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Archives of Physical Medicine and Rehabilitation

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Archives of Physical Medicine and Rehabilitation 2020;101:1780-8

ORIGINAL RESEARCH

The Effect of Proprioceptive Exercises on Balance and


Physical Function in Institutionalized Older Adults: A
Randomized Controlled Trial
Luis Espejo-Antúnez, PhD,a José Manuel Pérez-Mármol, PhD,b
M. de los Ángeles Cardero-Durán, PhD,c José Vicente Toledo-Marhuenda, PhD,d
Manuel Albornoz-Cabello, PhDe
From the aDepartment of Medical-Surgical Therapy, Medicine Faculty, Extremadura University, Badajoz; bDepartment of Physiotherapy, Faculty
of Health Sciences, University of Granada, Granada; cPuente Real II Healthcare Center, Avda. Federico Mayor Zaragoza, Badajoz; dDepartment
of Pathology and Surgery, Area of Physiotherapy, Medicine Faculty, Miguel Hernández University, Alicante; and eDepartment of Physiotherapy,
University of Sevilla, Sevilla, Spain.

Abstract
Objectives: To evaluate the efficacy of a proprioceptive exercise program on functional mobility, musculoskeletal endurance, dynamic and static
balance, gait, and risk of falls in institutionalized older adults.
Design: Randomized, single-blind, controlled trial.
Setting: A Spanish nursing home in the autonomous community of Extremadura, Spain.
Participants: An initial sample was created by recruiting 148 older adult volunteers. The final sample (NZ42) was randomly divided into 2
groups.
Interventions: Both the control and experimental group received physical therapy treatment based on a combination of adapted exercises and
other physical therapy techniques (physical therapy intervention program) for a period of 12 weeks. This program consisted of 45 minutes (group
intervention) plus 100 minutes (individual intervention) a week, for a total of 36 sessions (29 hours). The experimental group received a
proprioceptive training program during the same intervention period, which was conducted twice weekly (24 sessions), with each session lasting
55 minutes.
Main Outcome Measures: Timed Up and Go (TUG), Cooper, Tinetti, 1-leg stance, and the Morse Fall Scale (MFS).
Results: Analysis of variance showed a time  group interaction in TUG score (FZ10.41, PZ.002), Cooper test (FZ5.94, PZ.019), Tinetti
score (FZ6.41, PZ.015), and MFS scores (FZ5.24, PZ.028). Differences between groups were achieved for TUG scores (dZ0.76), Tinetti
scores (dZ1.12), 1-leg stance test scores (dZ0.77), and MFS scale scores (dZ0.85). In the experimental group, within-group analyses
showed pre- to post-treatment differences for TUG scores (dZ0.72), Cooper test scores in meters (dZ0.18), Tinetti scores (dZ0.60), 1-leg stance
scores (dZ0.55), and MFS scores (dZ0.42).
Conclusions: A proprioceptive exercise program demonstrated significant improvements compared with the control group in areas such as
functional mobility, musculoskeletal endurance, balance, gait, and risk of falls in institutionalized older adults. This study may help to enhance our
understanding of the impact of a specific protocol for a proprioceptive rehabilitation program.
Archives of Physical Medicine and Rehabilitation 2020;101:1780-8
ª 2020 by the American Congress of Rehabilitation Medicine

Aging is defined as a natural process characterized by structural factors, such as inactivity.1 The worldwide population is
and functional changes that can be accelerated by disease or other progressively aging, which is commonly associated with a
deterioration of physical health, functional performance, and
Disclosures: none.
autonomy.2 Functional impairments may be associated with al-
Clinical Trial Registration No.: NCT02541305. terations in balance and are an important predictive factor in

