Nucleus Chromatin Nitrogenous Bases Complementarity Clinical Relevance

Purines Adenine A T 2 Hydrogen Bonds

Hodgman Guanine Drug-Induced Lupus

%
G C 3 Hydrogen Bonds
weak bonds
Cytosine
Nucleoplasm
⑧
Pyrimidines Uracil (RNA) L R " Sulfonamides
• ⑧ Thymine
H OH
3’
Hydralazine
Nuclear Envelope
op

O A
• Chromosome T Anti-Histone INH
Pentose Sugars Anti-Parallel
Antibodies Procainamide
B Dino
Sugar O Arrangement
Nuclear Pores Phosphate Phenytoin
• •
Backbone
OH H •
L R
5 CH2 5 CH2 5’ 3’ 3’ 5’
• , O O
DO

4 1 4 1 O T H OH
N N Phosphodiester
Bond A
DNA Histone Loopy
3 2 3 2 Huntington’s Disease
+ + + OH OH
Nuclear Envelope +
+ +
Continuous
Fiber
OH H STRONG BOND OH H
O
+ Deaceytlation Transcription
•

Ribose Deoxyribose 5’ 3’
Outer Membrane + + : Tight OH
•

O G
+ + Helical H OH +
Ribosomes + + + :
Fibers C Neuron
Inner Membrane Octamer Phosphate Group OH H ngf
Injury/Death
Nucleosome
O
Lamins H2 A (2)
Basal Ganglia
H H2 B (2) O - charged •
•

BOBA
•

H 3 (2) O C
- Linker Protein - O—P—O - 5 H OH
Nuclear Pores - +++++++++++ H 4 (2) Boo
bonds to G Hyperkinetic
(Charge) Lysine ++++ :
O : 5th carbon 3 Movement
Out mRNA Arginine ++++ OH H O Disorder
•
Boso 5’
In Nucleotides Nucleoside Purine/Pyrimidine Synthesis Inhibitors
Epigenetics •

OH
•
Double Helix
Nucleoplasm Modify DNA CH2
O
Anticancer Drugs/Antibiotics/Antivirals/
CPG
cgcgcg Islands - gene Antiparasitic/Immunosuppressants
transcription
Nucleolus CH 3 CH 3 Nitrogenous
- Purine Synthesis
rRNA Synthesis OH H Base Minor Groove 6MP, Azathioprine, Ribavirin,
Modify Histones Major
Subunits (proteins) Pentose Groove Mycophenolate
Dactinomycin
Ribosomes Deacetylase - Pyrimidine Synthesis
- DNA Replication MTX, TMP, Pyrmethamine
Chromatin - Acetyl
CH 3
Histones CH Sugar3 Nucleotide - Purine/Pyrimidine Synthesis
2-3 CH Phosphate3

DNA Backbone
Hydroxyurea
•
•
10 Nucleotides/Turn
+ CH2
O
Heterochromatin - Transcription Nitrogenous
Acetyl Bases
Highly Condensed
-0%
No Transcription Transcription owe OH H
Euchromatin + Nucleotide ☒Bo•BB•
Loose Chromatin →Byo€§%$ OH
Transcription Nucleic OH
•

Acid PO4 3 -
Cell Replication Chromosomes

Cell Biology | DNA Structure & Organization A '

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