ml N/S (diluted solu. Must
always be inverted at least 6 times during
mixing to insure thorough distribution of
drug).
vial of 100 mg is diluted in 50-100 ml& 200
mg to 100-200ml .200 mg is given over at
least 30 mins.
diluted in compatible fluid in 100-250ml and
given by iv infusion over a minimum of 30
mins.
Ca salts are irritant ad may
cause tissue necrosis & sloughing if given
IM or SC ,and when given IV should be
given with care to avoid extravasation!.
aciclovir,azithromycin,
allopurinol ,CCB,ciprodar,fluconazole all
may increase theophylline level&
increase its side effects.
it can also chelate aluminuim to reduce
overload in pts with end stage renal
failure .(100 mg desferrioxamine could
chelate 8.5 mg of ferric iron ,and 4.1 of
aluminuim.
test dose(in first use only): give 25 mg by
iv infusion over 15 min. stop infusion and
observe pt carefully for signs of allergic
reaction , if none give the remainder of
infusion.
for intermitant (in cytotoxic chemotherapy
only) : add to 50 ml of compatible fluid and
give by iv infusion over at least 15 min.. For
continuous (diluted in 500 ml of fluid then
given over 8-12hrs)
it may be given (unlicnesed)by S.C
infusion in palliative care to treat N&V
and also to treat hiccups due to gastric
distension.

add to 50-100 ml of fluid and give by iv could be given as continuous infusion for
infusion over at least 15min. up to 24 hrs.

reconstitute each vial by adding 5 ml of fluid

then add to 500ml(if 5 vials) then give by iv
infusion at a rate of 8mg/hr (20ml /hr).

add the dose to 50 ml of fluid and give by iv absorption is irregular if given im and
infusion over 15-30 min. there is a risk of hematoma!!

for iv injection give at a rate of 1ml/min caution in hematuria(clots formed in renal

(100mg/min). .. For continuous infusion give system can lead to obstructive renal
at a dose of 25 -50 mg/kg/day . impairment). Do not give if there is a
history of thromboembolic disease .