0003-9993/20/$36 - see front matter ª 2020 by the American Congress of Rehabilitation Medicine
https://doi.org/10.1016/j.apmr.2020.06.010
Proprioceptive exercises in older adults 1781

various health conditions.3 Approximately one-third of adults body functions.13,18 Nevertheless, to our knowledge, research on
aged 65 years and older experience a fall at least once a year.4 the independent effects of proprioceptive exercises on functions
Moreover, people who have fallen once are at a higher risk of such as general mobility, balance, and gait, or on the risk of falls in
falling again, increasing the healthcare costs of national health institutionalized older adults remains inadequate. Findings in this
systems in several countries.5,6 Low levels of physical exercise are specific area of rehabilitation are needed to provide clinical
associated with poor postural control, which is another major knowledge for the appropriate design and planning of physical
factor linked to an increased risk of falling. Hence, physical exercise interventions in this population.
decline in terms of balance, postural control, and gait typically The main objective of this randomized controlled trial was to
lead to the institutionalization of older individuals, increasing the evaluate the efficacy of a proprioceptive exercise program on
demand for long-term care.1-6 functional mobility, musculoskeletal endurance, dynamic and
Health care centers belonging to private and public health static balance, gait, and the risk of falls compared with a control
systems usually provide assistance to older adults in residential group in institutionalized older adults.
care facilities, hospitals, or nursing homes.7 Long-term residential
care is increasingly in demand once the patient is discharged
from hospital and before they are able to return to a community Methods
setting.8 Therefore, prevention plans and health promotion
schemes for older adults have become increasingly important in Design
recent decades, while reducing age-related disability has become
an essential public health goal.9 Previous literature provides This study was a randomized, single-blind, controlled trial. This
evidence of rehabilitation programs using therapeutic physical trial was registered on ClinicalTrials.gov (NCT no.: 02541305).
exercises in the recovery process of common disorders in older CONSORT statements were used to conduct and report the trial.
people.10,11 Various therapeutic approaches have shown their
efficacy in improving health and functional movement in older Participants
adults.6,12,13
Proprioception is defined as “.the perception of joint and An initial sample was created by recruiting 148 older adult
body movement as well as position of the body, or body segments, volunteers from a Spanish nursing home. Convenience sampling
in space,”14 whereas kinesthetic sense is defined as “the sense of was used for recruitment (ie, any participants who were qualified
position and movement of our limbs.”15(p1) Although proprio- for the trial were accepted). The final sample (NZ42) was
ception and kinesthesia are involved in maintaining position, randomly divided into control and experimental groups, each
balance, and movements when the eyes are both opened and comprising 21 participants. The control group (15 women, 6 men)
closed, these functions must be evaluated and trained with the eyes received only a physical therapy intervention program. The
closed. Proprioceptive exercises performed with the eyes closed experimental group (14 women, 7 men) participated in the
reinforce the information sent and processed by the central ner- physical therapy program plus a proprioceptive training program.
vous system. The reception (on a sensory and perceptual level) Figure 1 depicts a flowchart of participant recruitment during
and processing of this information in older adults may be altered. the study.
If physical therapists stimulate these functions through exercises The inclusion criteria were (1) adults older than 65 years old,
with closed eyes and actively direct attention toward body posi- (2) who were living in an institutionalized setting, (3) who were
tions and movements, the synaptic system that organizes this in- participating voluntarily in the study, (4) who had experienced a
formation at the neuronal level may specifically be stimulated. In fall in the past year (documented by the medical staff of the center
addition, these exercises likely integrate the proprioceptive inputs in the 12 months before the inclusion of the participant in the
with other balance components such as the vestibular system (the study), and (5) who had a physician’s prescription that the reha-
inner ear), the body scheme (cognitive), base of support, body bilitation intervention would be appropriate and potentially
(trunk) symmetry, trunk sway, and the center of gravity. In line beneficial. The exclusion criteria were (1) patients with cognitive
with this, although proprioception is an essential aspect of bal- decline (score 24 in the official Spanish version of the Mini-
ance, proprioceptive exercises may specifically be used to improve Mental Status Examination for older adults)19 or those unable to
proprioceptive and kinesthetic integration in the brain, that is, the understand or take part in the measurement process, (2) patients
increase of synaptic connections for the perception of static and unable to tolerate moderate physical activity owing to cardiovas-
dynamic positions in space.16,17 cular or respiratory illness, (3) patients with disorders affecting
The lack of scientific evidence and conclusions on the efficacy balance different from those caused by aging such as dizziness or
of physical rehabilitation on health variables has led to a wide vestibular disorders that require medication with a potential effect
variety of different experimental protocols.6 For example, car- on balance, as well as balance disorders secondary to taking any
diovascular training or exercises to enhance strength, flexibility, medication or other medical causes, and (4) patients with a high
and balance have been shown to significantly improve physical risk of falls (51 points on the Morse Fall Scale [MFS]).
and mental health, as well as having positive effects on various The Ethics Research Committee from the University of
Extremadura (Spain) approved the study protocol (approval no.:
17//2013). This protocol complied with all the principles of the
List of abbreviations: Declaration of Helsinki as amended in 2013.
MDC95 minimum detectable change at the 95%
confidence level
MFS Morse Fall Scale Randomization
OLS 1-leg stance
Participants were randomly allocated to the experimental or
TUG timed Up and Go
control groups. The randomization was performed by asking the

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1782 L. Espejo-Antúnez et al

Fig 1 Flow diagram of patient recruitment following CONSORT guidelines.

participant to pick a number out of an envelope. A researcher Physical therapy intervention program (control group)
aware of the study design conducted enrollment and group This program was based on a multicomponent physical therapy
assignment. The primary outcome measure was the timed Up and intervention with a combination of exercises adapted to older
Go (TUG) test. Participants from both groups were assessed both adults (in-group) and other physical therapy techniques (individ-
at the beginning of the first session (baseline evaluation) and after ually). In previous studies, multicomponent physical therapy
the last session (post-treatment evaluation). The researcher protocols have been used as control groups (standard package) to
conducting the evaluations was blinded to the group assignment evaluate the impacts of different novel physical therapy in-
and allocation. terventions in various older adult populations.21,22 The standard
physical therapy services provided in nursing homes, aged care
facilities, and other related services in Spain are based on
Interventions providing these multifaceted interventions,23 which are similar to
The interventions were conducted at the Puente Real II nursing the physical therapy protocol used in the previous studies.21,22
home in the city of Badajoz, in the autonomous community of The physical exercise was divided into different sections that
Extremadura, Spain (supplemental appendix S1, available online were performed in the following order: warm-up, general mobility
only at http://www.archives-pmr.org/). Both the control and exercises in sitting and standing positions, games, stretching, and
experimental groups received physical therapy treatment based on return to rest. Exercise sessions were performed once a week
a combination of adapted exercises and other physical therapy (Monday) for a duration of 45 minutes per session.24,25 Individ-
techniques. The experimental group also underwent a proprio- ually, participants from the control group received infrared
ceptive training program during the same 12-week intervention thermotherapy, neuromuscular electrical stimulation, and manual
period. The interventions were supervised by 2 physical therapists therapy across a range of motion exercises on the spine and upper
with more than 10 years of experience with older adults. An and lower limbs twice a week (Wednesday and Friday) for a
adherence rate to the interventions of 75% was established as a duration of 50 minutes per session.24,25 Hence, the control group
minimum for participants to be included in the final analysis.20 had 45 minutes of group intervention plus 100 minutes of

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Proprioceptive exercises in older adults 1783

individual intervention each week, with a total of 36 sessions intervention program of the control group, the experimental group
(29h) (see supplemental appendix S1). participated in a proprioceptive training rehabilitation program 2
days per week (Tuesday and Thursday), for a total of 24 sessions
Physical therapy intervention program and proprioceptive (22h) during the same 12-week period. Each exercise session had
exercise program (experimental group) a duration of 55 minutes with 3 phases: 15 minutes of warm-up
Both the experimental group and the control group received the with slow walking, mobility, and stretching exercises, followed by
physical therapy intervention program. Although it was conducted a 30-minute proprioceptive exercise program, and 10 minutes to
on Monday, Wednesday, and Friday (at the same time) for both cool down using muscle stretches and relaxation exercises
groups, the therapy was administered in different rooms for each (see supplemental appendix S1; fig 2).23 Because only the
group to avoid any possible risk of contamination between them in experimental group participated in a proprioceptive training
the institutional setting. In addition to the physical therapy rehabilitation program during the same 12-week period, the

Fig 2 Images of the proprioceptive therapeutic exercises illustrating the proprioceptive program protocol (main phaseeproprioceptive exercise
session).

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1784 L. Espejo-Antúnez et al

participants from both groups were encouraged not to discuss the of 42. This calculation showed that a sample size of 21 participants
intervention outside their cohort. per group was needed for a confidence interval of 95%, with a power
of 80%, assuming a bilateral significance of .05.
Outcome measures
All instruments were applied in a single day for each participant
and the times for baseline and post-treatment testing were
Results
consistent for each individual participant. The rater was blinded to Of the 45 older adults who volunteered to participate in the study,
group allocation and was the same researcher who collected the 3 did not meet the inclusion criteria. There were no significant
baseline clinical data. Demographic, anthropometric, and clinical baseline differences between the treatment groups in any of the
data were collected using a self-assessment questionnaire devel- sociodemographic or clinical characteristics (P.05 for all
oped for this study. The primary outcome was functional mobility comparisons). Sociodemographic and clinical characteristics at
measured by the TUG test,26,27 exhibiting an SEM of 1.27 seconds baseline are shown in table 1. There were no differences between
for the current sample study, and a minimum detectable change at groups (proprioceptive training program vs control group) in the
the 95% confidence level (MDC95) of 3.12 seconds. The sec- outcome measures at baseline (table 2).
ondary outcome measures were as follows: Cooper test,28 showing The 22 mixed analysis of variance revealed a time  group
an SEM of 2.14 minutes and an MDC95 of 4.01 minutes; Tinetti interaction for TUG (FZ10.41, PZ.002), Cooper test (FZ5.94,
scale,29,30 with an SEM of 0.41 points and an MDC95 of 1.79 PZ.019), Tinetti (FZ6.41, PZ.015), and MFS scores
points; 1-leg stance (OLS) test,30,31 with an SEM of 2.03 points (FZ5.241, PZ.028). The post hoc analyses showed significant
and an MDC95 of 3.96 s; and MFS,32 showing an SEM of 1.11 differences between the experimental and control groups post-
seconds and an MDC95 of 2.92 seconds. For a more extended treatment for mean scores of TUG (mean experimental, 15.74;
instrument description, please see supplemental appendix S1. mean control, 22.50; Cohen’s d, 0.76), Tinetti scores (mean
experimental, 23.05; mean control, 19.88; Cohen’s d, 1.12), mean
Statistical analysis scores of OLS (mean experimental, 25.15; mean control, 15.42;
Cohen’s d, 0.77), and mean MFS scores (mean experimental,
Data analysis was performed using SPSS version 20.0.a A 13.00; mean control, 25.57; Cohen’s d, 0.85). Pre- and post-
descriptive analysis was performed for each of the variables. The treatment means, SD, and differences between groups are
normality of the variables was evaluated using the Shapiro-Wilk shown in table 2.
test, which showed a normal distribution for all the variables In the experimental group, within-group analyses showed pre-
and, thus, parametric tests were appropriate. Data were reported as to post-treatment differences for TUG scores (mean pretreatment,
mean  SD. The demographic and clinical variables of the groups 20.68; mean post-treatment, 15.74; Cohen’s d, 0.72),
at baseline were compared using the chi-square test for categorical Cooper scores in meters (mean pretreatment, 416.79; mean post-
data and the independent-samples t test for quantitative data. A 2- treatment, 449.42; Cohen’s d, 0.18), Tinetti scores (mean
way repeated measure analysis of variance was performed to pretreatment, 21.47; mean post-treatment, 23.05; Cohen’s d,
analyze the interaction effects of time (at baseline and 3mo post- 0.60), OLS scores (mean pretreatment, 17.94; mean post-
treatment) in the 2 intervention groups (experimental and control treatment, 25.15; Cohen’s d, 0.55), and MFS scores (mean pre-
group). The independent and paired-samples t tests were used for treatment, 19.10; mean post-treatment, 13.00; Cohen’s d, 0.42).
comparisons between and within groups, respectively. The effect However, in the control group, within-group differences were not
size for between-group and within-group mean differences was achieved (P>.05), except for Cooper test scores with a decline in
calculated using Cohen’s d coefficient. A significance level of musculoskeletal endurance. Pre- and postintervention means,
P<.05 was used. SDs, and differences for each group are shown in table 2.

Sample size estimation


G*power 3.1 softwareb was used to calculate the sample size
Discussion
required to detect changes in the primary outcome (TUG test). The objective of this study was to evaluate the efficacy of a
Assuming an effect size (F-test) of 0.4 for between-group differ- proprioceptive exercise program on physical performance factors
ences, an alpha level of .05, and power of 80%, a total sample size of such as functional mobility, musculoskeletal endurance, dynamic
40 participants was estimated. The sample was inflated by 5% to and static balance, gait, and the risk of falls in institutionalized
account for potential dropouts, resulting in a final target sample size older adults. The proprioceptive exercise program combined

Table 1 Sociodemographic and clinical characteristics of the study participants


Experimental Control
Group (nZ21), Group (nZ21),
Sociodemographic and Clinical Characteristics Mean  SD or n (%) Mean  SD or n (%)
Age, y 83.216.59 82.726.40
Sex (male/female) 7 (33.30)/14 (66.70) 6 (28.60)/15 (71.40)
Weight, kg 69.136.72 71.25.83
Height, m 1.583.05 1.594.09
Body mass index, kg/m2 27.854.59 28.14.15

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Proprioceptive exercises in older adults


Table 2 Differences between groups pre- and post-treatment, and differences pre- to postintervention for each group
Differences Within 95% CI of the 95% CI of the
Group Difference Differences Difference
(Pre- to Between
Outcome Postintervention Lower Upper Groups (Pre- and Lower Upper
Measure Group Time Mean  SD in Each Group) Bound Bound P Value Cohen’s d Postintervention) Bound Bound P Value Cohen’s d
TUG, s Control Pre 22.1710.68 0.24 -2.58 2.10 .834 0.03 1.49 -6.79 3.93 .593 0.16
Post 22.5010.86 6.76 -11.76 -1.48 .013* 0.76
Experimental Pre 20.687.45 -4.95y 2.55 7.35 <.001z 0.72
Post 15.746.21
Cooper test, m Control Pre 405.11190.55 -45.91y -8.57 104.57 .009 0.25 11.68 114.23 115.28 .993 0.06
Post 359.24174.44 90.22 -25.87 183.20 .122 0.52
Experimental Pre 416.79194.98 32.63y 65.82 5.53 .024* 0.18
Post 449.42171.96
Tinetti scale, 0- Control Pre 20.722.80 -0.85 -0.11 1.38 .080 0.30 0.75 -0.98 2.22 .438 0.28
56 points Post 19.88 2.89 3.17 0.38 3.71 .017* 1.12
Experimental Pre 21.472.63 1.58 1.23 2.97 .041* 0.60
Post 23.052.76
OLS scale, s Control Pre 16.5513.58 -1.13 -4.69 12.64 .253 0.09 1.39 -1.82 14.58 .124 0.11
Post 15.42 12.01 9.73 3.43 21.33 .001z 0.77
Experimental Pre 17.9412.74 7.21y 2.06 13.79 .017* 0.55
Post 25.15 13.35
MFS, 0-125 Control Pre 26.3320.23 0.76 -6.50 8.02 .830 0.04 7.24 -19.05 4.57 .222 0.38
points Post 25.5719.07 12.57 -22.26 -2.88 .012* 0.85
Experimental Pre 19.1017.51 6.10y -0.02 12.21 .031* 0.42
Post 13.0010.89
* P<.05.
y
Exceeded the MDC95 for the measure.
z
P<.001: comparison between groups and pre-post-intervention for each group (proprioceptive exercises program vs control group).

1785
1786 L. Espejo-Antúnez et al

with a physical therapy intervention program demonstrated improved static balance when balance was assessed with the OLS
significantly higher improvements in all physical functions test.39,40 Several factors may account for the differences between
compared with the control group, except for postural steadiness. this study and the aforementioned clinical trials. The previous
The effect sizes for the between-group differences ranged from studies may have used samples with a lower or higher mean age,
moderate to high. In the experimental group, the magnitude of the interventions were not conducted individually as in this study,
postintervention improvements ranged from low to moderate. and the older adults included in these studies were not institu-
Although studies can be found in the literature on the effect of tionalized.39,40 Similarly, the optimization of posture control de-
rehabilitation interventions on these physical components in older pends not only on variables analyzed in a controlled situation, but
adults, to our knowledge, this is the first clinical trial to use a also on the integrated response during a specific task and other
specific proprioceptive program for a sample of institutionalized parameters such as sight, cognitive-spatial mapping, and
older adults. These findings may provide novel insights and muscle fatigue.39
practical information for professionals in the clinical and With regard to the risk of falls, significant between-group
research fields and may also help in designing and implementing differences and improvement after the experimental group
future rehabilitation sessions and additional studies in this intervention were obtained (6.10 points), which was above the
population. MDC95 for the current sample (2.92 points). Many different types
This study revealed a significant improvement in the primary of interventions have been conducted to prevent and reduce the
outcome (functional mobility) for the experimental group. After risk of falls.6 Giordano et al41 achieved a reduced incidence of
intervention, the mean difference between groups was 6.76 falls in older adults discharged from the hospital in a community
seconds in the TUG test, which was interpreted as significant in context after implementing a home telemanagement program. In
terms of the time to execute the test. Additionally, the pre-post addition, a systematic review performed by Cadore et al13 reported
differences in TUG scores after experimental intervention were that 7 trials demonstrated a lower incidence of falls after physical
higher than those reported by Kristensen et al26 in older adults training in comparison with a control group. However, although
(4.95s vs 1.8s), while also achieving the MDC95 established for there is evidence supporting the effect of multifactorial in-
the current sample (3.12s). Consistent with this finding, terventions on reducing the risk of falls, specific proprioceptive
musculoskeletal endurance, measured in total walking distance training programs for Spanish institutionalized older adults have
with the Cooper test, significantly improved after experimental not yet been implemented.6
intervention, with a mean difference of 32.63 meters compared
with pretreatment values, which was higher than the 4.01 meters
reported for the current sample as the MDC95. These findings may Study limitations
be the result of the movements included in the intensive The current study presents some limitations. First, the sample
proprioceptive training program. These movements were similar was recruited from a single institution and may not be suitable for
to those naturally inherent to the performance of the basic and extrapolation to other populations. Future studies should include
instrumental activities of daily living,33 which probably other contexts, such as retirement homes and outpatient hospital
reinforced the vestibular and proprioceptive systems, kinesthetic settings, to extrapolate the results to the overall population of
awareness, and attentional resources. These results are consistent older adults. Second, the long-term efficacy of the proprioceptive
with previous studies conducted with institutionalized older adult exercise program was not measured, which could be used to
population samples.13,34 However, these studies differed from the derive clinical implications from the study. Third, the assessors
present study. In this study, the selected sample was different who collected the data were blinded to the group allocation.
(institutionalized older adults), other outcome measures were However, it was not possible to conceal the group assignment
included, and the proprioceptive intervention program used was a from the researchers involved in the intervention. Fourth, the
specific protocol designed for this specific research outcome measures used did not specifically target improvements
(including different proprioceptive exercises compared with in proprioception, but the effect on standard measures is an
other studies). important finding. Although the study intervention protocol was
It is likely that the improvements in dynamic balance observed based on proprioceptive aspects, we focused on physical
after the proprioceptive program are owing to the fact that this functional improvements because these allow older adults to live
intervention addresses sensorimotor components and processes more independently. Proprioceptive and kinesthetic functions are
involved in balance. These components usually include proprio- directly involved in maintaining position, balance, and move-
ceptive and vestibular systems, body scheme, base of support, ments performed with and without visual inputs. Some
body symmetry, or trunk sway.35,36 Several studies have instruments for evaluating proprioception exist, but they are
concluded that proprioceptive training in older adults can enhance usually costly, the evidence regarding their validity is limited or
inter- and intramuscular coordination, enabling a correct dynamic unknown, and they normally evaluate proprioception of isolated
balance.37 Regarding postural steadiness as measured by the OLS joints. Finally, although participants were advised not to
test, although this is an essential component or phase of walking discuss the intervention outside their cohort, there is always some
patterns, the time  group interaction was not found to be sig- risk of contamination between the groups in an institu-
nificant. However, the results of our study reported a significant tional setting.
increase of 7.21 seconds from pre- to post-treatment for the single-
leg stance position in the experimental group, which was higher
than the MDC95 for the current sample of 3.96 seconds. These Conclusions
improvements were also greater than the clinically significant
improvement reported by Maribo et al38 (6.88s). Previous in- From a clinical perspective, the inclusion of proprioceptive
terventions based on several physical exercises significantly exercises in rehabilitation sessions twice a week for at least 12

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Proprioceptive exercises in older adults 1787

weeks has the potential to benefit functional mobility, musculo- 10. Pérez-Mármol JM, Garcı́a-Rı́os MC, Ortega-Valdivieso MA, et al.
skeletal endurance, and dynamic and static balance, gait, as well Effectiveness of a fine motor skills rehabilitation program on upper
as to reduce the risk of falls in institutionalized older adults. limb disability, manual dexterity, pinch strength, range of fingers
motion, performance in activities of daily living, functional indepen-
dency, and general self-efficacy in hand osteoarthritis: a randomized
clinical trial. J Hand Ther 2017;30:262-73.
Suppliers 11. Rogers MW, Tamulevicius N, Coetsee MF, Curry BF, Semple SJ.
Knee osteoarthritis and the efficacy of kinesthesia, balance & agility
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Keywords different exercise interventions on risk of falls, gait ability,
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Randomized Controlled Trial; Rehabilitation 14. Sherrington C. The integrative action of the nervous system. New
Haven: Yale University Press; 1906.
15. Allen TJ, Proske U. Effect of muscle fatigue on the sense of limb
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Corresponding author 16. Guerraz M, Provost S, Narison R, Brugnon A, Virolle S, Bresciani JP.
José Manuel Pérez-Mármol PhD, Department of Physiotherapy, Integration of visual and proprioceptive afferents in kinesthesia.
Neuroscience 2012;223:258-68.
Occupational Therapy, Faculty of Health Sciences, University of
17. El-Wishy A, Elsayed E. Effect of proprioceptive training program on
Granada, Av. de la Ilustración, 60, 18016 Granada, Spain. E- balance in patients with diabetic neuropathy: a controlled randomized
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